ID24639A - 2-{3-[4-(2-t-butil-6-trifluorometil-4-pirimidil)-1-piperazinil] propiltio}-4-pirimidinol fumarat - Google Patents

2-{3-[4-(2-t-butil-6-trifluorometil-4-pirimidil)-1-piperazinil] propiltio}-4-pirimidinol fumarat

Info

Publication number
ID24639A
ID24639A IDW20000266A ID20000266A ID24639A ID 24639 A ID24639 A ID 24639A ID W20000266 A IDW20000266 A ID W20000266A ID 20000266 A ID20000266 A ID 20000266A ID 24639 A ID24639 A ID 24639A
Authority
ID
Indonesia
Prior art keywords
propiltio
piperazinil
butil
pyrimidinol
pyrimidyl
Prior art date
Application number
IDW20000266A
Other languages
English (en)
Indonesian (id)
Inventor
Stefan Blank
Dorothea Sarck
Hans-Jorg Treiber
Stefan Koser
Bernd Schafer
Thomas Hoger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ID24639A publication Critical patent/ID24639A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IDW20000266A 1997-08-14 1998-08-14 2-{3-[4-(2-t-butil-6-trifluorometil-4-pirimidil)-1-piperazinil] propiltio}-4-pirimidinol fumarat ID24639A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19735410A DE19735410A1 (de) 1997-08-14 1997-08-14 2-{3-[4-(2-t-Butyl-6-trifluormethylpyrimidin-4-yl)piperazin-1-yl]propylmercapto}pyrimidin-4-ol-fumarat
PCT/EP1998/005178 WO1999009015A1 (de) 1997-08-14 1998-08-14 2-{3-[4-(2-t-butyl-6- trifluormethylpyrimidin-4-yl) piperrazin-1-yl] propylmercapto} pyrimidin-4-ol-fumarat

Publications (1)

Publication Number Publication Date
ID24639A true ID24639A (id) 2000-07-27

Family

ID=7839072

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20000266A ID24639A (id) 1997-08-14 1998-08-14 2-{3-[4-(2-t-butil-6-trifluorometil-4-pirimidil)-1-piperazinil] propiltio}-4-pirimidinol fumarat

Country Status (25)

Country Link
US (1) US20010020022A1 (pl)
EP (2) EP1003728B1 (pl)
JP (1) JP4444492B2 (pl)
KR (1) KR100571945B1 (pl)
CN (1) CN1267286A (pl)
AR (1) AR016605A1 (pl)
AT (1) ATE525362T1 (pl)
AU (1) AU749575B2 (pl)
BG (1) BG104122A (pl)
BR (1) BR9811177A (pl)
CA (1) CA2301297A1 (pl)
CO (1) CO4960663A1 (pl)
DE (1) DE19735410A1 (pl)
ES (1) ES2374156T3 (pl)
HU (1) HUP0003710A3 (pl)
ID (1) ID24639A (pl)
IL (1) IL134246A (pl)
NO (1) NO314935B1 (pl)
NZ (1) NZ502675A (pl)
PL (1) PL201927B1 (pl)
SK (1) SK1182000A3 (pl)
TR (1) TR200000406T2 (pl)
TW (1) TW467912B (pl)
WO (1) WO1999009015A1 (pl)
ZA (1) ZA987239B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311012T3 (es) * 2000-03-27 2009-02-01 ABBOTT GMBH & CO. KG Ligandos del receptor d3 de la dopamina para el tratamiento de la adiccion.
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
CA2574827C (en) * 2004-08-09 2013-05-07 Abbott Gmbh & Co. Kg 4-piperazinyl-pyrimidine compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor
CN102887860B (zh) * 2012-09-29 2015-07-01 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法
DK2906221T3 (da) 2012-10-11 2019-07-22 Southern Res Inst Urinstof og amidderivater af aminoalkylpiperaziner og anvendelse deraf
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung

Also Published As

Publication number Publication date
WO1999009015A1 (de) 1999-02-25
KR100571945B1 (ko) 2006-04-18
TW467912B (en) 2001-12-11
PL338603A1 (en) 2000-11-06
BG104122A (en) 2000-11-30
EP1003728A1 (de) 2000-05-31
HUP0003710A3 (en) 2002-01-28
AU749575B2 (en) 2002-06-27
NO20000665D0 (no) 2000-02-10
PL201927B1 (pl) 2009-05-29
BR9811177A (pt) 2000-07-25
JP4444492B2 (ja) 2010-03-31
EP2272833A1 (de) 2011-01-12
DE19735410A1 (de) 1999-02-18
CO4960663A1 (es) 2000-09-25
AR016605A1 (es) 2001-07-25
NZ502675A (en) 2001-06-29
ZA987239B (en) 2000-02-14
NO20000665L (no) 2000-02-10
TR200000406T2 (tr) 2000-05-22
CA2301297A1 (en) 1999-02-25
ATE525362T1 (de) 2011-10-15
CN1267286A (zh) 2000-09-20
IL134246A (en) 2002-11-10
US20010020022A1 (en) 2001-09-06
ES2374156T3 (es) 2012-02-14
SK1182000A3 (en) 2000-09-12
EP1003728B1 (de) 2011-09-21
HUP0003710A2 (hu) 2001-10-28
JP2001515070A (ja) 2001-09-18
KR20010022833A (ko) 2001-03-26
NO314935B1 (no) 2003-06-16
IL134246A0 (en) 2001-04-30
AU9342698A (en) 1999-03-08

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