HUT75223A - Process for the production of combinatorial compound libraries - Google Patents

Process for the production of combinatorial compound libraries Download PDF

Info

Publication number
HUT75223A
HUT75223A HU9601588A HU9601588A HUT75223A HU T75223 A HUT75223 A HU T75223A HU 9601588 A HU9601588 A HU 9601588A HU 9601588 A HU9601588 A HU 9601588A HU T75223 A HUT75223 A HU T75223A
Authority
HU
Hungary
Prior art keywords
ligand
library
ligands
tag
group
Prior art date
Application number
HU9601588A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9601588D0 (en
Inventor
Eduard Felder
Ian Timothy William Matthews
Hans Rink
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of HU9601588D0 publication Critical patent/HU9601588D0/hu
Publication of HUT75223A publication Critical patent/HUT75223A/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9601588A 1993-12-09 1994-11-28 Process for the production of combinatorial compound libraries HUT75223A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810864 1993-12-09

Publications (2)

Publication Number Publication Date
HU9601588D0 HU9601588D0 (en) 1996-08-28
HUT75223A true HUT75223A (en) 1997-04-28

Family

ID=8215084

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9601588A HUT75223A (en) 1993-12-09 1994-11-28 Process for the production of combinatorial compound libraries

Country Status (9)

Country Link
EP (1) EP0733213A1 (ja)
JP (1) JPH09508355A (ja)
AU (1) AU1068295A (ja)
CA (1) CA2175078A1 (ja)
FI (1) FI962371L (ja)
HU (1) HUT75223A (ja)
IL (1) IL111906A0 (ja)
NO (1) NO962186L (ja)
WO (1) WO1995016209A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034110B2 (en) 1994-01-05 2006-04-25 Arqule, Inc. Method of identifying chemical compounds having selected properties for a particular application
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
AU5110096A (en) * 1995-03-28 1996-10-16 Novartis Ag Process for the production of combinatorial compound libraries
AU7247896A (en) * 1995-09-29 1997-04-17 Scripps Research Institute, The Protein signature analysis
EP0868427B1 (en) * 1995-12-18 2003-05-14 Praecis Pharmaceuticals Incorporated Methods for identifying compounds that bind to a target
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
ATE481487T1 (de) 1998-11-27 2010-10-15 Ucb Sa Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
AU3494500A (en) * 1999-02-17 2000-09-04 Deltagen Proteomics, Inc. Methods for substrate-ligand interaction screening
WO2000057183A1 (en) * 1999-03-23 2000-09-28 Biovation Limited Protein isolation and analysis
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
WO2000066259A1 (en) 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7351540B1 (en) 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
WO2001086296A2 (en) * 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
DE10117274B4 (de) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
EP1967525B1 (en) 2001-05-08 2012-11-14 Darwin Molecular Corporation A method for regulating immune function in primates using the foxp3 protein
CA2466861A1 (en) * 2001-11-06 2003-07-10 Agilix Corporation Sensitive coded detection systems
EP1572976B1 (en) 2002-11-21 2010-09-15 Celltech R & D, Inc. Modulating immune responses
DE602005023286D1 (de) 2004-03-31 2010-10-14 Kazuo Shinya Verfahren zum biosubstanzeinfang, zur strukturanalyse oder/und identifizierung unter verwendung einer markierungssubstanz
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02104595A (ja) * 1988-03-04 1990-04-17 Univ Alabama 非ペプチドのペプチド相当物及びそのデザイン方法
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DE69227895D1 (de) * 1991-02-04 1999-01-28 Akzo Nobel Nv FAKTOR IIa INHIBITOREN
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries

Also Published As

Publication number Publication date
NO962186D0 (no) 1996-05-29
IL111906A0 (en) 1995-03-15
EP0733213A1 (en) 1996-09-25
AU1068295A (en) 1995-06-27
WO1995016209A1 (en) 1995-06-15
FI962371A7 (fi) 1996-06-07
HU9601588D0 (en) 1996-08-28
FI962371A0 (fi) 1996-06-07
JPH09508355A (ja) 1997-08-26
NO962186L (no) 1996-05-29
CA2175078A1 (en) 1995-06-15
FI962371L (fi) 1996-06-07

Similar Documents

Publication Publication Date Title
HUT75223A (en) Process for the production of combinatorial compound libraries
EP0705279B1 (en) Topologically segregated, encoded solid phase libraries
Salmon et al. Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.
US6008058A (en) Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
EP1310510B1 (en) Topologically segregated, encoded solid phase libraries
US5635598A (en) Selectively cleavabe linners based on iminodiacetic acid esters for solid phase peptide synthesis
Huang et al. Main chain and side chain chiral methylated somatostatin analogs: Syntheses and conformational analyses
US4897445A (en) Method for synthesizing a peptide containing a non-peptide bond
WO1996030392A1 (en) Process for the production of combinatorial compound libraries
EP0257742B1 (en) Method of synthesizing a peptide containing a non-peptide bond
AU744812B2 (en) Process for the preparation of resin-bound cyclic peptides
JP4215822B2 (ja) タンパク質分解酵素の基質および阻害剤
PL169616B1 (pl) Sposób ustalania sekwencji ligandu biooligomerowego dla czasteczki akceptorowej PL PL
JPH11500741A (ja) バックボーン環化ペプチド類似体のライブラリー
KR100237126B1 (ko) 펩티드 유사체의 신속한 합성 및 검색방법
US6194544B1 (en) Cyclic semi-random peptide libraries
Zahariev et al. Synthesis of ‘difficult’peptides free of aspartimide and related products, using peptoid methodology
Chen et al. [12] One bead-one compound combinatorial peptide library: Different types of screening
Lebl et al. Screening of completely random one-bead one-peptide libraries for activities in solution
US5846841A (en) Motif Libraries
US5990277A (en) Semipeptoid farnesyl protein transferase inhibitors and analogs thereof
Slaninová et al. Magnesium and biological activity of oxytocin analogues modified on aromatic ring of amino acid in position 2
MXPA00010056A (en) Process for the preparation of resin-bound cyclic peptides

Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: NOVARTIS AG., CH

DFD9 Temporary protection cancelled due to non-payment of fee