ATE264313T1 - Substituierte oxazole und thiazole derivate als hppar-gamma und hppar-alpha aktivatore - Google Patents
Substituierte oxazole und thiazole derivate als hppar-gamma und hppar-alpha aktivatoreInfo
- Publication number
- ATE264313T1 ATE264313T1 AT99944335T AT99944335T ATE264313T1 AT E264313 T1 ATE264313 T1 AT E264313T1 AT 99944335 T AT99944335 T AT 99944335T AT 99944335 T AT99944335 T AT 99944335T AT E264313 T1 ATE264313 T1 AT E264313T1
- Authority
- AT
- Austria
- Prior art keywords
- hppar
- gamma
- thiazole derivatives
- substituted oxazole
- alpha activators
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000007978 oxazole derivatives Chemical class 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817118.4A GB9817118D0 (en) | 1998-08-07 | 1998-08-07 | Pharmaceutical compounds |
| PCT/EP1999/005666 WO2000008002A1 (en) | 1998-08-07 | 1999-08-05 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264313T1 true ATE264313T1 (de) | 2004-04-15 |
Family
ID=10836805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99944335T ATE264313T1 (de) | 1998-08-07 | 1999-08-05 | Substituierte oxazole und thiazole derivate als hppar-gamma und hppar-alpha aktivatore |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6498174B1 (de) |
| EP (1) | EP1102757B1 (de) |
| JP (1) | JP2002522426A (de) |
| KR (1) | KR20010085340A (de) |
| CN (1) | CN1321152A (de) |
| AP (1) | AP2001002066A0 (de) |
| AR (1) | AR020001A1 (de) |
| AT (1) | ATE264313T1 (de) |
| AU (1) | AU5731099A (de) |
| BR (1) | BR9912866A (de) |
| CA (1) | CA2339773A1 (de) |
| CO (1) | CO5070570A1 (de) |
| CZ (1) | CZ2001490A3 (de) |
| DE (1) | DE69916457T2 (de) |
| EA (1) | EA200100105A1 (de) |
| EE (1) | EE200100074A (de) |
| ES (1) | ES2220110T3 (de) |
| GB (1) | GB9817118D0 (de) |
| HR (1) | HRP20010095A2 (de) |
| HU (1) | HUP0103469A3 (de) |
| ID (1) | ID29543A (de) |
| IL (1) | IL141248A0 (de) |
| IS (1) | IS5840A (de) |
| MA (1) | MA26668A1 (de) |
| NO (1) | NO20010628L (de) |
| PE (1) | PE20000947A1 (de) |
| PL (1) | PL345882A1 (de) |
| SK (1) | SK1962001A3 (de) |
| TR (1) | TR200100372T2 (de) |
| WO (1) | WO2000008002A1 (de) |
| ZA (1) | ZA200100983B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016120A1 (en) | 1999-08-27 | 2001-03-08 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| EP1939188A1 (de) * | 1999-09-22 | 2008-07-02 | Bristol-Myers Squibb Company | Oxa- und Thiazol-Derivate zur Verwendung als Wirkstoffe gegen Diabetes und Übergewicht |
| TWI302149B (en) | 1999-09-22 | 2008-10-21 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| GB0002667D0 (en) * | 2000-02-04 | 2000-03-29 | Glaxo Group Ltd | medicamesnts |
| GB0031103D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| US20040072838A1 (en) | 2000-12-20 | 2004-04-15 | Pierette Banker | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors |
| EP1394154A4 (de) * | 2001-03-23 | 2005-05-18 | Takeda Pharmaceutical | Fünfgliedriges heterocyclisches alkansäurederivat |
| GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| RU2278859C2 (ru) * | 2001-05-15 | 2006-06-27 | Ф.Хоффманн-Ля Рош Аг | Замещенные карбоновыми кислотами оксазоловые производные в качестве ppar-альфа и гамма-активаторов при лечении диабета |
| CZ20033450A3 (cs) | 2001-05-29 | 2004-05-12 | Kyotoápharmaceuticaláindustriesźáltd | Heterocyklická sloučenina a její lékařské použití |
| WO2002096904A1 (en) * | 2001-05-29 | 2002-12-05 | Kyoto Pharmaceutical Industries, Ltd. | Novel heterocyclic derivatives and medicinal use thereof |
