ID23424A - Glikokonjugat dari 20(s)-kamptotesin - Google Patents

Glikokonjugat dari 20(s)-kamptotesin

Info

Publication number: ID23424A
Authority: ID; Indonesia
Prior art keywords: glikokonjugus; camptotesin; camptothecin; relates; oncoses
Prior art date: 1997-05-14

Application number

IDW991361A

Other languages

English (en)

Inventor

Hans-Georg Lerchen

Karsten Von Dem Bruch

Jorg Baumgarten

Michael Sperzel

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-14

Filing date

1998-04-05

Publication date

2000-04-20

1998-01-14 Priority claimed from DE19801037A external-priority patent/DE19801037A1/de

1998-03-25 Priority claimed from DE1998113137 external-priority patent/DE19813137A1/de

1998-04-05 Application filed by Bayer Ag filed Critical Bayer Ag

2000-04-20 Publication of ID23424A publication Critical patent/ID23424A/id

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 2
SHZGCJCMOBCMKK-KGJVWPDLSA-N beta-L-fucose Chemical group C[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-KGJVWPDLSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Electrically Operated Instructional Devices (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IDW991361A 1997-05-14 1998-04-05 Glikokonjugat dari 20(s)-kamptotesin ID23424A (id)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE19720043		1997-05-14
DE19737477		1997-08-28
DE19801037A DE19801037A1 (de)	1997-05-14	1998-01-14	Glycokonjugate von 20(S)-Camptothecin
DE1998113137 DE19813137A1 (de)	1998-03-25	1998-03-25	Glycokonjugate von 20(S)-Camptothecin
PCT/EP1998/002620 WO1998051703A1 (de)	1997-05-14	1998-05-04	Glycokonjugate von 20(s)-camptothecin

Publications (1)

Publication Number	Publication Date
ID23424A true ID23424A (id)	2000-04-20

Family

ID=27438596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW991361A ID23424A (id)	1997-05-14	1998-04-05	Glikokonjugat dari 20(s)-kamptotesin

Country Status (19)

