IE43241L - Vehicle composition containing azacycloalkan-2-ones - Google Patents

Vehicle composition containing azacycloalkan-2-ones

Info

Publication number
IE43241L
IE43241L IE761330A IE133076A IE43241L IE 43241 L IE43241 L IE 43241L IE 761330 A IE761330 A IE 761330A IE 133076 A IE133076 A IE 133076A IE 43241 L IE43241 L IE 43241L
Authority
IE
Ireland
Prior art keywords
physiologically active
active agents
effective
topically
vehicles
Prior art date
Application number
IE761330A
Other versions
IE43241B1 (en
Original Assignee
Nelson Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/588,248 external-priority patent/US3989815A/en
Priority claimed from US05/588,247 external-priority patent/US3989816A/en
Priority claimed from US05/588,235 external-priority patent/US3991203A/en
Application filed by Nelson Res & Dev filed Critical Nelson Res & Dev
Publication of IE43241L publication Critical patent/IE43241L/en
Publication of IE43241B1 publication Critical patent/IE43241B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/41—Devices for promoting penis erection
    • A61F2005/415—Devices for promoting penis erection by inflatable means

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Cosmetics (AREA)

Abstract

This invention relates to compositions for carrying physiologically active agents through body membranes. Many physiologically active agents are best applied topically to obtain desirable results. The greatest problem in applying physiologically active agents topically is that the skin is such an effective barrier to penetration. Vehicles such as USP cold cream, ethanol and various ointments, oils, solvents, and emulsions have been used heretofore to apply physiologically active ingredients locally. Most such vehicles are not effective to carry significant amounts of physiologically active agents through the skin. The present invention relates to compositions useful in topically administering a physiologically active agent to a human or animal comprising the agent and an effective, non-toxic amount of a compound having the structural formula Where R' is H or a lower alkyl group having 1-4 carbon atoms, m is 3-7,n is 0-17, and R is -CH3 , or where R" = H or Halogen and R' has the same meaning as above, with the provisio that if m + 3 and R + -CH3 then n is no 0-4. [CA1076028A]
IE1330/76A 1975-06-19 1976-06-18 Vehicle composition containing 1-substituted azacycloalkan-2-ones IE43241B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58823475A 1975-06-19 1975-06-19
US05/588,248 US3989815A (en) 1975-06-19 1975-06-19 Novel N-bis-azacyclopentan-2-onyl alkanes
US05/588,247 US3989816A (en) 1975-06-19 1975-06-19 Vehicle composition containing 1-substituted azacycloheptan-2-ones
US05/588,235 US3991203A (en) 1975-06-19 1975-06-19 Vehicle composition containing 1-substituted azacyclopentan-2-ones

Publications (2)

Publication Number Publication Date
IE43241L true IE43241L (en) 1976-12-19
IE43241B1 IE43241B1 (en) 1981-01-14

Family

ID=27504982

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1330/76A IE43241B1 (en) 1975-06-19 1976-06-18 Vehicle composition containing 1-substituted azacycloalkan-2-ones

Country Status (7)