| US6861440B2 (en) | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
| TW200300681A (en) * | 2001-11-12 | 2003-06-16 | Ono Pharmaceutical Co | Carboxylic acid derivative compound and medicament containing same as active ingredient |
| JP3884736B2 (ja) * | 2002-01-17 | 2007-02-21 | トーアエイヨー株式会社 | ハロゲノベンジルアミノプロピオン酸誘導体 |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
| KR100474202B1 (ko) * | 2002-05-04 | 2005-03-08 | 강헌중 | 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 |
| PL374818A1 (en) | 2002-07-03 | 2005-10-31 | F.Hoffmann-La Roche Ag | Oxazole derivatives and their use as insulin sensitizers |
| JP4579681B2 (ja) | 2002-07-09 | 2010-11-10 | ブリストル−マイヤーズ スクイブ カンパニー | 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法 |
| ATE483699T1 (de) * | 2002-08-30 | 2010-10-15 | Hoffmann La Roche | Neue 2-arylthiazolverbindungen als ppar-alpha und gamma agonisten |
| WO2004024726A1 (en) | 2002-09-12 | 2004-03-25 | F. Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| AR041481A1 (es) * | 2002-10-07 | 2005-05-18 | Hoffmann La Roche | Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar |
| DE60323130D1 (de) | 2002-11-25 | 2008-10-02 | Hoffmann La Roche | Indolderivaten |
| US7268157B2 (en) * | 2002-11-26 | 2007-09-11 | Shenzhen Chipscreen Biosciences, Ltd. | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
| US7192970B2 (en) | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| RU2342362C2 (ru) * | 2002-11-26 | 2008-12-27 | Шэньчжэнь Чипскрин Байосайенсиз Лтд. | Замещенные производные арилалкановой кислоты как пан агонисты рапп с высокой антигипергликемической и антигиперлипидемической активностью |
| ATE437876T1 (de) | 2003-06-20 | 2009-08-15 | Hoffmann La Roche | Hexahydropyridoisochinoline als dpp-iv- inhibitoren |
| MXPA05013904A (es) | 2003-06-20 | 2006-02-24 | Hoffmann La Roche | Derivados de pirido[2,1-a] isoquinolinas como inhibidores de dipeptidil-peptidasa iv(dpp-iv). |
| US7825278B2 (en) | 2004-05-06 | 2010-11-02 | The Regents Of The University Of California | Substituted enaminones, their derivatives and uses thereof |
| CN100467456C (zh) | 2004-05-24 | 2009-03-11 | 北京摩力克科技有限公司 | 作为hPPARα和/或hPPARγ激活剂的α-哌嗪取代的苯丙酸衍生物 |
| CN100436430C (zh) * | 2004-05-24 | 2008-11-26 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物 |
| CN100344618C (zh) | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物 |
| CN1896069B (zh) * | 2005-07-15 | 2011-10-05 | 中国科学院上海药物研究所 | 一类取代噻唑-4酮化合物、制备方法和用途 |
| CN101007790B (zh) * | 2006-01-27 | 2011-03-30 | 北京摩力克科技有限公司 | 草氨酸衍生物、其制备方法和医药用途 |
| KR101130380B1 (ko) * | 2006-06-13 | 2012-04-23 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도 |
| GB0719180D0 (en) * | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
| EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| US20120094959A1 (en) | 2010-10-19 | 2012-04-19 | Bonnie Blazer-Yost | Treatment of cystic diseases |
| WO2022052982A1 (zh) * | 2020-09-14 | 2022-03-17 | 昭明泽康（北京）生物医药科技有限公司 | PPARα（过氧化物酶体增殖物激活受体α）配体在制备药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| US6062509A (en) | 1994-12-23 | 2000-05-16 | Hexcel Corporation | Retrofit centerline luggage bin assemblies compatible with existing aircraft bin supports |
| JPH08325263A (ja) * | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−アミノ−３−フェニルプロピオン酸誘導体 |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| RU2174121C2 (ru) * | 1996-08-19 | 2001-09-27 | Джапан Тобакко Инк. | Производные пропионовой кислоты и фармацевтическая композиция на их основе |
