PT92177A - Processo para a preparacao de um precursor de insulina em estreptomicetes - Google Patents

Processo para a preparacao de um precursor de insulina em estreptomicetes

Info

Publication number: PT92177A
Authority: PT; Portugal
Prior art keywords: lys; streptomicetes; preparation; gene; insulin precursor
Prior art date: 1988-11-03

Application number

PT92177A

Other languages

English (en)

Other versions

PT92177B (pt

Inventor

Eugen Uhlmann

Klaus-Peter Koller

Gunther Johannes Riess

Holger Wallmeier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-03

Filing date

1989-11-02

Publication date

1990-05-31

1988-11-03 Priority claimed from DE3837273A external-priority patent/DE3837273A1/de

1989-08-19 Priority claimed from DE19893927449 external-priority patent/DE3927449A1/de

1989-11-02 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-05-31 Publication of PT92177A publication Critical patent/PT92177A/pt

1995-06-30 Publication of PT92177B publication Critical patent/PT92177B/pt

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 2
239000002243 precursor Substances 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 3
108020001507 fusion proteins Proteins 0.000 abstract 2
102000037865 fusion proteins Human genes 0.000 abstract 2
NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 abstract 1
108010076181 Proinsulin Proteins 0.000 abstract 1
241001655322 Streptomycetales Species 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
108010054155 lysyllysine Proteins 0.000 abstract 1
229950001790 tendamistat Drugs 0.000 abstract 1
108010037401 tendamistate Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT92177A 1988-11-03 1989-11-02 Processo para a preparacao de um precursor de insulina em estreptomicetes PT92177B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3837273A DE3837273A1 (de)	1987-05-05	1988-11-03	Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE19893927449 DE3927449A1 (de)	1989-08-19	1989-08-19	Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten

Publications (2)

Publication Number	Publication Date
PT92177A true PT92177A (pt)	1990-05-31
PT92177B PT92177B (pt)	1995-06-30

Family

ID=25873834

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT92177A PT92177B (pt)	1988-11-03	1989-11-02	Processo para a preparacao de um precursor de insulina em estreptomicetes

Country Status (18)

Country	Link
EP (1)	EP0367163B1 (pt)
JP (1)	JPH02219588A (pt)
KR (1)	KR900008040A (pt)
CN (1)	CN1042378A (pt)
AT (1)	ATE132531T1 (pt)
AU (1)	AU619054B2 (pt)
CA (1)	CA2002062A1 (pt)
DE (1)	DE58909556D1 (pt)
DK (1)	DK546889A (pt)
ES (1)	ES2081826T3 (pt)
FI (1)	FI95600C (pt)
GR (1)	GR3018738T3 (pt)
HU (1)	HU209596B (pt)
IE (1)	IE893530L (pt)
IL (1)	IL92178A (pt)
NO (1)	NO894363L (pt)
NZ (1)	NZ231222A (pt)
PT (1)	PT92177B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3714866A1 (de) *	1987-05-05	1988-11-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
US5426036A (en) *	1987-05-05	1995-06-20	Hoechst Aktiengesellschaft	Processes for the preparation of foreign proteins in streptomycetes
DE4012818A1 (de) *	1990-04-21	1991-10-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
CZ283234B6 (cs) *	1990-09-05	1998-02-18	Hoechst Aktiengesellschaft	Enymatický způsob konverse preproinsulinů na insuliny
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
KR20110059602A (ko)	2008-08-07	2011-06-02	바이오콘 리미티드	인슐린 화합물의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3418274A1 (de) *	1984-05-17	1985-11-21	Hoechst Ag, 6230 Frankfurt	Signalpeptid fuer die exkretion von peptiden in streptomyceten
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
DE3707150A1 (de) *	1987-03-06	1988-09-15	Hoechst Ag	Tendamistat-derivate
DE3714866A1 (de) *	1987-05-05	1988-11-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten

1989
- 1989-10-28 EP EP89120056A patent/EP0367163B1/de not_active Expired - Lifetime
- 1989-10-28 ES ES89120056T patent/ES2081826T3/es not_active Expired - Lifetime
- 1989-10-28 DE DE58909556T patent/DE58909556D1/de not_active Expired - Fee Related
- 1989-10-28 AT AT89120056T patent/ATE132531T1/de not_active IP Right Cessation
- 1989-11-01 NZ NZ231222A patent/NZ231222A/xx unknown
- 1989-11-01 IL IL9217889A patent/IL92178A/en not_active IP Right Cessation
- 1989-11-01 AU AU43950/89A patent/AU619054B2/en not_active Ceased
- 1989-11-01 FI FI895184A patent/FI95600C/fi not_active IP Right Cessation
- 1989-11-02 PT PT92177A patent/PT92177B/pt not_active IP Right Cessation
- 1989-11-02 HU HU895649A patent/HU209596B/hu not_active IP Right Cessation
- 1989-11-02 DK DK546889A patent/DK546889A/da not_active Application Discontinuation
- 1989-11-02 IE IE893530A patent/IE893530L/xx unknown
- 1989-11-02 KR KR1019890015844A patent/KR900008040A/ko not_active Abandoned
- 1989-11-02 CA CA002002062A patent/CA2002062A1/en not_active Abandoned
- 1989-11-02 NO NO89894363A patent/NO894363L/no unknown
- 1989-11-02 JP JP1287282A patent/JPH02219588A/ja active Pending
- 1989-11-03 CN CN89108320A patent/CN1042378A/zh active Pending
1996
- 1996-01-19 GR GR960400123T patent/GR3018738T3/el unknown