Country Link
JP (1) JPS6037092B2 (en)
AU (1) AU504943B2 (en)
CA (1) CA1076028A (en)
DE (1) DE2627772A1 (en)
FR (1) FR2314731A1 (en)
GB (1) GB1553309A (en)
IE (1) IE43241B1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405616A (en) * 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US4525199A (en) * 1981-05-04 1985-06-25 Nelson Research & Development Co. Method of improved pest control
JPS536327A (en) * 1976-07-08 1978-01-20 Mizusawa Industrial Chem Waterrresistant gypsum cureemolding structure
US4311481A (en) 1981-01-23 1982-01-19 Nelson Research & Development Company Method for improved dyeing
JPS5995212A (en) * 1982-11-23 1984-06-01 Nitto Electric Ind Co Ltd Base composition and pharmaceutical composition for external use
LU84514A1 (en) * 1982-12-09 1984-10-22 Oreal STABLE COMPOSITION FOR LOCAL CORTICOTHERAPY CONTAINING HYDROCORTISONE IN SOLUBILIZED CONDITIONS
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
JPH0627074B2 (en) * 1984-07-25 1994-04-13 日東電工株式会社 Pharmaceutical composition
JPS61130207A (en) * 1984-11-30 1986-06-18 Sunstar Inc Hair tonic agent
DE68902753T2 (en) * 1988-02-29 1993-01-21 Pfizer MEANS FOR INCREASING THE TRANSDERMAL PENETRATION FLOW.
JPH0742215B2 (en) * 1990-07-04 1995-05-10 花王株式会社 Hair treatment composition
JPH0742214B2 (en) * 1990-07-04 1995-05-10 花王株式会社 Hair treatment composition
JPH0742213B2 (en) * 1990-07-04 1995-05-10 花王株式会社 Hair treatment composition
US6284754B1 (en) 1992-01-20 2001-09-04 Schwarz Pharma Ag Pharmaceutical compositions containing 1-oleylazacycloheptan-2-one as enhancing agent of transport across biological membranes
ES2160623T3 (en) * 1992-12-31 2001-11-16 Sunkyong Ind Ltd PHARMACEUTICAL COMPOSITIONS IMPROVED FOR PENETRATION IN THE SKIN OF PIROXICAM.
DE4341572C1 (en) * 1993-12-07 1995-06-22 Univ Dresden Tech Timing belt transmission
DE19641437A1 (en) * 1996-10-08 1998-04-09 Basf Ag 1,3-bis (N-lactamyl) propanes and their pharmaceutical and cosmetic use
MY149038A (en) 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
CA2580119A1 (en) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
JP4504210B2 (en) * 2005-01-25 2010-07-14 花王株式会社 Hair dye composition
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
CL2008000582A1 (en) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd CYCLE COMPOUNDS DERIVED FROM CONDENSED OXIMORPHOLINE; PHARMACES THAT INCLUDE SUCH COMPOUNDS; AND ITS USE TO TREAT ALZHEIMER'S DISEASE, SENILE DEMENTIA, DOWN SYNDROME OR AMYLOIDOSIS.
JP5517339B2 (en) 2007-03-01 2014-06-11 コスメディ製薬株式会社 Transdermal absorption preparation and method for producing percutaneous absorption preparation
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
ES2529648T3 (en) 2007-08-31 2015-02-24 Eisai R&D Management Co., Ltd. Polycyclic compound
JP2012020991A (en) 2010-06-16 2012-02-02 Takasago Internatl Corp Transdermal absorption promoter, and external skin formulation thereof
EP3395368A1 (en) 2014-10-30 2018-10-31 Asahi Kasei Kabushiki Kaisha Transdermal absorption enhancer and transdermal absorption enhancement aid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE859016C (en) * 1944-07-06 1952-12-11 Basf Ag Process for the preparation of N-substituted lactams
DE1053736B (en) * 1956-03-02 1959-03-26 Konink Nl Gist & Spiritusfabri Process to increase the solubility of therapeutically active substances in water
DE1192208B (en) * 1960-05-13 1965-05-06 Basf Ag Process for the production of lactams
US3268397A (en) * 1963-10-04 1966-08-23 Gen Aniline & Film Corp Method of controlling nematodes with nu-(branched-chained-alkyl) lactams
FR2001768A1 (en) * 1968-02-12 1969-10-03 Gillette Co N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration
CA1003847A (en) * 1971-10-29 1977-01-18 G A F Corporation Low molecular weight complexes of lactams and phenolic compounds
CH573404A5 (en) * 1972-07-28 1976-03-15 Inventa Ag

Also Published As

Publication number Publication date
JPS521035A (en) 1977-01-06
DE2627772A1 (en) 1976-12-30
IE43241B1 (en) 1981-01-14
JPS6037092B2 (en) 1985-08-24
FR2314731B1 (en) 1978-11-03
AU504943B2 (en) 1979-11-01
GB1553309A (en) 1979-09-26
DE2627772C2 (en) 1991-04-25
FR2314731A1 (en) 1977-01-14
CA1076028A (en) 1980-04-22
AU1506376A (en) 1977-12-22

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Legal Events

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MK9A Patent expired