IE43381B1 - Antigenic compositions - Google Patents

Antigenic compositions

Info

Publication number: IE43381B1
Authority: IE; Ireland
Prior art keywords: erythrocytes; adhesion factor; composition; antigenic; antigenic composition
Prior art date: 1975-06-12

Application number

IE1248/76A

Other languages

English (en)

Other versions

IE43381L (en

Original Assignee

Unilever Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-12

Filing date

1976-06-10

Publication date

1981-02-11

1976-06-10 Application filed by Unilever Ltd filed Critical Unilever Ltd

1976-12-12 Publication of IE43381L publication Critical patent/IE43381L/xx

1981-02-11 Publication of IE43381B1 publication Critical patent/IE43381B1/en

Links

239000000203 mixture Substances 0.000 title claims description 32
230000000890 antigenic effect Effects 0.000 title claims description 26
210000003743 erythrocyte Anatomy 0.000 claims abstract description 38
241000287828 Gallus gallus Species 0.000 claims abstract description 15
241000588724 Escherichia coli Species 0.000 claims abstract description 8
206010012735 Diarrhoea Diseases 0.000 claims abstract description 7
230000032696 parturition Effects 0.000 claims abstract description 4
238000000034 method Methods 0.000 claims description 15
230000035931 haemagglutination Effects 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
210000003022 colostrum Anatomy 0.000 claims description 5
235000021277 colostrum Nutrition 0.000 claims description 5
230000000369 enteropathogenic effect Effects 0.000 claims description 5
239000003937 drug carrier Substances 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 3
230000005875 antibody response Effects 0.000 claims description 2
230000010065 bacterial adhesion Effects 0.000 claims description 2
239000003755 preservative agent Substances 0.000 claims description 2
230000002335 preservative effect Effects 0.000 claims description 2
238000010348 incorporation Methods 0.000 claims 1
229960005486 vaccine Drugs 0.000 abstract description 14
239000000427 antigen Substances 0.000 abstract description 8
102000036639 antigens Human genes 0.000 abstract description 8
108091007433 antigens Proteins 0.000 abstract description 8
241000282887 Suidae Species 0.000 abstract description 4
239000000243 solution Substances 0.000 description 16
239000000463 material Substances 0.000 description 8
241000894006 Bacteria Species 0.000 description 6
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
238000005119 centrifugation Methods 0.000 description 6
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
239000003921 oil Substances 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
230000000181 anti-adherent effect Effects 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
238000003556 assay Methods 0.000 description 3
239000000872 buffer Substances 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
108010033478 E coli K88 antigen Proteins 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
230000000875 corresponding effect Effects 0.000 description 2
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
231100000249 enterotoxic Toxicity 0.000 description 2
230000002242 enterotoxic effect Effects 0.000 description 2
239000000284 extract Substances 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000002480 mineral oil Substances 0.000 description 2
235000010446 mineral oil Nutrition 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
239000002953 phosphate buffered saline Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
238000012216 screening Methods 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
JDRAOGVAQOVDEB-KTKRTIGZSA-N (3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl) (z)-octadec-9-enoate Chemical compound OC1COC2C(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC21 JDRAOGVAQOVDEB-KTKRTIGZSA-N 0.000 description 1
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
241000220438 Arachis Species 0.000 description 1
235000003911 Arachis Nutrition 0.000 description 1
101710146739 Enterotoxin Proteins 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
239000001263 FEMA 3042 Substances 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
241000449980 Mansa Species 0.000 description 1
102000007474 Multiprotein Complexes Human genes 0.000 description 1
108010085220 Multiprotein Complexes Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241001494479 Pecora Species 0.000 description 1
LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
238000005273 aeration Methods 0.000 description 1
230000004520 agglutination Effects 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
108010079058 casein hydrolysate Proteins 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000000147 enterotoxin Substances 0.000 description 1
231100000655 enterotoxin Toxicity 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000020243 first infant milk formula Nutrition 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000008098 formaldehyde solution Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
239000006916 nutrient agar Substances 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
230000008855 peristalsis Effects 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
229940033123 tannic acid Drugs 0.000 description 1
235000015523 tannic acid Nutrition 0.000 description 1
229920002258 tannic acid Polymers 0.000 description 1
238000004448 titration Methods 0.000 description 1
238000002255 vaccination Methods 0.000 description 1
230000001018 virulence Effects 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
239000002569 water oil cream Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6006—Cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

IE1248/76A 1975-06-12 1976-06-10 Antigenic compositions IE43381B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB25221/75A GB1553664A (en)	1975-06-12	1975-06-12	Antigenic compositions

Publications (2)

Publication Number	Publication Date
IE43381L IE43381L (en)	1976-12-12
IE43381B1 true IE43381B1 (en)	1981-02-11

Family

ID=10224176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1248/76A IE43381B1 (en)	1975-06-12	1976-06-10	Antigenic compositions

Country Status (13)

