HUE059313T2 - 5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1- il)pirazolo[l,5-A]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére - Google Patents

5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1- il)pirazolo[l,5-A]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére

Info

Publication number: HUE059313T2
Authority: HU; Hungary
Prior art keywords: pyrazolo; difluorophenyl; pyrazol; pyrrolidin; treating cancer
Prior art date: 2017-12-15

Application number

HUE18836977A

Other languages

English (en)

Hungarian (hu)

Inventor

Kollol Pal

Stephane Ciblat

Vincent Albert

Nicolas Bruneau-Latour

Jonathan Boudreault

Original Assignee

Pyramid Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-12-15

Filing date

2018-12-12

Publication date

2022-11-28

2018-12-12 Application filed by Pyramid Biosciences Inc filed Critical Pyramid Biosciences Inc

2022-11-28 Publication of HUE059313T2 publication Critical patent/HUE059313T2/hu

Links

FWDOVLGKHCXRFF-UHFFFAOYSA-N FC1=C(C=C(C=C1)F)C1N(CCC1)C1=NC=2N(C=C1)N=CC=2N1N=CC=C1 Chemical class FC1=C(C=C(C=C1)F)C1N(CCC1)C1=NC=2N(C=C1)N=CC=2N1N=CC=C1 FWDOVLGKHCXRFF-UHFFFAOYSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HUE18836977A 2017-12-15 2018-12-12 5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1- il)pirazolo[l,5-A]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére HUE059313T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201762599490P	2017-12-15	2017-12-15

Publications (1)

Publication Number	Publication Date
HUE059313T2 true HUE059313T2 (hu)	2022-11-28

Family

ID=65139120

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HUE18836977A HUE059313T2 (hu)	2017-12-15	2018-12-12	5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1- il)pirazolo[l,5-A]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére
HUE22152688A HUE069285T2 (hu)	2017-12-15	2018-12-12	5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(lH-pirazol-1- il)pirazolo[l,5-a]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HUE22152688A HUE069285T2 (hu)	2017-12-15	2018-12-12	5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(lH-pirazol-1- il)pirazolo[l,5-a]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére

Country Status (26)

