IE42124L - 17,21-diesters of the pregnane series - Google Patents
17,21-diesters of the pregnane seriesInfo
- Publication number
- IE42124L IE42124L IE751708A IE170875A IE42124L IE 42124 L IE42124 L IE 42124L IE 751708 A IE751708 A IE 751708A IE 170875 A IE170875 A IE 170875A IE 42124 L IE42124 L IE 42124L
- Authority
- IE
- Ireland
- Prior art keywords
- diesters
- pregnane series
- alpha
- compound
- formula
- Prior art date
Links
- 150000003128 pregnanes Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
17 alpha ,21-Diesters of 17 alpha ,21-dihydroxysteroids of the pregnane series corresponding to the formula I in which the symbols X, Y, R<1> and R<2> have the meaning stated in Claim 1 are prepared by reacting a compound which has the group -CH2OCO(CH2)nZ in position 21, where Z is a substituent which can easily be replaced, with a compound of the formula H-NR<3>R<4>. The compounds are distinguished not only by a good topical antiinflammatory effect but also by an excellent systemic antiinflammatory effect. <IMAGE>
[GB1516095A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33786/74A GB1516095A (en) | 1974-07-31 | 1974-07-31 | 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42124L true IE42124L (en) | 1976-01-31 |
| IE42124B1 IE42124B1 (en) | 1980-06-04 |
Family
ID=10357423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1708/75A IE42124B1 (en) | 1974-07-31 | 1975-07-30 | 17,21-diesters of 17,21-dihydroxy steroids of the pregnaneseries |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS51125059A (en) |
| BE (1) | BE831931A (en) |
| CA (1) | CA1058610A (en) |
| CH (1) | CH615442A5 (en) |
| DE (1) | DE2534051A1 (en) |
| DK (1) | DK139303B (en) |
| ES (1) | ES439852A1 (en) |
| FR (1) | FR2280383A1 (en) |
| GB (1) | GB1516095A (en) |
| IE (1) | IE42124B1 (en) |
| NL (1) | NL7509075A (en) |
| SE (1) | SE7508654L (en) |
| ZA (1) | ZA754907B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| FR2600653B1 (en) * | 1986-06-24 | 1988-12-16 | Pasteur Strasbourg Universite | COMPOUNDS FOR ASSOCIATIVE SYNTHESIS OF SULFUR OR NON-SULFUR AMINO ACIDS WITH D-4 PREGNENE 3,20-DIONE DERIVATIVES OR WITH D-1,4 PREGNADIENE 3,20-DIONE DERIVATIVES WITH GLUCOCORTICOID AND ANTI-INFLAMMATORY PROPERTIES, METHODS OBTAINED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. PHARMACOLOGICAL PROPERTIES AND APPLICATIONS |
| DE4333920A1 (en) | 1993-10-05 | 1995-04-13 | Hoechst Ag | Corticoid-17,21-dicarboxylic acid esters and corticosteroid-17-carboxylic acid ester-21-carbonic acid esters, processes for their preparation and medicaments containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1044212B (en) * | 1971-03-17 | 1980-03-20 | Sigma Tau Ind Farmaceuti | ESTERS OF BESAMETAZONE AND BETAMETAZONE |
| GB1440063A (en) * | 1972-08-11 | 1976-06-23 | Glaxo Lab Ltd | 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids |
-
1974
- 1974-07-31 GB GB33786/74A patent/GB1516095A/en not_active Expired
-
1975
- 1975-07-30 SE SE7508654A patent/SE7508654L/en unknown
- 1975-07-30 NL NL7509075A patent/NL7509075A/en not_active Application Discontinuation
- 1975-07-30 BE BE158780A patent/BE831931A/en unknown
- 1975-07-30 CA CA232,579A patent/CA1058610A/en not_active Expired
- 1975-07-30 ZA ZA00754907A patent/ZA754907B/en unknown
- 1975-07-30 DK DK346975AA patent/DK139303B/en unknown
- 1975-07-30 IE IE1708/75A patent/IE42124B1/en unknown
- 1975-07-30 ES ES439852A patent/ES439852A1/en not_active Expired
- 1975-07-30 FR FR7523787A patent/FR2280383A1/en active Granted
- 1975-07-30 CH CH996575A patent/CH615442A5/en not_active IP Right Cessation
- 1975-07-30 JP JP50092137A patent/JPS51125059A/en active Pending
- 1975-07-30 DE DE19752534051 patent/DE2534051A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NL7509075A (en) | 1976-02-03 |
| ES439852A1 (en) | 1977-03-01 |
| AU8353175A (en) | 1977-02-03 |
| DE2534051A1 (en) | 1976-02-19 |
| DK139303B (en) | 1979-01-29 |
| CH615442A5 (en) | 1980-01-31 |
| JPS51125059A (en) | 1976-11-01 |
| ZA754907B (en) | 1976-07-28 |
| GB1516095A (en) | 1978-06-28 |
| FR2280383A1 (en) | 1976-02-27 |
| DK346975A (en) | 1976-02-01 |
| BE831931A (en) | 1976-01-30 |
| IE42124B1 (en) | 1980-06-04 |
| FR2280383B1 (en) | 1978-10-06 |
| SE7508654L (en) | 1976-02-02 |
| DK139303C (en) | 1979-08-06 |
| CA1058610A (en) | 1979-07-17 |
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