ID27417A - Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya - Google Patents

Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya

Info

Publication number
ID27417A
ID27417A IDW20010033A ID20010033A ID27417A ID 27417 A ID27417 A ID 27417A ID W20010033 A IDW20010033 A ID W20010033A ID 20010033 A ID20010033 A ID 20010033A ID 27417 A ID27417 A ID 27417A
Authority
ID
Indonesia
Prior art keywords
immunoglobulin
product
iga
intravena
giving
Prior art date
Application number
IDW20010033A
Other languages
English (en)
Indonesian (id)
Inventor
Laursen Inga
Teisner Borge
Original Assignee
Statens Seruminstitut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID27417(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Statens Seruminstitut filed Critical Statens Seruminstitut
Publication of ID27417A publication Critical patent/ID27417A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IDW20010033A 1998-06-09 1999-06-09 Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya ID27417A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201909 1998-06-09
US10205598P 1998-09-28 1998-09-28

Publications (1)

Publication Number Publication Date
ID27417A true ID27417A (id) 2001-04-05

Family

ID=26150417

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20010033A ID27417A (id) 1998-06-09 1999-06-09 Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya

Country Status (22)

Country Link
EP (4) EP1493751A1 (de)
JP (1) JP5478519B2 (de)
KR (1) KR100501263B1 (de)
CN (1) CN1196714C (de)
AT (1) ATE277950T1 (de)
AU (1) AU753468B2 (de)
BR (1) BR9911131A (de)
CA (1) CA2330170C (de)
CZ (1) CZ297199B6 (de)
DE (1) DE69920693T2 (de)
DK (1) DK1084147T3 (de)
ES (1) ES2229784T3 (de)
HU (1) HU228076B1 (de)
ID (1) ID27417A (de)
IL (1) IL140155A (de)
NZ (1) NZ509135A (de)
PL (1) PL196770B1 (de)
PT (1) PT1084147E (de)
RU (1) RU2197500C2 (de)
SK (1) SK288128B6 (de)
TR (1) TR200100303T2 (de)
WO (1) WO1999064462A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2158776B1 (es) * 1999-04-13 2002-03-16 Apc Europ S A Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.
AUPQ026799A0 (en) * 1999-05-10 1999-06-03 Csl Limited Method of increasing protein stability by removing immunoglobulin aggregates
AU4079001A (en) * 2000-03-10 2001-09-17 Medinnova As Composition for the treatment of heart failure
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
ES2184594B1 (es) 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
FR2824568B1 (fr) 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
US20030223985A1 (en) * 2002-05-29 2003-12-04 The Lauridsen Group. Incorporated Globulin protein to lower cholesterol in humans
EP3225625A1 (de) 2002-09-11 2017-10-04 Chugai Seiyaku Kabushiki Kaisha Proteinaufreinigungsverfahren
JPWO2004087761A1 (ja) * 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
EP1532983A1 (de) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulinpräparationen mit erhöhter Stabilität
US20070244305A1 (en) * 2004-01-30 2007-10-18 Suomen Punainen Risti Veripalvelu Process for The Manufacture of Virus Safe Immunoglobulin
EP1713904B1 (de) 2004-01-30 2016-06-29 Shire Pharmaceuticals Ireland Limited Herstellung und reinigung rekombinanter arylsulfatase a
RU2252780C1 (ru) * 2004-04-30 2005-05-27 Аваков Анатолий Эдуардович Способ получения иммуноглобулинового препарата