Country	Link
US (1)	US6506734B1 (id)
EP (1)	EP0981542B1 (id)
JP (1)	JP2001526661A (id)
CN (1)	CN1255926A (id)
AT (1)	ATE272648T1 (id)
AU (1)	AU744425B2 (id)
BG (1)	BG103872A (id)
BR (1)	BR9809637A (id)
CA (1)	CA2291436A1 (id)
HU (1)	HUP0003174A3 (id)
ID (1)	ID23424A (id)
IL (1)	IL132534A0 (id)
NO (1)	NO995481L (id)
NZ (1)	NZ500990A (id)
PL (1)	PL336697A1 (id)
SK (1)	SK154899A3 (id)
TR (1)	TR199902775T2 (id)
TW (1)	TW495512B (id)
WO (1)	WO1998051703A1 (id)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19909979A1 (de) *	1999-03-06	2000-09-07	Bayer Ag	Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin
DE10005275A1 (de) *	2000-02-07	2001-08-09	Bayer Ag	Neuartige Glycokonjugate
EP1219634A1 (en) *	2000-12-27	2002-07-03	Bayer Aktiengesellschaft	Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
US6350756B1 (en) *	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6403604B1 (en)	2001-03-01	2002-06-11	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
EP1238678A1 (en)	2001-03-08	2002-09-11	Bayer Aktiengesellschaft	Enzyme-activated cytostatic conjugates with integrin ligands
US6933302B2 (en)	2002-06-03	2005-08-23	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
US7875602B2 (en) *	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
US7766293B2 (en) *	2006-04-25	2010-08-03	Raffel Systems, Llc	Lighted cup holder for seating arrangements
US10046068B2 (en)	2013-03-15	2018-08-14	Arizona Board Of Regents On Behalf Of Arizona State University	Saccharide conjugates
WO2014145109A1 (en) *	2013-03-15	2014-09-18	Arizona Board Of Regents, For And On Behalf Of, Arizona State University	Sugar-linker-drug conjugates
CN103333172B (zh) *	2013-06-28	2015-09-30	兰州大学	喜树碱缩氨基硫脲类化合物及其制备方法和用途
CN105566338B (zh) *	2014-10-08	2017-11-21	兰州大学	一种喜树碱类化合物及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6019790A (ja)	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
US4943579A (en)	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
US5004758A (en)	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP2524803B2 (ja)	1988-03-29	1996-08-14	株式会社ヤクルト本社	新規なカンプトテシン誘導体およびその製造法
ES2165346T3 (es) *	1989-09-15	2002-03-16	Res Triangle Inst	Analogos de 10,11-metilendioxi-20(rs)-camptotecina y 10,11-metilendioxi-20(s)-camptotecina.
US5552154A (en)	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
DE4106101A1 (de)	1991-02-27	1992-09-03	Bayer Ag	Fucose-markierte cytostatika
JP3126799B2 (ja)	1992-03-31	2001-01-22	第一製薬株式会社	光学活性カンプトテシン誘導体及びその製法
DE4236237A1 (de) *	1992-10-27	1994-04-28	Behringwerke Ag	Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
JP2610792B2 (ja) *	1993-02-26	1997-05-14	株式会社ディ・ディ・エス研究所	多糖誘導体および薬物担体
US6214345B1 (en) *	1993-05-14	2001-04-10	Bristol-Myers Squibb Co.	Lysosomal enzyme-cleavable antitumor drug conjugates
GB9320781D0 (en) *	1993-10-08	1993-12-01	Erba Carlo Spa	Polymer-bound camptothecin derivatives
US5646159A (en)	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
US5646262A (en) *	1994-07-28	1997-07-08	Georgetown University	Antisense oligonucleotides against hepatitis B viral replication
US5496830A (en)	1994-09-14	1996-03-05	Johns Hopkins University	Inhibition of hemoflagellates by camptothecin compounds
GB9504065D0 (en) *	1995-03-01	1995-04-19	Pharmacia Spa	Poly-pyrrolecarboxamidonaphthalenic acid derivatives
DE19512484A1 (de) *	1995-04-04	1996-10-17	Bayer Ag	Kohlenhydratmodifizierte Cytostatika
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
CA2192725C (en) *	1995-12-28	2004-04-20	Kenji Tsujihara	Camptothecin derivatives
WO1998014459A1 (de) *	1996-09-30	1998-04-09	Bayer Aktiengesellschaft	Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung)
DE19640969A1 (de)	1996-10-04	1998-04-16	Bayer Ag	20-0-verknüpfte Glycokonjugate von Camptothecin

1998
- 1998-04-05 ID IDW991361A patent/ID23424A/id unknown
- 1998-05-04 EP EP98925527A patent/EP0981542B1/de not_active Expired - Lifetime
- 1998-05-04 JP JP54875198A patent/JP2001526661A/ja active Pending
- 1998-05-04 BR BR9809637-0A patent/BR9809637A/pt not_active IP Right Cessation
- 1998-05-04 AT AT98925527T patent/ATE272648T1/de not_active IP Right Cessation
- 1998-05-04 CA CA002291436A patent/CA2291436A1/en not_active Abandoned
- 1998-05-04 SK SK1548-99A patent/SK154899A3/sk unknown
- 1998-05-04 WO PCT/EP1998/002620 patent/WO1998051703A1/de not_active Ceased
- 1998-05-04 NZ NZ500990A patent/NZ500990A/xx unknown
- 1998-05-04 TR TR1999/02775T patent/TR199902775T2/xx unknown
- 1998-05-04 PL PL98336697A patent/PL336697A1/xx unknown
- 1998-05-04 CN CN98805102A patent/CN1255926A/zh active Pending
- 1998-05-04 US US09/403,872 patent/US6506734B1/en not_active Expired - Fee Related
- 1998-05-04 HU HU0003174A patent/HUP0003174A3/hu unknown
- 1998-05-04 AU AU77615/98A patent/AU744425B2/en not_active Ceased
- 1998-05-14 IL IL13253498A patent/IL132534A0/xx unknown
- 1998-05-14 TW TW087107434A patent/TW495512B/zh active
1999
- 1999-11-09 NO NO995481A patent/NO995481L/no not_active Application Discontinuation
- 1999-11-10 BG BG103872A patent/BG103872A/xx unknown

