ID29543A - TURUNAN-TURUNAN OKSAZOL DAN TIAZOL YANG DISUBSTITUSI SEBAGAI AKTIVATOR-AKTIVATOR τhPPAR DAN αhPPAR - Google Patents

TURUNAN-TURUNAN OKSAZOL DAN TIAZOL YANG DISUBSTITUSI SEBAGAI AKTIVATOR-AKTIVATOR τhPPAR DAN αhPPAR

Info

Publication number
ID29543A
ID29543A IDW20010541A ID20010541A ID29543A ID 29543 A ID29543 A ID 29543A ID W20010541 A IDW20010541 A ID W20010541A ID 20010541 A ID20010541 A ID 20010541A ID 29543 A ID29543 A ID 29543A
Authority
ID
Indonesia
Prior art keywords
τhppar
αhppar
osazol
tiazol
activators
Prior art date
Application number
IDW20010541A
Other languages
English (en)
Inventor
John L Collins
Milana Dazube
Jeffrey A Oplinger
Timothy M Willson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ID29543A publication Critical patent/ID29543A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IDW20010541A 1998-08-07 1999-08-05 TURUNAN-TURUNAN OKSAZOL DAN TIAZOL YANG DISUBSTITUSI SEBAGAI AKTIVATOR-AKTIVATOR τhPPAR DAN αhPPAR ID29543A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9817118.4A GB9817118D0 (en) 1998-08-07 1998-08-07 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ID29543A true ID29543A (id) 2001-09-06

Family

ID=10836805

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20010541A ID29543A (id) 1998-08-07 1999-08-05 TURUNAN-TURUNAN OKSAZOL DAN TIAZOL YANG DISUBSTITUSI SEBAGAI AKTIVATOR-AKTIVATOR τhPPAR DAN αhPPAR

Country Status (31)

Country Link
US (1) US6498174B1 (id)
EP (1) EP1102757B1 (id)
JP (1) JP2002522426A (id)
KR (1) KR20010085340A (id)
CN (1) CN1321152A (id)
AP (1) AP2001002066A0 (id)
AR (1) AR020001A1 (id)
AT (1) ATE264313T1 (id)
AU (1) AU5731099A (id)
BR (1) BR9912866A (id)
CA (1) CA2339773A1 (id)
CO (1) CO5070570A1 (id)
CZ (1) CZ2001490A3 (id)
DE (1) DE69916457T2 (id)
EA (1) EA200100105A1 (id)
EE (1) EE200100074A (id)
ES (1) ES2220110T3 (id)
GB (1) GB9817118D0 (id)
HR (1) HRP20010095A2 (id)
HU (1) HUP0103469A3 (id)
ID (1) ID29543A (id)
IL (1) IL141248A0 (id)
IS (1) IS5840A (id)
MA (1) MA26668A1 (id)
NO (1) NO20010628L (id)
PE (1) PE20000947A1 (id)
PL (1) PL345882A1 (id)
SK (1) SK1962001A3 (id)
TR (1) TR200100372T2 (id)
WO (1) WO2000008002A1 (id)
ZA (1) ZA200100983B (id)

Families Citing this family (42)

