IE40003L - Imidazoles - Google Patents
ImidazolesInfo
- Publication number
- IE40003L IE40003L IE741746A IE174674A IE40003L IE 40003 L IE40003 L IE 40003L IE 741746 A IE741746 A IE 741746A IE 174674 A IE174674 A IE 174674A IE 40003 L IE40003 L IE 40003L
- Authority
- IE
- Ireland
- Prior art keywords
- lower alkyl
- alkyl
- formula
- sulphonyl
- cpd
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 241000894006 Bacteria Species 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 241000224483 Coccidia Species 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 241000242678 Schistosoma Species 0.000 abstract 1
- 241001502500 Trichomonadida Species 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 229940124339 anthelmintic agent Drugs 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- XMWZWFFVDSIGJD-UHFFFAOYSA-N n-methyl-3-(1-methyl-5-nitroimidazol-2-yl)-2-oxoimidazolidine-1-carbothioamide Chemical compound O=C1N(C(=S)NC)CCN1C1=NC=C([N+]([O-])=O)N1C XMWZWFFVDSIGJD-UHFFFAOYSA-N 0.000 abstract 1
- 239000011368 organic material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivs. of formula (I): (where one of R1 and R2 is H or lower alkyl and the other is NO2; R3 is lower alkyl, hydroxyalkyl, alkoxyalkyl, alkyl-sulphonyl-alkyl or aminoalkyl; R4 is O or S; X is CO and R5 is lower alkoxy, NH2 or mono- or di(lower alkyl)-amino or X is CS, SO or SO2 and R5 is lower alkyl, aryl, NH2 or mono- or di-(lower alkyl)-amino; and "alk" is lower alkylene with 2-4 C-atoms in the alkylene chain) (e. g. 1-(methyl-thiocarbamoyl)-2-oxo-3-(1-methyl-5-nitro-2-imidazolyl)-- tetrahydroimidazole) and their salts and N-oxides are new cpds. They may be prepd. e.g. by reacting a cpd. of formula (II) (where Z is a reactive esterified or etherified hydroxy gp., a free or etherified mercapto group, an ammonium gp. or a sulphonyl gp.) with a cpd. of formula (III). (I) are antimicrobial and anthelmintic agents active against bacteria (esp. gram-negative bacteria), protozoa and worms such as trichomonads, schistosomes, coccidia and, especially, amoebae. (I) may thus be used for therapeutic purposes, as animal feed additives, and for protecting organic materials against microbial degradation.
[FR2244498A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1366773A CH592653A5 (en) | 1973-09-24 | 1973-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40003L true IE40003L (en) | 1975-03-24 |
| IE40003B1 IE40003B1 (en) | 1979-02-14 |
Family
ID=4394325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1746/74A IE40003B1 (en) | 1973-09-24 | 1974-08-22 | New imidazoles and processes for their production |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5910347B2 (en) |
| AR (2) | AR212578A1 (en) |
| AT (1) | AT337692B (en) |
| BE (1) | BE820206A (en) |
| BG (2) | BG22813A3 (en) |
| CH (1) | CH592653A5 (en) |
| CS (1) | CS195689B2 (en) |
| DD (1) | DD114814A5 (en) |
| DE (1) | DE2444070A1 (en) |
| DK (1) | DK447474A (en) |
| DO (1) | DOP1981002973A (en) |
| ES (1) | ES430352A1 (en) |
| FI (1) | FI62293C (en) |
| FR (1) | FR2244498A1 (en) |
| HU (1) | HU171562B (en) |
| IE (1) | IE40003B1 (en) |
| IL (1) | IL45536A (en) |
| NL (1) | NL7412482A (en) |
| NO (1) | NO141895C (en) |
| OA (1) | OA04828A (en) |
| PH (1) | PH13743A (en) |
| PL (3) | PL95689B1 (en) |
| RO (1) | RO70190A (en) |
| SE (1) | SE416300B (en) |
| SU (3) | SU542473A3 (en) |
| YU (3) | YU37337B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5956254U (en) * | 1982-10-05 | 1984-04-12 | 住友金属鉱山株式会社 | retaining wall block |
| DE4426757A1 (en) * | 1994-07-28 | 1996-02-01 | Bayer Ag | 2-imidazolidinone derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944061A (en) * | 1957-09-20 | 1960-07-05 | Acyl derivatives and process | |
| IL39283A (en) * | 1971-05-03 | 1976-01-30 | Ciba Geigy Ag | Substituted 2-oxo or thioxo-3-(5-nitro-imidazol-2-yl)-tetrahydroimidazoles and their manufacture |
| BE795068A (en) * | 1972-02-08 | 1973-08-07 | Ciba Geigy | NEW 4- OR 5-NITRO-INMIDAZOLES AND METHODS FOR THEIR PREPARATION |
-
1973
- 1973-09-24 CH CH1366773A patent/CH592653A5/xx not_active IP Right Cessation
-
1974
- 1974-08-21 DK DK447474A patent/DK447474A/da not_active Application Discontinuation
- 1974-08-22 IE IE1746/74A patent/IE40003B1/en unknown
- 1974-08-26 IL IL45536A patent/IL45536A/en unknown
- 1974-09-06 SE SE7411296A patent/SE416300B/en not_active IP Right Cessation
- 1974-09-12 FI FI2669/74A patent/FI62293C/en active
- 1974-09-14 DE DE2444070A patent/DE2444070A1/en not_active Ceased
- 1974-09-18 FR FR7431471A patent/FR2244498A1/en active Granted
- 1974-09-20 NL NL7412482A patent/NL7412482A/en not_active Application Discontinuation
- 1974-09-20 NO NO743395A patent/NO141895C/en unknown
- 1974-09-21 OA OA55302A patent/OA04828A/en unknown
- 1974-09-23 DD DD181273A patent/DD114814A5/xx unknown
- 1974-09-23 PL PL1974185100A patent/PL95689B1/en unknown
- 1974-09-23 BG BG029300A patent/BG22813A3/en unknown
- 1974-09-23 YU YU2559/74A patent/YU37337B/en unknown
- 1974-09-23 RO RO7487513A patent/RO70190A/en unknown
- 1974-09-23 AR AR255685A patent/AR212578A1/en active
- 1974-09-23 PL PL1974174285A patent/PL96510B1/en unknown
- 1974-09-23 SU SU2063056A patent/SU542473A3/en active
- 1974-09-23 BE BE148776A patent/BE820206A/en not_active IP Right Cessation
- 1974-09-23 PH PH16324A patent/PH13743A/en unknown
- 1974-09-23 AT AT762174A patent/AT337692B/en not_active IP Right Cessation
- 1974-09-23 BG BG027754A patent/BG22823A3/en unknown
- 1974-09-23 PL PL1974185103A patent/PL95691B1/en unknown
- 1974-09-24 CS CS746554A patent/CS195689B2/en unknown
- 1974-09-24 HU HU74CI00001509A patent/HU171562B/en unknown
- 1974-09-24 JP JP49110385A patent/JPS5910347B2/en not_active Expired
- 1974-09-24 ES ES430352A patent/ES430352A1/en not_active Expired
-
1975
- 1975-01-01 AR AR258970A patent/AR207980A1/en active
- 1975-07-02 SU SU7502149414A patent/SU571191A3/en active
- 1975-07-02 SU SU7502149413A patent/SU564812A3/en active
-
1980
- 1980-11-24 YU YU2982/80A patent/YU37338B/en unknown
- 1980-11-24 YU YU2983/80A patent/YU37339B/en unknown
-
1981
- 1981-02-09 DO DO1981002973A patent/DOP1981002973A/en unknown
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