Country	Link
JP (1)	JPS51151322A (fr)
AU (1)	AU513801B2 (fr)
BE (1)	BE842814A (fr)
CA (1)	CA1061252A (fr)
DE (1)	DE2626350C2 (fr)
DK (1)	DK146312C (fr)
ES (1)	ES448827A1 (fr)
FR (1)	FR2313942A1 (fr)
GB (1)	GB1553664A (fr)
IE (1)	IE43381B1 (fr)
IT (1)	IT1078623B (fr)
NL (1)	NL7606379A (fr)
ZA (1)	ZA763370B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ205392A (en) *	1982-09-02	1987-03-06	Unilever Plc	Preparation of immunoglobulins against e.coli pili
DK219084D0 (da) *	1984-05-02	1984-05-02	Frederik Carl Peter Lindberg	Antigen
IL78775A (en) *	1985-05-15	1992-06-21	Biotech Australia Pty Ltd	Oral vaccines

1975
- 1975-06-12 GB GB25221/75A patent/GB1553664A/en not_active Expired
1976
- 1976-06-07 AU AU14705/76A patent/AU513801B2/en not_active Expired
- 1976-06-07 ZA ZA00763370A patent/ZA763370B/xx unknown
- 1976-06-10 BE BE167812A patent/BE842814A/fr not_active IP Right Cessation
- 1976-06-10 CA CA254,599A patent/CA1061252A/fr not_active Expired
- 1976-06-10 FR FR7617555A patent/FR2313942A1/fr active Granted
- 1976-06-10 IE IE1248/76A patent/IE43381B1/en unknown
- 1976-06-11 ES ES448827A patent/ES448827A1/es not_active Expired
- 1976-06-11 DE DE2626350A patent/DE2626350C2/de not_active Expired
- 1976-06-11 DK DK263076A patent/DK146312C/da not_active IP Right Cessation
- 1976-06-11 JP JP51068603A patent/JPS51151322A/ja active Pending
- 1976-06-14 IT IT68467/76A patent/IT1078623B/it active
- 1976-06-14 NL NL7606379A patent/NL7606379A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA763370B (en)	1978-01-25
DK263076A (da)	1976-12-13
IT1078623B (it)	1985-05-08
ES448827A1 (es)	1977-08-01
FR2313942B1 (fr)	1979-01-12
AU513801B2 (en)	1981-01-08
DE2626350C2 (de)	1984-09-13
FR2313942A1 (fr)	1977-01-07
CA1061252A (fr)	1979-08-28
AU1470576A (en)	1977-12-15
DK146312B (da)	1983-09-05
BE842814A (fr)	1976-12-10
JPS51151322A (en)	1976-12-25
DK146312C (da)	1984-02-20
DE2626350A1 (de)	1977-05-12
NL7606379A (nl)	1976-12-14
IE43381L (en)	1976-12-12
GB1553664A (en)	1979-09-26

Publication	Publication Date	Title
CA2517911C (fr)	2017-06-27	Composition et methode pour le traitement et la prevention d'infections bacteriennes enteriques
Porter et al.	1974	Intestinal antibody secretion in the young pig in response to oral immunization with Escherichia coli
US4136167A (en)	1979-01-23	Process for reducing the incidence of neonatal diarrhoea in pigs
JP2002501526A (ja)	2002-01-15	乳汁における免疫グロブリンａの生成方法
JPH0657663B2 (ja)	1994-08-03	多機能特異的抗体の製造方法
KR100221452B1 (ko)	1999-09-15	장감염에 대한 백신조성물의 제조방법
JPS58146513A (ja)	1983-09-01	鳥感染性気管支炎ワクチン
CA1184115A (fr)	1985-03-19	Vaccins contre la bronchite infectieuse des volailles et procede de preparation
JPH02160726A (ja)	1990-06-20	ワクチン
AU705186B2 (en)	1999-05-20	Multivalent bovine coronavirus vaccine and method of treating bovine coronavirus infection
Rees et al.	1989	Antibody production by the pig colon during infection with Treponema hyodysenteriae
Panigrahy et al.	1979	Antibiotic-induced immunosuppression and levamisole-induced immunopotentiation in turkeys
JP2004137286A (ja)	2004-05-13	腸原生動物のワクチン類
WO2020104640A1 (fr)	2020-05-28	Vaccin pour la protection contre streptococcus suis
Ingram et al.	1965	Immunological responses of young animals. I. Review of the literature
JP3072353B2 (ja)	2000-07-31	胃炎，胃または十二指腸潰瘍予防食品
Roshdy et al.	2020	Reduction of milk contamination with aflatoxin-M1 through vaccination of dairy cattle with aflatoxin-B1 vaccine.
EP0930316B1 (fr)	2004-05-06	Produit oral pour la prévention et le traitement des gastroentérites infectieuses des veaux
RU2043771C1 (ru)	1995-09-20	Вакцина против эшерихиоза животных
NZ199561A (en)	1985-07-12	Vaccine against enzootic abortion in ewes
KR100423983B1 (ko)	2004-03-22	대장균, 살모넬라 엔테라이티디스, 살모넬라 티피뮤리움, 전염성 위장염 바이러스에 대한 특수면역단백질을 공유하는 계란생산방법과 그 생산방법으로 제조된 특수면역단백질을 함유한 계란, 난황, 사료
Gay et al.	1964	Studies on colibacillosis of calves. I. The antibody acquired by calves as the result of vaccination of the dam
CA1061252A (fr)	1979-08-28	Compose antigenique
Tarrant et al.	1965	Serological characteristics and general chemical nature of the in vitro exoantigens of T. cruzi
Brotherston et al.	1970	Development of a non-infective protective antigen against louping-ill (arborirus group B): Laboratory experiments