HUP0100836A2 - Oxamidok mint IMPDH-inhibitorok - Google Patents

Oxamidok mint IMPDH-inhibitorok

Info

Publication number: HUP0100836A2
Authority: HU; Hungary
Prior art keywords: hydrogen; heterocyclyl; lower alkyl; impd; halo
Prior art date: 2000-02-24

Application number

HU0100836A

Other languages

English (en)

Hungarian (hu)

Inventor

Michael John Broadhurst

Christopher Huw Hill

David Nigel Hurst

Philip Stephen Jones

Paul Brittain Kay

Ian Reginald Kilford

Robert Murray Mckinnell

Original Assignee

F.Hoffmann-La Roche Ag.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-24

Filing date

2001-02-21

Publication date

2001-10-28

2000-02-24 Priority claimed from GB0004392A external-priority patent/GB0004392D0/en

2000-08-17 Priority claimed from GB0020322A external-priority patent/GB0020322D0/en

2001-02-21 Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.

2001-04-28 Publication of HU0100836D0 publication Critical patent/HU0100836D0/hu

2001-10-28 Publication of HUP0100836A2 publication Critical patent/HUP0100836A2/hu

Links

101150088003 IMPDH gene Proteins 0.000 title 1
YIKSCQDJHCMVMK-UHFFFAOYSA-N Oxamide Chemical class NC(=O)C(N)=O YIKSCQDJHCMVMK-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
230000005764 inhibitory process Effects 0.000 abstract 2
KWKRTNFTBCZAGB-UHFFFAOYSA-N n'-phenyloxamide Chemical class NC(=O)C(=O)NC1=CC=CC=C1 KWKRTNFTBCZAGB-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
101710088194 Dehydrogenase Proteins 0.000 abstract 1
GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
230000001861 immunosuppressant effect Effects 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
235000013902 inosinic acid Nutrition 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000003431 oxalo group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000009790 rate-determining step (RDS) Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HU0100836A 2000-02-24 2001-02-21 Oxamidok mint IMPDH-inhibitorok HUP0100836A2 (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0004392A GB0004392D0 (en)	2000-02-24	2000-02-24	Oxamide derivatives
GB0020322A GB0020322D0 (en)	2000-08-17	2000-08-17	Oxamide derivatives

Publications (2)

Publication Number	Publication Date
HU0100836D0 HU0100836D0 (en)	2001-04-28
HUP0100836A2 true HUP0100836A2 (hu)	2001-10-28

Family

ID=26243721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0100836A HUP0100836A2 (hu)	2000-02-24	2001-02-21	Oxamidok mint IMPDH-inhibitorok

Country Status (9)

Country	Link
CO (1)	CO5300390A1 (id)
CZ (1)	CZ2001667A3 (id)
HR (1)	HRP20010127A2 (id)
HU (1)	HUP0100836A2 (id)
ID (1)	ID29372A (id)
IL (1)	IL141543A0 (id)
MA (1)	MA26755A1 (id)
NO (1)	NO20010900L (id)
PL (1)	PL346098A1 (id)

2001
- 2001-02-21 IL IL14154301A patent/IL141543A0/xx unknown
- 2001-02-21 CZ CZ2001667A patent/CZ2001667A3/cs unknown
- 2001-02-21 HU HU0100836A patent/HUP0100836A2/hu unknown
- 2001-02-21 HR HRP20010127 patent/HRP20010127A2/hr not_active Application Discontinuation
- 2001-02-22 NO NO20010900A patent/NO20010900L/no not_active Application Discontinuation
- 2001-02-22 CO CO01014294A patent/CO5300390A1/es not_active Application Discontinuation
- 2001-02-22 MA MA26144A patent/MA26755A1/fr unknown
- 2001-02-22 ID IDP20010157D patent/ID29372A/id unknown
- 2001-02-23 PL PL34609801A patent/PL346098A1/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
MA26755A1 (fr)	2004-12-20
CZ2001667A3 (cs)	2001-10-17
HRP20010127A2 (en)	2001-12-31
CO5300390A1 (es)	2003-07-31
HU0100836D0 (en)	2001-04-28
PL346098A1 (en)	2001-08-27
IL141543A0 (en)	2002-03-10
NO20010900D0 (no)	2001-02-22
NO20010900L (no)	2001-08-27
ID29372A (id)	2001-08-30

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