ES430352A1 - PROCEDURE FOR OBTAINING NEW IMIDAZOLES. - Google Patents
PROCEDURE FOR OBTAINING NEW IMIDAZOLES.Info
- Publication number
- ES430352A1 ES430352A1 ES430352A ES430352A ES430352A1 ES 430352 A1 ES430352 A1 ES 430352A1 ES 430352 A ES430352 A ES 430352A ES 430352 A ES430352 A ES 430352A ES 430352 A1 ES430352 A1 ES 430352A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- lower alkyl
- group
- amino
- alk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 2
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining new imidazoles of formula I **(See formula)** where one of the radicals R1 and R2 means hydrogen or lower alkyl and the other one means the nitro group, R3 means lower alkyl, hydroxyalkyl, lower alkoxy-lower alkyl, lower alkyl-sulfonyl-lower alkyl or aminoalkyl, R4 means oxo or thio, X signifies a carbonyl, thiocarbonyl, sulfinyl or sulfonyl group and, when X signifies a carbonyl group, R5 signifies lower alkoxy, amino, lower alkyl-amino or dialkyl lower amino, and when X signifies thiocarbonyl, sulfinyl or sulfonyl it means lower alkyl, aryl, amino, lower alkyl-amino or dialkyl lower-amino and "alk" means lower alkylene with 2-4 carbon atoms in the alkylene chain, its salts and N-oxides, characterized in that a) an imidazole of formula II **(See formula)** where R1, R2 and R3 have the meanings above and Z means an esterified hydroxy group, capable of reaction, an ethereal hydroxy group, capable of reaction, a free or ether mercapto group, an ammonium group or a sulfonyl group, is reacted with a compound of formula III **(See formula)** where R4, R5, X and alk have the meaning indicated above, or b) an imidazole of formula IV **(See formula)** where R3, R4, R5, X and alk have the meanings above, and one of the residues R'1 and R'2 means hydrogen or lower alkyl and the other one means hydrogen, is nitrated, or c) an imidazole of formula V **(See formula)** where R1, R2, R3, R4 and alk have the meanings indicated above, it is reacted with a compound of formula VI Z-X-R5 where X and R5 have the above meanings and Z means an esterified hydroxy group, capable of reaction, an ethereal hydroxy group, capable of reaction, a free or ether mercapto group, an ammonium group or a sulfonyl group, or d) an imidazole of formula VII **(See formula)** where R1, R2, R3, R4 and alk have the meanings indicated above, it is reacted with a compound of formula VIII H2N - X - R5 (VIII) where R5 and X have the meanings indicated in formula I and, if desired, substituents are introduced, modified or dissociated within the scope of the definition of the final products, and/or the racemate mixtures obtained are separated into the pure racemates., and/or the racemates obtained in the optical antipodes, and/or the salts obtained are transformed into the free compounds or into other salts or the free compounds obtained into their salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1366773A CH592653A5 (en) | 1973-09-24 | 1973-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES430352A1 true ES430352A1 (en) | 1976-09-16 |
Family
ID=4394325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES430352A Expired ES430352A1 (en) | 1973-09-24 | 1974-09-24 | PROCEDURE FOR OBTAINING NEW IMIDAZOLES. |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5910347B2 (en) |
| AR (2) | AR212578A1 (en) |
| AT (1) | AT337692B (en) |
| BE (1) | BE820206A (en) |
| BG (2) | BG22823A3 (en) |
| CH (1) | CH592653A5 (en) |
| CS (1) | CS195689B2 (en) |
| DD (1) | DD114814A5 (en) |
| DE (1) | DE2444070A1 (en) |
| DK (1) | DK447474A (en) |
| DO (1) | DOP1981002973A (en) |
| ES (1) | ES430352A1 (en) |
| FI (1) | FI62293C (en) |
| FR (1) | FR2244498A1 (en) |
| HU (1) | HU171562B (en) |
| IE (1) | IE40003B1 (en) |
| IL (1) | IL45536A (en) |
| NL (1) | NL7412482A (en) |
| NO (1) | NO141895C (en) |
| OA (1) | OA04828A (en) |
| PH (1) | PH13743A (en) |
| PL (3) | PL96510B1 (en) |
| RO (1) | RO70190A (en) |
| SE (1) | SE416300B (en) |
| SU (3) | SU542473A3 (en) |
| YU (3) | YU37337B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5956254U (en) * | 1982-10-05 | 1984-04-12 | 住友金属鉱山株式会社 | retaining wall block |
| DE4426757A1 (en) * | 1994-07-28 | 1996-02-01 | Bayer Ag | 2-imidazolidinone derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944061A (en) * | 1957-09-20 | 1960-07-05 | Acyl derivatives and process | |
| IL39283A (en) * | 1971-05-03 | 1976-01-30 | Ciba Geigy Ag | Substituted 2-oxo or thioxo-3-(5-nitro-imidazol-2-yl)-tetrahydroimidazoles and their manufacture |
