IE36010L - Antibiotic axenomycin d. - Google Patents
Antibiotic axenomycin d.Info
- Publication number
- IE36010L IE36010L IE710537A IE53771A IE36010L IE 36010 L IE36010 L IE 36010L IE 710537 A IE710537 A IE 710537A IE 53771 A IE53771 A IE 53771A IE 36010 L IE36010 L IE 36010L
- Authority
- IE
- Ireland
- Prior art keywords
- axenomycine
- antibiotic
- methanol
- isopropanol
- silica gel
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- GYVHWLFMGIWANO-UHFFFAOYSA-N axenomycin Chemical compound C1C(O)CC(O)CC(O)CC(O)CCCC(O)C(O)C(C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)CC)OC(=O)CC(O)C(C)C(O)CC(O)CCCC(O)CCC(C)C(O)C2(O)C(=O)OC1CC2=O GYVHWLFMGIWANO-UHFFFAOYSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000002609 medium Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241001342522 Vampyrum spectrum Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 229910052500 inorganic mineral Chemical class 0.000 abstract 1
- DGEYTDCFMQMLTH-UHFFFAOYSA-N methanol;propan-2-ol Chemical compound OC.CC(C)O DGEYTDCFMQMLTH-UHFFFAOYSA-N 0.000 abstract 1
- 239000011707 mineral Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1285163 Antibiotic axenomycine D SOC FARMACEUTICI ITALIA 30 April 1971 [4 May 1970] 12382/71 Addition to 1219709 Heading C2A The new antibiotic axenomycine D is characterized as follows: melting-point 174 to 175 C. with decomposition; elementary analysis C=60À25%, H=7À92%, 0=30À35%; optical rotation [α] D <SP>22</SP> = + 11 degrees (C=0À5 in methanol); U.V. spectrum (in methanol) has maxima at 250, 255 (E 1cm. <SP>1%</SP> =138), 265-268 (shoulder) and 330 mÁ; I.R. absorption peaks at 3440, 2980, 2950, 2890, 1735, 1705, 1675, 1630, 1610, 1465, 1385, 1355, 1290, 1265, 1195, 1170, 1115, 1080, 1050, 1005, 995, 975, 945, 925, 895, 865, 810 and 700 cm<SP>-1</SP>; Rf=0À35 on silica gel (in ethyl acetate : isopropanol : water =100 : 35 : 5); soluble in alcohols and insoluble in water and benzene. Axenomycine D is prepared by cultivating Streptomyces lisandri or an axenomycine D-producing strain thereof in an aqueous medium containing assimilable sources of carbon, nitrogen and mineral salts, the medium containing 10% by weight or more of assimilable carbon and the cultivation being carried out with stirring corresponding to an absorbed power of 2 to 4 watts per litre and with an air flux of 0À7 to 2 litres per litre of medium per minute, and isolating axenomycin D from the cultivated medium. The usual nutrients may be used, preferably with the exception of phosphates, which are said to decrease the yield of antibiotic. The axenomycine D may be recovered from the separated mycelium by extraction with an alcohol, e.g. butanol. The extract is concentrated and the product purified by chromatography on silica gel, evaporation of the active fractions and recrystallization from methanol-isopropanol. Axenomycine D has antihelmintic, antiprotozoal and antifungal activity.
[GB1285163A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24144/70A IT1044819B (en) | 1970-05-04 | 1970-05-04 | ANTIBIOTIC COMPOUND |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36010L true IE36010L (en) | 1971-11-04 |
| IE36010B1 IE36010B1 (en) | 1976-07-21 |
Family
ID=11212205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE537/71A IE36010B1 (en) | 1970-05-04 | 1971-04-29 | Antibiotic compound |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5422520B1 (en) |
| AT (1) | AT303256B (en) |
| BE (1) | BE766606R (en) |
| CA (1) | CA981199A (en) |
| CH (1) | CH518360A (en) |
| CS (1) | CS170544B2 (en) |
| DE (1) | DE2121248C3 (en) |
| DK (1) | DK127559B (en) |
| ES (1) | ES390826A2 (en) |
| FR (1) | FR2092128B2 (en) |
| GB (1) | GB1285163A (en) |
| IE (1) | IE36010B1 (en) |
| IT (1) | IT1044819B (en) |
| NL (1) | NL153272B (en) |
| NO (1) | NO131549C (en) |
| SU (1) | SU377991A3 (en) |
| YU (1) | YU35163B (en) |
| ZA (1) | ZA712820B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL153271B (en) * | 1968-06-11 | 1977-05-16 | Farmaceutici Italia | METHOD FOR PREPARING ANTIBIOTICS USING A STREPTOMYCES ORGANISM AND MEDICINAL PRODUCTS CONTAINING ANTIBIOTICS. |
-
1970
- 1970-05-04 IT IT24144/70A patent/IT1044819B/en active
-
1971
- 1971-04-20 NL NL717105286A patent/NL153272B/en unknown
- 1971-04-29 DE DE2121248A patent/DE2121248C3/en not_active Expired
- 1971-04-29 CS CS3108A patent/CS170544B2/cs unknown
- 1971-04-29 YU YU1077/71A patent/YU35163B/en unknown
- 1971-04-29 SU SU1646887A patent/SU377991A3/ru active
- 1971-04-29 IE IE537/71A patent/IE36010B1/en unknown
- 1971-04-30 AT AT373071A patent/AT303256B/en not_active IP Right Cessation
- 1971-04-30 NO NO1613/71A patent/NO131549C/no unknown
- 1971-04-30 ZA ZA712820A patent/ZA712820B/en unknown
- 1971-04-30 DK DK209371AA patent/DK127559B/en unknown
- 1971-04-30 FR FR7115543A patent/FR2092128B2/fr not_active Expired
- 1971-04-30 GB GB02382/71A patent/GB1285163A/en not_active Expired
- 1971-05-01 JP JP2937671A patent/JPS5422520B1/ja active Pending
- 1971-05-03 CH CH650871A patent/CH518360A/en not_active IP Right Cessation
- 1971-05-03 BE BE766606A patent/BE766606R/en active
- 1971-05-03 ES ES390826A patent/ES390826A2/en not_active Expired
- 1971-05-04 CA CA112,065A patent/CA981199A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2092128B2 (en) | 1974-10-18 |
| ES390826A2 (en) | 1973-06-01 |
| NO131549B (en) | 1975-03-10 |
| ZA712820B (en) | 1972-01-26 |
| CS170544B2 (en) | 1976-08-27 |
| SU377991A3 (en) | 1973-04-17 |
| FR2092128A2 (en) | 1972-01-21 |
| GB1285163A (en) | 1972-08-09 |
| DK127559B (en) | 1973-11-26 |
| CA981199A (en) | 1976-01-06 |
| DE2121248B2 (en) | 1978-06-22 |
| YU35163B (en) | 1980-09-25 |
| NO131549C (en) | 1975-06-18 |
| IT1044819B (en) | 1980-04-21 |
| AT303256B (en) | 1972-11-27 |
| BE766606R (en) | 1971-11-03 |
| JPS5422520B1 (en) | 1979-08-07 |
| DE2121248C3 (en) | 1979-03-15 |
| YU107771A (en) | 1980-03-15 |
| IE36010B1 (en) | 1976-07-21 |
| NL7105286A (en) | 1971-11-08 |
| DE2121248A1 (en) | 1971-11-18 |
| CH518360A (en) | 1972-01-31 |
| NL153272B (en) | 1977-05-16 |
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