IE33174L - Antibiotic 66-40 - Google Patents
Antibiotic 66-40Info
- Publication number
- IE33174L IE33174L IE690865A IE86569A IE33174L IE 33174 L IE33174 L IE 33174L IE 690865 A IE690865 A IE 690865A IE 86569 A IE86569 A IE 86569A IE 33174 L IE33174 L IE 33174L
- Authority
- IE
- Ireland
- Prior art keywords
- antibiotic
- mull
- condensation products
- aldehydes
- ketones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
1,274,518. Antibiotic 66-40. SCHERICO Ltd. 24 June, 1969 [27 June, 1968; 16 Dec., 1968], No. 31887/69. Heading C2A. Novel Antibiotic 66-40 having the formula and characterized as being a basic pseudooligosaccharide having the following properties: elemental analysis, C = 49À80, H = 8À20, N = 14À95 and 0=27À05; molecular weight 447À26; empirical formula C 19 H 37 N 5 O 7 .H 2 O; melting point 185-190 C.; equivalent weight 92; pKa 8À0; [α]<SP>26</SP> D + 188À9 (C = 0À3% in H 2 O); U.V. absorption: transparent between 220 and 440 mÁ; I.R. absorption peaks at 2À98, 3À05, 3À16, 3À35- 3À50 (mull), 5À93, 6À25, 6À82 (mull), 7À25 (mull), 8À77, 9À00, 9À47, 9À72-10À07, 10À46, 11À97, 12À75 and 13À45-13À90 Á; and forming hydrates and other solvates, condensation products with aldehydes and ketones and salts with acids, is prepared by aerobically cultivating Micromonospora inyoensis (NRRL 3292). The condensation products, which are probably Schiff bases, are formed by reacting 66-40 with aldehydes and/or ketones such as acetaldehyde, acetone, methyl - ethyl - ketone, crotonaldehyde, furfural, cyclopentylacetaldehyde, vanillin, veratraldehyde, benzophenone, benzaldehyde, acetophenone, salicylaldehyde and pyridoxal. Antibiotic 66-40 has bacteriostatic activity on Gram-positive and Gram-negative bacteria and Rickettsia. Pharmaceutical compositions comprise the antibiotic 66-40 or its acid addition salts or aldehyde or ketone condensation products together with a pharmaceutically acceptable carrier or diluent, and may be in forms for topical, oral or parenteral administration.
[GB1274518A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74074268A | 1968-06-27 | 1968-06-27 | |
| US79730468A | 1968-12-16 | 1968-12-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33174L true IE33174L (en) | 1969-12-27 |
| IE33174B1 IE33174B1 (en) | 1974-04-03 |
Family
ID=27113740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE865/69A IE33174B1 (en) | 1968-06-27 | 1969-06-24 | Antibiotic 66-40 and methods for its production |
Country Status (26)
| Country | Link |
|---|---|
| AT (2) | AT299448B (en) |
| BE (1) | BE735145A (en) |
| BG (1) | BG15881A3 (en) |
| BR (1) | BR6910078D0 (en) |
| CA (1) | CA931515A (en) |
| CH (2) | CH529833A (en) |
| CS (1) | CS149666B2 (en) |
| CY (1) | CY817A (en) |
| DE (1) | DE1932309C3 (en) |
| DK (1) | DK126510B (en) |
| ES (1) | ES368762A1 (en) |
| FI (1) | FI46177C (en) |
| FR (1) | FR2011732B1 (en) |
| GB (1) | GB1274518A (en) |
| IE (1) | IE33174B1 (en) |
| IL (1) | IL32476A (en) |
| IT (1) | IT1033250B (en) |
| KE (1) | KE2540A (en) |
| LU (1) | LU58942A1 (en) |
| MY (1) | MY7500184A (en) |
| NL (1) | NL155886B (en) |
| NO (1) | NO129960B (en) |
| OA (1) | OA04043A (en) |
| RO (1) | RO57462A (en) |
| SE (2) | SE366560B (en) |
