HUT71237A - Pharmaceutical compositions for treating resistant neoplasms containing 2-phenyl-3-aroil-benzotiophene derivatives and process for their preparation - Google Patents

Pharmaceutical compositions for treating resistant neoplasms containing 2-phenyl-3-aroil-benzotiophene derivatives and process for their preparation Download PDF

Info

Publication number: HUT71237A
Authority: HU; Hungary
Prior art keywords: salts; compound; formula; resistance; compounds
Prior art date: 1993-10-15

Application number

HU9402961A

Other languages

English (en)

Hungarian (hu)

Other versions

HU9402961D0 (en

Inventor

James Jacob Starling

Anne Hollins Dantzig

Srinivasan Chandraserkhar

Robert Lee Shepard

Mark Alan Winter

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-13

Publication date

1995-11-28

1994-10-13 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1995-02-28 Publication of HU9402961D0 publication Critical patent/HU9402961D0/hu

1995-11-28 Publication of HUT71237A publication Critical patent/HUT71237A/hu

Links

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TVZISJTYELEYPI-UHFFFAOYSA-N hypodiphosphoric acid Chemical compound OP(O)(=O)P(O)(O)=O TVZISJTYELEYPI-UHFFFAOYSA-N 0.000 description 1
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SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
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IWYDHOAUDWTVEP-UHFFFAOYSA-M mandelate Chemical class [O-]C(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-M 0.000 description 1
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QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical class COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 1
238000002156 mixing Methods 0.000 description 1
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PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical class C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
150000006636 nicotinic acid Chemical class 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
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150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
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239000002244 precipitate Substances 0.000 description 1
UORVCLMRJXCDCP-UHFFFAOYSA-N propynoic acid Chemical class OC(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-N 0.000 description 1
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CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical class OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 1
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239000011734 sodium Substances 0.000 description 1
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235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical class [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
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JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
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GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical class C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Steroid Compounds (AREA)

HU9402961A 1993-10-15 1994-10-13 Pharmaceutical compositions for treating resistant neoplasms containing 2-phenyl-3-aroil-benzotiophene derivatives and process for their preparation HUT71237A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13767893A	1993-10-15	1993-10-15

Publications (2)

Publication Number	Publication Date
HU9402961D0 HU9402961D0 (en)	1995-02-28
HUT71237A true HUT71237A (en)	1995-11-28

Family

ID=22478575

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9402961A HUT71237A (en)	1993-10-15	1994-10-13	Pharmaceutical compositions for treating resistant neoplasms containing 2-phenyl-3-aroil-benzotiophene derivatives and process for their preparation

Country Status (17)

Country	Link
EP (1)	EP0652004B1 (fr)
JP (1)	JPH07149638A (fr)
KR (1)	KR950010891A (fr)
CN (1)	CN1108094A (fr)
AT (1)	ATE220323T1 (fr)
AU (1)	AU670518B2 (fr)
CA (1)	CA2118096A1 (fr)
CZ (1)	CZ253694A3 (fr)
DE (1)	DE69430940T2 (fr)
DK (1)	DK0652004T3 (fr)
ES (1)	ES2179063T3 (fr)
HU (1)	HUT71237A (fr)
IL (1)	IL111287A0 (fr)
NO (1)	NO943874L (fr)
PT (1)	PT652004E (fr)
RU (1)	RU94037233A (fr)
ZA (1)	ZA948025B (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5441964A (en) *	1993-10-15	1995-08-15	Eli Lilly And Company	Methods for inhibiting bone loss using substituted benzothiophene
MY113757A (en) *	1994-08-22	2002-05-31	Lilly Co Eli	Methods of inhibiting endometrial cancer
ATE200623T1 (de) *	1994-08-22	2001-05-15	Lilly Co Eli	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der primären endometriumhyperplasie
JPH10505348A (ja) *	1994-08-31	1998-05-26	イーライ・リリー・アンド・カンパニー	耐性腫瘍の同定および治療方法
IL115582A0 (en) *	1994-10-14	1996-01-19	Lilly Co Eli	Methods for treating resistant tumors
ZA961564B (en) *	1995-02-28	1997-08-27	Lilly Co Eli	Methods of inhibiting ovarian cancer.
US5843974A (en) *	1995-06-06	1998-12-01	Eli Lilly And Company	Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
WO1997017069A1 (fr) *	1995-11-07	1997-05-15	Eli Lilly And Company	Procedes pour traiter des tumeurs resistantes
EA199800678A1 (ru) *	1996-01-29	1999-02-25	Эли Лилли Энд Компани	Способ ингибирования мышечно-апоневротических фиброматозов (десмоидных опухолей)
US5670523A (en) *	1996-01-29	1997-09-23	Eli Lilly And Company	Methods of inhibiting musculoaponeurotic fibromatoses (desmoid tumors)
ID15917A (id) *	1996-01-29	1997-08-21	Lilly Co Eli	Metode untuk menghambat tumor usus besar
TW442286B (en) *	1996-02-28	2001-06-23	Pfizer	New therapeutic uses of estrogen agonists
IL120266A (en)	1996-02-28	2005-05-17	Pfizer	Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
CZ341297A3 (cs) *	1996-10-30	1998-05-13	Eli Lilly And Company	Způsob zlepšení léčby nebo profylaxe rakoviny prsu
US6025373A (en) *	1997-04-22	2000-02-15	Eli Lilly And Company	Methods for reducing fibrinogen
US7425565B2 (en) *	2002-05-09	2008-09-16	Cedars-Sinai Medical Center	Use of benzothiopenes to treat and prevent prostate cancer
WO2002089801A1 (fr) *	2001-05-10	2002-11-14	Cedars Sinai Medical Center	Utilisation de benzothiophenes pour traiter et prevenir le cancer de la prostate
FR2873692B1 (fr) *	2004-07-29	2006-12-01	Univ Claude Bernard Lyon	COMPOSITIONS CONTENANT, EN ASSOCIATION AVEC UN AGENT ANTIMICROBIEN, UN COMPOSE THIOPHENIQUE OU BENZOTHIOPHENIQUE DE FORMULE(I)PRESENTANT UNE ACTIVITE INHIBITRICE DE POMPE NorA

