HUE060672T2 - Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására - Google Patents
Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállításáraInfo
- Publication number
- HUE060672T2 HUE060672T2 HUE18192520A HUE18192520A HUE060672T2 HU E060672 T2 HUE060672 T2 HU E060672T2 HU E18192520 A HUE18192520 A HU E18192520A HU E18192520 A HUE18192520 A HU E18192520A HU E060672 T2 HUE060672 T2 HU E060672T2
- Authority
- HU
- Hungary
- Prior art keywords
- acetylglucosamine
- microorganisms
- methods
- containing oligosaccharides
- producing sialylated
- Prior art date
Links
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 title 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 title 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 229950006780 n-acetylglucosamine Drugs 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782999P | 2013-03-14 | 2013-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE060672T2 true HUE060672T2 (hu) | 2023-04-28 |
Family
ID=51581464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE18192520A HUE060672T2 (hu) | 2013-03-14 | 2014-03-14 | Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9758803B2 (hu) |
| EP (3) | EP2970872B1 (hu) |
| CA (1) | CA2904091A1 (hu) |
| DE (1) | DE14769797T1 (hu) |
| DK (2) | DK3467100T3 (hu) |
| ES (2) | ES2930286T3 (hu) |
| HU (1) | HUE060672T2 (hu) |
| WO (1) | WO2014153253A1 (hu) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2707379A4 (en) | 2011-05-13 | 2014-10-08 | Glycosyn LLC | USE OF PURIFIED 2'-FUCOSYLLACTOSIS, 3-FUCOSYLLACTOSIS AND LACTODIFUCOTETRAOSE AS PREBIOTICS |
| WO2014078661A1 (en) * | 2012-11-16 | 2014-05-22 | Kongsberg Actuation Systems Ii, Inc. | Method of forming a hose assembly |
| HUE060672T2 (hu) | 2013-03-14 | 2023-04-28 | Glycosyn LLC | Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására |
| US9688970B2 (en) * | 2013-10-01 | 2017-06-27 | Kentucky Bioprocessing, Inc. | Plant-based recombinant butyrylcholinesterase production methods |
| US11926858B2 (en) | 2014-06-27 | 2024-03-12 | Glycom A/S | Oligosaccharide production |
| CN113684233B (zh) | 2014-06-27 | 2024-11-29 | 格礼卡姆股份公司 | 寡糖的制备 |
| US20170204443A1 (en) * | 2014-07-14 | 2017-07-20 | Basf Se | Biotechnological production of lnt, lnnt and the fucosylated derivatives thereof |
| WO2016094836A1 (en) * | 2014-12-12 | 2016-06-16 | The Regents Of The University Of California | Reduction of milk glycans and their degradation products in the neonate gut |
| ES2991621T3 (es) | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| CN107267578B (zh) * | 2016-04-05 | 2020-06-30 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| WO2017174039A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| WO2017174037A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| DK3445770T3 (da) | 2016-04-19 | 2026-02-23 | Glycom As | Separering af oligosaccharider fra fermenteringssuppe |
| EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
| US10407516B2 (en) | 2016-10-31 | 2019-09-10 | Glycom A/S | Crystalline HMO |
| WO2018165072A1 (en) | 2017-03-07 | 2018-09-13 | DePuy Synthes Products, Inc. | Bioresorbable exopolysaccharides |
| WO2018165077A1 (en) | 2017-03-07 | 2018-09-13 | DePuy Synthes Products, Inc. | Bioresorbable exopolysaccharides |
| US11214588B2 (en) | 2017-06-30 | 2022-01-04 | Glycom A/S | Synthesis of oligosaccharides |
| CN119655445A (zh) | 2017-07-12 | 2025-03-21 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| US20210087599A1 (en) * | 2017-07-26 | 2021-03-25 | Jennewein Biotechnologie Gmbh | Sialyltransferases and their use in producing sialylated oligosaccharides |
