IE34433L - Modified allergens - Google Patents
Modified allergensInfo
- Publication number
- IE34433L IE34433L IE100170A IE100170A IE34433L IE 34433 L IE34433 L IE 34433L IE 100170 A IE100170 A IE 100170A IE 100170 A IE100170 A IE 100170A IE 34433 L IE34433 L IE 34433L
- Authority
- IE
- Ireland
- Prior art keywords
- pref
- carbodiimide
- allergy
- modified
- modified allergens
- Prior art date
Links
- 239000013566 allergen Substances 0.000 title 1
- 239000000463 material Substances 0.000 abstract 4
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- 208000026935 allergic disease Diseases 0.000 abstract 2
- 230000007815 allergy Effects 0.000 abstract 2
- OJUGVDODNPJEEC-UHFFFAOYSA-N phenylglyoxal Chemical compound O=CC(=O)C1=CC=CC=C1 OJUGVDODNPJEEC-UHFFFAOYSA-N 0.000 abstract 2
- CJGMVHVKJXBIDT-UHFFFAOYSA-N 2-nitroindene-1,3-dione Chemical compound C1=CC=C2C(=O)C([N+](=O)[O-])C(=O)C2=C1 CJGMVHVKJXBIDT-UHFFFAOYSA-N 0.000 abstract 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- XNPOFXIBHOVFFH-UHFFFAOYSA-N N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide Chemical compound C1CCCCC1N=C=NCCN1CCOCC1 XNPOFXIBHOVFFH-UHFFFAOYSA-N 0.000 abstract 1
- 229920001744 Polyaldehyde Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229920001470 polyketone Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
Abstract
The allergy producing properties of the material are lowered by inter and/or intra molecular action. Pref. the material is reacted with a polyaldehyde, polyketone, carbodiimide, epihalohydrin, or inorganic cyanate in acid medium, to give a modified material insoluble or barely soluble in water. Cpds. esp. used are glutaraldehyde, phenylglyoxal, 2-nitroindane-1,3-dione at pH 4-8 or, 1-cyclohexyl-3-(2-morpholino-ethyl)-carbodiimide metho-p-toluenesulphonate, or KCN at pH is approx. 5. Pref. the allergy inducing material is pollen(s).
[DE2039223A1]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3928969 | 1969-08-06 | ||
| GB23853/70A GB1282163A (en) | 1969-08-06 | 1969-08-06 | Modified allergens and a process for their preparation |
| GB2362170 | 1970-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34433L true IE34433L (en) | 1971-02-06 |
| IE34433B1 IE34433B1 (en) | 1975-05-14 |
Family
ID=27258241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE100170A IE34433B1 (en) | 1969-08-06 | 1970-08-04 | Modified allergens and a process for their preparation |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS4935413B1 (en) |
| AT (1) | AT297930B (en) |
| BE (1) | BE754523A (en) |
| CA (1) | CA950358A (en) |
| CH (2) | CH570418A5 (en) |
| DE (1) | DE2039223C3 (en) |
| DK (1) | DK127954B (en) |
| ES (1) | ES382486A1 (en) |
| IE (1) | IE34433B1 (en) |
| NL (1) | NL168419C (en) |
| NO (1) | NO135015C (en) |
| SE (1) | SE396694B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1492973A (en) * | 1974-02-16 | 1977-11-23 | Beecham Group Ltd | Process for preparing injectable compositions |
| US4234569A (en) * | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| DE19543592C1 (en) * | 1995-11-23 | 1997-02-20 | Gsf Forschungszentrum Umwelt | Pollen test medium contains pollen slurry in soln. of L-sugars contg. boron cpds. |
| ES2208884T3 (en) * | 1996-01-25 | 2004-06-16 | Schering Aktiengesellschaft | IMPROVED CONTRACT AGENT SOLUTIONS FOR INTRAVASAL ADMINISTRATION. |
| IT1391559B1 (en) | 2008-09-01 | 2012-01-11 | Lofarma Spa | ALLERGOIDS DERIVED FROM ALLERGENS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3098693A (en) * | 1960-05-27 | 1963-07-23 | Little Inc A | Treatment of protein and peptide materials to form amide linkages |
-
0
- BE BE754523D patent/BE754523A/en not_active IP Right Cessation
-
1970
- 1970-07-28 NO NO293070A patent/NO135015C/no unknown
- 1970-08-04 NL NL7011548A patent/NL168419C/en not_active IP Right Cessation
- 1970-08-04 IE IE100170A patent/IE34433B1/en unknown
- 1970-08-04 CA CA089,875,A patent/CA950358A/en not_active Expired
- 1970-08-05 SE SE1078370A patent/SE396694B/en unknown
- 1970-08-05 ES ES382486A patent/ES382486A1/en not_active Expired
- 1970-08-05 AT AT711870A patent/AT297930B/en not_active IP Right Cessation
- 1970-08-06 CH CH1268774A patent/CH570418A5/xx not_active IP Right Cessation
- 1970-08-06 DK DK405670A patent/DK127954B/en not_active IP Right Cessation
- 1970-08-06 CH CH1184170A patent/CH569743A5/xx not_active IP Right Cessation
- 1970-08-06 JP JP6841270A patent/JPS4935413B1/ja active Pending
- 1970-08-06 DE DE19702039223 patent/DE2039223C3/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2039223B2 (en) | 1980-08-07 |
| CH569743A5 (en) | 1975-11-28 |
| ES382486A1 (en) | 1974-06-16 |
| JPS4935413B1 (en) | 1974-09-21 |
| NL168419B (en) | 1981-11-16 |
| NL168419C (en) | 1982-04-16 |
| AT297930B (en) | 1972-04-10 |
| NO135015C (en) | 1977-01-26 |
| DK127954B (en) | 1974-02-11 |
| CH570418A5 (en) | 1975-12-15 |
| NO135015B (en) | 1976-10-18 |
| CA950358A (en) | 1974-07-02 |
| NL7011548A (en) | 1971-02-09 |
| BE754523A (en) | 1971-02-08 |
| DE2039223C3 (en) | 1981-04-30 |
| SE396694B (en) | 1977-10-03 |
| IE34433B1 (en) | 1975-05-14 |
| DE2039223A1 (en) | 1971-02-18 |
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