IE39999L - Pyrazole -4- acetic acid derivatives. - Google Patents
Pyrazole -4- acetic acid derivatives.Info
- Publication number
- IE39999L IE39999L IE741705A IE170574A IE39999L IE 39999 L IE39999 L IE 39999L IE 741705 A IE741705 A IE 741705A IE 170574 A IE170574 A IE 170574A IE 39999 L IE39999 L IE 39999L
- Authority
- IE
- Ireland
- Prior art keywords
- aug
- derivatives
- pharmaceutical compositions
- acid derivatives
- pyrazole
- Prior art date
Links
- PXWJTOHJADWQQO-UHFFFAOYSA-N 2-(1h-pyrazol-4-yl)acetic acid Chemical class OC(=O)CC=1C=NNC=1 PXWJTOHJADWQQO-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical compound [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001458 anti-acid effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000000026 anti-ulcerogenic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229940083761 high-ceiling diuretics pyrazolone derivative Drugs 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- 230000008338 local blood flow Effects 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229940099273 magnesium trisilicate Drugs 0.000 abstract 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 abstract 1
- 235000019793 magnesium trisilicate Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 abstract 1
- 150000004892 pyridazines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1475806 Pharmaceutical compositions of 5- Halo-1, 3-diphenyl pyrazole-4-acetic acids BYK GULDEN LOMBERG CHEMISCHE FABRIK GmbH 14 Aug 1974 [16 Aug 1973] 35740/74 Heading A5B [Also in Division C2] Pharmaceutical compositions comprising a compound of the formula I in which Ph 1 and Ph 2 are the same or different phenyl radicals in which the substituents thereon, where present, are not hydrolysable and halogen is a fluorine chlorine or bromine atom or their salts with organic or inorganic bases and a pharmaceutically acceptable medicament vehicle show anti-inflammatory, antipyretic and analgesic activity when administered orally, parenterally, topically or rectally. The compositions may also contain other inflammatory agents such as a corticosteroid, analgesics, particularly pyrazolone derivatives e.g. prednisolone and dexamethasone, muscle relaxants such as pyridazine derivatives and carbamates, antiulcerogenics, antiacid materials such as magnesium trisilicate and aluminium hydroxide, substances which encourage local blood circulation such as nicotinic acid derivatives and dimethyl sulphoxide, local anesthetics such as lidocain and vitamins.
[GB1475806A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU68238A LU68238A1 (en) | 1973-08-16 | 1973-08-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39999L true IE39999L (en) | 1975-02-16 |
| IE39999B1 IE39999B1 (en) | 1979-02-14 |
Family
ID=19727442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1705/74A IE39999B1 (en) | 1973-08-16 | 1974-08-15 | New halogenopyrazole derivatives, a method for producing them and medicaments containing them |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5230515B2 (en) |
| AT (1) | AT339892B (en) |
| BE (1) | BE818912A (en) |
| CA (1) | CA1048499A (en) |
| CH (1) | CH601250A5 (en) |
| DE (2) | DE2462459C3 (en) |
| DK (1) | DK136953B (en) |
| ES (1) | ES429247A1 (en) |
| FI (1) | FI57584C (en) |
| FR (1) | FR2240732B1 (en) |
| GB (1) | GB1475806A (en) |
| IE (1) | IE39999B1 (en) |
| LU (1) | LU68238A1 (en) |
| NL (1) | NL169070C (en) |
| NO (1) | NO140733C (en) |
| SE (1) | SE409454B (en) |
| YU (1) | YU222474A (en) |
| ZA (1) | ZA745252B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5297383A (en) * | 1976-02-13 | 1977-08-16 | Ngk Spark Plug Co | Ceramic honeycomb structures for exhaust gas purification |
| HUP0304101A3 (en) * | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
-
1973
- 1973-08-16 LU LU68238A patent/LU68238A1/xx unknown
-
1974
- 1974-08-13 DE DE2462459A patent/DE2462459C3/en not_active Expired
- 1974-08-13 DE DE2438779A patent/DE2438779C3/en not_active Expired
- 1974-08-14 ES ES429247A patent/ES429247A1/en not_active Expired
- 1974-08-14 YU YU02224/74A patent/YU222474A/en unknown
- 1974-08-14 GB GB3574074A patent/GB1475806A/en not_active Expired
- 1974-08-14 FR FR7428162A patent/FR2240732B1/fr not_active Expired
- 1974-08-14 CH CH1111874A patent/CH601250A5/xx not_active IP Right Cessation
- 1974-08-15 SE SE7410419A patent/SE409454B/en unknown
- 1974-08-15 NL NLAANVRAGE7410921,A patent/NL169070C/en not_active IP Right Cessation
- 1974-08-15 DK DK438174AA patent/DK136953B/en unknown
- 1974-08-15 IE IE1705/74A patent/IE39999B1/en unknown
- 1974-08-15 NO NO742941A patent/NO140733C/en unknown
- 1974-08-15 CA CA74207072A patent/CA1048499A/en not_active Expired
- 1974-08-15 FI FI2422/74A patent/FI57584C/en active
- 1974-08-15 JP JP49093786A patent/JPS5230515B2/ja not_active Expired
- 1974-08-15 ZA ZA00745252A patent/ZA745252B/en unknown
- 1974-08-16 AT AT671174A patent/AT339892B/en not_active IP Right Cessation
- 1974-08-16 BE BE147661A patent/BE818912A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO140733B (en) | 1979-07-23 |
| NO140733C (en) | 1979-10-31 |
| JPS5049278A (en) | 1975-05-01 |
| FR2240732B1 (en) | 1978-07-21 |
| CA1048499A (en) | 1979-02-13 |
| LU68238A1 (en) | 1975-05-21 |
| FI57584C (en) | 1980-09-10 |
| DK136953C (en) | 1978-05-29 |
| YU222474A (en) | 1983-04-27 |
| ES429247A1 (en) | 1976-08-16 |
| BE818912A (en) | 1975-02-17 |
| DK136953B (en) | 1977-12-19 |
| DE2438779C3 (en) | 1979-09-20 |
| IE39999B1 (en) | 1979-02-14 |
| NL7410921A (en) | 1975-02-18 |
| DK438174A (en) | 1975-04-28 |
| GB1475806A (en) | 1977-06-10 |
| NL169070C (en) | 1982-06-01 |
| FI57584B (en) | 1980-05-30 |
| ZA745252B (en) | 1976-03-31 |
| DE2462459C3 (en) | 1979-10-04 |
| DE2462459B2 (en) | 1979-02-08 |
| DE2438779B2 (en) | 1979-01-25 |
| NL169070B (en) | 1982-01-04 |
| FI242274A7 (en) | 1975-02-17 |
| AT339892B (en) | 1977-11-10 |
| SE7410419L (en) | 1975-02-17 |
| JPS5230515B2 (en) | 1977-08-09 |
| SE409454B (en) | 1979-08-20 |
| NO742941L (en) | 1975-03-17 |
| ATA671174A (en) | 1977-03-15 |
| CH601250A5 (en) | 1978-06-30 |
| FR2240732A1 (en) | 1975-03-14 |
| DE2438779A1 (en) | 1975-02-27 |
| DE2462459A1 (en) | 1977-04-07 |
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