HUT77363A - 5-Lipoxigenáz inhibitor hatású azolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

5-Lipoxigenáz inhibitor hatású azolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number: HUT77363A
Authority: HU; Hungary
Prior art keywords: alkyl; compounds; halo; cyano; alkylene
Prior art date: 1994-10-18

Application number

HU9701853A

Other languages

English (en)

Other versions

HU221543B (hu

Inventor

Takashi Mano

Kazunari Nakao

Yoshiyuki Okumura

Rodney W. Stevens

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-18

Filing date

1995-05-29

Publication date

1998-03-30

1995-05-29 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1998-03-30 Publication of HUT77363A publication Critical patent/HUT77363A/hu

2002-11-28 Publication of HU221543B publication Critical patent/HU221543B/hu

Links

150000001875 compounds Chemical class 0.000 title abstract 3
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title abstract 2
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000007980 azole derivatives Chemical class 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
-1 hydroxy, cyano, amino Chemical group 0.000 abstract 6
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000002947 alkylene group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 2
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000005564 oxazolylene group Chemical group 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000005551 pyridylene group Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005557 thiazolylene group Chemical group 0.000 abstract 1
125000005556 thienylene group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HU9701853A 1994-10-18 1995-05-29 5-Lipoxigenáz inhibitor hatású azolszármazékok és a vegyületeket tartalmazó gyógyászati készítmények HU221543B (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9401747		1994-10-18
PCT/IB1995/000408 WO1996011911A1 (en)	1994-10-18	1995-05-29	5-lipoxygenase inhibitors

Publications (2)

Publication Number	Publication Date
HUT77363A true HUT77363A (hu)	1998-03-30
HU221543B HU221543B (hu)	2002-11-28

Family

ID=14098722

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9701853A HU221543B (hu)	1994-10-18	1995-05-29	5-Lipoxigenáz inhibitor hatású azolszármazékok és a vegyületeket tartalmazó gyógyászati készítmények

Country Status (31)

Country	Link
EP (1)	EP0787127B1 (hu)
JP (1)	JP3032579B2 (hu)
CN (1)	CN1093536C (hu)
AT (1)	ATE198474T1 (hu)
AU (1)	AU681520B2 (hu)
BG (1)	BG61768B1 (hu)
CA (1)	CA2202057C (hu)
CO (1)	CO4480026A1 (hu)
CZ (1)	CZ287350B6 (hu)
DE (1)	DE69519804T2 (hu)
DK (1)	DK0787127T3 (hu)
ES (1)	ES2153033T3 (hu)
FI (1)	FI971632A0 (hu)
GR (1)	GR3035471T3 (hu)
HU (1)	HU221543B (hu)
IL (1)	IL115581A (hu)
LV (1)	LV11468B (hu)
MY (1)	MY114680A (hu)
NO (1)	NO314629B1 (hu)
NZ (1)	NZ285163A (hu)
PE (1)	PE49196A1 (hu)
PL (1)	PL180104B1 (hu)
RU (1)	RU2136666C1 (hu)
SI (1)	SI9500392A (hu)
SK (1)	SK281577B6 (hu)
TR (1)	TR199501274A2 (hu)
TW (1)	TW411339B (hu)
UA (1)	UA45312C2 (hu)
WO (1)	WO1996011911A1 (hu)
YU (1)	YU65995A (hu)
ZA (1)	ZA958748B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6239285B1 (en)	1998-02-06	2001-05-29	Pfizer Inc	Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
US6194585B1 (en) *	1998-12-22	2001-02-27	Pfizer Inc.	Process for preparing 5-lipoxygenase inhibitors
SG87145A1 (en) *	1999-08-31	2002-03-19	Pfizer Prod Inc	Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
US6344563B1 (en) *	1999-08-31	2002-02-05	Timothy Norris	Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
US6346624B1 (en) *	1999-08-31	2002-02-12	Pfizer Inc	Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
AU4589701A (en)	2000-03-24	2001-10-08	Cocensys Inc	Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
DK1383874T3 (da) *	2001-04-20	2010-05-03	Novozymes As	Varianter af lipogygenase og deres anvendelse
GB0302094D0 (en)	2003-01-29	2003-02-26	Pharmagene Lab Ltd	EP4 receptor antagonists
GB0324269D0 (en)	2003-10-16	2003-11-19	Pharmagene Lab Ltd	EP4 receptor antagonists
GEP20125386B (en) *	2006-11-27	2012-01-25	Pfizer Prod Inc	Pyrazole analogs
EP2225229A1 (en)	2007-11-26	2010-09-08	Pfizer Inc.	Pyrazole derivatives as 5-lo inhibitors
KR20140138243A (ko) *	2012-02-28	2014-12-03	피라말 엔터프라이지즈 리미티드	G 단백질 연결 수용체 작용물질로서의 페닐알칸산 유도체
BR112020018094A2 (pt)	2018-03-08	2020-12-22	Incyte Corporation	Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2001730A6 (es) *	1987-01-14	1988-06-01	Ferrer Int	Procedimiento de obtencion del acio 2,3-dihidro-5-(b-(1h-imidazol-1-il) etoxi)-1h-inden-1-carboxilico
EP0462830B1 (en) *	1990-06-21	1995-10-18	Zeneca Limited	Cyclic ether derivatives
IE913866A1 (en) *	1990-11-28	1992-06-03	Ici Plc	Aryl derivatives
EP0505122A1 (en) *	1991-03-21	1992-09-23	Zeneca Limited	Alpha, alpha-dialkylbenzyl derivatives
EP0540165A1 (en) *	1991-10-03	1993-05-05	Zeneca Limited	Alkanoic acid derivatives
ES2103130T3 (es) *	1993-06-14	1997-08-16	Pfizer	Inhibidores imidazoles como la lipoxigenasa.

