IE40858L - 2-heterocyclylalkylthiobenzimidazoles - Google Patents

2-heterocyclylalkylthiobenzimidazoles

Info

Publication number
IE40858L
IE40858L IE750307A IE30775A IE40858L IE 40858 L IE40858 L IE 40858L IE 750307 A IE750307 A IE 750307A IE 30775 A IE30775 A IE 30775A IE 40858 L IE40858 L IE 40858L
Authority
IE
Ireland
Prior art keywords
formula
compounds
compound
image
radicals
Prior art date
Application number
IE750307A
Other versions
IE40858B1 (en
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IE40858L publication Critical patent/IE40858L/en
Publication of IE40858B1 publication Critical patent/IE40858B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula I <IMAGE> whose radicals are specified in Patent Claim 1, are obtained by reaction of a compound of the formula IV <IMAGE> containing radicals as in Patent Claim 1, with a compound of the formula V, Z<1>-B-Het, in which B is the group -CH2- or -CH(CH3)- and Z<1> denotes a reactive, esterified hydroxyl group or -SH. The compounds of the formula I can be used for affecting gastric acid secretion of mammals, in particular humans. They are best suited for the treatment, for example, of gastric ulcers or similar disorders. [SE7402101L]
IE307/75A 1974-02-18 1975-02-17 New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion IE40858B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7402101A SE418966B (en) 1974-02-18 1974-02-18 ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects

Publications (2)

Publication Number Publication Date
IE40858L true IE40858L (en) 1975-08-18
IE40858B1 IE40858B1 (en) 1979-08-29

Family

ID=20320233

Family Applications (1)

Application Number Title Priority Date Filing Date
IE307/75A IE40858B1 (en) 1974-02-18 1975-02-17 New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion

Country Status (23)

