HUP0200366A2 - Novel compounds - Google Patents
Novel compounds Download PDFInfo
- Publication number
- HUP0200366A2 HUP0200366A2 HU0200366A HUP0200366A HUP0200366A2 HU P0200366 A2 HUP0200366 A2 HU P0200366A2 HU 0200366 A HU0200366 A HU 0200366A HU P0200366 A HUP0200366 A HU P0200366A HU P0200366 A2 HUP0200366 A2 HU P0200366A2
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- polypeptide
- leu
- seq
- polynucleotide
- sequence
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Claims (4)
1. Izolált polipeptid, amely a szekvencialistában 2. azonosítószámon megadott aminosav-szekvenciával, a szekvencialistában 2. azonosítószámon megadott szekvencia teljes terjedelmére nézve, legalább 70%-ban azonos aminosavszekvenciát tartalmaz.
2. Az 1. igénypont szerinti izolált polipeptid, amelyben az aminosav-szekvencia legalább 95%-ban azonos a szekvencialistában 2. azonosítószámon megadott aminosavszekvenciával .
3. Az 1. igénypont szerinti, a szekvencialistában 2. azonosítószámon megadott szekvencia szerinti aminosavszekvenciát tartalmazó polipeptid.
4. A szekvencialistában 2. azonosítószámon megadott szekvencia szerinti polipeptid.
5. Az 1-4. igénypontok bármelyike szerinti polipeptid immunogén fragmentumát tartalmazó polipeptid, amely képes a szekvencialistában 2. azonosítószámon megadott szekvencia szerinti polipeptidet felismerő immunválasz kiváltására.
6· Az 1-5. igénypontok bármelyike szerinti polipeptid, amely polipeptid nagyobb fúziós protein részét képezi.
7. Az 1-6. igénypontok bármelyike szerinti, proteinvivőanyaghoz kémiai úton konjugált polipeptid.
8. Az 1-6. igénypontok bármelyike szerinti polipeptidet kódoló izolált polinukleotid.
- 106 -
9. Izolált polinukleotid, amely a szekvencialistában 2. azonosítószámon megadott aminosav-szekvenciával, a szekvencialistában 2. azonosítószámon megadott szekvencia teljes terjedelmére nézve legalább 70%-ban azonos aminosavszekvenciát tartalmazó polipeptidet kódoló nukleotidszekvenciát tartalmaz; vagy az izolált polinukleotiddal komplementer nukleotidszekvenciát.
10. Izolált polinukleotid, amely a szekvencialistában 2. azonosítószámon megadott aminosav-szekvenciával, a kódoló régió teljes terjedelmére nézve legalább 70%-ban azonos aminosav-szekvenciát tartalmazó polipeptidet kódoló nukleotidszekvenciát tartalmaz; vagy az izolált polinukleotiddal komplementer nukleotidszekvenciát.
11. Izolált polinukleotid, amely a szekvencialistában 1. azonosítószámon megadott szekvencia szerinti nukleotidszekvenciával, a szekvencialistában 1. azonosítószámon megadott szekvencia teljes terjedelmére nézve legalább 70%-ban azonos nukleotidszekvenciát tartalmaz; vagy az izolált polinukleotiddal komplementer nukleotidszekvenciát.
12. A 8-11. igénypontok bármelyike szerinti izolált polinukleotid, amely esetében az azonosság legalább 95%-os.
13. Izolált polinukleotid, amely az alábbiak bármelyike :
(a) a szekvencialistában 2. azonosítószámon megadott szekvencia szerinti polipeptidet kódoló nukleotidszekvenciát tartalmazó polinukleotid;
(b) a szekvencialistában 1. azonosítószámon megadott szekvencia szerinti polinukleotid;
- 107 - (c) megfelelő könyvtárnak a szekvencialistában 1. azonosítószámon megadott szekvencia, vagy annak fragmentuma szerinti szekvenciájú jelzett próbával, sztringens hibridizációs körülmények között történt szkrínelésével előállítható polinukleotid, amely polinukleotid a szekvencialistában 2. azonos!tószámon megadott szekvencia szerinti proteinhez hasonló immunogén tulajdonságú proteint kódol, vagy az izolált polinukleotiddal komplementer nukleotidszekvencia.