| YU (1) | YU34906B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4297486A (en) * | 1979-04-04 | 1981-10-27 | Toyo Jozo Kabushiki Kaisha | Aminoglycoside antibiotic G-367-1 and method for the production thereof |
| JPS5629598A (en) * | 1979-08-18 | 1981-03-24 | Toyo Jozo Co Ltd | Novel amino sugar antibiotic g-367-2 and its preparation |
-
1969
- 1969-06-24 IL IL32476A patent/IL32476A/en unknown
- 1969-06-24 IE IE865/69A patent/IE33174B1/en unknown
- 1969-06-24 CA CA055286A patent/CA931515A/en not_active Expired
- 1969-06-24 AT AT597469A patent/AT299448B/en not_active IP Right Cessation
- 1969-06-24 CH CH976669A patent/CH529833A/en not_active IP Right Cessation
- 1969-06-24 SE SE08942/69A patent/SE366560B/xx unknown
- 1969-06-24 FR FR696921096A patent/FR2011732B1/fr not_active Expired
- 1969-06-24 NL NL6909642.A patent/NL155886B/en not_active IP Right Cessation
- 1969-06-24 YU YU1616/69A patent/YU34906B/en unknown
- 1969-06-24 IT IT18634/69A patent/IT1033250B/en active
- 1969-06-24 CH CH971771A patent/CH529743A/en not_active IP Right Cessation
- 1969-06-24 OA OA53648A patent/OA04043A/en unknown
- 1969-06-24 CY CY817A patent/CY817A/en unknown
- 1969-06-24 FI FI691859A patent/FI46177C/en active
- 1969-06-24 GB GB31887/69A patent/GB1274518A/en not_active Expired
- 1969-06-24 BR BR210078/69A patent/BR6910078D0/en unknown
- 1969-06-24 LU LU58942D patent/LU58942A1/xx unknown
- 1969-06-24 SE SE7009228A patent/SE376425B/xx unknown
- 1969-06-24 NO NO02633/69A patent/NO129960B/no unknown
- 1969-06-24 AT AT613570A patent/AT297929B/en not_active IP Right Cessation
- 1969-06-25 BE BE735145D patent/BE735145A/xx not_active IP Right Cessation
- 1969-06-25 ES ES368762A patent/ES368762A1/en not_active Expired
- 1969-06-25 DK DK343169AA patent/DK126510B/en not_active IP Right Cessation
- 1969-06-26 RO RO60355A patent/RO57462A/ro unknown
- 1969-06-26 CS CS694518A patent/CS149666B2/en unknown
- 1969-06-26 DE DE1932309A patent/DE1932309C3/en not_active Expired
- 1969-06-26 BG BG012532A patent/BG15881A3/en unknown
-
1975
- 1975-07-10 KE KE2540*UA patent/KE2540A/en unknown
- 1975-12-30 MY MY1984/75A patent/MY7500184A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT299448B (en) | 1972-06-26 |
| ES368762A1 (en) | 1971-04-01 |
| NL6909642A (en) | 1969-12-30 |
| CH529743A (en) | 1972-10-31 |
| OA04043A (en) | 1979-10-15 |
| BE735145A (en) | 1969-12-29 |
| KE2540A (en) | 1975-07-18 |
| NL155886B (en) | 1978-02-15 |
| SE366560B (en) | 1974-04-29 |
| AT297929B (en) | 1972-04-10 |
| CA931515A (en) | 1973-08-07 |
| RO57462A (en) | 1974-12-15 |
| CH529833A (en) | 1972-10-31 |
| FR2011732B1 (en) | 1973-01-12 |
| GB1274518A (en) | 1972-05-17 |
| IT1033250B (en) | 1979-07-10 |
| CY817A (en) | 1976-12-01 |
| MY7500184A (en) | 1975-12-31 |
| BG15881A3 (en) | 1972-04-12 |
| NO129960B (en) | 1974-06-17 |
| DE1932309B2 (en) | 1974-06-20 |
| IL32476A (en) | 1972-09-28 |
| FI46177C (en) | 1973-01-10 |
| IE33174B1 (en) | 1974-04-03 |
| YU161669A (en) | 1979-10-31 |
| DK126510B (en) | 1973-07-23 |
| IL32476A0 (en) | 1969-08-27 |
| DE1932309A1 (en) | 1970-01-29 |
| YU34906B (en) | 1980-04-30 |
| FR2011732A1 (en) | 1970-03-06 |
| CS149666B2 (en) | 1973-07-25 |
| DE1932309C3 (en) | 1975-02-20 |
| BR6910078D0 (en) | 1973-02-08 |
| SE376425B (en) | 1975-05-26 |
| FI46177B (en) | 1972-10-02 |
| LU58942A1 (en) | 1969-11-11 |
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