1994
- 1994-10-18 SK SK1287-95A patent/SK281577B6/sk unknown
1995
- 1995-05-29 NZ NZ285163A patent/NZ285163A/en unknown
- 1995-05-29 WO PCT/IB1995/000408 patent/WO1996011911A1/en not_active Ceased
- 1995-05-29 JP JP8513058A patent/JP3032579B2/ja not_active Expired - Fee Related
- 1995-05-29 ES ES95918121T patent/ES2153033T3/es not_active Expired - Lifetime
- 1995-05-29 EP EP95918121A patent/EP0787127B1/en not_active Expired - Lifetime
- 1995-05-29 AU AU24174/95A patent/AU681520B2/en not_active Ceased
- 1995-05-29 PL PL95319727A patent/PL180104B1/pl not_active IP Right Cessation
- 1995-05-29 DK DK95918121T patent/DK0787127T3/da active
- 1995-05-29 CZ CZ19971177A patent/CZ287350B6/cs not_active IP Right Cessation
- 1995-05-29 DE DE69519804T patent/DE69519804T2/de not_active Expired - Fee Related
- 1995-05-29 AT AT95918121T patent/ATE198474T1/de not_active IP Right Cessation
- 1995-05-29 HU HU9701853A patent/HU221543B/hu not_active IP Right Cessation
- 1995-05-29 CA CA002202057A patent/CA2202057C/en not_active Expired - Fee Related
- 1995-05-29 RU RU97106099/04A patent/RU2136666C1/ru not_active IP Right Cessation
- 1995-05-29 CN CN95195926A patent/CN1093536C/zh not_active Expired - Fee Related
- 1995-09-12 TW TW084109522A patent/TW411339B/zh not_active IP Right Cessation
- 1995-10-02 CO CO95045652A patent/CO4480026A1/es unknown
- 1995-10-12 IL IL11558195A patent/IL115581A/xx not_active IP Right Cessation
- 1995-10-13 UA UA95104510A patent/UA45312C2/uk unknown
- 1995-10-16 MY MYPI95003103A patent/MY114680A/en unknown
- 1995-10-17 PE PE1995282113A patent/PE49196A1/es not_active Application Discontinuation
- 1995-10-17 ZA ZA958748A patent/ZA958748B/xx unknown
- 1995-10-17 YU YU65995A patent/YU65995A/sh unknown
- 1995-10-17 LV LVP-95-313A patent/LV11468B/en unknown
- 1995-10-17 SI SI9500392A patent/SI9500392A/sl unknown
- 1995-10-18 BG BG100070A patent/BG61768B1/bg unknown
- 1995-10-18 TR TR95/01274A patent/TR199501274A2/xx unknown
1997
- 1997-04-17 FI FI971632A patent/FI971632A0/fi not_active IP Right Cessation
- 1997-04-17 NO NO19971773A patent/NO314629B1/no unknown
2001
- 2001-02-23 GR GR20010400310T patent/GR3035471T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE198474T1 (de)	2001-01-15
MY114680A (en)	2002-12-31
UA45312C2 (uk)	2002-04-15
PL180104B1 (pl)	2000-12-29
BG100070A (bg)	1996-05-31
CO4480026A1 (es)	1997-07-09
TW411339B (en)	2000-11-11
CA2202057C (en)	2001-10-09
RU2136666C1 (ru)	1999-09-10
DK0787127T3 (da)	2001-02-05
SK281577B6 (sk)	2001-05-10
ZA958748B (en)	1997-04-17
SK128795A3 (en)	1996-07-03
IL115581A0 (en)	1996-01-19
LV11468A (lv)	1996-08-20
CZ287350B6 (en)	2000-10-11
EP0787127A1 (en)	1997-08-06
CN1093536C (zh)	2002-10-30
JPH11507322A (ja)	1999-06-29
AU2417495A (en)	1996-05-06
HU221543B (hu)	2002-11-28
CZ117797A3 (cs)	1998-06-17
SI9500392A (en)	1996-08-31
TR199501274A2 (tr)	1996-06-21
NO971773D0 (no)	1997-04-17
IL115581A (en)	1999-10-28
PL319727A1 (en)	1997-08-18
WO1996011911A1 (en)	1996-04-25
ES2153033T3 (es)	2001-02-16
LV11468B (en)	1996-12-20
NO971773L (no)	1997-06-17
NZ285163A (en)	1998-08-26
DE69519804D1 (de)	2001-02-08
NO314629B1 (no)	2003-04-22
CN1169722A (zh)	1998-01-07
AU681520B2 (en)	1997-08-28
YU65995A (sh)	1999-06-15
DE69519804T2 (de)	2001-04-19
JP3032579B2 (ja)	2000-04-17
GR3035471T3 (en)	2001-05-31
EP0787127B1 (en)	2001-01-03
FI971632A7 (fi)	1997-04-17
BG61768B1 (bg)	1998-05-29
CA2202057A1 (en)	1996-04-25
PE49196A1 (es)	1996-11-21
FI971632A0 (fi)	1997-04-17

