SE8302517L - PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-0 (MAYTANSINOL) - Google Patents

PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-0 (MAYTANSINOL)

Info

Publication number
SE8302517L
SE8302517L SE8302517A SE8302517A SE8302517L SE 8302517 L SE8302517 L SE 8302517L SE 8302517 A SE8302517 A SE 8302517A SE 8302517 A SE8302517 A SE 8302517A SE 8302517 L SE8302517 L SE 8302517L
Authority
SE
Sweden
Prior art keywords
antibiotic
preparation
maytansinol
procedure
agent
Prior art date
Application number
SE8302517A
Other languages
Swedish (sv)
Other versions
SE8302517D0 (en
SE446004B (en
Inventor
E Higashide
M Asai
S Tanida
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP52037166A external-priority patent/JPS6034556B2/en
Priority claimed from US05/811,448 external-priority patent/US4162940A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of SE8302517D0 publication Critical patent/SE8302517D0/en
Publication of SE8302517L publication Critical patent/SE8302517L/en
Publication of SE446004B publication Critical patent/SE446004B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.

Claims (1)

1. Patenkrav Forfarande fOr framstHlining av en forening med formeln av CH3 OCH3 k N.nretecknat av aft man underkastar antibiotikan C-15003 med den allmanna formeln i vilken R hetecknar CH3 OO-CO2-CO2-CH3 eller 3 CO3 -CO-CU -CU , reduktiv hydrolys.A patent for the preparation of a compound having the formula of CH 3 OCH 3 k N. characterized by submitting the antibiotic C-15003 of the general formula in which R represents CH CU, reductive hydrolysis.
SE8302517A 1977-03-31 1983-05-03 PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-O (MAYTANSINOL) SE446004B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP52037166A JPS6034556B2 (en) 1977-03-31 1977-03-31 Antibiotic C-15003
US05/811,448 US4162940A (en) 1977-03-31 1977-06-29 Method for producing Antibiotic C-15003 by culturing nocardia

Publications (3)

Publication Number Publication Date
SE8302517D0 SE8302517D0 (en) 1983-05-03
SE8302517L true SE8302517L (en) 1983-05-03
SE446004B SE446004B (en) 1986-08-04

Family

ID=26376254

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7711542A SE442873B (en) 1977-03-31 1977-10-13 PROCEDURE FOR PREPARING A NEW ANTIBIOTICUM C-15003 WITH STATED FORM BY CULTIVATION OF NOCARDIA NO C-15003 (IFO 13726, FERM 3992, ATCC 31281)
SE8302517A SE446004B (en) 1977-03-31 1983-05-03 PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-O (MAYTANSINOL)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7711542A SE442873B (en) 1977-03-31 1977-10-13 PROCEDURE FOR PREPARING A NEW ANTIBIOTICUM C-15003 WITH STATED FORM BY CULTIVATION OF NOCARDIA NO C-15003 (IFO 13726, FERM 3992, ATCC 31281)

Country Status (16)

Country Link
CA (1) CA1107212A (en)
CS (1) CS214749B2 (en)
DE (1) DE2746209A1 (en)
DK (1) DK458877A (en)
ES (2) ES463207A1 (en)
GB (1) GB1586688A (en)
GR (1) GR66051B (en)
HU (1) HU178359B (en)
IE (1) IE46064B1 (en)
IT (1) IT1094308B (en)
NL (1) NL188102C (en)
PH (2) PH13381A (en)
PL (2) PL122289B1 (en)
PT (1) PT67854B (en)
SE (2) SE442873B (en)
YU (2) YU245377A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5562090A (en) * 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55102583A (en) * 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
DE19940131B4 (en) * 1998-08-24 2004-12-02 Pfefferle, Christoph, Dr. Method and device for obtaining biologically active substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336399A (en) * 1971-06-24 1973-11-07 Lepetit Spa 3-formylrifamycin sv derivatives
DE2241418A1 (en) * 1972-08-23 1974-03-07 S Morris Kupchan Antileukemic ansamacrolides - from Maytenus ovatus

Also Published As

Publication number Publication date
YU245377A (en) 1983-01-21
PL124349B1 (en) 1983-01-31
SE442873B (en) 1986-02-03
NL188102B (en) 1991-11-01
ES472230A1 (en) 1979-04-01
YU178582A (en) 1984-08-31
SE8302517D0 (en) 1983-05-03
IE46064L (en) 1978-09-30
SE446004B (en) 1986-08-04
IT7821818A0 (en) 1978-03-30
DE2746209A1 (en) 1978-10-19
HU178359B (en) 1982-04-28
PT67854A (en) 1978-04-01
ES463207A1 (en) 1979-01-01
CS214749B2 (en) 1982-05-28
DK458877A (en) 1978-10-01
NL7711274A (en) 1978-10-03
IT1094308B (en) 1985-07-26
GB1586688A (en) 1981-03-25
PH13381A (en) 1980-03-25
IE46064B1 (en) 1983-02-09
CA1107212A (en) 1981-08-18
NL188102C (en) 1992-04-01
SE7711542L (en) 1978-10-01
PT67854B (en) 1980-05-05
PL201541A1 (en) 1978-10-09
PH15985A (en) 1983-05-18
GR66051B (en) 1981-01-14
PL122289B1 (en) 1982-07-31
DE2746209C2 (en) 1990-10-31

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