HUP0401880A2 - Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0401880A2
HUP0401880A2 HU0401880A HUP0401880A HUP0401880A2 HU P0401880 A2 HUP0401880 A2 HU P0401880A2 HU 0401880 A HU0401880 A HU 0401880A HU P0401880 A HUP0401880 A HU P0401880A HU P0401880 A2 HUP0401880 A2 HU P0401880A2
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Hungary
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straight
group
branched
atom
aryl
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HU0401880A
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English (en)
Inventor
Mohammad R. Marzabadi
John Wetzel
John E. Deleon
Yu Jiang
Kai Lu
Bharat Lagu
Chien-An Chen
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Synaptic Pharmaceutical Corporation
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Publication date
Application filed by Synaptic Pharmaceutical Corporation filed Critical Synaptic Pharmaceutical Corporation
Publication of HUP0401880A2 publication Critical patent/HUP0401880A2/hu

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány MCH-1-receptorok szelektív antagonistáira vonatkozik. Atalálmány tárgyát képezik az alábbi vegyületek: ahol a képletben R1jelentése hidrogénatom, egyenes vagy elágazó szénláncú 1-7 szénatomosalkil-, monofluoralkil- vagy polifluoralkil-, aril- vagyheteroarilcsoport, ahol a képletben az aril- vagy heteroarilcsoportadott esetben egy vagy több F-, Cl-, Br-, I-atommal, CN-, NO2-, CH3-,CF3-, COR2-, CO2R2-, fenil-, fenoxi- vagy egyenes vagy elágazószénláncú 1-7 szénatomos alkilcsoporttal helyettesített; ahol R2jelentése egyenes vagy elágazó szénláncú 3-4 szénatomos alkil vagyciklopropilcsoport; R3 jelentése aril- vagy heteroariIcsoport, ahol aképletben az aril- vagy heteroarilcsoport adott esetben egy vagy többF-, Cl-, Br-, I-atommal, CN-, NO2-, egyenes vagy elágazó szénláncú 1-7szénatomos alkilcsoporttal helyettesített; A jelentése H-, F-, Cl-,Br-atom, CN-, NO2-, COR3-, CO2R3-, egyenes vagy elágazó szénláncú 1-7szénatomos alkil-, monofluoralkil- vagy polifluoralkilcsoport; Xjelentése O-atom vagy NH-csoport; és ahol a képletben n jelentése 0-5értékű egész szám, ideértve a szélső értékeket. A találmány tárgyátképezik továbbá a találmány szerinti vegyületeket tartalmazógyógyászati készítmények és eljárások ezen készítmények előállítására. Ó
HU0401880A 2001-07-05 2002-07-03 Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk HUP0401880A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89979401A 2001-07-05 2001-07-05
US4258202A 2002-01-09 2002-01-09
PCT/US2002/021063 WO2003004027A1 (en) 2001-07-05 2002-07-03 Substituted anilinic piperidines as mch selective antagonists

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HUP0401880A2 true HUP0401880A2 (hu) 2005-01-28

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HU0401880A HUP0401880A2 (hu) 2001-07-05 2002-07-03 Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Country Status (15)

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EP (1) EP1411942A4 (hu)
JP (1) JP2004536104A (hu)
KR (1) KR20040027870A (hu)
CN (1) CN1671386A (hu)
CA (1) CA2454613A1 (hu)
CO (1) CO5670352A2 (hu)
EA (1) EA005934B1 (hu)
HU (1) HUP0401880A2 (hu)
IL (1) IL159697A0 (hu)
IS (1) IS7085A (hu)
MX (1) MXPA03011886A (hu)
NO (1) NO20040028L (hu)
NZ (1) NZ530221A (hu)
PL (1) PL366624A1 (hu)
WO (1) WO2003004027A1 (hu)

Families Citing this family (104)

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Publication number Priority date Publication date Assignee Title
US6727264B1 (en) 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
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