Legal Events

Date	Code	Title	Description
2006-02-28	MM4A	Lapse of definitive patent protection due to non-payment of fees

Publication	Publication Date	Title
HUT77363A (hu)	1998-03-30	5-Lipoxigenáz inhibitor hatású azolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
FI70888B (fi)	1986-07-18	Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara
EP0629622A4 (hu)	1995-01-18
DE60017582D1 (de)	2005-02-24	Tricyclische derivate der pyrazolcarbonsäure, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
KR920701167A (ko)	1992-08-11	약제학적 활성 화합물
DK0418845T3 (da)	1995-09-18	Pyrazolderivater, fremgangsmåder til fremstilling deraf og farmaceutisk præparat omfattende samme
NO913750D0 (no)	1991-09-24	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
IL88901A0 (en)	1989-08-15	Substituted pyrrole,pyrazole and triazole derivatives,their preparation and pharmaceutical compositions containing them
CA2440222A1 (en)	2002-09-19	Triazolopyridines as anti-inflammatory agents
KR890014500A (ko)	1989-10-24	트리아졸 유도체, 그의 제법 및 살균제로서의 그의 용도
CA2379903A1 (en)	2002-10-04	Novel benzotriazoles anti-inflammatory compounds
US4652582A (en)	1987-03-24	Antiinflammatory-2-halo-4,5-diarylpyrroles
AU8811401A (en)	2002-04-02	Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
RU97106099A (ru)	1999-04-27	Ингибиторы 5-липоксигеназы
CA2219359A1 (en)	1996-10-31	Hydantoin derivatives as intermediates for pharmaceutical active compounds
HUT52038A (en)	1990-06-28	Process for producing alpha-cyano-beta-oxo-propion-amides
MX9702814A (es)	1997-06-28	Inhibidores de la 5-lipoxigenasa.
FI74948B (fi)	1987-12-31	Foerfarande foer framstaellning av nya farmaceutiskt aktiva 1-substituerade-3-cykloalkylsulfonylpyrrolidin -2,5-dion-derivat.
CA2232267A1 (en)	1997-03-27	Novel imidazole lipoxygenase inhibitors
KR970707099A (ko)	1997-12-01	5-리폭시게나제 저해제(5-lipoxygenase inhibitors)
EP0420086A3 (en)	1991-11-06	Pyrimidoindole derivatives and processes for preparation thereof
JPH02311479A (ja)	1990-12-27	キノリン誘導体
TH32725A (th)	1999-03-20	การเตรียมการและการใช้งานอนุพันธ์กรดคาร์บอกซิลิกแบบใหม่