-
1998
- 1998-08-07 GB GBGB9817118.4A patent/GB9817118D0/en not_active Ceased
-
1999
- 1999-08-04 CO CO99049333A patent/CO5070570A1/es unknown
- 1999-08-04 AR ARP990103874A patent/AR020001A1/es not_active Application Discontinuation
- 1999-08-05 EA EA200100105A patent/EA200100105A1/ru unknown
- 1999-08-05 EE EEP200100074A patent/EE200100074A/xx unknown
- 1999-08-05 WO PCT/EP1999/005666 patent/WO2000008002A1/en not_active Ceased
- 1999-08-05 MA MA25716A patent/MA26668A1/fr unknown
- 1999-08-05 AU AU57310/99A patent/AU5731099A/en not_active Abandoned
- 1999-08-05 PE PE1999000790A patent/PE20000947A1/es not_active Application Discontinuation
- 1999-08-05 AP APAP/P/2001/002066A patent/AP2001002066A0/en unknown
- 1999-08-05 HR HR20010095A patent/HRP20010095A2/hr not_active Application Discontinuation
- 1999-08-05 HU HU0103469A patent/HUP0103469A3/hu unknown
- 1999-08-05 ES ES99944335T patent/ES2220110T3/es not_active Expired - Lifetime
- 1999-08-05 KR KR1020017001617A patent/KR20010085340A/ko not_active Withdrawn
- 1999-08-05 CN CN99811640A patent/CN1321152A/zh active Pending
- 1999-08-05 US US09/762,445 patent/US6498174B1/en not_active Expired - Fee Related
- 1999-08-05 SK SK196-2001A patent/SK1962001A3/sk unknown
- 1999-08-05 CA CA002339773A patent/CA2339773A1/en not_active Abandoned
- 1999-08-05 EP EP99944335A patent/EP1102757B1/de not_active Expired - Lifetime
- 1999-08-05 JP JP2000563635A patent/JP2002522426A/ja active Pending
- 1999-08-05 ID IDW20010541A patent/ID29543A/id unknown
- 1999-08-05 BR BR9912866-7A patent/BR9912866A/pt not_active Application Discontinuation
- 1999-08-05 AT AT99944335T patent/ATE264313T1/de not_active IP Right Cessation
- 1999-08-05 IL IL14124899A patent/IL141248A0/xx unknown
- 1999-08-05 CZ CZ2001490A patent/CZ2001490A3/cs unknown
- 1999-08-05 PL PL99345882A patent/PL345882A1/xx not_active Application Discontinuation
- 1999-08-05 DE DE69916457T patent/DE69916457T2/de not_active Expired - Lifetime
- 1999-08-05 TR TR2001/00372T patent/TR200100372T2/xx unknown
-
2001
- 2001-02-05 IS IS5840A patent/IS5840A/is unknown
- 2001-02-05 ZA ZA200100983A patent/ZA200100983B/en unknown
- 2001-02-06 NO NO20010628A patent/NO20010628L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2339773A1 (en) | 2000-02-17 |
| KR20010085340A (ko) | 2001-09-07 |
| BR9912866A (pt) | 2001-10-30 |
| SK1962001A3 (en) | 2001-11-06 |
| HUP0103469A3 (en) | 2002-08-28 |
| HRP20010095A2 (en) | 2002-02-28 |
| EP1102757B1 (de) | 2004-04-14 |
| AP2001002066A0 (en) | 2001-03-31 |
| GB9817118D0 (en) | 1998-10-07 |
| DE69916457D1 (de) | 2004-05-19 |
| WO2000008002A1 (en) | 2000-02-17 |
| EP1102757A1 (de) | 2001-05-30 |
| TR200100372T2 (tr) | 2001-09-21 |
| AR020001A1 (es) | 2002-03-27 |
| DE69916457T2 (de) | 2005-04-14 |
| US6498174B1 (en) | 2002-12-24 |
| CO5070570A1 (es) | 2001-08-28 |
| CZ2001490A3 (cs) | 2001-08-15 |
| ZA200100983B (en) | 2002-03-05 |
| MA26668A1 (fr) | 2004-12-20 |
| ID29543A (id) | 2001-09-06 |
| AU5731099A (en) | 2000-02-28 |
| IS5840A (is) | 2001-02-05 |
| EE200100074A (et) | 2002-06-17 |
| NO20010628L (no) | 2001-04-06 |
| EA200100105A1 (ru) | 2001-08-27 |
| IL141248A0 (en) | 2002-03-10 |
| JP2002522426A (ja) | 2002-07-23 |
| PE20000947A1 (es) | 2000-09-22 |
| NO20010628D0 (no) | 2001-02-06 |
| PL345882A1 (en) | 2002-01-14 |
| HUP0103469A2 (hu) | 2002-01-28 |
| ES2220110T3 (es) | 2004-12-01 |
| CN1321152A (zh) | 2001-11-07 |
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