IE38177B1 - Cyclic derivatives of 1,4-benzene disulphonamide - Google Patents

Cyclic derivatives of 1,4-benzene disulphonamide

Info

Publication number: IE38177B1
Authority: IE; Ireland
Prior art keywords: methoxypiperidinosulphonyl; pharmaceutically acceptable; alkylene; formula; oxo
Prior art date: 1972-08-12

Application number

IE1344/73A

Other languages

English (en)

Other versions

IE38177L (en

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-08-12

Filing date

1973-08-07

Publication date

1978-01-18

1973-08-07 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1974-02-12 Publication of IE38177L publication Critical patent/IE38177L/xx

1978-01-18 Publication of IE38177B1 publication Critical patent/IE38177B1/xx

Links

UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
125000004122 cyclic group Chemical group 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000004043 oxo group Chemical group O=* 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
150000003456 sulfonamides Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
JHYQFLQSZORYNF-UHFFFAOYSA-N 4-(4-methoxypiperidin-1-yl)sulfonyl-3-(trifluoromethyl)aniline Chemical compound C1CC(OC)CCN1S(=O)(=O)C1=CC=C(N)C=C1C(F)(F)F JHYQFLQSZORYNF-UHFFFAOYSA-N 0.000 abstract 1
ZTVRDUIZRARMTM-UHFFFAOYSA-N 4-(4-methoxypiperidin-1-yl)sulfonyl-3-(trifluoromethyl)benzenesulfonyl chloride Chemical compound COC1CCN(CC1)S(=O)(=O)C1=C(C=C(C=C1)S(=O)(=O)Cl)C(F)(F)F ZTVRDUIZRARMTM-UHFFFAOYSA-N 0.000 abstract 1
QMPYGKMZUAEVSB-UHFFFAOYSA-N 4-methoxy-1-[4-nitro-2-(trifluoromethyl)phenyl]sulfonylpiperidine Chemical compound C1CC(OC)CCN1S(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1C(F)(F)F QMPYGKMZUAEVSB-UHFFFAOYSA-N 0.000 abstract 1
ZEYSHALLPAKUHG-UHFFFAOYSA-N 4-methoxypiperidine Chemical compound COC1CCNCC1 ZEYSHALLPAKUHG-UHFFFAOYSA-N 0.000 abstract 1
ICROHEDUOASYFB-UHFFFAOYSA-N 4-nitro-2-(trifluoromethyl)benzenesulfonyl chloride Chemical compound [O-][N+](=O)C1=CC=C(S(Cl)(=O)=O)C(C(F)(F)F)=C1 ICROHEDUOASYFB-UHFFFAOYSA-N 0.000 abstract 1
229910021591 Copper(I) chloride Inorganic materials 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
239000003610 charcoal Substances 0.000 abstract 1
OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 abstract 1
-1 cyclic amine Chemical class 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B31/00—Disazo and polyazo dyes of the type A->B->C, A->B->C->D, or the like, prepared by diazotising and coupling
- C09B31/02—Disazo dyes
- C09B31/12—Disazo dyes from other coupling components "C"
- C09B31/14—Heterocyclic components

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IE1344/73A 1972-08-12 1973-08-07 Cyclic derivatives of 1,4-benzene disulphonamide IE38177B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB3772072A GB1380009A (en)	1972-08-12	1972-08-12	Cyclic derivatives of 1,4-benzene disulphonamide

Publications (2)

Publication Number	Publication Date
IE38177L IE38177L (en)	1974-02-12
IE38177B1 true IE38177B1 (en)	1978-01-18

Family

ID=10398552

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1344/73A IE38177B1 (en)	1972-08-12	1973-08-07	Cyclic derivatives of 1,4-benzene disulphonamide

Country Status (16)

Country	Link
US (1)	US3867390A (fr)
JP (2)	JPS59508B2 (fr)
AT (1)	AT331248B (fr)
AU (1)	AU5908473A (fr)
BE (1)	BE803373A (fr)
CA (1)	CA978945A (fr)
DE (1)	DE2340010A1 (fr)
ES (1)	ES417806A1 (fr)
FR (1)	FR2195449B1 (fr)
GB (1)	GB1380009A (fr)
IE (1)	IE38177B1 (fr)
IN (1)	IN139006B (fr)
LU (1)	LU68211A1 (fr)
NL (1)	NL162641C (fr)
SE (1)	SE385008B (fr)
ZA (1)	ZA735474B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4070361A (en) *	1977-04-21	1978-01-24	E. R. Squibb & Sons, Inc.	Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof
DE2720654A1 (de) *	1977-05-07	1978-11-16	Bayer Ag	Azolyl-alkancarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
GB1572226A (en) *	1977-11-03	1980-07-30	Hoechst Uk Ltd	Pharmaceutical preparations in solid unit dosage form
JPS5922023A (ja) *	1982-07-27	1984-02-04	Hoya Corp	ビ−ムスプリツタ−