14. A 8-13. igénypontok bármelyike szerinti izolált polinukleotidot tartalmazó expressziós vektor.
15. A 14. igénypont szerinti expressziós vektort tartalmazó rekombináns élő mikroorganizmus.
16. A 14. igénypont szerinti expressziós vektort vagy a 8-13. igénypontok bármelyike szerinti polinukleotidot tartalmazó gazdasejt.
17. Eljárás az 1-7. igénypontok bármelyike szerinti polipeptid előállítására azzal jellemezve, hogy a 16. igénypont szerinti gazdasejtet a polipeptid előállítására és a polipeptid tápoldatból történő kinyerésére alkalmas körülmények között tenyésztjük.
18. Az 1-7. igénypontok bármelyike szerinti polipeptidet hatékony mennyiségét és gyógyászatilag elfogadott vivőanyagot tartalmazó vakcina.
19. A 8-13. igénypontok bármelyike szerinti polinukleotid hatékony mennyiségét és gyógyászatilag hatékony vivőanyagot tartalmazó vakcina.
20. Hatékony mennyiségű, az 1-7. igénypontok bármelyike szerinti polipeptiddel végzett in vitro terheléssel módosított, vagy in vitro genetikai úton, az 1-7. igénypontok bármelyike szerinti polipeptid expresszálására módosított antigénbemutató-sejteket és gyógyászatilag hatékony vivőanyagot tartalmazó vakcina.
21. A 18-20. igénypontok bármelyike szerinti vakcina, amely TH-l-et indukáló adjuvánst is tartalmaz.
22. A 21. igénypont szerinti vakcina, amelyben a TH1et indukáló adjuváns 3D-MPL, QS21, QS21 és koleszterin keveréke, vagy CpG oligonukleotid.
23. Az 1-5. igénypontok bármelyike szerinti polipeptidre vagy immunológiai fragmentumra immunspecifikus antitest .
24. Szűrővizsgálati eljárás az 1-5. igénypontok bármelyike szerinti polipeptid funkcióját serkentő vagy gátló vegyületek azonosítására azzal jellemezve, hogy az eljárás az alábbiak közül egy vagy több eljárást tartalmaz:
(a) a vegyületjelölthöz közvetlenül vagy közvetetten kapcsolt jelzés segítségével megmérjük a vegyületjelölt kötődését a polipeptidhez (vagy a polipeptidet hordozó sejtekhez vagy membránokhoz) vagy annak fúziósproteinjéhez,· (b) kompetitor jelenlétében megmérjük a vegyületjelölt kötődését a polipeptidhez (vagy a polipeptidet hordozó sejtekhez vagy membránokhoz) vagy annak fúziósproteinjéhez,·
- 109 - (c) a polipeptidet hordozó sejtek vagy sejtmembránok vizsgálatára alkalmas kimutatási rendszerrel teszteljük, hogy vajon a vegyületjelölt eredményez-e valamilyen, a polipeptid aktiválását vagy gátlását mutató jelet;
(d) a vegyületjelöltet összekeverjük az 1-7. igénypontok bármelyike szerinti- polipeptidet tartalmazó oldattal, megmérjük a polipeptid aktivitását a keverékben, és standarddal összehasonlítjuk a keverékben mért aktivitást; vagy (e) például ELISA vizsgálat alkalmazásával kimutatjuk a vegyületjelölt hatását a polipeptidet vagy a polipeptidet sejtekben kódoló mRNS képződésén.
25. Eljárás valamely alany kezelésére immunmegelőzéssel vagy immunterápiával azzal jellemezve, hogy az eljárásban az 1-5. igénypontok bármelyike szerinti molekulával immunválaszokat indukálunk oly módon, hogy az 1-7. igénypontok bármelyike szerinti polipeptidet vagy a 8-13. igénypontok bármelyike szerinti polinukleotidot emlősfaj immunrendszeréből származó sejtekkel in vitro inkubálunk, és a betegség kezelése céljából ezeket az aktivált immunsejteket infúzióval visszajuttatjuk az emlősfajba.
