HUE052100T2 - Eljárás aktivált véralvadási faktor X (FXA) inhibitorának alõállítására - Google Patents
Eljárás aktivált véralvadási faktor X (FXA) inhibitorának alõállításáraInfo
- Publication number
- HUE052100T2 HUE052100T2 HUE15752746A HUE15752746A HUE052100T2 HU E052100 T2 HUE052100 T2 HU E052100T2 HU E15752746 A HUE15752746 A HU E15752746A HU E15752746 A HUE15752746 A HU E15752746A HU E052100 T2 HUE052100 T2 HU E052100T2
- Authority
- HU
- Hungary
- Prior art keywords
- fxa
- blood coagulation
- coagulation factor
- activated blood
- producing inhibitor
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014028266 | 2014-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE052100T2 true HUE052100T2 (hu) | 2021-04-28 |
Family
ID=53878215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE15752746A HUE052100T2 (hu) | 2014-02-18 | 2015-02-13 | Eljárás aktivált véralvadási faktor X (FXA) inhibitorának alõállítására |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9920071B2 (fr) |
| EP (1) | EP3109251B1 (fr) |
| JP (1) | JP6639381B2 (fr) |
| KR (1) | KR102371784B1 (fr) |
| CN (1) | CN106459087B (fr) |
| CA (1) | CA2940001C (fr) |
| ES (1) | ES2815352T3 (fr) |
| HU (1) | HUE052100T2 (fr) |
| WO (1) | WO2015125710A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105753888B (zh) * | 2016-04-05 | 2017-09-01 | 乐普药业股份有限公司 | 一种游离态依度沙班的制备方法 |
| US10301322B2 (en) | 2016-12-27 | 2019-05-28 | Apotex Inc. | Processes for the preparation of edoxaban and intermediates thereof |
| US10737774B2 (en) | 2018-01-05 | 2020-08-11 | Gopro, Inc. | Unmanned aerial vehicle propeller assembly |
| KR102087080B1 (ko) * | 2018-06-08 | 2020-03-10 | 주식회사 가피바이오 | 에독사반의 제조용 중간체의 제조 방법 및 에독사반의 제조 방법 |
| CN109942600B (zh) * | 2019-04-15 | 2021-08-20 | 内蒙古京东药业有限公司 | 一种依度沙班的制备方法 |
| KR102333564B1 (ko) * | 2019-11-28 | 2021-12-01 | 동방에프티엘(주) | 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로 |
| CN111393456B (zh) * | 2020-03-31 | 2022-07-12 | 内蒙古京东药业有限公司 | 一种由三氯乙酮鎓盐衍生物制备依度沙班的方法 |
| CN111763169B (zh) * | 2020-06-30 | 2023-06-27 | 浙江苏泊尔制药有限公司 | 一种改良的依度沙班中间体的制备方法 |
| CN111763222B (zh) * | 2020-08-03 | 2021-05-25 | 珠海市海瑞德新材料科技有限公司 | 用于制备依度沙班游离碱的中间体及其制备方法和应用 |
| CN111848647B (zh) * | 2020-08-03 | 2021-11-23 | 珠海市海瑞德新材料科技有限公司 | 甲基四氢吡啶并噻唑类活性化合物及其制备方法和应用 |
| KR102577696B1 (ko) * | 2020-11-16 | 2023-09-14 | 주식회사 보령 | 에독사반 토실산염 또는 그 수화물의 제조방법 |
| CN112940012B (zh) * | 2021-05-17 | 2021-09-03 | 上海翰森生物医药科技有限公司 | 一种依度沙班及其中间体的制备方法 |
| CN114456194B (zh) * | 2021-12-14 | 2023-07-07 | 浙江九洲药业股份有限公司 | 甲苯磺酸艾多沙班的中间体及其制备方法 |
| CN116178295A (zh) * | 2023-01-28 | 2023-05-30 | 山东亿盛实业股份有限公司 | 一种苯唑草酮代谢物t283的制备方法 |
| KR20250049636A (ko) | 2023-10-05 | 2025-04-14 | 주식회사 파마코스텍 | 신규한 에독사반 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| KR100863113B1 (ko) | 2001-06-20 | 2008-10-13 | 다이이찌 산쿄 가부시키가이샤 | 디아민 유도체 |
