HUT75679A - Compositions for treating hypoxia-associated ocular complications - Google Patents

Compositions for treating hypoxia-associated ocular complications Download PDF

Info

Publication number: HUT75679A
Authority: HU; Hungary
Prior art keywords: composition; hemoxygenase; inducer; osmoprotective; buffer
Prior art date: 1993-06-18

Application number

HU9502003A

Other languages

English (en)

Hungarian (hu)

Other versions

HU9502003D0 (en

Inventor

Stanley W Huth

Original Assignee

Allergan Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-18

Filing date

1994-06-16

Publication date

1997-05-28

1993-06-18 Priority claimed from US08/079,025 external-priority patent/US5389383A/en

1994-06-16 Application filed by Allergan Inc filed Critical Allergan Inc

1995-09-28 Publication of HU9502003D0 publication Critical patent/HU9502003D0/hu

1997-05-28 Publication of HUT75679A publication Critical patent/HUT75679A/hu

Links

239000000203 mixture Substances 0.000 title claims description 58
206010021143 Hypoxia Diseases 0.000 title claims description 18
230000007954 hypoxia Effects 0.000 title claims description 18
239000003795 chemical substances by application Substances 0.000 claims description 37
230000001033 osmoprotective effect Effects 0.000 claims description 26
239000000872 buffer Substances 0.000 claims description 24
208000010444 Acidosis Diseases 0.000 claims description 18
208000026545 acidosis disease Diseases 0.000 claims description 17
239000000411 inducer Substances 0.000 claims description 17
230000007950 acidosis Effects 0.000 claims description 16
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 12
239000012528 membrane Substances 0.000 claims description 10
UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical group C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 claims description 10
238000011282 treatment Methods 0.000 claims description 7
239000004471 Glycine Substances 0.000 claims description 6
229930003779 Vitamin B12 Natural products 0.000 claims description 4
238000011321 prophylaxis Methods 0.000 claims description 4
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 4
235000019163 vitamin B12 Nutrition 0.000 claims description 4
239000011715 vitamin B12 Substances 0.000 claims description 4
229910021627 Tin(IV) chloride Inorganic materials 0.000 claims description 3
229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 2
IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 2
SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical compound [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 claims description 2
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
229960001763 zinc sulfate Drugs 0.000 claims description 2
229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical group CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 claims 1
235000011150 stannous chloride Nutrition 0.000 claims 1
AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims 1
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239000004480 active ingredient Substances 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical class Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 3
239000000645 desinfectant Substances 0.000 description 3
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PAJPWUMXBYXFCZ-UHFFFAOYSA-N 1-aminocyclopropanecarboxylic acid Chemical compound OC(=O)C1(N)CC1 PAJPWUMXBYXFCZ-UHFFFAOYSA-N 0.000 description 2
AQTFKGDWFRRIHR-UHFFFAOYSA-L 3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoate;cobalt(2+);hydron Chemical compound [Co+2].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 AQTFKGDWFRRIHR-UHFFFAOYSA-L 0.000 description 2
NCAJWYASAWUEBY-UHFFFAOYSA-N 3-[20-(2-carboxyethyl)-9,14-diethyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(21),2,4,6(24),7,9,11,13,15,17,19-undecaen-4-yl]propanoic acid Chemical compound N1C2=C(C)C(CC)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 NCAJWYASAWUEBY-UHFFFAOYSA-N 0.000 description 2
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 2
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YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
229910052745 lead Inorganic materials 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
239000002997 ophthalmic solution Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
150000004032 porphyrins Chemical group 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229950003776 protoporphyrin Drugs 0.000 description 1
238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
229940039790 sodium oxalate Drugs 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
RQVZIJIQDCGIKI-UHFFFAOYSA-M sodium;oxamate Chemical compound [Na+].NC(=O)C([O-])=O RQVZIJIQDCGIKI-UHFFFAOYSA-M 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
239000004034 viscosity adjusting agent Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

HU9502003A 1993-06-18 1994-06-16 Compositions for treating hypoxia-associated ocular complications HUT75679A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/079,025 US5389383A (en)	1993-06-18	1993-06-18	Method for treating hypoxia-associated ocular complications
US18555694A	1994-01-24	1994-01-24

Publications (2)

Publication Number	Publication Date
HU9502003D0 HU9502003D0 (en)	1995-09-28
HUT75679A true HUT75679A (en)	1997-05-28

Family

ID=26761550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9502003A HUT75679A (en)	1993-06-18	1994-06-16	Compositions for treating hypoxia-associated ocular complications

Country Status (6)