Country	Link
US (4)	US11230546B2 (es)
EP (2)	EP3724191B9 (es)
JP (1)	JP7321183B2 (es)
KR (1)	KR102738182B1 (es)
CN (1)	CN111819179B (es)
AU (1)	AU2018383571B2 (es)
CA (1)	CA3084814A1 (es)
DK (2)	DK4053128T3 (es)
EA (1)	EA202091475A1 (es)
ES (2)	ES2908773T3 (es)
FI (1)	FI4053128T3 (es)
HR (2)	HRP20220464T1 (es)
HU (2)	HUE059313T2 (es)
IL (1)	IL275059B2 (es)
LT (2)	LT4053128T (es)
MX (1)	MX2020006293A (es)
PL (2)	PL4053128T3 (es)
PT (2)	PT3724191T (es)
RS (1)	RS66124B1 (es)
SA (1)	SA520412192B1 (es)
SG (1)	SG11202005237SA (es)
SI (2)	SI4053128T1 (es)
SM (1)	SMT202400435T1 (es)
TW (1)	TWI848925B (es)
WO (1)	WO2019118584A1 (es)
ZA (2)	ZA202003483B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG11202005237SA (en)	2017-12-15	2020-07-29	Pyramid Biosciences Inc	5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
GB201813791D0 (en) *	2018-08-23	2018-10-10	Benevolental Bio Ltd	Organic compounds
CN111718350B (zh) *	2019-03-19	2021-04-13	华中师范大学	吡唑取代的吡唑并嘧啶化合物和药物组合物及其应用
US20220177477A1 (en) *	2019-03-19	2022-06-09	Central China Normal University	Pyrazolopyrimidine compound, pharmaceutical composition, and application therefor
CN111848626B (zh) *	2019-04-30	2021-11-30	江苏柯菲平医药股份有限公司	Trk激酶抑制剂及其用途
CN112979654B (zh) *	2019-12-16	2024-03-19	赛诺哈勃药业（成都）有限公司	杂芳基稠环化合物、其制备方法及应用
IL296921A (en) *	2020-04-15	2022-12-01	Pyramid Biosciences Inc	Methods for making receptor tyrosine kinase inhibitors
CN114437077B (zh) *	2020-11-04	2024-01-30	浙江同源康医药股份有限公司	用作激酶抑制剂的化合物及其应用
CN114437075B (zh) *	2020-11-03	2026-01-30	上海瑶琪生物科技有限公司	用作ntrk激酶抑制剂的化合物及其应用
KR102541026B1 (ko) *	2020-11-11	2023-06-12	주식회사 한독	Trk 억제제 화합물의 제조 방법
EP4262802A4 (en) *	2020-12-15	2024-11-13	Children's Hospital Medical Center	MULTI-CYCLIC COMPOUNDS INHIBITING IRAK AND FLT3 AND THEIR USES
WO2024051631A1 (zh) *	2022-09-07	2024-03-14	苏州朗睿生物医药有限公司	一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4911920A (en)	1986-07-30	1990-03-27	Alcon Laboratories, Inc.	Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr)	1985-10-03	1988-12-02	Merck Sharp & Dohme	Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja)	1991-01-15	1997-03-26	アルコンラボラトリーズインコーポレイテッド	局所的眼薬組成物
US5212162A (en)	1991-03-27	1993-05-18	Alcon Laboratories, Inc.	Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
KR101324804B1 (ko) *	2008-05-13	2013-11-01	아이알엠 엘엘씨	키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물
MY169791A (en) *	2008-10-22	2019-05-15	Array Biopharma Inc	Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
EP2348860B1 (en)	2008-10-31	2015-05-27	Genentech, Inc.	Pyrazolopyrimidine jak inhibitor compounds and methods
US8591943B2 (en)	2009-04-09	2013-11-26	Merck Sharp & Dohme Corp.	Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US8865726B2 (en)	2009-09-03	2014-10-21	Array Biopharma Inc.	Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
WO2012034095A1 (en) *	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
WO2012125668A1 (en) *	2011-03-17	2012-09-20	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
CN104302649B (zh) *	2012-03-09	2017-06-23	莱西肯医药有限公司	基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
US20140288043A1 (en)	2013-03-19	2014-09-25	Genentech, Inc.	Pyrazolopyridine compounds
WO2015143652A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
FR3029769A1 (fr) *	2014-12-10	2016-06-17	Tornier Sa	Kit pour une prothese d'epaule
CA2971024C (en) *	2014-12-15	2023-09-26	Handok Inc.	Fused ring heteroaryl compounds and their use as trk inhibitors
AR103297A1 (es)	2014-12-30	2017-05-03	Forma Therapeutics Inc	Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina
JP6475084B2 (ja)	2015-05-21	2019-02-27	臼井国際産業株式会社	トルクセンサ用シャフトの製造設備およびその製造方法
DE102016219374B4 (de)	2016-10-06	2018-06-14	Siemens Aktiengesellschaft	Langzeitstabile und stoffschlüssige Strompfadverbindung für Nieder-, Mittelspannungs- und/oder Hochspannungsanlagen bzw. –Schaltgeräte mittels Nanomaterialien
SG11202005237SA (en)	2017-12-15	2020-07-29	Pyramid Biosciences Inc	5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
CN112398593B (zh)	2019-08-13	2024-08-16	上海朗帛通信技术有限公司	一种被用于无线通信的节点中的方法和装置
IL296921A (en)	2020-04-15	2022-12-01	Pyramid Biosciences Inc	Methods for making receptor tyrosine kinase inhibitors

