HUT53675A - Process for producing insulin preproduct in streptomycetes - Google Patents

Process for producing insulin preproduct in streptomycetes

Info

Publication number: HUT53675A
Authority: HU; Hungary
Prior art keywords: streptomycetes; preproduct; lys; gene; producing insulin
Prior art date: 1988-11-03

Application number

HU895649A

Other languages

English (en)

Other versions

HU209596B (en

HU895649D0 (en

Inventor

Klaus Peter Koller

Guenther Johannes Rieb

Eugen Uhlmann

Holger Wallmeier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-03

Filing date

1989-11-02

Publication date

1990-11-28

1988-11-03 Priority claimed from DE3837273A external-priority patent/DE3837273A1/de

1989-08-19 Priority claimed from DE19893927449 external-priority patent/DE3927449A1/de

1989-11-02 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-01-28 Publication of HU895649D0 publication Critical patent/HU895649D0/hu

1990-11-28 Publication of HUT53675A publication Critical patent/HUT53675A/hu

1994-08-29 Publication of HU209596B publication Critical patent/HU209596B/hu

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
241001655322 Streptomycetales Species 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 3
108020001507 fusion proteins Proteins 0.000 abstract 2
102000037865 fusion proteins Human genes 0.000 abstract 2
NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 abstract 1
108010076181 Proinsulin Proteins 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
108010054155 lysyllysine Proteins 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
229950001790 tendamistat Drugs 0.000 abstract 1
108010037401 tendamistate Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HU895649A 1988-11-03 1989-11-02 Process for producing of insuline pro-product in streptomyceten HU209596B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3837273A DE3837273A1 (de)	1987-05-05	1988-11-03	Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE19893927449 DE3927449A1 (de)	1989-08-19	1989-08-19	Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten

Publications (3)

Publication Number	Publication Date
HU895649D0 HU895649D0 (en)	1990-01-28
HUT53675A true HUT53675A (en)	1990-11-28
HU209596B HU209596B (en)	1994-08-29

Family

ID=25873834

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU895649A HU209596B (en)	1988-11-03	1989-11-02	Process for producing of insuline pro-product in streptomyceten

Country Status (18)

Country	Link
EP (1)	EP0367163B1 (hu)
JP (1)	JPH02219588A (hu)
KR (1)	KR900008040A (hu)
CN (1)	CN1042378A (hu)
AT (1)	ATE132531T1 (hu)
AU (1)	AU619054B2 (hu)
CA (1)	CA2002062A1 (hu)
DE (1)	DE58909556D1 (hu)
DK (1)	DK546889A (hu)
ES (1)	ES2081826T3 (hu)
FI (1)	FI95600C (hu)
GR (1)	GR3018738T3 (hu)
HU (1)	HU209596B (hu)
IE (1)	IE893530L (hu)
IL (1)	IL92178A (hu)
NO (1)	NO894363L (hu)
NZ (1)	NZ231222A (hu)
PT (1)	PT92177B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4012818A1 (de)	1990-04-21	1991-10-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
US5426036A (en) *	1987-05-05	1995-06-20	Hoechst Aktiengesellschaft	Processes for the preparation of foreign proteins in streptomycetes
DE3714866A1 (de) *	1987-05-05	1988-11-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
KR100188800B1 (ko)	1990-09-05	1999-06-01	이센브룩, 라피세	프리프로인슐린을 인슐린으로 전환시키기 위한 효소적 방법
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
PL2307441T3 (pl)	2008-08-07	2016-09-30		Sposób otrzymywania związków insuliny

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3418274A1 (de) *	1984-05-17	1985-11-21	Hoechst Ag, 6230 Frankfurt	Signalpeptid fuer die exkretion von peptiden in streptomyceten
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
DE3707150A1 (de) *	1987-03-06	1988-09-15	Hoechst Ag	Tendamistat-derivate
DE3714866A1 (de) *	1987-05-05	1988-11-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten

