ID24175A - Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannya - Google Patents
Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannyaInfo
- Publication number
- ID24175A ID24175A IDW20000933A ID20000933A ID24175A ID 24175 A ID24175 A ID 24175A ID W20000933 A IDW20000933 A ID W20000933A ID 20000933 A ID20000933 A ID 20000933A ID 24175 A ID24175 A ID 24175A
- Authority
- ID
- Indonesia
- Prior art keywords
- drivings
- imidazol
- making
- living activity
- farnesil
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 229950008696 farnesil Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19970063858 | 1997-11-28 | ||
| KR1019980011359A KR19990066679A (ko) | 1997-11-28 | 1998-03-31 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR1019980023698A KR20000002788A (ko) | 1998-06-23 | 1998-06-23 | 피라졸 구조를 갖는 파네실 전이효소 억제제 및그의 제조방법 |
| KR1019980024423A KR19990062439A (ko) | 1997-11-28 | 1998-06-26 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR19980031512 | 1998-08-03 | ||
| KR1019980046457A KR20000015758A (ko) | 1998-08-03 | 1998-10-30 | 피롤 구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID24175A true ID24175A (id) | 2000-07-13 |
Family
ID=27555104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW20000933A ID24175A (id) | 1997-11-28 | 1998-11-25 | Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannya |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6268363B1 (es) |
| EP (1) | EP1045846B1 (es) |
| JP (2) | JP3548118B2 (es) |
| CN (1) | CN1188407C (es) |
| AR (1) | AR017700A1 (es) |
| AT (1) | ATE239014T1 (es) |
| AU (1) | AU731272B2 (es) |
| BR (1) | BR9815423A (es) |
| CA (1) | CA2310629A1 (es) |
| DE (1) | DE69814167T2 (es) |
| ES (1) | ES2193590T3 (es) |
| HU (1) | HUP0004238A3 (es) |
| ID (1) | ID24175A (es) |
| IL (1) | IL135473A0 (es) |
| NZ (1) | NZ504013A (es) |
| PL (1) | PL340729A1 (es) |
| RU (1) | RU2179975C1 (es) |
| WO (1) | WO1999028315A1 (es) |
Families Citing this family (63)
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| CN1158277C (zh) * | 1998-02-02 | 2004-07-21 | Lg化学株式会社 | 具有哌啶结构的法尼转移酶抑制剂及其制备方法 |
| KR100395300B1 (ko) * | 1999-08-11 | 2003-08-27 | 주식회사 엘지생명과학 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| ATE277039T1 (de) * | 1999-04-13 | 2004-10-15 | Lg Chem Investment Ltd | Farnesyltransferase-inhibitoren die eine pyrrolstruktur haben und verfahren zu ihrer herstellung |
| FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
| KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물 |
| KR100412334B1 (ko) * | 2000-02-22 | 2003-12-31 | 주식회사 엘지생명과학 | 4-치환된-1ｈ-피롤-3-카복실산 에스테르의 새로운 제조방법 |
| EP1275646A4 (en) * | 2000-03-30 | 2003-05-28 | Sagami Chem Res | INDOLYLPYRROL DERIVATIVES AND CELL DEATH INHIBITORS |
| US7304061B2 (en) * | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| RU2311415C2 (ru) * | 2002-08-23 | 2007-11-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч | Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения |
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| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
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| MXPA06000401A (es) * | 2003-07-10 | 2006-03-17 | Osi Pharm Inc | Derivados de naftileno como inhibidores de citocromo p450. |
| EP2272566A3 (en) | 2003-08-18 | 2013-01-02 | MedImmune, LLC | Humanisation of antibodies |
| US7214825B2 (en) | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
| US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
| US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
| EP1758874A1 (en) * | 2004-05-29 | 2007-03-07 | 7TM Pharma A/S | Substituted thiazoleacetic acids as crth2 ligands |
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| CA2602035C (en) | 2005-03-18 | 2015-06-16 | Medimmune, Inc. | Framework-shuffling of antibodies |
| KR20080025174A (ko) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | 응집 및 단편화 프로파일이 최적화된 항체 제제 |
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| AU2007290570C1 (en) | 2006-08-28 | 2013-08-15 | Kyowa Kirin Co., Ltd. | Antagonistic human LIGHT-specific human monoclonal antibodies |
| CA2682292A1 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Llc | Aqueous formulation comprising an anti-human interferon alpha antibody |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| US8633297B2 (en) | 2007-10-31 | 2014-01-21 | Medimmune, Llc | Protein scaffolds |
| EP2095819A1 (en) * | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| US9540443B2 (en) | 2011-01-26 | 2017-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
| NZ630363A (en) | 2012-07-25 | 2018-09-28 | Celldex Therapeutics Inc | Anti-kit antibodies and uses thereof |
| CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| SG11201509982UA (es) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
