DK3467100T3 - Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider - Google Patents
Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider Download PDFInfo
- Publication number
- DK3467100T3 DK3467100T3 DK18192520.7T DK18192520T DK3467100T3 DK 3467100 T3 DK3467100 T3 DK 3467100T3 DK 18192520 T DK18192520 T DK 18192520T DK 3467100 T3 DK3467100 T3 DK 3467100T3
- Authority
- DK
- Denmark
- Prior art keywords
- acetyglucosamine
- sialylated
- microorganisms
- production
- methods
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782999P | 2013-03-14 | 2013-03-14 | |
| EP14769797.3A EP2970872B1 (en) | 2013-03-14 | 2014-03-14 | Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3467100T3 true DK3467100T3 (da) | 2022-11-14 |
Family
ID=51581464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14769797.3T DK2970872T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og N-acetylglucosamin-holdige oligosaccharider |
| DK18192520.7T DK3467100T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14769797.3T DK2970872T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og N-acetylglucosamin-holdige oligosaccharider |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9758803B2 (da) |
| EP (3) | EP4166650A1 (da) |
| CA (1) | CA2904091A1 (da) |
| DE (1) | DE14769797T1 (da) |
| DK (2) | DK2970872T3 (da) |
| ES (2) | ES2700274T3 (da) |
| HU (1) | HUE060672T2 (da) |
| WO (1) | WO2014153253A1 (da) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158517A1 (en) | 2011-05-13 | 2012-11-22 | Glycosyn LLC | The use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| EP2919978B1 (en) * | 2012-11-16 | 2016-10-12 | Kongsberg Actuation Systems II, Inc. | Method of forming a hose assembly |
| DE14769797T1 (de) * | 2013-03-14 | 2016-06-23 | Glycosyn LLC | Mikroorganismen und Verfahren zur Herstellung sialylierter und N-acetylglucosamin-haltiger Oligosaccharide |
| US9688970B2 (en) | 2013-10-01 | 2017-06-27 | Kentucky Bioprocessing, Inc. | Plant-based recombinant butyrylcholinesterase production methods |
| ES3002778T3 (en) * | 2014-06-27 | 2025-03-07 | Glycom As | Oligosaccharide production |
| US11926858B2 (en) | 2014-06-27 | 2024-03-12 | Glycom A/S | Oligosaccharide production |
| AU2015291487A1 (en) * | 2014-07-14 | 2017-02-16 | Basf Se | Biotechnological production of LNT, LNnT and the fucosylated derivatives thereof |
| WO2016094836A1 (en) * | 2014-12-12 | 2016-06-16 | The Regents Of The University Of California | Reduction of milk glycans and their degradation products in the neonate gut |
| ES2991621T3 (es) | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| WO2017174039A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| WO2017174037A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| CN107267576B (zh) * | 2016-04-05 | 2020-08-21 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
| DK3445770T3 (da) | 2016-04-19 | 2026-02-23 | Glycom As | Separering af oligosaccharider fra fermenteringssuppe |
| EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
| US10407516B2 (en) | 2016-10-31 | 2019-09-10 | Glycom A/S | Crystalline HMO |
| US10767205B2 (en) | 2017-03-07 | 2020-09-08 | DePuy Synthes Products, Inc. | Bacterium for the production of an exopolysaccharide comprising N-acetylglucosamine and D-glucose |
| US10633682B2 (en) | 2017-03-07 | 2020-04-28 | DePuy Synthes Products, Inc. | Bioresorbable exopolysaccharides |
| WO2019003135A1 (en) | 2017-06-30 | 2019-01-03 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| CN110914284B (zh) | 2017-07-12 | 2025-01-07 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| BR112020001628A2 (pt) * | 2017-07-26 | 2020-07-21 | Jennewein Biotechnologie Gmbh | sialiltransferases e uso das mesmas na produção de oligossacarídeos sialilados |