Also Published As

Publication number	Publication date
FI895184A0 (fi)	1989-11-01
DE58909556D1 (de)	1996-02-15
NO894363L (no)	1990-05-04
EP0367163A2 (de)	1990-05-09
HUT53675A (en)	1990-11-28
CN1042378A (zh)	1990-05-23
EP0367163A3 (de)	1991-03-06
FI95600C (fi)	1996-02-26
PT92177B (pt)	1995-06-30
JPH02219588A (ja)	1990-09-03
FI95600B (fi)	1995-11-15
NZ231222A (en)	1991-08-27
ATE132531T1 (de)	1996-01-15
HU209596B (en)	1994-08-29
DK546889A (da)	1990-05-04
EP0367163B1 (de)	1996-01-03
CA2002062A1 (en)	1990-05-03
AU4395089A (en)	1990-05-10
AU619054B2 (en)	1992-01-16
DK546889D0 (da)	1989-11-02
ES2081826T3 (es)	1996-03-16
KR900008040A (ko)	1990-06-02
IL92178A (en)	1995-11-27
GR3018738T3 (en)	1996-04-30
IL92178A0 (en)	1990-07-26
HU895649D0 (en)	1990-01-28
NO894363D0 (no)	1989-11-02
IE893530L (en)	1990-05-03

Legal Events

Date

Code

Title

Description

1997-10-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970630

Publication	Publication Date	Title
DE68921614D1 (de)	1995-04-13	Farbmonitor zur darstellung von optisch übereinstimmenden bildern mit reproduzierenden darstellungen.
DE69034022D1 (de)	2003-01-09	Verfahren zur Herstellung von Fusionsproteinen
AU2894289A (en)	1989-08-10	Domain-modified constant region antibodies
BR8802702A (pt)	1988-12-27	Catalisador para uso na producao de acido acrilico e processo para preparacao,com boa reprodutibilidade,de um catalisador que e usado na producao de acido acrilico
DE3864585D1 (de)	1991-10-10	Dns-molekule, codierend fuer non-a-non-b-hepatitis-antigene und ihre verwendung zur herstellung dieser antigene.
ATE113077T1 (de)	1994-11-15	Stabile integration von dna in bakterielle genome.
DK121788A (da)	1988-03-07	Il-6, fremgangsmaade til dets fremstilling samt dets anvendelse
PT90939A (pt)	1989-12-29	Processo para a preparacao de mini-proinsulina
ATE125869T1 (de)	1995-08-15	Wachstumshormonfusionsproteine.
ATE106746T1 (de)	1994-06-15	Arzneimittel zur subkutanen oder intramuskulären applikation enthaltend polypeptide.
DK13788A (da)	1988-03-15	Fremgangsmaade til fremstilling af et polypeptid
AU619054B2 (en)	1992-01-16	A process for the preparation of an insulin precursor in streptomycetes
DE3881023D1 (de)	1993-06-17	Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
NZ239652A (en)	1992-09-25	Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
EP0315118A3 (en)	1990-09-19	Dna coding for endothelin and use thereof
IL90719A0 (en)	1990-01-18	Novel nuclei acids and polypeptides encoded thereby
DE58909265D1 (de)	1995-07-06	Verwendung einer mit immobilisierten Molekülen bzw. Substanzen versehenen Membrane.
PT90768A (pt)	1989-12-29	Processo para a preparacao de vectores de expressao e de proteinas nao fundidas usando esses vectores em microorganismos
IE881338L (en)	1988-11-05	A process for the preparation of foreign proteins in¹streptomycetes
PT88913A (pt)	1988-12-01	Processo para a preparacao da proteina pp4-x anticoagulante
DE3583107D1 (de)	1991-07-11	Plasmide zur erhoehten produktion von penicillin g-amidase.
SE8400858L (sv)	1985-08-18	Optisk integrerad vagledarkomponent
ATE62879T1 (de)	1991-05-15	Verfahren zur herstellung von prismatischen behaeltern mit ebenen giebelflaechen ohne seitliche ohren.