| AU2014332442B2 (en) | 2013-08-26 | 2019-12-19 | Biontech Research And Development, Inc. | Nucleic acids encoding human antibodies to Sialyl-Lewis |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9856324B2 (en) | 2014-06-04 | 2018-01-02 | MabVax Therapeutics, Inc. | Human monoclonal antibodies to ganglioside GD2 |
| JP6800853B2 (ja) | 2014-12-11 | 2020-12-16 | ピエール、ファーブル、メディカマン | 抗ｃ１０ｏｒｆ５４抗体およびその使用 |
| KR20250005465A (ko) | 2015-03-03 | 2025-01-09 | 키맵 리미티드 | 항체, 용도 및 방법 |
| EP3383911B1 (en) | 2015-12-02 | 2021-01-20 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
| EP3383908A1 (en) | 2015-12-02 | 2018-10-10 | Stsciences, Inc. | Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator) |
| EP3519392A1 (en) | 2016-09-29 | 2019-08-07 | Bayer CropScience Aktiengesellschaft | Novel 5-substituted imidazole derivatives |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN111051346A (zh) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法 |
| KR20200015602A (ko) | 2017-05-31 | 2020-02-12 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도 |
| KR20200026209A (ko) | 2017-06-06 | 2020-03-10 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법 |
| WO2019073069A1 (en) | 2017-10-13 | 2019-04-18 | Boehringer Ingelheim International Gmbh | HUMAN ANTIBODIES AGAINST THOMSEN-NEW ANTIGEN (TN) |
| CN112740043A (zh) | 2018-07-20 | 2021-04-30 | 皮埃尔法布雷医药公司 | Vista受体 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
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| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
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| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300688A1 (en) | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
| US5681795A (en) * | 1994-03-02 | 1997-10-28 | Zeneca Limited | 3-benzoyl pyrrole and pyrazole herbicides |
| US5756528A (en) | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU710242B2 (en) | 1996-03-29 | 1999-09-16 | Therakos, Inc. | Photopheresis treatment of leukocytes |
| WO1997036585A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1997036876A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2001509131A (ja) * | 1996-04-03 | 2001-07-10 | メルク エンド カンパニー インコーポレーテッド | ファルネシルプロテイントランスフェラーゼの阻害剤 |
| CA2249617A1 (en) * | 1996-04-03 | 1997-10-09 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
| JP2000507590A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
-
1998
- 1998-11-25 CA CA002310629A patent/CA2310629A1/en not_active Abandoned
- 1998-11-25 NZ NZ504013A patent/NZ504013A/en unknown
- 1998-11-25 RU RU2000116633/04A patent/RU2179975C1/ru not_active IP Right Cessation
- 1998-11-25 WO PCT/KR1998/000377 patent/WO1999028315A1/en not_active Ceased
- 1998-11-25 AU AU15083/99A patent/AU731272B2/en not_active Ceased
- 1998-11-25 IL IL13547398A patent/IL135473A0/xx unknown
- 1998-11-25 DE DE69814167T patent/DE69814167T2/de not_active Expired - Fee Related
- 1998-11-25 CN CNB988114976A patent/CN1188407C/zh not_active Expired - Fee Related
- 1998-11-25 AT AT98959231T patent/ATE239014T1/de not_active IP Right Cessation
- 1998-11-25 US US09/554,646 patent/US6268363B1/en not_active Expired - Fee Related
- 1998-11-25 ES ES98959231T patent/ES2193590T3/es not_active Expired - Lifetime
- 1998-11-25 PL PL98340729A patent/PL340729A1/xx unknown
- 1998-11-25 EP EP98959231A patent/EP1045846B1/en not_active Expired - Lifetime
- 1998-11-25 BR BR9815423-0A patent/BR9815423A/pt not_active Application Discontinuation
- 1998-11-25 ID IDW20000933A patent/ID24175A/id unknown
- 1998-11-25 HU HU0004238A patent/HUP0004238A3/hu unknown
- 1998-11-25 JP JP2000523207A patent/JP3548118B2/ja not_active Expired - Fee Related
- 1998-11-30 AR ARP980106048A patent/AR017700A1/es not_active Application Discontinuation
-
2001
- 2001-03-20 US US09/813,437 patent/US6518429B2/en not_active Expired - Fee Related
- 2001-10-03 JP JP2001307368A patent/JP2002161092A/ja active Pending
- 2001-12-03 US US10/005,262 patent/US6472526B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1188407C (zh) | 2005-02-09 |
| PL340729A1 (en) | 2001-02-26 |
| US6472526B1 (en) | 2002-10-29 |
| ES2193590T3 (es) | 2003-11-01 |
| NZ504013A (en) | 2002-02-01 |
| BR9815423A (pt) | 2000-10-17 |
| EP1045846B1 (en) | 2003-05-02 |
| US20020137769A1 (en) | 2002-09-26 |
| JP3548118B2 (ja) | 2004-07-28 |
| AU1508399A (en) | 1999-06-16 |
| CN1279680A (zh) | 2001-01-10 |
| JP2002161092A (ja) | 2002-06-04 |
| DE69814167T2 (de) | 2004-02-26 |
| WO1999028315A1 (en) | 1999-06-10 |
| RU2000116633A (ru) | 2004-02-20 |
| ATE239014T1 (de) | 2003-05-15 |
| US6268363B1 (en) | 2001-07-31 |
| HUP0004238A2 (hu) | 2001-05-28 |
| EP1045846A1 (en) | 2000-10-25 |
| RU2179975C1 (ru) | 2002-02-27 |
| IL135473A0 (en) | 2001-05-20 |
| HUP0004238A3 (en) | 2001-07-30 |
| US6518429B2 (en) | 2003-02-11 |
| JP2001524550A (ja) | 2001-12-04 |
| DE69814167D1 (de) | 2003-06-05 |
| CA2310629A1 (en) | 1999-06-10 |
| AR017700A1 (es) | 2001-09-12 |
| AU731272B2 (en) | 2001-03-29 |
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