Country	Link
EP (1)	EP0707495A1 (ja)
JP (1)	JP2000507200A (ja)
AU (1)	AU7174294A (ja)
HU (1)	HUT75679A (ja)
IL (1)	IL109762A0 (ja)
WO (1)	WO1995000176A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5955111A (en) *	1996-10-08	1999-09-21	Hartford Hospital	Methods and compositions for inducing production of stress proteins
IT1288708B1 (it) *	1996-10-17	1998-09-23	Achille Sandoli	Composizione farmaceutica comprendente trometamina per il trattamento per via topica dell'acne vulgaris.
US9492582B2 (en)	2000-11-08	2016-11-15	Fxs Ventures, Llc	Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20060078626A1 (en) *	2000-11-08	2006-04-13	Bioconcept Laboratories	Opthalmic and contact lens solutions with a peroxide source and a cationic polymeric preservative
US9308264B2 (en)	2000-11-08	2016-04-12	Fxs Ventures, Llc	Ophthalmic contact lens solutions containing forms of vitamin B
AU2720602A (en)	2000-11-08	2002-05-21	Bio Concept Lab	Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
JP2007507528A (ja) *	2003-10-03	2007-03-29	ボストン，ジユデイス	四量体酸素を含む方法、組成物、装置
JP5616616B2 (ja) *	2008-12-10	2014-10-29	ロート製薬株式会社	シリコーンハイドロゲルコンタクトレンズ用点眼剤
JP2015147759A (ja) *	2014-01-08	2015-08-20	日油株式会社	点眼剤
JP2022509875A (ja) *	2018-11-30	2022-01-24	ハイムバイオカンパニー、リミテッド	酸症の予防または治療用薬学組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5102670A (en) *	1990-09-14	1992-04-07	Abraham Nader G	Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels

1994
- 1994-05-24 IL IL10976294A patent/IL109762A0/xx unknown
- 1994-06-16 WO PCT/US1994/006824 patent/WO1995000176A1/en not_active Ceased
- 1994-06-16 JP JP7502956A patent/JP2000507200A/ja not_active Ceased
- 1994-06-16 EP EP94920755A patent/EP0707495A1/en not_active Withdrawn
- 1994-06-16 AU AU71742/94A patent/AU7174294A/en not_active Abandoned
- 1994-06-16 HU HU9502003A patent/HUT75679A/hu unknown

Also Published As

Publication number	Publication date
AU7174294A (en)	1995-01-17
HU9502003D0 (en)	1995-09-28
IL109762A0 (en)	1994-08-26
JP2000507200A (ja)	2000-06-13
WO1995000176A1 (en)	1995-01-05
EP0707495A1 (en)	1996-04-24

Legal Events

Date	Code	Title	Description
1998-03-02	DFD9	Temporary protection cancelled due to non-payment of fee

Publication	Publication Date	Title
US5389383A (en)	1995-02-14	Method for treating hypoxia-associated ocular complications
CA1259542A (en)	1989-09-19	Disinfecting and preserving solutions for contact lenses and methods of use
US5817277A (en)	1998-10-06	Method and composition for disinfecting contact lenses
CN101932301B (zh)	2013-03-27	含有两性表面活性剂和透明质酸的眼科组合物
CA2266599C (en)	2002-03-26	Method and composition for rewetting contact lenses and relieving eye dryness
EP2155271B1 (en)	2017-03-08	Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
IE893780L (en)	1990-05-29	Aqueous ophthalmic solutions
WO2003086442A2 (en)	2003-10-23	Ophthalmic, pharmaceutical and other healthcare preparations with naturally occuring plant compounds, extracts and derivatives
NL2002214C2 (en)	2010-05-18	Contact lens care solution.
HUT75679A (en)	1997-05-28	Compositions for treating hypoxia-associated ocular complications
JP3175742B1 (ja)	2001-06-11	コンタクトレンズ用眼科用組成物
JP5235420B2 (ja)	2013-07-10	ソフトコンタクトレンズ用点眼・装着液
EP0669803B1 (en)	1999-12-15	Use of amidoamines in ophthalmic compositions
CA1330923C (en)	1994-07-26	Cleaning, conditioning, storing and wetting system and method for rigid gas permeable contact lenses and other contact lenses
JP2001253822A (ja)	2001-09-18	角膜細胞回復剤組成物
US5627214A (en)	1997-05-06	Use of diamines in ophthalmic compositions
JP2006023512A (ja)	2006-01-26	コンタクトレンズケア方法及び組成物
US20060209253A1 (en)	2006-09-21	Method and composition for eliminating ocular hypoxic acidosis
HK1005164B (en)	1998-12-24	Aqueous ophthalmic solutions and method for preserving same
HK1021619B (en)	2002-02-22	Method and composition for rewetting contact lenses and relieving eye dryness