ID25797A - Senyawa-senyawa untuk diagnosis antemortem penyakit alzheimer dan pencitraan in vivo serta pencegahan pengendapan amiloid - Google Patents

Senyawa-senyawa untuk diagnosis antemortem penyakit alzheimer dan pencitraan in vivo serta pencegahan pengendapan amiloid

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Publication number
ID25797A
ID25797A IDW20001067D ID20001067D ID25797A ID 25797 A ID25797 A ID 25797A ID W20001067 D IDW20001067 D ID W20001067D ID 20001067 D ID20001067 D ID 20001067D ID 25797 A ID25797 A ID 25797A
Authority
ID
Indonesia
Prior art keywords
antemorteme
amiloid
diagnosis
deposition
prevention
Prior art date
Application number
IDW20001067D
Other languages
English (en)
Indonesian (id)
Inventor
William E Klunk
Jay W Pettegrew
Chester A Mathis Jr
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Publication of ID25797A publication Critical patent/ID25797A/id

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/10—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Cell Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDW20001067D 1997-11-06 1998-11-06 Senyawa-senyawa untuk diagnosis antemortem penyakit alzheimer dan pencitraan in vivo serta pencegahan pengendapan amiloid ID25797A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/968,902 US6417178B1 (en) 1994-07-19 1997-11-06 Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits

Publications (1)

Publication Number Publication Date
ID25797A true ID25797A (id) 2000-11-02

Family

ID=25514917

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001067D ID25797A (id) 1997-11-06 1998-11-06 Senyawa-senyawa untuk diagnosis antemortem penyakit alzheimer dan pencitraan in vivo serta pencegahan pengendapan amiloid

Country Status (18)

