IE44103L - Heterocyclic thioalkyl -amines, -guanidines and -thioureas - Google Patents
Heterocyclic thioalkyl -amines, -guanidines and -thioureasInfo
- Publication number
- IE44103L IE44103L IE762363A IE236376A IE44103L IE 44103 L IE44103 L IE 44103L IE 762363 A IE762363 A IE 762363A IE 236376 A IE236376 A IE 236376A IE 44103 L IE44103 L IE 44103L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- thioureas
- guanidines
- amines
- bromo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- RXNZFHIEDZEUQM-UHFFFAOYSA-N 2-bromo-1,3-thiazole Chemical group BrC1=NC=CS1 RXNZFHIEDZEUQM-UHFFFAOYSA-N 0.000 abstract 1
- IMRWILPUOVGIMU-UHFFFAOYSA-N 2-bromopyridine Chemical group BrC1=CC=CC=N1 IMRWILPUOVGIMU-UHFFFAOYSA-N 0.000 abstract 1
- 102000003710 Histamine H2 Receptors Human genes 0.000 abstract 1
- 108090000050 Histamine H2 Receptors Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 230000031018 biological processes and functions Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical group C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds are disclosed which may be represented by the formula: wherein Het1 and Het2 may each be imidazole which may be substituted by methyl or bromo, pyridine which may be substituted with hydroxyl, methoxy, chloro or bromo, thiazole or isothiazole; X is sulphur, NH2, NOH, NCN, or CHNO2; B1 and B2 are lower alkylene groups such that either B1 is (CH2)2 or (CH2)3 and B2 is -CH2CHR-, -CHRCH2-, , or wherein R is methyl or ethyl or B1 and B2 are both selected from and . The compounds are useful in blocking histamine H2-receptors and act to inhibit the biological actions of histamines which are not inhibited by "antihistamines". The compounds find use for example, as inhibitors of gastric acid secretion, as anti-inflammatory agents and as agents which act on the cardiovascular system.
[CA1070316A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB46732/75A GB1573611A (en) | 1975-11-12 | 1975-11-12 | Heterocyclic thioalkyl-amines-guanidines and -thioureas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44103L true IE44103L (en) | 1977-05-12 |
| IE44103B1 IE44103B1 (en) | 1981-08-12 |
Family
ID=10442384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2363/76A IE44103B1 (en) | 1975-11-12 | 1976-10-26 | Heterocyclic thioalkyl-amines,-guanidines and thioureas |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5262274A (en) |
| AT (1) | AT350583B (en) |
| AU (1) | AU508143B2 (en) |
| BE (1) | BE848108A (en) |
| CA (1) | CA1070316A (en) |
| DE (1) | DE2649546A1 (en) |
| DK (1) | DK503176A (en) |
| ES (1) | ES453263A1 (en) |
| FI (1) | FI763209A7 (en) |
| FR (1) | FR2331342A1 (en) |
| GB (1) | GB1573611A (en) |
| HU (1) | HU175667B (en) |
| IE (1) | IE44103B1 (en) |
| IL (1) | IL50748A0 (en) |
| LU (1) | LU76162A1 (en) |
| NL (1) | NL7611590A (en) |
| NO (1) | NO763812L (en) |
| NZ (1) | NZ182309A (en) |
| PT (1) | PT65759B (en) |
| SE (1) | SE7611405L (en) |
| SU (1) | SU634668A3 (en) |
| ZA (1) | ZA766201B (en) |
-
1975
- 1975-11-12 GB GB46732/75A patent/GB1573611A/en not_active Expired
-
1976
- 1976-10-12 NZ NZ182309A patent/NZ182309A/en unknown
- 1976-10-14 SE SE7611405A patent/SE7611405L/en unknown
- 1976-10-18 ZA ZA766201A patent/ZA766201B/en unknown
- 1976-10-19 CA CA263,718A patent/CA1070316A/en not_active Expired
- 1976-10-20 NL NL7611590A patent/NL7611590A/en not_active Application Discontinuation
- 1976-10-21 AU AU18900/76A patent/AU508143B2/en not_active Expired
- 1976-10-22 IL IL50748A patent/IL50748A0/en unknown
- 1976-10-26 PT PT65759A patent/PT65759B/en unknown
- 1976-10-26 IE IE2363/76A patent/IE44103B1/en unknown
- 1976-10-29 DE DE19762649546 patent/DE2649546A1/en not_active Withdrawn
- 1976-11-04 AT AT819776A patent/AT350583B/en active
- 1976-11-08 BE BE172167A patent/BE848108A/en not_active IP Right Cessation
- 1976-11-08 DK DK503176A patent/DK503176A/en not_active Application Discontinuation
- 1976-11-09 NO NO763812A patent/NO763812L/no unknown
- 1976-11-09 FI FI763209A patent/FI763209A7/fi not_active Application Discontinuation
- 1976-11-10 LU LU76162A patent/LU76162A1/xx unknown
- 1976-11-10 FR FR7633962A patent/FR2331342A1/en active Granted
- 1976-11-10 JP JP51135826A patent/JPS5262274A/en active Pending
- 1976-11-11 HU HU76SI1548A patent/HU175667B/en unknown
- 1976-11-11 SU SU762418884A patent/SU634668A3/en active
- 1976-11-12 ES ES453263A patent/ES453263A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA766201B (en) | 1977-09-28 |
| PT65759B (en) | 1978-04-27 |
| FR2331342A1 (en) | 1977-06-10 |
| NO763812L (en) | 1977-05-13 |
| FR2331342B1 (en) | 1980-03-07 |
| PT65759A (en) | 1976-11-01 |
| FI763209A7 (en) | 1977-05-13 |
| NZ182309A (en) | 1978-07-10 |
| DE2649546A1 (en) | 1977-05-26 |
| AT350583B (en) | 1979-06-11 |
| DK503176A (en) | 1977-05-13 |
| AU1890076A (en) | 1978-04-27 |
| BE848108A (en) | 1977-05-09 |
| GB1573611A (en) | 1980-08-28 |
| NL7611590A (en) | 1977-05-16 |
| SU634668A3 (en) | 1978-11-25 |
| SE7611405L (en) | 1977-05-13 |
| ES453263A1 (en) | 1978-01-16 |
| IE44103B1 (en) | 1981-08-12 |
| IL50748A0 (en) | 1976-12-31 |
| JPS5262274A (en) | 1977-05-23 |
| CA1070316A (en) | 1980-01-22 |
| AU508143B2 (en) | 1980-03-13 |
| HU175667B (en) | 1980-09-28 |
| ATA819776A (en) | 1978-11-15 |
| LU76162A1 (en) | 1977-05-18 |
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