| BE795068A (en) * | 1972-02-08 | 1973-08-07 | Ciba Geigy | NEW 4- OR 5-NITRO-INMIDAZOLES AND METHODS FOR THEIR PREPARATION |
-
1973
- 1973-09-24 CH CH1366773A patent/CH592653A5/xx not_active IP Right Cessation
-
1974
- 1974-08-21 DK DK447474A patent/DK447474A/da not_active Application Discontinuation
- 1974-08-22 IE IE1746/74A patent/IE40003B1/en unknown
- 1974-08-26 IL IL45536A patent/IL45536A/en unknown
- 1974-09-06 SE SE7411296A patent/SE416300B/en not_active IP Right Cessation
- 1974-09-12 FI FI2669/74A patent/FI62293C/en active
- 1974-09-14 DE DE2444070A patent/DE2444070A1/en not_active Ceased
- 1974-09-18 FR FR7431471A patent/FR2244498A1/en active Granted
- 1974-09-20 NL NL7412482A patent/NL7412482A/en not_active Application Discontinuation
- 1974-09-20 NO NO743395A patent/NO141895C/en unknown
- 1974-09-21 OA OA55302A patent/OA04828A/en unknown
- 1974-09-23 PL PL1974174285A patent/PL96510B1/en unknown
- 1974-09-23 PL PL1974185103A patent/PL95691B1/en unknown
- 1974-09-23 AR AR255685A patent/AR212578A1/en active
- 1974-09-23 AT AT762174A patent/AT337692B/en not_active IP Right Cessation
- 1974-09-23 BG BG027754A patent/BG22823A3/en unknown
- 1974-09-23 BE BE148776A patent/BE820206A/en not_active IP Right Cessation
- 1974-09-23 YU YU2559/74A patent/YU37337B/en unknown
- 1974-09-23 PH PH16324A patent/PH13743A/en unknown
- 1974-09-23 RO RO7487513A patent/RO70190A/en unknown
- 1974-09-23 PL PL1974185100A patent/PL95689B1/en unknown
- 1974-09-23 SU SU2063056A patent/SU542473A3/en active
- 1974-09-23 DD DD181273A patent/DD114814A5/xx unknown
- 1974-09-23 BG BG029300A patent/BG22813A3/en unknown
- 1974-09-24 HU HU74CI00001509A patent/HU171562B/en unknown
- 1974-09-24 CS CS746554A patent/CS195689B2/en unknown
- 1974-09-24 JP JP49110385A patent/JPS5910347B2/en not_active Expired
- 1974-09-24 ES ES430352A patent/ES430352A1/en not_active Expired
-
1975
- 1975-01-01 AR AR258970A patent/AR207980A1/en active
- 1975-07-02 SU SU7502149414A patent/SU571191A3/en active
- 1975-07-02 SU SU7502149413A patent/SU564812A3/en active
-
1980
- 1980-11-24 YU YU2982/80A patent/YU37338B/en unknown
- 1980-11-24 YU YU2983/80A patent/YU37339B/en unknown
-
1981
- 1981-02-09 DO DO1981002973A patent/DOP1981002973A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8402591A1 (en) | PROCEDURE FOR THE OBTAINING OF PIRAZOLOOXACINAS, PIRAZOLOTIACINAS AND PIRAZOLOQUINOLINAS. | |
| ES444523A1 (en) | Additives for functional fluids | |
| ES394541A1 (en) | 1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides | |
| ES384491A1 (en) | Phenylacetylguanidines | |
| ES417638A1 (en) | PROCEDURE TO PREPARE 2,4,5-TRISUSTITUED OXAZOLES. | |
| ES327432A1 (en) | Procedure for the preparation of heterociclic compounds. (Machine-translation by Google Translate, not legally binding) | |
| ES415021A1 (en) | Process for preparing herbicidal triazines | |
| ES385627A2 (en) | Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES409296A1 (en) | Fused ring indole derivatives | |
| ES475565A1 (en) | A PROCEDURE FOR THE PREPARATION OF NEW INDOL DERIVATIVES | |
| GB1019784A (en) | New benzene-sulphonyl-semicarbazides | |
| ES323083A1 (en) | PROCEDURE FOR THE MANUFACTURE OF NAPHTHALENE DERIVATIVES. | |
| ES333485A1 (en) | Procedure for the preparation of new substituteed urea derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES8104210A1 (en) | Novel 1,1,3,5-substituted biuret compound and a pharmaceutical composition containing the same | |
| ES384182A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW TERTIARY BUTANOLES BASICALLY REPLACED. | |
| KR830006237A (en) | Method for preparing carbamoyloxyamino-1,4-benzodiazepine | |
| ES378034A1 (en) | Herbicidal halodinitro-1,3-phenylenediamine compounds | |
| DE3671445D1 (en) | PHENYL-PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT. | |
| ES424288A1 (en) | Procedure for obtaining imidazoles. (Machine-translation by Google Translate, not legally binding) | |
| ES299125A1 (en) | Procedure for the production of biological substances (Machine-translation by Google Translate, not legally binding) | |
| ES388181A1 (en) | 5,10-methano-dibenzo-a,d-cycloheptene derivatives and a process for their manufacture | |
| ES321534A1 (en) | PROCEDURE FOR THE PREPARATION OF DIHIDRODIBENZOCICLOHEPTENO COMPOUNDS. | |
| ES424720A1 (en) | Process for preparing sulphoxides | |
| ES447392A1 (en) | Conversion of esters | |
| GB1148102A (en) | Production of new hexahydropyrimidine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19880406 |