26. A 25. igénypont szerinti eljárás azzal jellemezve, hogy a kezelést ovárium- vagy vastagbélrák kezelésére alkalmazzuk.
27. Az 1-5. igénypontok bármelyike szerinti polipeptid agonistája vagy antagonistája.
- 110 - -· V
28. Vegyület, amely:
(a) az 1-5. igénypontok bármelyike szerinti polipeptid agonistája vagy antagonistája;
(b) a 8-13. igénypontok bármelyike szerinti izolált polinukleotid; vagy (c) az 1-5. igénypontok bármelyike szerinti polipeptidet kódoló nukleotidszekvencia expresszióját moduláló nukleinsav-molekula;
terápiás célokra való-alkalmazásra.
29. Eljárás a 1-5. igénypontok bármelyike szerinti polinukleotid expressziójával vagy aktivitásával kapcsolatos betegség diagnosztizálására vagy betegségre való fogékonyság diagnosztizálására alanyban azzal jellemezve, hogy az alanyból származó mintát a polinukleotid jelenlétére vagy mennyiségére nézve analizáljuk.
30. Eljárás a 8-13. igénypontok bármelyike szerinti polinukleotid expressziójával vagy aktivitásával kapcsolatos betegség diagnosztizálására vagy betegségre való fogékonyság diagnosztizálására alanyban azzal jellemezve, hogy az alanyból származó mintát a polinukleotid jelenlétére vagy mennyiségére nézve analizáljuk.
31. A 29. igénypont szerinti eljárás azzal jellemezve, hogy a betegség a vastagbél vagy az ovárium rákos megbetegedése .
32. A 30. igénypont szerinti eljárás azzal jellemezve, hogy a betegség a vastagbél vagy az ovárium rákos megbetegedése .
- Ill -
33. Izolált polinukleotid, amely (a) a szekvencialistában 3. azonosítószámon megadott szekvencia szerinti nukleotidszekvenciával, a szekvencialistában 3. azonositószámon megadott szekvencia teljes terjedelmére nézve legalább 90%-ban azonos nukleotidszekvenciát tartalmaz;
(b) a szekvencialistában 3. azonosítószámon megadott dl szekvencia szerinti polinukleotidot tartalmazó, izolált polinukleotid;
(c) a szekvencialistában 3. azonosítószámon megadott szekvencia szerinti polinukleotid.
34. A 14. igénypont szerinti expressziós vektort vagy a 15. igénypont szerinti élő mikroorganizmust tartalmazó élő vakcinakészitmény.
35. A 8-13. igénypont szerinti polinukleotid alkalmazása karcinóma kezelésére szolgáló gyógyszer előállítására.
36. A 8-13. igénypont szerinti polinukleotid alkalmazása vastagbél- vagy ovárium-karcinóma kezelésére szolgáló gyógyszer előállítására.
37. Az 1-7. igénypont szerinti polipeptid alkalmazása karcinóma kezelésére szolgáló gyógyszer előállítására.
38. Az 1-7. igénypont szerinti polipeptid alkalmazása vastagbél- vagy ovárium-karcinóma kezelésére szolgáló gyógyszer előállítására.