| WO2003000657A1 (fr) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
| EP1415992B1 (fr) | 2001-08-09 | 2012-05-02 | Daiichi Sankyo Company, Limited | Derives de diamine |
| JP4266092B2 (ja) * | 2001-10-09 | 2009-05-20 | 第一三共株式会社 | ジアミン誘導体 |
| KR20050110612A (ko) | 2002-12-25 | 2005-11-23 | 다이이찌 세이야꾸 가부시기가이샤 | 디아민 유도체 |
| KR101215153B1 (ko) | 2003-11-12 | 2012-12-24 | 다이이찌 산쿄 가부시키가이샤 | 티아졸 유도체의 제조법 |
| WO2006129626A1 (fr) * | 2005-05-30 | 2006-12-07 | Kyowa Hakko Kogyo Co., Ltd. | Procede de fabrication d'un derive de [1,2,4]triazolo[1,5-c]pyrimidine |
| BRPI0615775B1 (pt) | 2005-09-16 | 2021-08-10 | Daiichi Sankyo Company, Limited | Processos para a produção de compostos derivados de diamida oticamente ativos |
| WO2010104078A1 (fr) * | 2009-03-10 | 2010-09-16 | 第一三共株式会社 | Procédé de production d'un dérivé de diamine |
| EP2513117B1 (fr) * | 2009-12-18 | 2013-08-28 | Janssen Pharmaceutica, N.V. | Thiazoles bicycliques en tant que modulateurs allostériques de récepteurs mGluR5 |
| HUE035506T2 (en) * | 2010-08-04 | 2018-05-02 | Daiichi Sankyo Co Ltd | Process for Preparing a Compound with a New Sandmeyer-Type Reaction Using a Nitric Dioxide Compound as a Reaction Catalyst |
| US9090632B2 (en) * | 2010-08-31 | 2015-07-28 | Vanderbilt University | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors |
| ES2607807T3 (es) * | 2012-08-07 | 2017-04-04 | Janssen Pharmaceutica Nv | Procedimiento para la preparación de los inibidores de las quinasas c-fms |
-
2015
- 2015-02-13 KR KR1020167021407A patent/KR102371784B1/ko active Active
- 2015-02-13 CN CN201580020396.9A patent/CN106459087B/zh active Active
- 2015-02-13 CA CA2940001A patent/CA2940001C/fr active Active
- 2015-02-13 ES ES15752746T patent/ES2815352T3/es active Active
- 2015-02-13 US US15/118,903 patent/US9920071B2/en active Active
- 2015-02-13 JP JP2016504075A patent/JP6639381B2/ja active Active
- 2015-02-13 WO PCT/JP2015/054001 patent/WO2015125710A1/fr not_active Ceased
- 2015-02-13 EP EP15752746.6A patent/EP3109251B1/fr active Active
- 2015-02-13 HU HUE15752746A patent/HUE052100T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6639381B2 (ja) | 2020-02-05 |
| EP3109251A4 (fr) | 2017-08-30 |
| CA2940001A1 (fr) | 2015-08-27 |
| JPWO2015125710A1 (ja) | 2017-03-30 |
| KR102371784B1 (ko) | 2022-03-07 |
| EP3109251A1 (fr) | 2016-12-28 |
| US9920071B2 (en) | 2018-03-20 |
| CN106459087B (zh) | 2019-04-09 |
| CN106459087A (zh) | 2017-02-22 |
| KR20160120282A (ko) | 2016-10-17 |
| ES2815352T3 (es) | 2021-03-29 |
| US20170050983A1 (en) | 2017-02-23 |
| WO2015125710A1 (fr) | 2015-08-27 |
| EP3109251B1 (fr) | 2020-07-15 |
| CA2940001C (fr) | 2019-01-15 |
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