Country Link
US (1) US6417178B1 (fr)
EP (1) EP1028941A2 (fr)
JP (1) JP2001522829A (fr)
KR (1) KR20010031872A (fr)
CN (1) CN1285818A (fr)
AU (1) AU1383399A (fr)
BR (1) BR9812776A (fr)
CA (1) CA2309626A1 (fr)
EE (1) EE200000278A (fr)
HU (1) HUP0100159A3 (fr)
ID (1) ID25797A (fr)
IL (1) IL135986A0 (fr)
NO (1) NO20002380L (fr)
OA (1) OA11377A (fr)
PL (1) PL348226A1 (fr)
SK (1) SK6732000A3 (fr)
TR (1) TR200001264T2 (fr)
WO (1) WO1999024394A2 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US6923964B1 (en) 1997-12-02 2005-08-02 Neuralab Limited Active immunization of AScr for prion disorders
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US6710226B1 (en) 1997-12-02 2004-03-23 Neuralab Limited Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20030147882A1 (en) * 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
AU2001239544A1 (en) * 2000-03-22 2001-10-03 Bf Research Institute, Inc. Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same
US6849249B2 (en) * 2001-04-27 2005-02-01 The Brigham And Women's Hospital, Inc. Ocular diagnosis of Alzheimer's Disease
US7107092B2 (en) 2000-08-21 2006-09-12 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
RU2324686C2 (ru) * 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
US6589504B1 (en) 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions
PE20020574A1 (es) * 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
CA2444214A1 (fr) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Inhibiteurs d'agregation de plaque amyloide et agents d'imagerie diagnostique
WO2003051374A2 (fr) * 2001-12-17 2003-06-26 New York State Office Of Mental Health SEQUESTRATION DE Aβ DANS LA REGION PERIPHERIQUE EN L'ABSENCE D'AGENTS IMMUNOMODULATEURS COMME APPROCHE THERAPEUTIQUE POUR LE TRAITEMENT OU LA PREVENTION DES MALADIES LIEES A LA BETA-AMYLOIDE
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20050043523A1 (en) * 2003-08-22 2005-02-24 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
WO2004100998A2 (fr) 2003-05-07 2004-11-25 General Electric Company Compositions et procedes de visualisation non effractive du beta-amyloide soluble
EP1641806B1 (fr) * 2003-05-29 2009-07-29 Jay W. Pettegrew Composes, compositions et procedes d'imagerie medicale permettant d'obtenir des image de troubles neuropsychiatriques
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
TWI306458B (en) 2003-05-30 2009-02-21 Elan Pharma Int Ltd Humanized antibodies that recognize beta amyloid peptide
US8236282B2 (en) * 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
GB0405193D0 (en) * 2004-03-08 2004-04-21 Medical Res Council Compounds
EP1838348B1 (fr) 2004-12-15 2013-06-26 Janssen Alzheimer Immunotherapy Anticorps du peptide beta-amyloide humanises utilises dans l'amelioration de la cognition
US7625560B2 (en) * 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7957507B2 (en) 2005-02-28 2011-06-07 Cadman Patrick F Method and apparatus for modulating a radiation beam
US8232535B2 (en) 2005-05-10 2012-07-31 Tomotherapy Incorporated System and method of treating a patient with radiation therapy
US7567694B2 (en) 2005-07-22 2009-07-28 Tomotherapy Incorporated Method of placing constraints on a deformation map and system for implementing same
CA2616301A1 (fr) 2005-07-22 2007-02-01 Tomotherapy Incorporated Procede et systeme pour l'evaluation de dose administree
JP5060476B2 (ja) 2005-07-22 2012-10-31 トモセラピー・インコーポレーテッド 放射線療法を受けている患者の呼吸位相を検出するシステムおよび方法
CN101268467B (zh) 2005-07-22 2012-07-18 断层放疗公司 用于评估治疗计划的实施中的质量保证标准的方法和系统
JP2009514559A (ja) 2005-07-22 2009-04-09 トモセラピー・インコーポレーテッド 線量体積ヒストグラムを用いて輪郭構造を生成するシステムおよび方法
EP1907065B1 (fr) 2005-07-22 2012-11-07 TomoTherapy, Inc. Methode et systeme pour adapter un programme de traitement de radiotherapie en fonction d'un modele biologique
US8442287B2 (en) 2005-07-22 2013-05-14 Tomotherapy Incorporated Method and system for evaluating quality assurance criteria in delivery of a treatment plan
