IE39332L - Biological extracts - Google Patents
Biological extractsInfo
- Publication number
- IE39332L IE39332L IE740367A IE36774A IE39332L IE 39332 L IE39332 L IE 39332L IE 740367 A IE740367 A IE 740367A IE 36774 A IE36774 A IE 36774A IE 39332 L IE39332 L IE 39332L
- Authority
- IE
- Ireland
- Prior art keywords
- glycopeptide
- infra
- cells
- immunostimulating
- red
- Prior art date
Links
- 239000000284 extract Substances 0.000 title 1
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 6
- 108010015899 Glycopeptides Proteins 0.000 abstract 6
- 102000002068 Glycopeptides Human genes 0.000 abstract 6
- 241000894006 Bacteria Species 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 3
- 230000003308 immunostimulating effect Effects 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 230000002051 biphasic effect Effects 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- 241000203716 Actinomycetaceae Species 0.000 abstract 1
- 241001046548 Anaerobium Species 0.000 abstract 1
- 241001307956 Chorioptes bovis Species 0.000 abstract 1
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 241000186225 Corynebacterium pseudotuberculosis Species 0.000 abstract 1
- 241000186246 Corynebacterium renale Species 0.000 abstract 1
- 241000186427 Cutibacterium acnes Species 0.000 abstract 1
- 241001464975 Cutibacterium granulosum Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001506004 Porotermes adamsoni Species 0.000 abstract 1
- 241001464976 Propionimicrobium lymphophilum Species 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 241000186064 Trueperella pyogenes Species 0.000 abstract 1
- 235000021258 carbohydrate absorption Nutrition 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1476422 Immunostimulating glycopeptide WELLCOME FOUNDATION Ltd 23 May 1974 [23 Feb 1973 14 Feb 1974] 9149/73 and 6759/74 Heading A5B [Also in Division C3] An immunostimulating glycopeptide capable of conferring on mammals and birds a resistance to tumours and pathogens is obtained from cell wall material of an immunostimulating bacterium of the Actinomycetaceae Family of Prevots classification. Bacteria specified include Corynebacterium parvum, C. anaerobium, C. granulosum, C. liquifaciens, C. pyogenes, C. lymphophilum, C. hepatodystrophicans, C. adamsoni, C. avidium, C. diphtheroides, C. renale cuniculi, C. acnes, C. equi and C. ovis. The glycopeptide is extracted by (a) culturing the bacteria, (b) harvesting the cells and (c) treating the cells with a biphasic extraction solvent comprising water and a phenol so as to yield the glycopeptide as an insoluble residue. The cells are generally subjected to lysis before extraction with the biphasic solvent. The glycopeptide may be recovered by centrifugation. The product is substantially insoluble in water, saline, methanol, ethanol, phenol, chloroform, dioxan, pyridine, dimethylformamide, diethylene glycol and hexane, has infra-red peptide absorption at 1550 and 1660 cm<SP>-1</SP>, infra-red carbohydrate absorption between 950 and 1100 cm<SP>-1</SP> with peak between 1050 and 1070 cm<SP>-1</SP>, has substantially no infra-red lipid absorption between 2850 and 2950 cm<SP>-1</SP> and after intravenous administration increases the liver and spleen weight of mice and increases the life expectancy of mice with tumours. The glycopeptide is combined with a carrier for use.
[GB1476422A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB914973A GB1476422A (en) | 1973-02-23 | 1973-02-23 | Biological extracts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39332L true IE39332L (en) | 1974-08-23 |
| IE39332B1 IE39332B1 (en) | 1978-09-13 |
Family
ID=9866339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE367/74A IE39332B1 (en) | 1973-02-23 | 1974-02-22 | Biological extracts |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5063196A (en) |
| AU (1) | AU6591074A (en) |
| BE (1) | BE811491A (en) |
| DE (1) | DE2408724A1 (en) |
| DK (1) | DK141757B (en) |
| FR (1) | FR2218888B1 (en) |
| GB (1) | GB1476422A (en) |
| HU (1) | HU173676B (en) |
| IE (1) | IE39332B1 (en) |
| IL (1) | IL44267A (en) |
| NL (1) | NL7402455A (en) |
| ZA (1) | ZA741189B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2410476B1 (en) * | 1977-11-30 | 1980-08-22 | Inst Nat Sante Rech Med | APPLICATION OF PEPTIDOGLYCANS EXTRACTED FROM BACTERIA, PARTICULARLY BACILLUS AS MEDICAMENTS, ESPECIALLY STIMULATING ANTI-TUMOR IMMUNITY |
| JPS58874B2 (en) * | 1979-08-30 | 1983-01-08 | 株式会社 目黒研究所 | Glycoprotein WENAC and its production method |
| FR2502496A2 (en) * | 1981-03-30 | 1982-10-01 | Pasteur Institut | Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity |
| US4479935A (en) * | 1980-04-22 | 1984-10-30 | Institut Pasteur | Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation |
| FR2480604A1 (en) * | 1980-04-22 | 1981-10-23 | Pasteur Institut | Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity |
| US4871488A (en) * | 1985-04-22 | 1989-10-03 | Albany Medical College Of Union University | Reconstituting viral glycoproteins into large phospholipid vesicles |
| LT3049430T (en) * | 2014-07-16 | 2019-04-10 | Depofarma S.P.A. | Parietal fraction of propionibacterium granulosum having immunomodulating action |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450815A (en) * | 1964-04-24 | 1969-06-17 | Princeton Lab Inc | Method of stimulating a host defense mechanism with an actinovaccine |
| US3529057A (en) * | 1964-08-14 | 1970-09-15 | Takeda Chemical Industries Ltd | Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections |
-
1973
- 1973-02-23 GB GB914973A patent/GB1476422A/en not_active Expired
-
1974
- 1974-02-22 ZA ZA00741189A patent/ZA741189B/en unknown
- 1974-02-22 NL NL7402455A patent/NL7402455A/xx not_active Application Discontinuation
- 1974-02-22 DE DE19742408724 patent/DE2408724A1/en not_active Withdrawn
- 1974-02-22 FR FR7406104A patent/FR2218888B1/fr not_active Expired
- 1974-02-22 BE BE141321A patent/BE811491A/en unknown
- 1974-02-22 DK DK96174AA patent/DK141757B/en unknown
- 1974-02-22 JP JP49021333A patent/JPS5063196A/ja active Pending
- 1974-02-22 HU HU74WE501A patent/HU173676B/en unknown
- 1974-02-22 AU AU65910/74A patent/AU6591074A/en not_active Expired
- 1974-02-22 IE IE367/74A patent/IE39332B1/en unknown
- 1974-02-22 IL IL44267A patent/IL44267A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5063196A (en) | 1975-05-29 |
| IL44267A (en) | 1978-07-31 |
| FR2218888A1 (en) | 1974-09-20 |
| IE39332B1 (en) | 1978-09-13 |
| DE2408724A1 (en) | 1974-09-05 |
| GB1476422A (en) | 1977-06-16 |
| ZA741189B (en) | 1975-09-24 |
| NL7402455A (en) | 1974-08-27 |
| HU173676B (en) | 1979-07-28 |
| BE811491A (en) | 1974-08-22 |
| FR2218888B1 (en) | 1976-12-03 |
| IL44267A0 (en) | 1974-05-16 |
| DK141757C (en) | 1980-10-27 |
| DK141757B (en) | 1980-06-09 |
| AU6591074A (en) | 1975-08-28 |
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