JPS5574797A - Preparation of protein polysaccharide having anti-tumor activity - Google Patents
Preparation of protein polysaccharide having anti-tumor activityInfo
- Publication number
- JPS5574797A JPS5574797A JP14982878A JP14982878A JPS5574797A JP S5574797 A JPS5574797 A JP S5574797A JP 14982878 A JP14982878 A JP 14982878A JP 14982878 A JP14982878 A JP 14982878A JP S5574797 A JPS5574797 A JP S5574797A
- Authority
- JP
- Japan
- Prior art keywords
- tumor activity
- reaction
- aqueous medium
- protein polysaccharide
- fruit bodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 229920001282 polysaccharide Polymers 0.000 title abstract 2
- 239000005017 polysaccharide Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- OIPPWFOQEKKFEE-UHFFFAOYSA-N orcinol Chemical compound CC1=CC(O)=CC(O)=C1 OIPPWFOQEKKFEE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 241000222518 Agaricus Species 0.000 abstract 1
- 241000272814 Anser sp. Species 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- CTYRPMDGLDAWRQ-UHFFFAOYSA-N phenyl hydrogen sulfate Chemical compound OS(=O)(=O)OC1=CC=CC=C1 CTYRPMDGLDAWRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare a protein polysaccharide having remarkable anti-tumor activity, by extracting fruit bodies of a novel fungus belonging to Agaricus genus, with an aqueous medium.
CONSTITUTION: Crushed fruit bodies of a novel fungus, Agricus heterosistes Heinem. et Goose (FERM-P No.4731) are extracted with 2W10 times volume of an aqueous medium at 50W100°C for about 1W10 hours. The extract is added with an water-soluble organic solvent such as alcohol or acetone, or with a salt such as calcium chloride. The precipitate is filtered or centrifuged, washed with ether, and dried to obtain the objective substance in powder form. The substance is pale gray powder, and 1% aqueous solution thereof exhibits pH6.0. Color reactions: positive to anthrone sulfate reaction, phenol sulfate reaction, etc.; negative to orcinol reaction.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14982878A JPS5574797A (en) | 1978-12-04 | 1978-12-04 | Preparation of protein polysaccharide having anti-tumor activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14982878A JPS5574797A (en) | 1978-12-04 | 1978-12-04 | Preparation of protein polysaccharide having anti-tumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5574797A true JPS5574797A (en) | 1980-06-05 |
Family
ID=15483559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14982878A Pending JPS5574797A (en) | 1978-12-04 | 1978-12-04 | Preparation of protein polysaccharide having anti-tumor activity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5574797A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6466127A (en) * | 1987-09-07 | 1989-03-13 | Nichirei Kk | Antitumor agent |
| JPH0278630A (en) * | 1988-09-14 | 1990-03-19 | Nichirei Corp | antitumor agent |
| US6093694A (en) * | 1996-12-20 | 2000-07-25 | Sumitomo Forestry Co., Ltd. | Antitumor active substances |
| JP2001240603A (en) * | 2000-02-29 | 2001-09-04 | Toei Shinyaku Kk | beta-1,3-BRANCHED beta-1,6-GLUCAN AND ALKALI EXTRACTED ESSENCE OF AGARICUS MUSHROOM |
| US6627201B2 (en) | 2001-04-03 | 2003-09-30 | Kabushiki Kaisha Sun Chlorella | Composition for drinking/eating and beverage/food |
| CN103070388A (en) * | 2013-02-04 | 2013-05-01 | 云南茂昽生物科技有限公司 | Delicate tricholoma matsutake active extract and preparation method and application thereof |
-
1978
- 1978-12-04 JP JP14982878A patent/JPS5574797A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6466127A (en) * | 1987-09-07 | 1989-03-13 | Nichirei Kk | Antitumor agent |
| JPH0278630A (en) * | 1988-09-14 | 1990-03-19 | Nichirei Corp | antitumor agent |
| US6093694A (en) * | 1996-12-20 | 2000-07-25 | Sumitomo Forestry Co., Ltd. | Antitumor active substances |
| JP2001240603A (en) * | 2000-02-29 | 2001-09-04 | Toei Shinyaku Kk | beta-1,3-BRANCHED beta-1,6-GLUCAN AND ALKALI EXTRACTED ESSENCE OF AGARICUS MUSHROOM |
| US6627201B2 (en) | 2001-04-03 | 2003-09-30 | Kabushiki Kaisha Sun Chlorella | Composition for drinking/eating and beverage/food |
| CN103070388A (en) * | 2013-02-04 | 2013-05-01 | 云南茂昽生物科技有限公司 | Delicate tricholoma matsutake active extract and preparation method and application thereof |
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