AU2005229674B2 (en) * 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
AU2006296399B2 (en) 2005-09-30 2011-01-20 Medimmune Limited Interleukin-13 antibody composition
US9309316B2 (en) 2005-12-20 2016-04-12 Bristol-Myers Squibb Company Stable subcutaneous protein formulations and uses thereof
FR2895263B1 (fr) 2005-12-26 2008-05-30 Lab Francais Du Fractionnement Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives
HUE042402T2 (hu) * 2006-04-04 2019-06-28 Chiesi Farm Spa Eljárás polipeptid töményítésére
RU2303995C1 (ru) * 2006-04-28 2007-08-10 Халлар Абдумуслимович Алиханов Средство, обладающее иммунорегуляторным свойством и его применение для лечения аутоиммунных заболеваний
SI2061803T2 (sl) 2006-08-28 2023-01-31 Ares Trading S.A. Postopek za čiščenje proteinov, ki vsebujejo FC
DE102007001521A1 (de) * 2007-01-10 2008-07-17 Matthias, Torsten, Dr. Verwendung von Cohn-Oncley-Fraktionen II und II/III zur Behandlung des systemischen Lupus erythematodes
UA85734C2 (ru) * 2007-02-14 2009-02-25 Костянтин Васильевич Курищук Способ инактивации вирусов при получении иммуноглобулина
UA85741C2 (ru) * 2007-02-27 2009-02-25 Костянтин Васильевич Курищук Способ получения иммуноглобулина
RU2352358C1 (ru) * 2007-10-04 2009-04-20 Наталия Васильевна Зубкова Способ приготовления вирусинактивированных растворов иммуноглобулинов
ES2533266T5 (es) 2007-10-30 2018-04-18 Genentech, Inc. Purificación de anticuerpos mediante cromatografía de intercambio catiónico
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
AU2009236305B2 (en) 2008-04-15 2014-04-10 Grifols Therapeutics Inc. Two-stage ultrafiltration/diafiltration
RU2410395C2 (ru) * 2008-05-04 2011-01-27 Институт биохимии и физиологии растений и микроорганизмов Российской Академии наук Способ получения моноспецифических антител к белкам растительных клеток
FR2939667B1 (fr) 2008-12-17 2012-01-27 Fractionnement Et Des Biotechonologies Lab Franc Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo
TWI445714B (zh) 2009-05-27 2014-07-21 Baxter Int 產製用於皮下使用之高濃度免疫球蛋白製備物之方法
US20130116413A1 (en) * 2009-12-29 2013-05-09 Dr. Reddy's Laboratories, Inc. Purification of proteins
WO2011095543A1 (en) 2010-02-04 2011-08-11 Csl Behring Ag Immunoglobulin preparation
EP2361636A1 (de) 2010-02-26 2011-08-31 CSL Behring AG Immunglobulinpräparat und Aufbewahrungssystem für ein Immunglobulinpräparat
GB201006753D0 (en) * 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
RU2467783C2 (ru) * 2010-07-30 2012-11-27 Закрытое акционерное общество "БиоХимМак СТ" Способ хроматографического выделения иммуноглобулина
ES2811526T3 (es) 2010-12-30 2021-03-12 Lab Francais Du Fractionnement Glicoles como agentes de inactivación de patógenos
EP2686334B2 (de) 2011-03-16 2020-07-01 F.Hoffmann-La Roche Ag Ionenaustausch-chromatografie mit verbesserter selektivität zur trennung von polypeptidmonomeren, -aggregaten und -fragmenten durch modulierung der mobilen phase
FR2974301B1 (fr) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
US10336992B2 (en) 2011-07-08 2019-07-02 Shire Human Genetic Therapies, Inc. Methods for purification of arylsulfatase A
SG11201400233TA (en) * 2011-08-26 2014-08-28 Baxter Int Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