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| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US5840871A (en) * | 1997-01-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Prostate-associated kallikrein |
| GB9806095D0 (en) * | 1998-03-20 | 1998-05-20 | Smithkline Beecham Biolog | Novel compounds |
| GB9806164D0 (en) * | 1998-03-20 | 1998-05-20 | Smithkline Beecham Biolog | Novel compounds |
| WO2000056891A2 (en) * | 1999-03-22 | 2000-09-28 | Incyte Pharmaceuticals, Inc. | Human transmembrane proteins |
| US7105315B2 (en) | 1999-06-16 | 2006-09-12 | Incyte Genomics, Inc. | Transmembrane protein differentially expressed in cancer |
| CA2371172A1 (en) * | 1999-04-09 | 2000-10-19 | Human Genome Sciences, Inc. | 50 human secreted proteins |
-
2000
- 2000-03-09 TR TR2001/02781T patent/TR200102781T2/xx unknown
- 2000-03-09 DE DE60031383T patent/DE60031383T2/de not_active Expired - Fee Related
- 2000-03-09 EP EP00910793A patent/EP1165778B1/en not_active Expired - Lifetime
- 2000-03-09 CN CNB008072612A patent/CN100430478C/zh not_active Expired - Fee Related
- 2000-03-09 IL IL14504700A patent/IL145047A0/xx unknown
- 2000-03-09 AT AT00910793T patent/ATE342727T1/de not_active IP Right Cessation
- 2000-03-09 PT PT00910793T patent/PT1165778E/pt unknown
- 2000-03-09 BR BR0008917-6A patent/BR0008917A/pt not_active Application Discontinuation
- 2000-03-09 ES ES00910793T patent/ES2273670T3/es not_active Expired - Lifetime
- 2000-03-09 AU AU32877/00A patent/AU756398B2/en not_active Ceased
- 2000-03-09 CZ CZ20013268A patent/CZ20013268A3/cs unknown
- 2000-03-09 CA CA002366147A patent/CA2366147A1/en not_active Abandoned
- 2000-03-09 JP JP2000603369A patent/JP2002538787A/ja active Pending
- 2000-03-09 HK HK02104688.7A patent/HK1044794B/en not_active IP Right Cessation
- 2000-03-09 DK DK00910793T patent/DK1165778T3/da active
- 2000-03-09 HU HU0200366A patent/HUP0200366A2/hu unknown
- 2000-03-09 NZ NZ513838A patent/NZ513838A/xx unknown
- 2000-03-09 WO PCT/EP2000/002048 patent/WO2000053748A2/en not_active Ceased
- 2000-03-09 KR KR1020017011531A patent/KR100674784B1/ko not_active Expired - Fee Related
- 2000-03-09 PL PL00350991A patent/PL350991A1/xx unknown
-
2001
- 2001-08-22 IL IL145047A patent/IL145047A/en active IP Right Grant
- 2001-09-04 NO NO20014293A patent/NO20014293L/no not_active Application Discontinuation
-
2005
- 2005-08-09 US US11/199,820 patent/US7470782B2/en not_active Expired - Fee Related
-
2008
- 2008-11-21 US US12/275,776 patent/US20090202577A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1165778B1 (en) | 2006-10-18 |
| NO20014293D0 (no) | 2001-09-04 |
| CN1370231A (zh) | 2002-09-18 |
| AU3287700A (en) | 2000-09-28 |
| PT1165778E (pt) | 2007-01-31 |
| ES2273670T3 (es) | 2007-05-16 |
| JP2002538787A (ja) | 2002-11-19 |
| KR20020008125A (ko) | 2002-01-29 |
| WO2000053748A3 (en) | 2001-01-11 |
| BR0008917A (pt) | 2002-01-15 |
| ATE342727T1 (de) | 2006-11-15 |
| TR200102781T2 (tr) | 2002-01-21 |
| US20090202577A1 (en) | 2009-08-13 |
| NO20014293L (no) | 2001-11-12 |
| NZ513838A (en) | 2003-02-28 |
| DE60031383D1 (de) | 2006-11-30 |
| CN100430478C (zh) | 2008-11-05 |
| US7470782B2 (en) | 2008-12-30 |
| IL145047A0 (en) | 2002-06-30 |
| DE60031383T2 (de) | 2007-11-15 |
| HK1044794A1 (en) | 2002-11-01 |
| WO2000053748A2 (en) | 2000-09-14 |
| HK1044794B (en) | 2007-05-18 |
| CZ20013268A3 (cs) | 2002-02-13 |
| AU756398B2 (en) | 2003-01-09 |
| EP1165778A2 (en) | 2002-01-02 |
| KR100674784B1 (ko) | 2007-01-25 |
| US20060052593A1 (en) | 2006-03-09 |
| DK1165778T3 (da) | 2007-02-12 |
| CA2366147A1 (en) | 2000-09-14 |
| IL145047A (en) | 2008-11-03 |
| PL350991A1 (en) | 2003-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |