HUP0101711A2 - Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására - Google Patents

Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására Download PDF

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Publication number
HUP0101711A2
HUP0101711A2 HU0101711A HUP0101711A HUP0101711A2 HU P0101711 A2 HUP0101711 A2 HU P0101711A2 HU 0101711 A HU0101711 A HU 0101711A HU P0101711 A HUP0101711 A HU P0101711A HU P0101711 A2 HUP0101711 A2 HU P0101711A2
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HU
Hungary
Prior art keywords
phosphate
xylulose
deoxy
dna
protein
Prior art date
Application number
HU0101711A
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English (en)
Hungarian (hu)
Inventor
Hassan Jomaa
Original Assignee
Hassan Jomaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19825585A external-priority patent/DE19825585A1/de
Priority claimed from DE19828097A external-priority patent/DE19828097A1/de
Priority claimed from DE19831639A external-priority patent/DE19831639C1/de
Priority claimed from DE19831637A external-priority patent/DE19831637A1/de
Application filed by Hassan Jomaa filed Critical Hassan Jomaa
Publication of HUP0101711A2 publication Critical patent/HUP0101711A2/hu

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445Plasmodium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Environmental Sciences (AREA)
HU0101711A 1998-04-14 1999-04-13 Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására HUP0101711A2 (hu)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE19816196 1998-04-14
DE19825585A DE19825585A1 (de) 1998-04-14 1998-06-09 Verwendung von Aminohydrocarbylphosphonsäurederivaten zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten, Pilze oder Viren hervorgerufen werden
DE19828097A DE19828097A1 (de) 1998-06-24 1998-06-24 Kombinationspräparat von Aminohydrocarbylphosphonsäurederivaten und Hemmern des Fettstoffwechsels
DE19831638 1998-07-15
DE19831639A DE19831639C1 (de) 1998-07-15 1998-07-15 Phosphororganische Verbindungen und ihre Verwendung
DE19831637A DE19831637A1 (de) 1998-07-15 1998-07-15 Verwendung von phosphororganischen Verbindungen zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten hervorgerufen werden
DE19843279 1998-09-22
PCT/EP1999/002463 WO1999052938A2 (de) 1998-04-14 1999-04-13 Identifizierung chemischer wirkstoffe zur hemmung des 1-desoxy-d-xylulose-5-phosphat-biosynthesewegs in parasiten

Publications (1)

Publication Number Publication Date
HUP0101711A2 true HUP0101711A2 (hu) 2001-09-28

Family

ID=27561757

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101711A HUP0101711A2 (hu) 1998-04-14 1999-04-13 Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására

Country Status (14)

Country Link
EP (1) EP1071959A2 (de)
JP (1) JP2002511486A (de)
CN (1) CN1297532A (de)
AP (1) AP2000001937A0 (de)
AU (1) AU753169B2 (de)
CA (1) CA2328157A1 (de)
HU (1) HUP0101711A2 (de)
IL (1) IL138721A0 (de)
MX (1) MXPA00010069A (de)
OA (1) OA11500A (de)
PL (1) PL358989A1 (de)
SK (1) SK15232000A3 (de)
TR (1) TR200002972T2 (de)
WO (1) WO1999052938A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2339519A1 (en) * 1998-08-05 2000-02-17 Sungene Gmbh & Co.Kgaa Dna sequence coding for a 1-deoxy-d-xylulose-5-phosphate synthase and the overproduction thereof in plants
AP2001002104A0 (en) * 1998-09-22 2001-03-31 Jomaa Pharmaka Gmbh Genes of the 1-desoxy-d-xylulose biosynthetic pathway.
JP2002532101A (ja) * 1998-12-14 2002-10-02 バッハー,アーデルバート テルペノイド類生合成阻害剤のためのスクリーニング
GB9901902D0 (en) * 1999-01-28 1999-03-17 New Royal Holloway & Bedford Manipulating isoprenoid expression
MXPA01011894A (es) * 1999-05-21 2002-06-21 Jomaa Pharmaka Gmbh Uso de genes de las trayectorias biosinteticas de fosfato de desoxi-d-xilulosa para alterar la concentracion de isoprenoides.
ATE373715T1 (de) 1999-08-04 2007-10-15 Adelbert Bacher Isoprenoid biosynthese
DE10021688A1 (de) * 2000-05-05 2001-11-15 Hassan Jomaa Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
CN102860999B (zh) * 2012-10-12 2014-04-09 西北大学 1-脱氧-d-木酮糖5-磷酸还原异构化酶抑制剂及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19752700A1 (de) * 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase

Also Published As

Publication number Publication date
CN1297532A (zh) 2001-05-30
TR200002972T2 (tr) 2001-01-22
PL358989A1 (en) 2004-08-23
IL138721A0 (en) 2001-10-31
EP1071959A2 (de) 2001-01-31
OA11500A (en) 2004-05-14
WO1999052938A2 (de) 1999-10-21
AU4481699A (en) 1999-11-01
SK15232000A3 (sk) 2001-05-10
AU753169B2 (en) 2002-10-10
JP2002511486A (ja) 2002-04-16
AP2000001937A0 (en) 2000-12-31
MXPA00010069A (es) 2002-08-06
CA2328157A1 (en) 1999-10-21
WO1999052938A3 (de) 1999-12-09

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