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AU7073400A (en) 1999-08-27 2001-03-26 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
EP1939188A1 (en) * 1999-09-22 2008-07-02 Bristol-Myers Squibb Company Oxa-and thiazole derivatives useful as antidiabetic and antiobesity agents
TWI260321B (en) 1999-09-22 2006-08-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
GB0002667D0 (en) * 2000-02-04 2000-03-29 Glaxo Group Ltd medicamesnts
GB0031103D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US20040072838A1 (en) 2000-12-20 2004-04-15 Pierette Banker Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
WO2002076959A1 (en) * 2001-03-23 2002-10-03 Takeda Chemical Industries, Ltd. Five-membered heterocyclic alkanoic acid derivative
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
DE60211891T2 (de) * 2001-05-15 2007-05-24 F. Hoffmann-La Roche Ag Carbonsäure-substituierte oxazol-derivate zur verwendung als ppar-alpha und -gamma aktivatoren zur behandlung von diabetes
BR0209711A (pt) 2001-05-29 2004-11-03 Kyoto Pharma Ind Composto heterocìclico e seu uso medicinal
HUP0400023A2 (hu) 2001-05-29 2004-04-28 Kyoto Pharmaceutical Industries, Ltd. Új heterociklusos származékok és gyógyászati alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
TW200300681A (en) 2001-11-12 2003-06-16 Ono Pharmaceutical Co Carboxylic acid derivative compound and medicament containing same as active ingredient
JP3884736B2 (ja) 2002-01-17 2007-02-21 トーアエイヨー株式会社 ハロゲノベンジルアミノプロピオン酸誘導体
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
KR100474202B1 (ko) * 2002-05-04 2005-03-08 강헌중 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
JP4290648B2 (ja) 2002-07-03 2009-07-08 エフ.ホフマン−ラ ロシュ アーゲー オキサゾール誘導体及びインスリン感作物質としてのそれらの使用
WO2004004665A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
PL375779A1 (en) * 2002-08-30 2005-12-12 F.Hoffmann-La Roche Ag Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists
EP1539746B1 (en) 2002-09-12 2006-11-15 F. Hoffmann-La Roche Ag N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
AR041481A1 (es) 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
MXPA05005445A (es) 2002-11-25 2005-08-26 Hoffmann La Roche Derivados de indolilo.
US7192970B2 (en) 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
US7268157B2 (en) 2002-11-26 2007-09-11 Shenzhen Chipscreen Biosciences, Ltd. Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity
RU2342362C2 (ru) * 2002-11-26 2008-12-27 Шэньчжэнь Чипскрин Байосайенсиз Лтд. Замещенные производные арилалкановой кислоты как пан агонисты рапп с высокой антигипергликемической и антигиперлипидемической активностью
AU2004251829B2 (en) 2003-06-20 2009-12-17 F. Hoffmann-La Roche Ag Hexahydropyridoisoqinolines as DPP-IV inhibitors
HRP20110018T1 (hr) 2003-06-20 2011-02-28 F. Hoffmann - La Roche Ag Derivati pirido(2,1-a)-izokinolina kao inhibitori dpp-iv
US7825278B2 (en) 2004-05-06 2010-11-02 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
CN100436430C (zh) * 2004-05-24 2008-11-26 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
CN100344618C (zh) * 2004-05-24 2007-10-24 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的N-芳丙烯酰基取代的酪氨酸衍生物
CN100467456C (zh) 2004-05-24 2009-03-11 北京摩力克科技有限公司 作为hPPARα和/或hPPARγ激活剂的α-哌嗪取代的苯丙酸衍生物
CN1896069B (zh) * 2005-07-15 2011-10-05 中国科学院上海药物研究所 一类取代噻唑-4酮化合物、制备方法和用途
CN101007790B (zh) * 2006-01-27 2011-03-30 北京摩力克科技有限公司 草氨酸衍生物、其制备方法和医药用途
JP4999923B2 (ja) * 2006-06-13 2012-08-15 中国科学院上海薬物研究所 複素環非ヌクレオシド系化合物、抗ウィルス医薬組成物、及びウィルス性疾病治療薬物
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
EP2135865A1 (de) 2008-06-17 2009-12-23 Bayer CropScience AG Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP2194052A1 (de) 2008-12-06 2010-06-09 Bayer CropScience AG Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
WO2011073098A1 (de) 2009-12-15 2011-06-23 Bayer Cropscience Ag 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren
US20120094959A1 (en) 2010-10-19 2012-04-19 Bonnie Blazer-Yost Treatment of cystic diseases
CN116367861A (zh) * 2020-09-14 2023-06-30 上海弼领生物技术有限公司 PPARα(过氧化物酶体增殖物激活受体α)配体在制备药物中的应用

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US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US6062509A (en) 1994-12-23 2000-05-16 Hexcel Corporation Retrofit centerline luggage bin assemblies compatible with existing aircraft bin supports
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規2−アミノ−3−フェニルプロピオン酸誘導体
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
EE03765B1 (et) * 1996-08-19 2002-06-17 Japan Tobacco Inc. Propioonhappe derivaadid ja nende kasutamine

Also Published As

Publication number Publication date
EP1102757B1 (en) 2004-04-14
BR9912866A (pt) 2001-10-30
HRP20010095A2 (en) 2002-02-28
IL141248A0 (en) 2002-03-10
AR020001A1 (es) 2002-03-27
SK1962001A3 (en) 2001-11-06
CZ2001490A3 (cs) 2001-08-15
WO2000008002A1 (en) 2000-02-17
ES2220110T3 (es) 2004-12-01
AP2001002066A0 (en) 2001-03-31
ATE264313T1 (de) 2004-04-15
US6498174B1 (en) 2002-12-24
HUP0103469A3 (en) 2002-08-28
IS5840A (is) 2001-02-05
EA200100105A1 (ru) 2001-08-27
NO20010628L (no) 2001-04-06
CN1321152A (zh) 2001-11-07
ZA200100983B (en) 2002-03-05
AU5731099A (en) 2000-02-28
MA26668A1 (fr) 2004-12-20
CA2339773A1 (en) 2000-02-17
TR200100372T2 (tr) 2001-09-21
EE200100074A (et) 2002-06-17
NO20010628D0 (no) 2001-02-06
HUP0103469A2 (hu) 2002-01-28
KR20010085340A (ko) 2001-09-07
PL345882A1 (en) 2002-01-14
CO5070570A1 (es) 2001-08-28
DE69916457D1 (de) 2004-05-19
JP2002522426A (ja) 2002-07-23
GB9817118D0 (en) 1998-10-07
DE69916457T2 (de) 2005-04-14
EP1102757A1 (en) 2001-05-30
PE20000947A1 (es) 2000-09-22

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