| CN107312738B (zh) * | 2017-07-26 | 2020-03-06 | 江南大学 | 一种高效生产果糖软骨素的重组大肠杆菌及其构建方法 |
| CA3073332A1 (en) | 2017-09-29 | 2019-04-04 | Frieslandcampina Nederland B.V. | Process for the purification of a neutral human milk oligosaccharide (hmo) from microbial fermentation |
| EP3473644A1 (en) * | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative production of n-acetylneuraminic acid |
| CN107739728A (zh) * | 2017-10-19 | 2018-02-27 | 江南大学 | 一种高效生产氨基葡萄糖的重组大肠杆菌及其应用 |
| EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| EP3724344A4 (en) * | 2017-12-15 | 2021-11-24 | Glycosyn LLC | SIALYLTRANSFERASES AND USES OF THEM |
| EP3575404B1 (en) * | 2018-05-28 | 2022-10-19 | Chr. Hansen HMO GmbH | Fermentative production of sialylated saccharides |
| CN109825465B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 基于平衡udp-糖供给合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
| CN109735480B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 一种合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
| CN110066801B (zh) * | 2019-04-30 | 2021-01-29 | 江南大学 | 一种枯草芽孢杆菌中唾液酸诱导表达元件及构建方法 |
| EP3772539A1 (en) * | 2019-08-08 | 2021-02-10 | Jennewein Biotechnologie GmbH | Sialyltransferases for the production of 6'-sialyllactose |
| EP3789495A1 (en) * | 2019-09-03 | 2021-03-10 | Jennewein Biotechnologie GmbH | Production of sialylated oligosaccharides in bacillus cells |
| WO2021019104A2 (en) | 2019-09-18 | 2021-02-04 | Basf Se | A production host for producing human milk oligosaccharides |
| WO2021160828A1 (en) | 2020-02-14 | 2021-08-19 | Inbiose N.V. | Kdo-free production hosts for oligosaccharide synthesis |
| EP3954778B1 (en) | 2020-08-10 | 2023-10-04 | Inbiose N.V. | Production of a mixture of neutral non-fucosylated oligosaccharides by a cell |
| US11331329B2 (en) | 2020-05-13 | 2022-05-17 | Glycosyn LLC | Fucosylated oligosaccharides for prevention of coronavirus infection |
| US11324766B2 (en) | 2020-05-13 | 2022-05-10 | Glycosyn LLC | 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation |
| US20250361477A1 (en) * | 2020-08-10 | 2025-11-27 | Inbiose N.V. | Production of an oligosaccharide mixture by a cell |
| CN116323927A (zh) * | 2020-08-10 | 2023-06-23 | 因比奥斯公司 | 双糖及/或寡糖的细胞生产 |
| US20230313252A1 (en) * | 2020-08-10 | 2023-10-05 | Inbiose N.V. | Cellular production of sialylated di and/or oligosaccharides |
| AU2021359711A1 (en) | 2020-10-16 | 2023-03-23 | Société des Produits Nestlé S. A. | Nutritional composition comprising human milk oligosaccharides |
| JP2023547175A (ja) | 2020-11-10 | 2023-11-09 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 栄養組成物 |
| AU2020483278A1 (en) * | 2020-12-22 | 2023-07-20 | Chr. Hansen HMO GmbH | Sialyltransferases for the production of 6'-sialyllactose |
| WO2023034973A1 (en) * | 2021-09-02 | 2023-03-09 | Amyris, Inc. | Methods of producing human milk oligosaccharides and compositions thereof |
| CN114350584B (zh) * | 2021-12-17 | 2024-03-01 | 嘉必优生物技术（武汉）股份有限公司 | 高产唾液酸乳糖的工程菌及其构建方法与应用 |
| AU2023246643A1 (en) | 2022-04-01 | 2024-10-10 | Inbiose N.V. | Sialyltransferases for the production of sialylated oligosaccharides |
| DK182291B1 (en) | 2022-12-09 | 2026-02-20 | Dsm Ip Assets Bv | Genetically modified udp-n- acetylglucosamine producing cells and methods using the same |
| KR20250144450A (ko) * | 2023-02-07 | 2025-10-10 | 인바이오스 엔.브이. | UDP-GlcNAc 의 합성이 감소된 세포에 의한 이당류 및/또는 젖 올리고당류의 생산 |
| CN116478894B (zh) * | 2023-03-21 | 2025-06-24 | 江南大学 | 一种提高唾液酸乳糖产量的基因工程菌及其生产方法 |
| DK181822B1 (en) * | 2023-06-07 | 2025-01-30 | Dsm Ip Assets Bv | Genetically engineered strains with reduced byproduct formation and methods and uses of same |