Also Published As

Publication number	Publication date
US6506734B1 (en)	2003-01-14
IL132534A0 (en)	2001-03-19
WO1998051703A1 (de)	1998-11-19
NZ500990A (en)	2000-09-29
JP2001526661A (ja)	2001-12-18
HUP0003174A3 (en)	2003-03-28
CA2291436A1 (en)	1998-11-19
BR9809637A (pt)	2000-07-11
EP0981542A1 (de)	2000-03-01
ATE272648T1 (de)	2004-08-15
TW495512B (en)	2002-07-21
PL336697A1 (en)	2000-07-03
NO995481D0 (no)	1999-11-09
CN1255926A (zh)	2000-06-07
BG103872A (en)	2000-07-31
SK154899A3 (en)	2000-08-14
TR199902775T2 (xx)	2000-07-21
NO995481L (no)	1999-11-09
HUP0003174A2 (hu)	2001-05-28
AU7761598A (en)	1998-12-08
EP0981542B1 (de)	2004-08-04
AU744425B2 (en)	2002-02-21

Publication	Publication Date	Title
NZ284846A (en)	1998-12-23	1-substituted-pyrazolo[3,4-b]pyridin-5-carboxylic acid derivatives, preparation, use, intermediates and pharmaceutical compositions thereof
TR200200785T2 (tr)	2002-09-23	8-Fenil-6,9-dihidro-[1,2,4] triazolo [3,4-i] purin-5-on türevleri
UA66750C2 (en)	2004-06-15	Substituted 1-phenylpirazole 3-carboxamides, a method for the preparation thereof and intermediary compounds, pharmaceutical composition having affinity to neurotensin receptors
GEP20053473B (en)	2005-03-25	High Potency Dihydroergotamine Compositions
AP9801169A0 (en)	1999-08-05	N-hydroxy-B-sulfonyl propionamide derivatives.
BR9709823B1 (pt)	2013-09-17	"compostos de amidas de ácido alqueno piridílico e alquino piridílico, métodos de preparação e uso dos mesmos, bem como medicamento".
ATE272648T1 (de)	2004-08-15	Glycokonjugate von 20(s)-camptothecin
MX9700885A (es)	1998-04-30	Nuevas heteroariloxazolidinonas.
HUP9902136A3 (en)	2000-03-28	Novel substituted cyclic amino acid derivatives use as pharmaceutical agents
NO971889D0 (no)	1997-04-24	Forbindelser og sammensetninger for levering av aktive midler
MX9605665A (es)	1997-05-31	Bis (resorcinil) triazinas.
DK0869808T3 (da)	2006-11-13	Anvendelse af Glu-Trp-dipeptider til fremstilling af et lægemiddel til behandling af forskellige tilstande, der involverer neovaskularisation
CA2024767A1 (en)	1991-03-08	Interferon-gamma receptor fragment and its production
AU1578688A (en)	1988-11-04	Pharmaceutical composition, for oral administration, designed to attenuate the effects of beta-lactamines
ATE210147T1 (de)	2001-12-15	Glycokonjugate von modifizierten camptothecin- derivaten(a- oder b-ring-verknüpfung)
DK0934329T3 (da)	2002-04-08	Glycokonjugater af modificerede camptothecinderivater (20-O-binding)
PL320916A1 (en)	1997-11-10	Derivatives of piperasino 2,5-dione as modulators of drug-fastness in respect to amny drugs
ES2173858T3 (es)	2002-11-01	Analogos de huperzina a.
MY133112A (en)	2007-10-31	3-amino-3-arylpropan-1-ol derivatives, and their preparation and use
MY120683A (en)	2005-11-30	New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
FR2757514B1 (fr)	1999-02-12	Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
BG104179A (en)	2000-10-31	Phanquinon administration for the treatment of the alzheimer's disease
MY120550A (en)	2005-11-30	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions.
BG102707A (bg)	1999-09-30	Нови триазолопурини, метод за тяхното получаване и тяхното приложение като лекарствени средства
AU8553898A (en)	1999-02-16	Use of 2,3-benzodiazepine derivatives for the preparation of pharmaceutical compositions to treat diseases connected with the endogenous opioid system