IE43490L - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- IE43490L IE43490L IE761544A IE154476A IE43490L IE 43490 L IE43490 L IE 43490L IE 761544 A IE761544 A IE 761544A IE 154476 A IE154476 A IE 154476A IE 43490 L IE43490 L IE 43490L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen
- lower alkyl
- formula
- aryl
- compounds
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Indole derivatives of the formula I <IMAGE> and the corresponding acid addition salts and quaternary ammonium salts of these compounds, in which formula R is hydrogen or lower alkyl, R<1> is hydrogen, lower alkyl, aryl-lower alkyl or aroyl, R<2> is hydrogen, lower alkyl or aryl, R<3> is hydrogen, halogen, lower alkoxy, aryl-lower alkoxy, hydroxyl or lower alkyl, R<4> is acyl, A is an alkylene radical or a mono- or diketo or hydroxyalkylene radical having 1 to 5 carbon atoms and X is oxygen or sulphur, are obtained by acylating a corresponding compound of the formula I in which R<4> is hydrogen, and optionally converting the resulting compounds into the quaternary ammonium salts. The compounds of the formula I which can be prepared according to the invention have a pharmacological activity, such as, for example, an action on the cardiovascular system and in particular a hypotensive and/or antihypertensive activity.
[GB1494805A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30001/75A GB1494805A (en) | 1975-07-17 | 1975-07-17 | Indole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43490L true IE43490L (en) | 1977-01-17 |
| IE43490B1 IE43490B1 (en) | 1981-03-11 |
Family
ID=10300645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1544/76A IE43490B1 (en) | 1975-07-17 | 1976-07-13 | Indole derivatives |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5212176A (en) |
| CH (1) | CH622013A5 (en) |
| GB (1) | GB1494805A (en) |
| IE (1) | IE43490B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1586817A (en) * | 1977-12-01 | 1981-03-25 | Wyeth John & Brother Ltd | Indole derivatives |
-
1975
- 1975-07-17 GB GB30001/75A patent/GB1494805A/en not_active Expired
-
1976
- 1976-07-13 IE IE1544/76A patent/IE43490B1/en unknown
- 1976-07-16 JP JP51084878A patent/JPS5212176A/en active Pending
- 1976-07-16 CH CH914476A patent/CH622013A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5212176A (en) | 1977-01-29 |
| GB1494805A (en) | 1977-12-14 |
| CH622013A5 (en) | 1981-03-13 |
| IE43490B1 (en) | 1981-03-11 |
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