| CN121419685A (zh) | 2023-07-06 | 2026-01-27 | 雀巢产品有限公司 | 用于肠道健康的饮食管理的组合 |
| WO2025045721A1 (en) * | 2023-08-25 | 2025-03-06 | Chr. Hansen A/S | N-acetylglucosaminyltransferase enzymes with altered substrate specificity and their use in fermentative oligosaccharide production |
| WO2025224348A1 (en) | 2024-04-26 | 2025-10-30 | Inbiose N.V. | Production of a milk oligosaccharide mixture |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796082B1 (fr) * | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
| US20080145899A1 (en) * | 2004-09-17 | 2008-06-19 | Neose Technologies Inc | Production of Oligosaccharides By Microorganisms |
| AU2007222375B2 (en) * | 2006-03-09 | 2012-12-20 | Centre National De La Recherche Scientifique (Cnrs) | Method of producing sialylated oligosaccharides |
| AU2007346659A1 (en) * | 2006-09-26 | 2008-08-14 | Syracuse University | Metabolically engineered Escherichia coli for enhanced production of sialic acid |
| JP2010505403A (ja) | 2006-10-03 | 2010-02-25 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） | 醗酵によるシアル酸（Ｎｅｕ５Ａｃ）の高収率生産 |
| AU2008240078B2 (en) * | 2007-04-16 | 2012-10-25 | Momenta Pharmaceuticals, Inc. | Multi-dimensional chromatographic methods for separating N-glycans |
| AU2012217650B9 (en) * | 2011-02-16 | 2017-09-14 | Glycosyn LLC | Biosynthesis of human milk oligosaccharides in engineered bacteria |
| EP2707379A4 (en) | 2011-05-13 | 2014-10-08 | Glycosyn LLC | USE OF PURIFIED 2'-FUCOSYLLACTOSIS, 3-FUCOSYLLACTOSIS AND LACTODIFUCOTETRAOSE AS PREBIOTICS |
| US9029136B2 (en) | 2012-07-25 | 2015-05-12 | Glycosyn LLC | Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides |
| HUE060672T2 (hu) * | 2013-03-14 | 2023-04-28 | Glycosyn LLC | Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására |
| CA2945661C (en) | 2014-05-15 | 2023-10-17 | Glycosyn LLC | Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides |
-
2014
- 2014-03-14 HU HUE18192520A patent/HUE060672T2/hu unknown
- 2014-03-14 DE DE14769797.3T patent/DE14769797T1/de active Pending
- 2014-03-14 WO PCT/US2014/029804 patent/WO2014153253A1/en not_active Ceased
- 2014-03-14 DK DK18192520.7T patent/DK3467100T3/da active
- 2014-03-14 EP EP14769797.3A patent/EP2970872B1/en not_active Not-in-force
- 2014-03-14 ES ES18192520T patent/ES2930286T3/es active Active
- 2014-03-14 EP EP18192520.7A patent/EP3467100B1/en not_active Revoked
- 2014-03-14 DK DK14769797.3T patent/DK2970872T3/da active
- 2014-03-14 US US14/776,216 patent/US9758803B2/en not_active Expired - Fee Related
- 2014-03-14 ES ES14769797T patent/ES2700274T3/es active Active
- 2014-03-14 CA CA2904091A patent/CA2904091A1/en active Pending
- 2014-03-14 EP EP22196607.0A patent/EP4166650A1/en not_active Withdrawn
-
2017
- 2017-09-11 US US15/700,978 patent/US10415069B2/en active Active
-
2019
- 2019-08-28 US US16/554,460 patent/US11618912B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4166650A1 (en) | 2023-04-19 |
| CA2904091A1 (en) | 2014-09-25 |
| US20180057849A1 (en) | 2018-03-01 |
| EP3467100B1 (en) | 2022-09-21 |
| WO2014153253A1 (en) | 2014-09-25 |
| DE14769797T1 (de) | 2016-06-23 |
| US20160024543A1 (en) | 2016-01-28 |
| US9758803B2 (en) | 2017-09-12 |
| EP2970872A1 (en) | 2016-01-20 |
| EP3467100A1 (en) | 2019-04-10 |
| ES2930286T3 (es) | 2022-12-09 |
| DK3467100T3 (da) | 2022-11-14 |
| EP2970872B1 (en) | 2018-09-05 |
| US20200190548A1 (en) | 2020-06-18 |
| ES2700274T3 (es) | 2019-02-14 |
| US10415069B2 (en) | 2019-09-17 |
| DK2970872T3 (da) | 2019-01-02 |
| EP2970872A4 (en) | 2016-11-09 |
| DK2970872T1 (da) | 2016-05-09 |
| US11618912B2 (en) | 2023-04-04 |
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