Country Link
JP (1) JPS5924157B2 (en)
AT (1) AT343659B (en)
AU (1) AU499639B2 (en)
BE (1) BE825655A (en)
CA (1) CA1060448A (en)
CH (1) CH616160A5 (en)
CS (1) CS194715B2 (en)
DD (1) DD119422A5 (en)
DE (1) DE2504252A1 (en)
DK (1) DK141122B (en)
FI (1) FI59590C (en)
FR (1) FR2261007B1 (en)
GB (1) GB1500043A (en)
HK (1) HK67080A (en)
HU (1) HU172141B (en)
IE (1) IE40858B1 (en)
LU (1) LU71872A1 (en)
MY (1) MY8100208A (en)
NL (1) NL7501917A (en)
NO (1) NO142401C (en)
SE (1) SE418966B (en)
SU (1) SU795476A3 (en)
ZA (1) ZA75558B (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (en) * 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
JPS5364103A (en) * 1976-09-24 1978-06-08 Hitachi Ltd Waste heat recovery boiler
IN148930B (en) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (en) * 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
US4343805A (en) * 1978-12-16 1982-08-10 John Wyeth & Brother Limited Heterocyclic compounds
AT373888B (en) * 1979-01-10 1984-02-27 Janssen Pharmaceutica Nv METHOD FOR PRODUCING NEW 4-PIPERIDINE AMINES AND THEIR ACID ADDITION SALTS
CH644116A5 (en) * 1980-08-21 1984-07-13 Hoffmann La Roche IMIDAZOLE DERIVATIVES.
DE3047388A1 (en) * 1980-12-16 1982-07-15 Basf Ag, 6700 Ludwigshafen ISATOGEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
DE3216843C2 (en) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridine derivatives, processes for their preparation and pharmaceuticals containing these compounds
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
SE8300736D0 (en) * 1983-02-11 1983-02-11 Haessle Ab NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US4503139A (en) * 1983-05-09 1985-03-05 Polaroid Corporation Photographic products and processes and novel compounds
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
US4767770A (en) * 1984-06-18 1988-08-30 Eli Lilly And Company Method of inhibiting aromatase
SE8505112D0 (en) * 1985-10-29 1985-10-29 Haessle Ab NOVEL PHARMACOLOGICAL COMPOUNDS
FR2593178B1 (en) * 1986-01-20 1988-04-29 Esteve Labor Dr 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.
SE8600658D0 (en) * 1986-02-14 1986-02-14 Haessle Ab NOVEL COMPOSITION OF MATTER
SE8604566D0 (en) * 1986-10-27 1986-10-27 Haessle Ab NOVEL COMPUNDS
SE8604998D0 (en) 1986-11-21 1986-11-21 Haessle Ab NOVEL PHARMACOLOGICAL COMPOUNDS
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH021280U (en) * 1988-06-14 1990-01-08
AU617217B2 (en) * 1988-09-20 1991-11-21 Hisamitsu Pharmaceutical Co., Inc. Novel dibenz(b,e)oxepin derivatives
SE8804628D0 (en) 1988-12-22 1988-12-22 Ab Haessle NEW COMPOUNDS
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (en) 1988-12-22 1988-12-22 Ab Haessle NEW THERAPEUTICALLY ACTIVE COMPOUNDS
JP2679745B2 (en) * 1989-06-29 1997-11-19 明治製菓株式会社 Azole derivatives and antiulcer agents containing them as active ingredients
JPH0347053U (en) * 1989-09-16 1991-04-30
US5049674A (en) 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (en) 1990-06-20 1990-06-20 Haessle Ab NEW COMPOUNDS
CA2192202A1 (en) * 1994-06-10 1995-12-21 Bernhard Kohl Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria
EP1206466B1 (en) * 1999-08-26 2005-10-12 aaiPharma Inc. Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
BR0308785A (en) * 2002-03-27 2005-01-11 Altana Pharma Ag Alkoxypyridine Derivatives
KR20050107433A (en) * 2003-02-25 2005-11-11 알타나 파마 아게 Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors
NZ546437A (en) * 2003-10-01 2009-09-25 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
JP2007507463A (en) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト Imidazo [4,5-b] pyridine derivatives as inducible NO synthase inhibitors
EP1673371B1 (en) * 2003-10-01 2008-08-06 Nycomed GmbH Imidazopyridine-derivatives as inducible no-synthase inhibitors
ATE399168T1 (en) * 2003-10-01 2008-07-15 Nycomed Gmbh IMIDAZOPYRIDINE DERIVATIVES AND THEIR USE AS INDUCIBLE NO-SYNTHASE INHIBITORS
EP1670798A1 (en) 2003-10-01 2006-06-21 Altana Pharma AG Aminopyridine-derivatives as inductible no-synthase inhibitors
DK2003130T3 (en) * 2006-03-10 2011-12-12 Arigen Pharmaceuticals Inc New pyridine derivative with anti-helicobacter pylori activity
EP2070923A1 (en) 2007-12-11 2009-06-17 Bayer CropScience AG Insecticide iminoheterocycles
WO2011150156A2 (en) * 2010-05-26 2011-12-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (en) * 1968-10-21 1971-06-03

Also Published As

Publication number Publication date
BE825655A (en) 1975-08-18
JPS5924157B2 (en) 1984-06-07
AU499639B2 (en) 1979-04-26
CA1060448A (en) 1979-08-14
ZA75558B (en) 1976-01-28
JPS50116474A (en) 1975-09-11
AT343659B (en) 1978-06-12
LU71872A1 (en) 1975-12-09
NO142401C (en) 1980-08-13
DK141122B (en) 1980-01-21
FI59590B (en) 1981-05-29
NL7501917A (en) 1975-08-20
FI59590C (en) 1981-09-10
SE418966B (en) 1981-07-06
DE2504252A1 (en) 1975-08-21
HU172141B (en) 1978-06-28
DD119422A5 (en) 1976-04-20
FR2261007B1 (en) 1978-11-24
MY8100208A (en) 1981-12-31
AU7820675A (en) 1976-08-19
SE7402101L (en) 1975-08-19
DE2504252C2 (en) 1989-02-02
CS194715B2 (en) 1979-12-31
HK67080A (en) 1980-12-05
IE40858B1 (en) 1979-08-29
DK54075A (en) 1975-10-20
DK141122C (en) 1980-07-07
CH616160A5 (en) 1980-03-14
GB1500043A (en) 1978-02-08
NO142401B (en) 1980-05-05
SU795476A3 (en) 1981-01-07
ATA113775A (en) 1977-10-15
NO750541L (en) 1975-08-19
FR2261007A1 (en) 1975-09-12
FI750421A7 (en) 1975-08-19

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