1989
- 1989-10-28 EP EP89120056A patent/EP0367163B1/de not_active Expired - Lifetime
- 1989-10-28 ES ES89120056T patent/ES2081826T3/es not_active Expired - Lifetime
- 1989-10-28 AT AT89120056T patent/ATE132531T1/de not_active IP Right Cessation
- 1989-10-28 DE DE58909556T patent/DE58909556D1/de not_active Expired - Fee Related
- 1989-11-01 NZ NZ231222A patent/NZ231222A/xx unknown
- 1989-11-01 FI FI895184A patent/FI95600C/fi not_active IP Right Cessation
- 1989-11-01 AU AU43950/89A patent/AU619054B2/en not_active Ceased
- 1989-11-01 IL IL9217889A patent/IL92178A/en not_active IP Right Cessation
- 1989-11-02 KR KR1019890015844A patent/KR900008040A/ko not_active Abandoned
- 1989-11-02 JP JP1287282A patent/JPH02219588A/ja active Pending
- 1989-11-02 IE IE893530A patent/IE893530L/xx unknown
- 1989-11-02 NO NO89894363A patent/NO894363L/no unknown
- 1989-11-02 DK DK546889A patent/DK546889A/da not_active Application Discontinuation
- 1989-11-02 PT PT92177A patent/PT92177B/pt not_active IP Right Cessation
- 1989-11-02 CA CA002002062A patent/CA2002062A1/en not_active Abandoned
- 1989-11-02 HU HU895649A patent/HU209596B/hu not_active IP Right Cessation
- 1989-11-03 CN CN89108320A patent/CN1042378A/zh active Pending
1996
- 1996-01-19 GR GR960400123T patent/GR3018738T3/el unknown

Also Published As

Publication number	Publication date
PT92177A (pt)	1990-05-31
GR3018738T3 (en)	1996-04-30
DK546889D0 (da)	1989-11-02
HU209596B (en)	1994-08-29
PT92177B (pt)	1995-06-30
FI95600C (fi)	1996-02-26
EP0367163B1 (de)	1996-01-03
CA2002062A1 (en)	1990-05-03
IE893530L (en)	1990-05-03
DE58909556D1 (de)	1996-02-15
NO894363L (no)	1990-05-04
ATE132531T1 (de)	1996-01-15
FI95600B (fi)	1995-11-15
JPH02219588A (ja)	1990-09-03
AU4395089A (en)	1990-05-10
DK546889A (da)	1990-05-04
IL92178A (en)	1995-11-27
IL92178A0 (en)	1990-07-26
EP0367163A3 (de)	1991-03-06
AU619054B2 (en)	1992-01-16
ES2081826T3 (es)	1996-03-16
NO894363D0 (no)	1989-11-02
CN1042378A (zh)	1990-05-23
KR900008040A (ko)	1990-06-02
EP0367163A2 (de)	1990-05-09
HU895649D0 (en)	1990-01-28
NZ231222A (en)	1991-08-27
FI895184A0 (fi)	1989-11-01

Legal Events

Date	Code	Title	Description
1997-08-28	HMM4	Cancellation of final prot. due to non-payment of fee

Publication	Publication Date	Title
EP0244234A3 (en)	1988-10-12	Transformation of trichoderma
AU7730481A (en)	1982-05-20	Hybrid human leukocyte interferons
GB8709871D0 (en)	1987-06-03	Peptides
GR3025873T3 (en)	1998-04-30	Stabilized factor VIII preparations
GR3025382T3 (en)	1998-02-27	Expression of human serum albumin in metholotrophic yeasts
EP0515516A4 (en)	1993-03-31	Totally synthetic affinity reagents
HUT53675A (en)	1990-11-28	Process for producing insulin preproduct in streptomycetes
AU660936B2 (en)	1995-07-13	Stationary position adjustment device for handling trolley
DE59409964D1 (de)	2002-01-03	Rekombinante D-Hydantoinase, Verfahren zur Herstellung und Verwendung
NZ239652A (en)	1992-09-25	Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
IL90719A0 (en)	1990-01-18	Novel nuclei acids and polypeptides encoded thereby
GB9207267D0 (en)	1992-05-13	Nisins
IE881338L (en)	1988-11-05	A process for the preparation of foreign proteins in¹streptomycetes
WO1990000179A3 (fr)	1990-03-08	Nouvelles proteins, adn les codant et leur usage
UA19109A (uk)	1997-12-25	Спосіб посилеhhя протилейкозhої активhості циклофосфаhу