HUP9900657A2 - Hypericum perforatum L. stabil kivonatai, ezeket tartalmazó gyógyszerkészítmények, és eljárás az extraktum előállítására - Google Patents

Hypericum perforatum L. stabil kivonatai, ezeket tartalmazó gyógyszerkészítmények, és eljárás az extraktum előállítására

Info

Publication number
HUP9900657A2
HUP9900657A2 HU9900657A HUP9900657A HUP9900657A2 HU P9900657 A2 HUP9900657 A2 HU P9900657A2 HU 9900657 A HU9900657 A HU 9900657A HU P9900657 A HUP9900657 A HU P9900657A HU P9900657 A2 HUP9900657 A2 HU P9900657A2
Authority
HU
Hungary
Prior art keywords
preparing
pharmaceutical compositions
same
compositions containing
hypericum perforatum
Prior art date
Application number
HU9900657A
Other languages
English (en)
Inventor
Clemens Erdelmeier
Eckhart Grethlein
Friedrich Lang
Rainer Oschmann
Original Assignee
Dr. Willmar Schwabe Gmbh & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27215529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9900657(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19619512A external-priority patent/DE19619512C5/de
Application filed by Dr. Willmar Schwabe Gmbh & Co. filed Critical Dr. Willmar Schwabe Gmbh & Co.
Publication of HUP9900657A2 publication Critical patent/HUP9900657A2/hu
Publication of HUP9900657A3 publication Critical patent/HUP9900657A3/hu
Publication of HU227069B1 publication Critical patent/HU227069B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/86—Use of additives, e.g. for stabilisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Fertilizers (AREA)

Abstract

A találmány hyperfőrint tartalmazó, Hypericűm perfőratűm L.-ből(lyűkaslevelű őrbáncfűből) nyert, javítőtt stabilitású kivőnatravőnatkőzik, amely a hyperfőrin bőmlásának vagy degradációjánakmegelőzésére stabilizátőrt tartalmaz. A találmány tárgyát képeziktővábbá az ilyen kivőnatőt tartalmazó gyógyszerkészítmények és akivőnat előállítási eljárása. ŕ
HU9900657A 1995-09-29 1996-09-27 Hypericum perforatum L. stabil kivonatai, ezeket tartalmazó gyógyszerkészítmények, és eljárás az extraktum elõállítására HU227069B1 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19536496 1995-09-29
DE19611374 1996-03-22
DE19619512A DE19619512C5 (de) 1995-09-29 1996-05-14 Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
PCT/DE1996/001876 WO1997013489A2 (de) 1995-09-29 1996-09-27 Stabiler extrakt aus hypericum perforatum l., verfahren zu seiner herstellung und pharmazeutische zubereitungen

Publications (3)

Publication Number Publication Date
HUP9900657A2 true HUP9900657A2 (hu) 1999-09-28
HUP9900657A3 HUP9900657A3 (en) 2000-02-28
HU227069B1 HU227069B1 (hu) 2010-06-28

Family

ID=27215529

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900657A HU227069B1 (hu) 1995-09-29 1996-09-27 Hypericum perforatum L. stabil kivonatai, ezeket tartalmazó gyógyszerkészítmények, és eljárás az extraktum elõállítására

Country Status (17)

Country Link
US (2) US6280736B1 (hu)
EP (1) EP0854726B2 (hu)
JP (1) JP3245654B2 (hu)
CN (1) CN1087943C (hu)
AT (1) ATE174511T1 (hu)
AU (1) AU709877B2 (hu)
BR (1) BRPI9611096B8 (hu)
CA (1) CA2233277C (hu)
DE (2) DE19646977A1 (hu)
EA (1) EA000948B1 (hu)
ES (1) ES2118686T5 (hu)
GR (1) GR3029412T3 (hu)
HU (1) HU227069B1 (hu)
NO (1) NO981352L (hu)
PL (1) PL186727B1 (hu)
TR (1) TR199800569T1 (hu)
WO (1) WO1997013489A2 (hu)