US7639853B2 (en) 2005-07-22 2009-12-29 Tomotherapy Incorporated Method of and system for predicting dose delivery
AU2006272742A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of delivering radiation therapy to a moving region of interest
EP1906827A4 (fr) 2005-07-22 2009-10-21 Tomotherapy Inc Systeme et methode pour evaluer une dose administree par un systeme de radiotherapie
CA2616306A1 (fr) 2005-07-22 2007-02-01 Tomotherapy Incorporated Procede et systeme de traitement de donnees relatives a un plan de traitement par radiotherapie
EP3175886B1 (fr) 2005-07-23 2018-06-27 TomoTherapy, Inc. Imagerie de radiothérapie et administration de radiothérapie par déplacement coordonné du portique et de la table
GB2453191A (en) * 2005-10-18 2009-04-01 Brigham & Womens Hospital Diagnosis of transmissible spongiform encephalopathy
CA2647147C (fr) 2006-04-11 2016-10-04 Neuroptix Corporation Imagerie oculaire
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2008118122A2 (fr) * 2006-05-08 2008-10-02 Molecular Neuroimaging, Llc Composés et sondes amyloïdes de ceux-ci pour des utilisations thérapeutiques et en imagerie
KR100836753B1 (ko) * 2006-09-08 2008-06-10 한국과학기술연구원 베타 아밀로이드 피브릴 형성 억제 화합물, 이의 제조 방법 및 이를 포함하는 약학 조성물
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
EP2152255A1 (fr) * 2007-05-21 2010-02-17 Neuroptix Corporation Formulations ophtalmiques d'agents de contraste amyloïde et procédés d'utilisation de celles-ci
DK2182983T3 (da) 2007-07-27 2014-07-14 Janssen Alzheimer Immunotherap Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
NZ585999A (en) * 2007-12-07 2011-05-27 Prana Biotechnology Ltd Transition metal complexes for therapy and diagnosis
US20090162280A1 (en) * 2007-12-20 2009-06-25 General Electric Company Detecting soluble a-beta
EP2247558B2 (fr) 2008-02-14 2024-07-03 Eli Lilly and Company Nouveaux agents d'imagerie pour la détection d'une dysfonction neurologique
WO2009146388A1 (fr) 2008-05-28 2009-12-03 The Trustees Of Columbia University In The City Of New York Procédés à base de voxel destinés à évaluer des sujets au moyen de la tomographie par émission de positons
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
US20130137120A1 (en) * 2010-01-28 2013-05-30 Panasonic Corporation Amyloid b measurement method
EP2368558A1 (fr) 2010-03-23 2011-09-28 Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch Composés azo diminuant la formation et la toxicité d'intermédiaires d'agrégation beta-amyloïde
CA2807683C (fr) 2010-08-16 2020-02-18 Cognoptix, Inc. Systeme et procede pour la detection de proteines amyloides
AU2013323198B2 (en) 2012-09-28 2018-03-29 Srinivasa R. Cheruku Dihydro-6-azaphenalene derivatives for the treatment of CNS, oncological diseases and related disorders
EP2962309B1 (fr) 2013-02-26 2022-02-16 Accuray, Inc. Collimateur multilame actionné par voie électromagnétique
AR098232A1 (es) 2013-10-31 2016-05-18 Cognoptix Inc Métodos de preparación de una formulación oftálmica y usos de la misma
EP3634442B1 (fr) 2017-05-24 2025-04-09 Tets, Viktor, Veniaminovich Procédé de diagnostic de la maladie de parkinson
US12535491B2 (en) 2018-04-30 2026-01-27 Viktor Veniaminovich Tets Vaccine comprising protein-targeted (PT) extracellular DNA isolated from bacterial matrix
US11918610B2 (en) * 2018-06-29 2024-03-05 Viktor Veniaminovich Tets Methods for diagnosis and treatment of type 1 diabetes
WO2020010214A1 (fr) 2018-07-03 2020-01-09 Tets Viktor Veniaminovich Procédé d'évaluation et d'inhibition du vieillissement et moyens de détermination de l'âge biologique
WO2025104079A1 (fr) * 2023-11-17 2025-05-22 Helmholtz-Zentrum für Infektionsforschung GmbH Dérivés d'acide salicylique et d'acide picolinique en tant qu'inhibiteurs de transporteurs du facteur de couplage énergétique (ecf) pour le traitement d'infections bactériennes