2018
- 2018-12-12 SG SG11202005237SA patent/SG11202005237SA/en unknown
- 2018-12-12 LT LTEP22152688.2T patent/LT4053128T/lt unknown
- 2018-12-12 LT LTEPPCT/US2018/065187T patent/LT3724191T/lt unknown
- 2018-12-12 ES ES18836977T patent/ES2908773T3/es active Active
- 2018-12-12 DK DK22152688.2T patent/DK4053128T3/da active
- 2018-12-12 EP EP18836977.1A patent/EP3724191B9/en active Active
- 2018-12-12 EA EA202091475A patent/EA202091475A1/ru unknown
- 2018-12-12 HU HUE18836977A patent/HUE059313T2/hu unknown
- 2018-12-12 MX MX2020006293A patent/MX2020006293A/es unknown
- 2018-12-12 HU HUE22152688A patent/HUE069285T2/hu unknown
- 2018-12-12 WO PCT/US2018/065187 patent/WO2019118584A1/en not_active Ceased
- 2018-12-12 DK DK18836977.1T patent/DK3724191T3/da active
- 2018-12-12 TW TW107144769A patent/TWI848925B/zh active
- 2018-12-12 PT PT188369771T patent/PT3724191T/pt unknown
- 2018-12-12 AU AU2018383571A patent/AU2018383571B2/en active Active
- 2018-12-12 EP EP22152688.2A patent/EP4053128B8/en active Active
- 2018-12-12 HR HRP20220464TT patent/HRP20220464T1/hr unknown
- 2018-12-12 KR KR1020207020360A patent/KR102738182B1/ko active Active
- 2018-12-12 SM SM20240435T patent/SMT202400435T1/it unknown
- 2018-12-12 JP JP2020551775A patent/JP7321183B2/ja active Active
- 2018-12-12 HR HRP20241426TT patent/HRP20241426T1/hr unknown
- 2018-12-12 RS RS20241146A patent/RS66124B1/sr unknown
- 2018-12-12 PL PL22152688.2T patent/PL4053128T3/pl unknown
- 2018-12-12 ES ES22152688T patent/ES2992993T3/es active Active
- 2018-12-12 CA CA3084814A patent/CA3084814A1/en active Pending
- 2018-12-12 SI SI201831163T patent/SI4053128T1/sl unknown
- 2018-12-12 CN CN201880080978.XA patent/CN111819179B/zh active Active
- 2018-12-12 FI FIEP22152688.2T patent/FI4053128T3/fi active
- 2018-12-12 PT PT221526882T patent/PT4053128T/pt unknown
- 2018-12-12 IL IL275059A patent/IL275059B2/en unknown
- 2018-12-12 SI SI201830632T patent/SI3724191T1/sl unknown
- 2018-12-12 US US16/772,253 patent/US11230546B2/en active Active
- 2018-12-12 PL PL18836977T patent/PL3724191T3/pl unknown
2020
- 2020-06-10 ZA ZA2020/03483A patent/ZA202003483B/en unknown
- 2020-06-13 SA SA520412192A patent/SA520412192B1/ar unknown
2021
- 2021-11-23 US US17/533,954 patent/US20220235055A1/en not_active Abandoned
2022
- 2022-05-27 ZA ZA2022/05900A patent/ZA202205900B/en unknown
- 2022-12-08 US US18/078,087 patent/US11739096B2/en active Active
2023
- 2023-08-11 US US18/233,226 patent/US12486276B2/en active Active

Also Published As

Publication number	Publication date
BR112020011775A2 (pt)	2020-11-17
IL275059B2 (en)	2023-11-01
AU2018383571B2 (en)	2023-09-21
PT4053128T (pt)	2024-10-15
US11739096B2 (en)	2023-08-29
JP7321183B2 (ja)	2023-08-04
CN111819179B (zh)	2023-09-01
US20220235055A1 (en)	2022-07-28
EP3724191B9 (en)	2022-05-18
EP4053128B8 (en)	2024-10-02
EP3724191B1 (en)	2022-01-26
TWI848925B (zh)	2024-07-21
EP3724191A1 (en)	2020-10-21
HUE069285T2 (hu)	2025-02-28
US12486276B2 (en)	2025-12-02
PL3724191T3 (pl)	2022-04-25
DK4053128T3 (da)	2024-10-21
SG11202005237SA (en)	2020-07-29
JP2021506954A (ja)	2021-02-22
ES2908773T3 (es)	2022-05-03
SI4053128T1 (sl)	2025-03-31
RS66124B1 (sr)	2024-11-29
AU2018383571A1 (en)	2020-06-18
ZA202205900B (en)	2023-11-29
US11230546B2 (en)	2022-01-25
LT3724191T (lt)	2022-04-25
CN111819179A (zh)	2020-10-23
PT3724191T (pt)	2022-03-07
DK3724191T3 (da)	2022-03-14
SMT202400435T1 (it)	2025-01-14
PL4053128T3 (pl)	2025-01-27
EP4053128B1 (en)	2024-08-21
SA520412192B1 (ar)	2022-08-11
US20230124248A1 (en)	2023-04-20
ES2992993T3 (en)	2024-12-20
HRP20220464T1 (hr)	2022-05-27
HRP20241426T1 (hr)	2024-12-20
LT4053128T (lt)	2024-11-25
MX2020006293A (es)	2020-12-03
SI3724191T1 (sl)	2022-06-30
IL275059A (en)	2020-07-30
IL275059B1 (en)	2023-07-01
TW201936194A (zh)	2019-09-16
KR20200099557A (ko)	2020-08-24
WO2019118584A1 (en)	2019-06-20
KR102738182B1 (ko)	2024-12-03
CA3084814A1 (en)	2019-06-20
EP4053128A1 (en)	2022-09-07
EA202091475A1 (ru)	2020-09-09
US20240246976A1 (en)	2024-07-25
US20210094956A1 (en)	2021-04-01
FI4053128T3 (fi)	2024-10-25
ZA202003483B (en)	2023-01-25

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ZA202003483B (en)	2023-01-25	5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
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