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DE19714450A1 (de) * 1997-04-08 1998-10-15 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung
US6113907A (en) * 1997-04-15 2000-09-05 University Of Southern California Pharmaceutical grade St. John's Wort
US6607754B1 (en) 1997-07-11 2003-08-19 Upsher-Smith Laboratories, Inc. Delivery of Hypericum perforatum (St. John's Wort) in tablet form
CA2312851A1 (en) * 1997-12-01 1999-06-10 Nicogen, Inc. Therapeutic and diagnostic methods dependent on cyp2a enzymes
ES2162520T3 (es) 1998-02-13 2001-12-16 Schwabe Willmar Gmbh & Co Medicamentos basados en hiperforina y/o extractos de hiperforina.
AU743956B2 (en) * 1998-02-13 2002-02-07 Dr. Willmar Schwabe Gmbh & Co Stable hyperforin salts, method for producing same and their use in the treatment of Alzheimer's disease
EP0965348B1 (de) * 1998-04-22 2000-07-19 Bionorica Arzneimittel GmbH Verfahren zur schonenden Gewinnung von Extraktfraktionen aus Hypericum perforatum L., diese enthaltende pharmazeutische Zubereitungen und Verwendung derselben
US6238671B1 (en) 1998-04-22 2001-05-29 Bionorica Arzneimittel Gmbh Process for the gentle recovery of extract fractions from hypericum, pharmaceutical preparations containing the same and their use
US6063401A (en) 1998-05-06 2000-05-16 M.E. Cody Products, Inc. Plantago major and hypericum perforatum compound for use in treating a tobacco or nicotine habit
IT1301679B1 (it) 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.
IT1301678B1 (it) 1998-06-10 2000-07-07 Indena Spa Estratti di hypericum perforatum e formulazioni che li contengono.
US6045825A (en) * 1998-06-17 2000-04-04 M. E. Cody Products, Inc. Plantago major and Piper methysticum compound for use in treating a tobacco or nicotine habit
WO2000025824A2 (de) * 1998-11-04 2000-05-11 Dr. Willmar Schwabe Gmbh & Co. Stabile zubereitungen mit hyperforin
DE19913333C2 (de) * 1999-03-24 2001-10-11 Univ Ludwigs Albert Hyperforin als Zytostatikum
EP1034782A1 (en) * 1999-03-04 2000-09-13 Andrea Singer Treatment of depression by using compounds which elevate the intracellular sodium concentration
WO2000054760A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia
US7195783B2 (en) 1999-07-09 2007-03-27 Fx Life Sciences International Gmbh Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics
ES2159270B1 (es) * 2000-03-06 2002-04-01 Asac Compania De Biotecnologia Oleorresina de hypericum perforatum l., procedimiento de obtencion y usos.
KR100407399B1 (ko) * 2000-08-22 2003-11-28 주식회사 뉴로넥스 세로토닌 ｎ-아세틸트란스퍼라제의 활성 억제제
DE10131641A1 (de) * 2000-12-22 2002-06-27 Schwabe Willmar Gmbh & Co Verbesserter und stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und Verwendung als topisches Arzneimittel
CN100534420C (zh) * 2001-09-25 2009-09-02 北京北大维信生物科技有限公司 一种治疗抑郁症的口服药
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
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US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US20050053678A1 (en) * 2001-10-03 2005-03-10 Gow Robert T. Methods and compositions for betel nut chewing gum
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
AU2003286725B2 (en) * 2002-10-29 2007-07-12 Transform Pharmaceuticals, Inc. Propofol with cysteine
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CN1304019C (zh) * 2003-05-29 2007-03-14 斯拉甫·艾白 复方一枝蒿胶囊
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
CN1917892A (zh) * 2003-10-24 2007-02-21 草本制药科学有限责任公司 包含冬青的方法和组合物
US20050176650A1 (en) * 2004-02-09 2005-08-11 Xanodyne Pharmacal, Inc. Stable parenteral formulation of levomepromazine and a method for stabilizing said formulation
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CN101744890A (zh) * 2008-12-08 2010-06-23 上海四埃美微科技有限公司 一种贯叶连翘提取物中金丝桃素的精制的方法
CN101984980B (zh) * 2010-11-05 2012-12-19 北京世纪博康医药科技有限公司 一种贯叶连翘提取物的提取方法、提取物和制药用途
RU2623084C2 (ru) * 2015-06-23 2017-06-21 Федеральное государственное бюджетное учреждение науки Институт биологии Коми научного центра Уральского отделения Российской академии наук Способ одновременного получения гиперицина и псевдогиперицина
CN106588827B (zh) * 2016-12-29 2019-03-08 广州领鲜生物科技有限公司 用于治疗溃疡性结肠炎的金丝海棠提取物的提取方法及应用
CN106668088A (zh) * 2017-02-08 2017-05-17 内蒙古昶辉生物科技股份有限公司 一种贯叶连翘提取物的制备方法
CN108936612A (zh) * 2018-06-28 2018-12-07 燕生（福建）生物工程有限公司 一种制备具有强抗氧化作用的燕窝提取液的方法

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Also Published As

Publication number Publication date
BRPI9611096B8 (pt) 2015-12-08
US20020031560A1 (en) 2002-03-14
ATE174511T1 (de) 1999-01-15
CA2233277C (en) 2002-04-02
EP0854726B1 (de) 1998-12-16
HUP9900657A3 (en) 2000-02-28
ES2118686T3 (es) 1999-04-16
ES2118686T1 (es) 1998-10-01
DE59601019D1 (de) 1999-01-28
EP0854726A2 (de) 1998-07-29
EP0854726B2 (de) 2009-07-29
NO981352D0 (no) 1998-03-25
US6280736B1 (en) 2001-08-28
CN1087943C (zh) 2002-07-24
EA199800304A1 (ru) 1998-10-29
AU709877B2 (en) 1999-09-09
WO1997013489A2 (de) 1997-04-17
CN1198097A (zh) 1998-11-04
JPH11500743A (ja) 1999-01-19
BR9611096A (pt) 1999-10-05
JP3245654B2 (ja) 2002-01-15
EA000948B1 (ru) 2000-06-26
NO981352L (no) 1998-03-25
PL186727B1 (pl) 2004-02-27
BR9611096B1 (pt) 2010-09-21
WO1997013489A3 (de) 1997-08-14
GR3029412T3 (en) 1999-05-28
AU1589197A (en) 1997-04-30
TR199800569T1 (xx) 1998-06-22
ES2118686T5 (es) 2009-12-11
PL328136A1 (en) 1999-01-18
HU227069B1 (hu) 2010-06-28
DE19646977A1 (de) 1998-01-15
CA2233277A1 (en) 1997-04-17

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