CN102532307B (zh) * 2012-02-22 2013-06-12 成都蓉生药业有限责任公司 一种制备人免疫球蛋白的方法
CN107551269A (zh) 2012-02-29 2018-01-09 百深公司 周围神经的IgG刺激髓鞘再生
BR112014022240A2 (pt) 2012-03-09 2017-08-01 Csl Behring Ag composições compreendendo imunoglobulinas semelhantes à secretoras
EP2636684A1 (de) 2012-03-09 2013-09-11 CSL Behring AG Vorbeugung von Infektionen
EP2636681A1 (de) 2012-03-09 2013-09-11 CSL Behring AG Verfahren zur Anreicherung von IgA
ES2381828B1 (es) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
SG11201407809QA (en) 2012-05-31 2014-12-30 Agency Science Tech & Res Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
WO2013180648A1 (en) 2012-05-31 2013-12-05 Agency For Science, Technology And Research Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
EP2877589B1 (de) 2012-07-26 2024-03-06 Momenta Pharmaceuticals, Inc. Glykoproteine mit entzündungshemmenden eigenschaften
CN112126634A (zh) 2013-01-09 2020-12-25 夏尔人类遗传性治疗公司 含用于纯化芳基硫酸酯酶a的方法
AU2013203043B2 (en) 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
WO2014186310A1 (en) 2013-05-13 2014-11-20 Momenta Pharmaceuticals, Inc. Methods for the treatment of neurodegeneration
US10144774B2 (en) 2013-07-01 2018-12-04 Csl Behring Ag Method for purifying IgG
EP3016729B1 (de) 2013-07-05 2020-03-25 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Affinitätschromatografiematrix
WO2015057622A1 (en) 2013-10-16 2015-04-23 Momenta Pharmaceuticals, Inc. Sialylated glycoproteins
CN103665100A (zh) * 2014-01-03 2014-03-26 华兰生物工程重庆有限公司 低温乙醇提取静注人免疫球蛋白的方法
KR101917196B1 (ko) 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
CN106456813B (zh) * 2014-04-15 2020-06-30 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
CN104004090A (zh) * 2014-06-12 2014-08-27 新疆德源生物工程有限公司 一种人免疫球蛋白的制备方法
CN104356231B (zh) * 2014-11-10 2017-08-08 北海开元生物科技有限公司 一种有效去除人免疫球蛋白多聚体的方法
US9556253B2 (en) 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
ES2988823T3 (es) 2014-12-03 2024-11-21 Csl Behring Ag Producto farmacéutico con mayor estabilidad que comprende inmunoglobulinas
FR3035971A1 (fr) 2015-05-07 2016-11-11 Lab Francais Du Fractionnement Composition enrichie en immunoglobulines polyclonales anti-a et/ou anti-b
KR101657690B1 (ko) 2015-06-05 2016-09-19 주식회사 녹십자홀딩스 혈장 유래 b형 간염 사람 면역글로불린 제제의 제조방법
CN105950576A (zh) * 2016-05-26 2016-09-21 成都远睿生物技术有限公司 一种从牛血中提取多种蛋白的方法
EP3275897A1 (de) * 2016-07-27 2018-01-31 Biotest AG Verfahren zur herstellung von immunoglobulinzusammensetzungen
CN107880116B (zh) * 2016-09-30 2023-02-03 盖立复集团公司 用于制备免疫球蛋白的方法
FR3064486A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Prevention d'une infection par le virus respiratoire syncytial dans les voies respiratoires superieures
FR3064485A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Traitement d'une infection par le virus respiratoire syncytial
FR3064484A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Composition d'immunoglobulines utiles pour traiter des infections virales
KR20190047376A (ko) 2017-10-27 2019-05-08 주식회사 녹십자 개선된 면역글로불린의 정제방법
CN109776675A (zh) * 2017-11-10 2019-05-21 北京博莱得利生物技术有限责任公司 两步离子交换层析法制备犬免疫球蛋白的方法
CN112574296B (zh) * 2020-12-30 2023-05-19 中国医学科学院输血研究所 一种模拟IVIg的多人份混合人血浆IgG样品的分离纯化方法
KR20230148961A (ko) * 2022-04-19 2023-10-26 에스케이플라즈마 주식회사 면역글로불린 정제방법
CN116236820A (zh) * 2023-03-24 2023-06-09 华兰生物工程重庆有限公司 一种单人份血浆IgG制品的连续生产系统