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US476336A (en) * 1892-06-07 Fabriken
US464775A (en) * 1891-12-08 Ors to tfie farbenfabrikek
US394841A (en) * 1888-12-18 Carl duisberg
US410057A (en) * 1889-08-27 Liams
US493413A (en) * 1893-03-14 Bruno richard seifert
US1314926A (en) * 1919-09-02 Chester e
US401024A (en) * 1889-04-09 Benfabriken
US2472965A (en) * 1949-06-14 Metallized tetrakisazo dyes
US718028A (en) * 1900-11-06 1903-01-06 Basf Ag Mixed disazo dye and process of making same.
US888522A (en) * 1908-02-01 1908-05-26 Farbenfab Vorm Bayer F & Co Red tetrazo dye.
US964920A (en) * 1910-04-13 1910-07-19 Corp Chem Fab Griesheim Elektron Disazo dye.
US982509A (en) * 1910-07-15 1911-01-24 Griesheim Elektron Chem Fab Disazo dyestuff.
US995161A (en) * 1910-12-13 1911-06-13 Griesheim Elektron Chem Fab Disazo dyes for wool.
US1784343A (en) * 1922-08-17 1930-12-09 Gen Aniline Works Inc Lew azo dyestuffs
US1660625A (en) * 1926-03-24 1928-02-28 Grasselli Dyestuff Corp Mordant disazo dyestuffs
DE454177C (de) 1926-03-25 1927-12-30 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von beizenziehenden Azofarbstoffen
US1757500A (en) * 1926-12-10 1930-05-06 British Dyestuffs Corp Ltd Relating to manufacture of new secondary disazo dyes from 1:8-aminonaphthol sulphonic acid
FR743076A (fr) * 1931-09-28 1933-03-23
US2012779A (en) * 1933-03-31 1935-08-27 Chem Ind Basel Chromiferous azo-dyestuff and process of making same
US2314023A (en) * 1939-08-08 1943-03-16 Chem Ind Basel Substantive azo dyestuffs and process of making same
US2367053A (en) * 1941-09-06 1945-01-09 Du Pont Disazo dyestuffs
US2803625A (en) * 1951-11-15 1957-08-20 Bayer Ag Chromium complex disazo dyestuffs
US2773864A (en) * 1952-04-19 1956-12-11 Gen Aniline & Film Corp Coupling assistants for polyazo dyes
US2912428A (en) 1956-03-07 1959-11-10 Ciba Ltd Process for the manufacture of azo pigments
US2954371A (en) * 1958-02-12 1960-09-27 Ciba Ltd Water insoluble disazo-dyestuffs
NL250565A (fr) * 1959-04-16
GB1028567A (en) * 1962-08-14 1966-05-04 Sumitomo Chemical Co Improvements in or relating to disazo dyestuffs
NL130680C (fr) * 1965-04-29
US3485814A (en) * 1965-08-12 1969-12-23 Du Pont Disazo sulfonic acid dyes
FR2036652A5 (en) 1969-03-06 1970-12-24 Ciba Geigy Naphthoxazole optical blueing agents
CH553807A (de) 1970-12-23 1974-09-13 Sandoz Ag Verfahren zur herstellung von dibenzthiophendioxidderivaten.
JPS547814B2 (fr) 1971-09-16 1979-04-10
DE2251703A1 (de) * 1972-10-21 1974-05-02 Hoechst Ag Verfahren zum faerben von synthetischen fasermaterialien aus organischen loesemitteln
JPS5516573B2 (fr) 1972-11-16 1980-05-02
DE2256171C3 (de) 1972-11-16 1979-07-26 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Disazopigmenten
US4006131A (en) * 1973-01-04 1977-02-01 Sandoz Ltd. Anionic disazo dyes having a 2,2'-dihalodiphenyl tetrazo component radical
JPS5817158A (ja) 1981-07-23 1983-02-01 Dainippon Ink & Chem Inc 紫外線を遮断する樹脂組成物
US4933156A (en) * 1987-04-08 1990-06-12 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
DE3725082A1 (de) * 1987-07-29 1989-02-09 Bayer Ag Disazofarbstoffe
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
DE59508602D1 (de) * 1994-12-12 2000-08-31 Ciba Sc Holding Ag Azofarbstoffe, Verfahren zu deren Herstellung und deren Verwendung
EP1110945A3 (fr) 1995-05-01 2003-05-07 University Of Pittsburgh Composés azo destinés au diagnostic avant la mort de la maladie d'Alzheimer, à l'imagerie in vivo ainsi qu'à la prévention du dépot de substance amyloide

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US6417178B1 (en) 2002-07-09
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AU1383399A (en) 1999-05-31
WO1999024394A9 (fr) 2001-05-31
SK6732000A3 (en) 2002-05-09
IL135986A0 (en) 2001-05-20
BR9812776A (pt) 2003-06-10
JP2001522829A (ja) 2001-11-20
HUP0100159A2 (hu) 2001-05-28
WO1999024394A3 (fr) 1999-08-19
NO20002380D0 (no) 2000-05-05
KR20010031872A (ko) 2001-04-16
WO1999024394A2 (fr) 1999-05-20
OA11377A (en) 2004-01-28
PL348226A1 (en) 2002-05-06
TR200001264T2 (tr) 2001-08-21
HUP0100159A3 (en) 2002-09-30
NO20002380L (no) 2000-07-04
CA2309626A1 (fr) 1999-05-20
EE200000278A (et) 2001-08-15

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