| CN107312738B (zh) * | 2017-07-26 | 2020-03-06 | 江南大学 | 一种高效生产果糖软骨素的重组大肠杆菌及其构建方法 |
| WO2019063757A1 (en) | 2017-09-29 | 2019-04-04 | Frieslandcampina Nederland B.V. | PROCESS FOR PURIFYING NEUTRAL HUMAN MILK (HMO) OLIGOSACCHARIDE FROM MICROBIAL FERMENTATION |
| EP3473644A1 (en) * | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative production of n-acetylneuraminic acid |
| CN107739728A (zh) * | 2017-10-19 | 2018-02-27 | 江南大学 | 一种高效生产氨基葡萄糖的重组大肠杆菌及其应用 |
| EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| CA3085931A1 (en) * | 2017-12-15 | 2019-06-20 | Glycosyn LLC | Sialyltransferases and uses thereof |
| FI3575404T3 (fi) | 2018-05-28 | 2023-01-13 | Sialyloitujen sakkaridejen fermentatiivinen tuotanto | |
| CN109825465B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 基于平衡udp-糖供给合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
| CN109735480B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 一种合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
| CN110066801B (zh) * | 2019-04-30 | 2021-01-29 | 江南大学 | 一种枯草芽孢杆菌中唾液酸诱导表达元件及构建方法 |
| EP3772539A1 (en) * | 2019-08-08 | 2021-02-10 | Jennewein Biotechnologie GmbH | Sialyltransferases for the production of 6'-sialyllactose |
| EP3789495A1 (en) * | 2019-09-03 | 2021-03-10 | Jennewein Biotechnologie GmbH | Production of sialylated oligosaccharides in bacillus cells |
| WO2021019104A2 (en) | 2019-09-18 | 2021-02-04 | Basf Se | A production host for producing human milk oligosaccharides |
| BR112022016022A2 (pt) | 2020-02-14 | 2022-10-11 | Inbiose Nv | Hospedeiros de produção livres de kdo para síntese de oligossacarídeos |
| CA3178744C (en) | 2020-05-13 | 2023-11-14 | Ardythe L. Morrow | Fucosylated oligosaccharides for prevention of coronavirus infection |
| WO2021231750A1 (en) | 2020-05-13 | 2021-11-18 | Glycosyn LLC | 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation |
| TW202221130A (zh) * | 2020-08-10 | 2022-06-01 | 比利時商因比奧斯公司 | 唾液酸化雙醣及/或寡醣的細胞生產 |
| TW202221129A (zh) * | 2020-08-10 | 2022-06-01 | 比利時商因比奧斯公司 | 雙醣及/或寡醣的細胞生產 |
| CA3188909A1 (en) * | 2020-08-10 | 2022-02-17 | Sofie AESAERT | Production of an oligosaccharide mixture by a cell |
| ES2966260T3 (es) | 2020-08-10 | 2024-04-19 | Inbiose Nv | Producción de una mezcla de oligosacáridos neutros no fucosilados por una célula |
| CA3193370A1 (en) | 2020-10-16 | 2022-04-21 | Carine Blanchard | Nutritional composition comprising human milk oligosaccharides |
| JP2023547175A (ja) | 2020-11-10 | 2023-11-09 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 栄養組成物 |
| AU2020483278A1 (en) * | 2020-12-22 | 2023-07-20 | Chr. Hansen HMO GmbH | Sialyltransferases for the production of 6'-sialyllactose |
| WO2023034973A1 (en) * | 2021-09-02 | 2023-03-09 | Amyris, Inc. | Methods of producing human milk oligosaccharides and compositions thereof |
| CN114350584B (zh) * | 2021-12-17 | 2024-03-01 | 嘉必优生物技术（武汉）股份有限公司 | 高产唾液酸乳糖的工程菌及其构建方法与应用 |
| AU2023246643A1 (en) | 2022-04-01 | 2024-10-10 | Inbiose N.V. | Sialyltransferases for the production of sialylated oligosaccharides |
| DK182291B1 (en) | 2022-12-09 | 2026-02-20 | Dsm Ip Assets Bv | Genetically modified udp-n- acetylglucosamine producing cells and methods using the same |
| CN120641559A (zh) * | 2023-02-07 | 2025-09-12 | 因比奥斯公司 | 由具有降低的UDP-GlcNAc合成的细胞来产生二糖和/或乳寡糖 |
| CN116478894B (zh) * | 2023-03-21 | 2025-06-24 | 江南大学 | 一种提高唾液酸乳糖产量的基因工程菌及其生产方法 |
| DK181822B1 (en) * | 2023-06-07 | 2025-01-30 | Dsm Ip Assets Bv | Genetically engineered strains with reduced byproduct formation and methods and uses of same |