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes

1994
- 1994-10-13 CN CN94117124A patent/CN1108094A/zh active Pending
- 1994-10-13 NO NO943874A patent/NO943874L/no unknown
- 1994-10-13 AT AT94307527T patent/ATE220323T1/de not_active IP Right Cessation
- 1994-10-13 CA CA002118096A patent/CA2118096A1/fr not_active Abandoned
- 1994-10-13 JP JP6247763A patent/JPH07149638A/ja not_active Withdrawn
- 1994-10-13 HU HU9402961A patent/HUT71237A/hu unknown
- 1994-10-13 ES ES94307527T patent/ES2179063T3/es not_active Expired - Lifetime
- 1994-10-13 KR KR1019940026162A patent/KR950010891A/ko not_active Withdrawn
- 1994-10-13 IL IL11128794A patent/IL111287A0/xx unknown
- 1994-10-13 CZ CZ942536A patent/CZ253694A3/cs unknown
- 1994-10-13 PT PT94307527T patent/PT652004E/pt unknown
- 1994-10-13 RU RU94037233/14A patent/RU94037233A/ru unknown
- 1994-10-13 DE DE69430940T patent/DE69430940T2/de not_active Expired - Fee Related
- 1994-10-13 AU AU75786/94A patent/AU670518B2/en not_active Ceased
- 1994-10-13 DK DK94307527T patent/DK0652004T3/da active
- 1994-10-13 ZA ZA948025A patent/ZA948025B/xx unknown
- 1994-10-13 EP EP94307527A patent/EP0652004B1/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1108094A (zh)	1995-09-13
RU94037233A (ru)	1996-08-27
PT652004E (pt)	2002-10-31
ES2179063T3 (es)	2003-01-16
EP0652004A1 (fr)	1995-05-10
AU7578694A (en)	1995-05-04
ZA948025B (en)	1996-04-15
DK0652004T3 (da)	2002-09-02
AU670518B2 (en)	1996-07-18
CZ253694A3 (en)	1995-05-17
JPH07149638A (ja)	1995-06-13
EP0652004B1 (fr)	2002-07-10
DE69430940D1 (de)	2002-08-14
ATE220323T1 (de)	2002-07-15
IL111287A0 (en)	1994-12-29
NO943874D0 (no)	1994-10-13
NO943874L (no)	1995-04-18
CA2118096A1 (fr)	1995-04-16
KR950010891A (ko)	1995-05-15
DE69430940T2 (de)	2003-04-03
HU9402961D0 (en)	1995-02-28

Legal Events

Date	Code	Title	Description
1997-06-30	DFC4	Cancellation of temporary protection due to refusal

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