HUT77943A - 2,5-Dioxo-piperazin-származékok, eljárás előállításukra és alkalmazásuk, valamint közbenső termékei - Google Patents
2,5-Dioxo-piperazin-származékok, eljárás előállításukra és alkalmazásuk, valamint közbenső termékei Download PDFInfo
- Publication number
- HUT77943A HUT77943A HU9800398A HU9800398A HUT77943A HU T77943 A HUT77943 A HU T77943A HU 9800398 A HU9800398 A HU 9800398A HU 9800398 A HU9800398 A HU 9800398A HU T77943 A HUT77943 A HU T77943A
- Authority
- HU
- Hungary
- Prior art keywords
- methyl
- compound
- phenyl
- ethyl
- dimethoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426224.3A GB9426224D0 (en) | 1994-12-23 | 1994-12-23 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT77943A true HUT77943A (hu) | 1998-12-28 |
Family
ID=10766589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9800398A HUT77943A (hu) | 1994-12-23 | 1995-12-22 | 2,5-Dioxo-piperazin-származékok, eljárás előállításukra és alkalmazásuk, valamint közbenső termékei |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0799222A1 (cs) |
| JP (1) | JPH10511384A (cs) |
| CN (1) | CN1175253A (cs) |
| AU (1) | AU698828B2 (cs) |
| BG (1) | BG101602A (cs) |
| BR (1) | BR9510410A (cs) |
| CA (1) | CA2207500A1 (cs) |
| CZ (1) | CZ190097A3 (cs) |
| FI (1) | FI972660A7 (cs) |
| GB (1) | GB9426224D0 (cs) |
| HU (1) | HUT77943A (cs) |
| IL (1) | IL116525A0 (cs) |
| NO (1) | NO972937L (cs) |
| NZ (1) | NZ297847A (cs) |
| PL (1) | PL320916A1 (cs) |
| SK (1) | SK83697A3 (cs) |
| TW (1) | TW358094B (cs) |
| WO (1) | WO1996020190A1 (cs) |
| ZA (1) | ZA9510909B (cs) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| HUP0001531A3 (en) * | 1996-10-18 | 2000-09-28 | Xenova Ltd Slough | Anthranilic acid derivatives as multi drug resistance modulators |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| IL142388A0 (en) | 1998-10-08 | 2002-03-10 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| JP4810043B2 (ja) * | 2000-01-18 | 2011-11-09 | ネリアス・ファーマシュティカルズ・インコーポレーテッド | 細胞分裂阻害剤及びその製造方法 |
| AU2001288829A1 (en) | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| DK1529044T5 (da) | 2002-08-02 | 2008-04-21 | Nereus Pharmaceuticals Inc | Dehydrophenylahistiner og analoger deraf og syntesen af dehydrophenylahistiner og analoger deraf |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN103396372B (zh) * | 2013-08-09 | 2015-05-20 | 中国科学院南海海洋研究所 | 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用 |
| HK1249052A1 (zh) | 2015-03-06 | 2018-10-26 | BeyondSpring Pharmaceuticals Inc. | 治疗与ras突变相关的癌症的方法 |
| EP3265091A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating a brain tumor |
| MX376122B (es) | 2015-07-13 | 2025-03-07 | Beyondspring Pharmaceuticals Inc | Composiciones de plinabulina. |
| SG11201806583XA (en) | 2016-02-08 | 2018-09-27 | Beyondspring Pharmaceuticals Inc | Compositions containing tucaresol or its analogs |
| BR112018074990A2 (pt) | 2016-06-06 | 2019-03-12 | Beyondspring Pharmaceuticals, Inc. | composição, usos e método para reduzir neutropenia |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| EP3576733A4 (en) | 2017-02-01 | 2020-11-25 | Beyondspring Pharmaceuticals, Inc. | NEUTROPENIA REDUCTION METHOD |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| EP4319751A4 (en) | 2021-04-09 | 2025-02-26 | Beyondspring Pharmaceuticals, Inc. | THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69310367T2 (de) * | 1992-07-10 | 1997-08-14 | Glaxo Lab Sa | Anilide-derivate |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