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364792A1 (de) * 1973-01-15 1974-07-18 South African Inventions Verfahren zum reinigen von gammaglobulin
US4296027A (en) * 1977-08-31 1981-10-20 The Regents Of The University Of Minnesota Pure intravenous human and animal gamma globulins
US4315919A (en) 1980-10-06 1982-02-16 Edward Shanbrom Depyrogenation process
US4314997A (en) 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products
US4764369A (en) 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US4606825A (en) * 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
NZ216094A (en) * 1985-05-15 1989-06-28 Commw Serum Lab Commission Method for purification of an immunoglobulin
DE4118912C1 (de) * 1991-06-08 1992-07-02 Biotest Pharma Gmbh, 6072 Dreieich, De
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
RU2094462C1 (ru) * 1995-11-14 1997-10-27 Оловникова Наталья Ивановна Моноклональный иммуноглобулин человека класса iggi против антигена d системы резус

Also Published As

Publication number Publication date
RU2197500C2 (ru) 2003-01-27
AU753468B2 (en) 2002-10-17
CA2330170A1 (en) 1999-12-16
BR9911131A (pt) 2001-03-06
PL196770B1 (pl) 2008-01-31
RU2001101454A (ru) 2003-01-20
WO1999064462A1 (en) 1999-12-16
DK1084147T3 (da) 2004-10-25
ES2229784T3 (es) 2005-04-16
EP2272870B1 (de) 2013-05-08
JP5478519B2 (ja) 2014-04-23
IL140155A (en) 2005-12-18
HUP0101988A2 (hu) 2001-09-28
DE69920693T2 (de) 2005-11-03
CN1311797A (zh) 2001-09-05
CA2330170C (en) 2010-11-02
EP1084147B1 (de) 2004-09-29
JP2011102314A (ja) 2011-05-26
SK288128B6 (sk) 2013-10-02
KR20010052733A (ko) 2001-06-25
HUP0101988A3 (en) 2004-10-28
EP2270044B1 (de) 2014-11-05
CN1196714C (zh) 2005-04-13
EP1084147A1 (de) 2001-03-21
NZ509135A (en) 2002-10-25
TR200100303T2 (tr) 2001-06-21
CZ297199B6 (cs) 2006-09-13
CZ20004534A3 (en) 2001-06-13
DE69920693D1 (de) 2004-11-04
EP2272870A1 (de) 2011-01-12
KR100501263B1 (ko) 2005-07-18
EP1493751A1 (de) 2005-01-05
HK1151044A1 (en) 2012-01-20
EP2270044A1 (de) 2011-01-05
IL140155A0 (en) 2002-02-10
HK1151045A1 (en) 2012-01-20
HU228076B1 (en) 2012-10-29
ATE277950T1 (de) 2004-10-15
PT1084147E (pt) 2005-01-31
AU4257299A (en) 1999-12-30
SK18662000A3 (sk) 2001-07-10
PL344671A1 (en) 2001-11-19

Similar Documents

Publication Publication Date Title
ID27417A (id) Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya
AU700788B2 (en) Liquid immunoglobulin formulations
Schwartz et al. Comparison of hydrophobic charge induction chromatography with affinity chromatography on protein A for harvest and purification of antibodies
EP0967995B1 (de) Immunoglobulin enthaltende zusammensetzung
AU749336B2 (en) Chromatographic method for high yield purification and viral inactivation of antibodies
RU1837880C (ru) Способ разделени белков крови
EP1268551B1 (de) EINE METHODE ZUR HERSTELLUNG VON IgG
CN102712673B (zh) 用于纯化含fc的蛋白的色谱方法
HU218463B (hu) Eljárás terápiás célra használható immunglobulin G koncentrátum előállítására
RU93046317A (ru) Хиндроитиназа, способ ее получения и содержание ее фармацевтические композиции
AU656552B2 (en) Process for isolating human albumin from supernatant IV, in particular IV-4, or from COHN's fraction V or from an analogous supernatant or fraction
CZ286271B6 (cs) Způsob výroby prostředku anti-D imunoglobulinu G a farmaceutický prostředek obsahující anti-D IgG
JPH08119997A (ja) フォンウィルブランド因子の高分子および低分子フラクション
CA2070882A1 (en) A process for large-scale production of antimicrobial peptide in high purity
JPS58159424A (ja) 静脈内投与可能なヒト免疫グロブリンの製法
CA2077888A1 (en) Method for purifying factor viii and preparations obtained
JPH1059866A (ja) 血液凝固第ｖｉｉ因子及び／もしくは活性化血液凝固第ｖｉｉ因子の製造方法
Sakamoto et al. Studies on the interaction between heparin and mouse bone collagenase
CA2065414A1 (en) Treatment of autoimmune disease
Ito et al. Interaction between normal human IgG3 carrying Gm (b1, b3),(g),(s, t) and protein A-Sepharose CL-4B
KR100297927B1 (ko) 인간에리스로포이에틴의정제방법
AU2002257887A2 (en) Process for preparing human immunoglobulin concentrates for therapeutic use