HUT76255A - Spider neurotoxins and method of producing the same - Google Patents

Spider neurotoxins and method of producing the same Download PDF

Info

Publication number: HUT76255A
Authority: HU; Hungary
Prior art keywords: leu; sequence; polypeptide; lys; glu
Prior art date: 1994-04-27

Application number

HU9602959A

Other languages

English (en)

Hungarian (hu)

Other versions

HU9602959D0 (en

Inventor

David Robert Bell

Irina Dulubova

Tatjana Genrikhovna Galkina

Eugene Grishin

Mikhail Vladimirovi Khovotchev

Valery Krasnoperov

Kirill Andreevich Pluzhnikov

Oleg Grigorievich Shamotienko

Peter Norman Russell Usherwood

Tatjana Volkova

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-27

Filing date

1995-04-24

Publication date

1997-07-28

1995-04-24 Application filed by British Tech Group filed Critical British Tech Group

1997-01-28 Publication of HU9602959D0 publication Critical patent/HU9602959D0/hu

1997-07-28 Publication of HUT76255A publication Critical patent/HUT76255A/hu

Links

238000000034 method Methods 0.000 title claims description 20
239000002581 neurotoxin Substances 0.000 title claims description 20
231100000618 neurotoxin Toxicity 0.000 title claims description 20
241000239290 Araneae Species 0.000 title description 6
108700012359 toxins Proteins 0.000 claims description 95
239000003053 toxin Substances 0.000 claims description 93
231100000765 toxin Toxicity 0.000 claims description 93
108090000765 processed proteins & peptides Proteins 0.000 claims description 85
102000004196 processed proteins & peptides Human genes 0.000 claims description 81
229920001184 polypeptide Polymers 0.000 claims description 80
108090000623 proteins and genes Proteins 0.000 claims description 79
101000966374 Latrodectus hasselti Delta-latroinsectotoxin-Lh1a Proteins 0.000 claims description 65
101000966385 Latrodectus hesperus Delta-latroinsectotoxin-Lhe1a Proteins 0.000 claims description 65
101000966383 Latrodectus tredecimguttatus Delta-latroinsectotoxin-Lt1a Proteins 0.000 claims description 65
239000002773 nucleotide Substances 0.000 claims description 46
125000003729 nucleotide group Chemical group 0.000 claims description 46
125000003275 alpha amino acid group Chemical group 0.000 claims description 45
239000002243 precursor Substances 0.000 claims description 45
102000004169 proteins and genes Human genes 0.000 claims description 37
241000238631 Hexapoda Species 0.000 claims description 34
230000014509 gene expression Effects 0.000 claims description 34
150000001413 amino acids Chemical class 0.000 claims description 30
239000002299 complementary DNA Substances 0.000 claims description 23
101710138657 Neurotoxin Proteins 0.000 claims description 17
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 16
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239000002917 insecticide Substances 0.000 claims description 9
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238000012545 processing Methods 0.000 claims description 8
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WIDZHJTYKYBLSR-DCAQKATOSA-N Leu-Glu-Glu Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O WIDZHJTYKYBLSR-DCAQKATOSA-N 0.000 description 8
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HQUXQAMSWFIRET-AVGNSLFASA-N Leu-Glu-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN HQUXQAMSWFIRET-AVGNSLFASA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
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NFNVDJGXRFEYTK-YUMQZZPRSA-N Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O NFNVDJGXRFEYTK-YUMQZZPRSA-N 0.000 description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
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Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Insects & Arthropods (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Environmental Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Pest Control & Pesticides (AREA)
Virology (AREA)
Dentistry (AREA)
Tropical Medicine & Parasitology (AREA)
Physics & Mathematics (AREA)
Agronomy & Crop Science (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Botany (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

HU9602959A 1994-04-27 1995-04-24 Spider neurotoxins and method of producing the same HUT76255A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9408466A GB9408466D0 (en)	1994-04-27	1994-04-27	Cloning and functional expression of neurotoxins

Publications (2)

Publication Number	Publication Date
HU9602959D0 HU9602959D0 (en)	1997-01-28
HUT76255A true HUT76255A (en)	1997-07-28

Family

ID=10754294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9602959A HUT76255A (en)	1994-04-27	1995-04-24	Spider neurotoxins and method of producing the same

Country Status (11)

Country	Link
EP (1)	EP0804571A1 (ja)
JP (1)	JP2000511761A (ja)
KR (1)	KR970702916A (ja)
CN (1)	CN1147272A (ja)
AU (1)	AU701101B2 (ja)
BR (1)	BR9507507A (ja)
CA (1)	CA2187920A1 (ja)
GB (2)	GB9408466D0 (ja)
HU (1)	HUT76255A (ja)
WO (1)	WO1995029235A1 (ja)
ZA (1)	ZA953384B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA99011191A (es) *	1999-12-03	2005-04-04	Univ Mexico Nacional Autonoma	Inmunogeno, anti-veneno y vacuna contra el venenode la arana viuda negra.
CL2007003884A1 (es)	2007-12-31	2009-09-25	Laboratorios Andromaco S A	Péptido derivado del veneno de la araña viuda negra, procedimiento para preparar dicho péptido, composición farmacéutica que lo comprende, y uso de dicha composición para la preparación de un medicamente útil para el tratamiento de la disfunción sexual.
CN114107353B (zh) *	2021-10-29	2024-07-23	成都佩德生物医药有限公司	一种高效表达多肽毒素的质粒及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE53517B1 (en) *	1981-06-17	1988-12-07	Celltech Ltd	Process for the production of a polypeptide
BR8900881A (pt) *	1988-02-25	1989-10-17	Sandoz Ag	Processos para a producao de uma proteina endotoxina toxica a insetos e composicao inseticida
EP0358557B1 (en) *	1988-09-06	1995-04-05	Plant Genetic Systems, N.V.	Plants transformed with a DNA sequence from bacillus thuringiensis lethal to lepidoptera
GB8909916D0 (en) *	1989-04-29	1989-06-14	Delta Biotechnology Ltd	Polypeptides
GB2242681A (en) *	1990-04-05	1991-10-09	Ciba Geigy Ag	Hirudin fragments
PL295547A1 (ja) *	1990-04-26	1992-10-05	Plant Genetic Systems Nv
GB2249099B (en) *	1990-09-26	1995-05-03	Squibb & Sons Inc	Squalene synthetase
JPH04148687A (ja) *	1990-10-09	1992-05-21	Asahi Chem Ind Co Ltd	Ｍ―ｃｓｆ活性ポリペプチドの安定的高発現組換えベクター
IL104419A0 (en) *	1992-01-24	1993-05-13	Fmc Corp	Insecticidally effective peptides