-
1994
- 1994-12-23 GB GBGB9426224.3A patent/GB9426224D0/en active Pending
-
1995
- 1995-12-21 ZA ZA9510909A patent/ZA9510909B/xx unknown
- 1995-12-22 JP JP8520301A patent/JPH10511384A/ja active Pending
- 1995-12-22 PL PL95320916A patent/PL320916A1/xx unknown
- 1995-12-22 EP EP95941797A patent/EP0799222A1/en not_active Withdrawn
- 1995-12-22 CN CN95197672A patent/CN1175253A/zh active Pending
- 1995-12-22 HU HU9800398A patent/HUT77943A/hu unknown
- 1995-12-22 SK SK836-97A patent/SK83697A3/sk unknown
- 1995-12-22 AU AU43100/96A patent/AU698828B2/en not_active Ceased
- 1995-12-22 BR BR9510410-0A patent/BR9510410A/pt not_active Application Discontinuation
- 1995-12-22 WO PCT/GB1995/003027 patent/WO1996020190A1/en not_active Ceased
- 1995-12-22 CA CA002207500A patent/CA2207500A1/en not_active Abandoned
- 1995-12-22 FI FI972660A patent/FI972660A7/fi unknown
- 1995-12-22 CZ CZ971900A patent/CZ190097A3/cs unknown
- 1995-12-22 NZ NZ297847A patent/NZ297847A/en unknown
- 1995-12-22 IL IL11652595A patent/IL116525A0/xx unknown
- 1995-12-23 TW TW084113836A patent/TW358094B/zh active
-
1997
- 1997-06-11 BG BG101602A patent/BG101602A/xx unknown
- 1997-06-23 NO NO972937A patent/NO972937L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ297847A (en) | 1999-04-29 |
| BG101602A (en) | 1998-02-27 |
| CN1175253A (zh) | 1998-03-04 |
| AU698828B2 (en) | 1998-11-05 |
| PL320916A1 (en) | 1997-11-10 |
| JPH10511384A (ja) | 1998-11-04 |
| EP0799222A1 (en) | 1997-10-08 |
| WO1996020190A1 (en) | 1996-07-04 |
| FI972660A0 (fi) | 1997-06-19 |
| NO972937D0 (no) | 1997-06-23 |
| CA2207500A1 (en) | 1996-07-04 |
| CZ190097A3 (cs) | 1998-01-14 |
| FI972660L (fi) | 1997-08-22 |
| SK83697A3 (en) | 1998-05-06 |
| FI972660A7 (fi) | 1997-08-22 |
| AU4310096A (en) | 1996-07-19 |
| IL116525A0 (en) | 1996-03-31 |
| BR9510410A (pt) | 1999-09-08 |
| TW358094B (en) | 1999-05-11 |
| ZA9510909B (en) | 1996-08-30 |
| NO972937L (no) | 1997-06-23 |
| GB9426224D0 (en) | 1995-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT77943A (hu) | 2,5-Dioxo-piperazin-származékok, eljárás előállításukra és alkalmazásuk, valamint közbenső termékei | |
| US6734203B2 (en) | Fused imidazolium derivatives | |
| JP6965360B2 (ja) | ｏ−アミノヘテロアリールアルキニル基含有化合物およびその製造方法と用途 | |
| KR100660309B1 (ko) | 시아노페닐 유도체 | |
| KR20020093086A (ko) | 축합 헤테로아릴 유도체 | |
| JP2010514689A (ja) | 癌、炎症およびウイルス感染症の処置のためのｃｄｋ阻害剤としてのヘテロアリール−ヘテロアリール化合物 | |
| CN101333192A (zh) | 作为钠通道阻滞剂的联芳基取代吡唑 | |
| JP2007509158A (ja) | 肥満、糖尿病、うつ病及び不安を治療するためのｍｃｈｒ１アンタゴニストとしての３−（４−アミノフェニル）チエノピリミド−４−オン誘導体 | |
| JP2021500334A (ja) | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法 | |
| EP2928466B1 (en) | Use of maleimide derivatives for preventing and treating leukemia | |
| CN112638376B (zh) | 取代的四氢环戊二烯并[c]吡咯、取代的二氢吡咯嗪、其类似物和其使用方法 | |
| AU700891B2 (en) | Piperazine-2,5-dione derivatives as modulators of multidrug resistance | |
| JP2004519486A (ja) | クロマン誘導体、その製造方法及びその抗腫瘍剤としての使用 | |
| JP7494224B2 (ja) | ビアリールジアルキルホスフィンオキシドｆｐｒ２アゴニスト | |
| JPWO2005080322A1 (ja) | フルオレン誘導体 | |
| JP2001328938A (ja) | シアノフェニル誘導体を有効成分とする医薬 | |
| CN1321116C (zh) | 氮杂环庚烷衍生物 | |
| KR101035709B1 (ko) | 신규2-치환아미노알킬레닐옥시-3-치환페닐에티닐-6-아미노퀴녹살린 유도체 | |
| JP2747013B2 (ja) | ブテン酸又はプロペン酸誘導体 | |
| JP2003529532A (ja) | ４−３−置換−アミノ−シクロブト−３−エン−１，２−ジオン及び平滑筋収縮に影響を及ぼすための使用 | |
| WO1998014430A1 (en) | Pyrimidine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary protection due to refusal |