| AU2024288910A1 (en) | 2023-07-06 | 2026-01-08 | Societe Des Produits Nestle S.A. | Combination for dietary management of gut health |
| CN121794370A (zh) * | 2023-08-25 | 2026-04-03 | 科·汉森有限公司 | 具有改变的底物特异性的n-乙酰葡糖胺基转移酶及其在发酵低聚糖生产中的用途 |
| WO2025224348A1 (en) | 2024-04-26 | 2025-10-30 | Inbiose N.V. | Production of a milk oligosaccharide mixture |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796082B1 (fr) * | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
| US20080145899A1 (en) * | 2004-09-17 | 2008-06-19 | Neose Technologies Inc | Production of Oligosaccharides By Microorganisms |
| WO2007101862A1 (en) * | 2006-03-09 | 2007-09-13 | Centre National De La Recherche Scientifique (Cnrs) | Method of producing sialylated oligosaccharides |
| MX2009003212A (es) * | 2006-09-26 | 2009-08-12 | Univ Syracuse | Escherichia coli metabolicamente desarrolla mediante ingenieria genetica para la produccion mejorada de acido sialico. |
| US20110165626A1 (en) | 2006-10-03 | 2011-07-07 | Centre National De La Recherche Scientifique (Cnrs | High yield production of sialic acid (neu5ac) by fermentation |
| EP2136896B1 (en) * | 2007-04-16 | 2015-01-21 | Momenta Pharmaceuticals, Inc. | Multi-dimensional chromatographic methods for separating n-glycans |
| DE12746649T1 (de) | 2011-02-16 | 2016-09-29 | Glycosyn LLC | Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien |
| WO2012158517A1 (en) | 2011-05-13 | 2012-11-22 | Glycosyn LLC | The use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US9029136B2 (en) | 2012-07-25 | 2015-05-12 | Glycosyn LLC | Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides |
| DE14769797T1 (de) | 2013-03-14 | 2016-06-23 | Glycosyn LLC | Mikroorganismen und Verfahren zur Herstellung sialylierter und N-acetylglucosamin-haltiger Oligosaccharide |
| ES2962258T3 (es) | 2014-05-15 | 2024-03-18 | Glycosyn LLC | Singenes de alfa(1,2) fucosiltransferasa para su utilización en la producción de oligosacáridos fucosilados |
-
2014
- 2014-03-14 DE DE14769797.3T patent/DE14769797T1/de active Pending
- 2014-03-14 WO PCT/US2014/029804 patent/WO2014153253A1/en not_active Ceased
- 2014-03-14 ES ES14769797T patent/ES2700274T3/es active Active
- 2014-03-14 CA CA2904091A patent/CA2904091A1/en active Pending
- 2014-03-14 EP EP22196607.0A patent/EP4166650A1/en not_active Withdrawn
- 2014-03-14 HU HUE18192520A patent/HUE060672T2/hu unknown
- 2014-03-14 US US14/776,216 patent/US9758803B2/en not_active Expired - Fee Related
- 2014-03-14 ES ES18192520T patent/ES2930286T3/es active Active
- 2014-03-14 EP EP14769797.3A patent/EP2970872B1/en active Active
- 2014-03-14 DK DK14769797.3T patent/DK2970872T3/da active
- 2014-03-14 EP EP18192520.7A patent/EP3467100B1/en not_active Revoked
- 2014-03-14 DK DK18192520.7T patent/DK3467100T3/da active
-
2017
- 2017-09-11 US US15/700,978 patent/US10415069B2/en active Active
-
2019
- 2019-08-28 US US16/554,460 patent/US11618912B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014153253A1 (en) | 2014-09-25 |
| US20180057849A1 (en) | 2018-03-01 |
| EP3467100B1 (en) | 2022-09-21 |
| EP2970872B1 (en) | 2018-09-05 |
| DK2970872T1 (da) | 2016-05-09 |
| US10415069B2 (en) | 2019-09-17 |
| US20160024543A1 (en) | 2016-01-28 |
| US9758803B2 (en) | 2017-09-12 |
| DK2970872T3 (da) | 2019-01-02 |
| EP4166650A1 (en) | 2023-04-19 |
| US11618912B2 (en) | 2023-04-04 |
| CA2904091A1 (en) | 2014-09-25 |
| ES2930286T3 (es) | 2022-12-09 |
| EP2970872A4 (en) | 2016-11-09 |
| US20200190548A1 (en) | 2020-06-18 |
| EP2970872A1 (en) | 2016-01-20 |
| EP3467100A1 (en) | 2019-04-10 |
| DE14769797T1 (de) | 2016-06-23 |
| HUE060672T2 (hu) | 2023-04-28 |
| ES2700274T3 (es) | 2019-02-14 |
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