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3165550A (en) *	1960-06-29	1965-01-12	Pfizer & Co C	N-substituted p-benzenedisulfonamides

1972
- 1972-08-12 GB GB3772072A patent/GB1380009A/en not_active Expired
1973
- 1973-08-07 AT AT691573A patent/AT331248B/de not_active IP Right Cessation
- 1973-08-07 IE IE1344/73A patent/IE38177B1/xx unknown
- 1973-08-07 DE DE19732340010 patent/DE2340010A1/de not_active Ceased
- 1973-08-08 BE BE134373A patent/BE803373A/fr unknown
- 1973-08-09 AU AU59084/73A patent/AU5908473A/en not_active Expired
- 1973-08-09 US US386854A patent/US3867390A/en not_active Expired - Lifetime
- 1973-08-09 NL NL7311000.A patent/NL162641C/xx not_active IP Right Cessation
- 1973-08-10 ZA ZA735474A patent/ZA735474B/xx unknown
- 1973-08-10 FR FR7329377A patent/FR2195449B1/fr not_active Expired
- 1973-08-10 CA CA178,508A patent/CA978945A/en not_active Expired
- 1973-08-10 LU LU68211A patent/LU68211A1/xx unknown
- 1973-08-10 SE SE7310996A patent/SE385008B/xx unknown
- 1973-08-11 JP JP48090450A patent/JPS59508B2/ja not_active Expired
- 1973-08-11 ES ES417806A patent/ES417806A1/es not_active Expired
- 1973-08-13 IN IN1864/CAL/73A patent/IN139006B/en unknown
1981
- 1981-07-24 JP JP56116291A patent/JPS5857431B2/ja not_active Expired

Also Published As

Publication number	Publication date
FR2195449A1 (fr)	1974-03-08
LU68211A1 (fr)	1975-05-21
DE2340010A1 (de)	1974-03-14
IN139006B (fr)	1976-04-24
SE385008B (sv)	1976-05-31
CA978945A (en)	1975-12-02
ES417806A1 (es)	1976-03-01
NL162641C (nl)	1980-06-16
JPS4985066A (fr)	1974-08-15
JPS5857431B2 (ja)	1983-12-20
BE803373A (fr)	1974-02-08
AU5908473A (en)	1975-02-13
NL162641B (nl)	1980-01-15
GB1380009A (en)	1975-01-08
JPS59508B2 (ja)	1984-01-07
ATA691573A (de)	1975-11-15
ZA735474B (en)	1974-08-28
US3867390A (en)	1975-02-18
FR2195449B1 (fr)	1977-09-09
IE38177L (en)	1974-02-12
AT331248B (de)	1976-08-10
JPS57131774A (en)	1982-08-14
NL7311000A (fr)	1974-02-14

Publication	Publication Date	Title
LV10456A (lv)	1995-02-20	Triazolpiridazina atvasinajumi to iegusanas panemiens un pielietojums
RU92004336A (ru)	1995-08-20	Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
IE812273L (en)	1982-03-30	Cephalosporin derivatives
AU591390B2 (en)	1989-11-30	Arylcyclobutylalkyl amines and their use as antidepressive medicines
GB1489280A (en)	1977-10-19	Indazole derivatives
IE41539L (en)	1975-11-30	Chroman derivatives.
EP0257741A3 (fr)	1989-09-06	Composés azabicycliques, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
IE45700L (en)	1978-03-29	PYRAZOLO (3,4-b) PYRIDINES
IE38177L (en)	1974-02-12	Heterocyclic disulphonamides
EP0712398A1 (fr)	1996-05-22	Benzopyrans et compositions pharmaceutiques les contenant
IE44014L (en)	1977-01-28	Amino-benzocycloheptenes.
IE42422L (en)	1974-11-25	Triazoloisoindole derivatives
US3919239A (en)	1975-11-11	Oxazolidine derivatives
GB1361863A (en)	1974-07-30	Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1410853A (en)	1975-10-22	Pharmaceutically useful prostaglandin derivatives
GB1394791A (en)	1975-05-21	Diphenylalkyllactamimide derivatives
GB1295040A (fr)	1972-11-01
GB1393979A (en)	1975-05-14	Piperidine derivatives
GB1492163A (en)	1977-11-16	Triazolobenzocycloalkylthiadiazine derivatives
IE35570B1 (en)	1976-03-18	Pyrimido isoquinolines
KR850700244A (ko)	1985-12-26	세팔로스포린 유도체 및 그 염의 제조방법
GB1346953A (en)	1974-02-13	Process for the preparation of substituted carbamates
SE8302027L (sv)	1983-04-12	Forfarande for framstellning av 3,7-disubstituerade 3 cefem-4-karboxylsyraforeningar
IE42625L (en)	1976-07-22	Thiazole 5-methanol derivatives
GB1427559A (en)	1976-03-10	2-substituted 6,7-benzomorphan derivatives and salts thereof