1994
- 1994-04-27 GB GB9408466A patent/GB9408466D0/en active Pending
1995
- 1995-04-24 GB GB9508298A patent/GB2288807B/en not_active Expired - Fee Related
- 1995-04-24 HU HU9602959A patent/HUT76255A/hu unknown
- 1995-04-24 AU AU22644/95A patent/AU701101B2/en not_active Ceased
- 1995-04-24 CN CN95192820A patent/CN1147272A/zh active Pending
- 1995-04-24 CA CA002187920A patent/CA2187920A1/en not_active Abandoned
- 1995-04-24 BR BR9507507A patent/BR9507507A/pt not_active Application Discontinuation
- 1995-04-24 JP JP07527465A patent/JP2000511761A/ja active Pending
- 1995-04-24 WO PCT/GB1995/000917 patent/WO1995029235A1/en not_active Ceased
- 1995-04-24 EP EP95915957A patent/EP0804571A1/en not_active Withdrawn
- 1995-04-26 ZA ZA953384A patent/ZA953384B/xx unknown
1996
- 1996-10-28 KR KR1019960706135A patent/KR970702916A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
GB9508298D0 (en)	1995-06-14
ZA953384B (en)	1996-01-12
JP2000511761A (ja)	2000-09-12
KR970702916A (ko)	1997-06-10
HU9602959D0 (en)	1997-01-28
GB2288807B (en)	1998-12-23
AU701101B2 (en)	1999-01-21
CA2187920A1 (en)	1995-11-02
BR9507507A (pt)	1997-09-02
GB2288807A (en)	1995-11-01
GB9408466D0 (en)	1994-06-22
AU2264495A (en)	1995-11-16
CN1147272A (zh)	1997-04-09
EP0804571A1 (en)	1997-11-05
WO1995029235A1 (en)	1995-11-02

Legal Events

Date	Code	Title	Description
2001-01-29	DFD9	Temporary protection cancelled due to non-payment of fee

Publication	Publication Date	Title
Liang et al.	2006	Molecular cloning and characterization of cecropin from the housefly (Musca domestica), and its expression in Escherichia coli
Shon et al.	1995	Purification, characterization, synthesis, and cloning of the lockjaw peptide from Conus purpurascens venom
Lai et al.	2002	Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
KR100872847B1 (ko)	2008-12-10	홍합 바이오접착제
KR101004745B1 (ko)	2011-01-04	홍합 접착제
JPH03155795A (ja)	1991-07-03	マウス・インターロイキン―６レセプター蛋白質
Gao et al.	2018	Mesobuthus venom-derived antimicrobial peptides possess intrinsic multifunctionality and differential potential as drugs
WO1989000048A1 (en)	1989-01-12	Bactericidal and/or bacteriostatic peptides, process for their isolation, their production and their applications
AU660433B2 (en)	1995-06-29	Production and use of tracheal antimicrobial peptides
JPH07503845A (ja)	1995-04-27	殺虫に有効なペプチド
JPH07242696A (ja)	1995-09-19	植物病原体に対して活性な抗菌性ペプチド、その使用法およびこれに関連するスクリーニング法
US6642203B1 (en)	2003-11-04	Crustacean antimicrobial peptides
JP3273314B2 (ja)	2002-04-08	抗菌ペプチド及びこれを有効成分とする抗菌剤
KR20000069450A (ko)	2000-11-25	항미생물 활성 폴리펩타이드
Pescatori et al.	1995	The Cloning of a cDNA Encoding a Protein (Latrodectin) which Co‐purifies with the α‐latrotoxin from the Black Widow Spider Latrodectus tredecimguttatus (Theridiidae)
EP2354157B1 (en)	2013-10-23	Nucleic acids and proteins of insect OR83B odorant receptor genes and uses thereof
CA2221793C (en)	2002-07-09	Novel antibacterial protein
CN110590925B (zh)	2021-05-07	蝶蛹金小蜂毒液蛋白PpVPG及其应用
GB2288807A (en)	1995-11-01	Delta-latroinsectotoxin
JP3290661B2 (ja)	2002-06-10	陸蛭からの新規トロンビン阻害性蛋白質
RU2325398C2 (ru)	2008-05-27	Антибактериальный белок хламизин в, ген, кодирующий его, и экспрессирующая его система
Liu et al.	2003	Cloning and characterization of a novel neurotoxin from the sea anemone Anthopleura sp.
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US5831061A (en)	1998-11-03	Nucleic acid encoding ecdysis-triggering hormone
MXPA96005045A (en)	1998-02-01	Spider neurotoxins and method for the production of mis