IE45082L - Derivatives of pyrimidone and thiopyrimidone - Google Patents
Derivatives of pyrimidone and thiopyrimidoneInfo
- Publication number
- IE45082L IE45082L IE762814A IE281476A IE45082L IE 45082 L IE45082 L IE 45082L IE 762814 A IE762814 A IE 762814A IE 281476 A IE281476 A IE 281476A IE 45082 L IE45082 L IE 45082L
- Authority
- IE
- Ireland
- Prior art keywords
- ring
- optionally substituted
- sulphur
- bromine
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
There is disclosed the preparation of compounds of the formula FORMULA 1 wherein Het is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen(preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridyl ring optionally substituted by lower alkyl (preferably methyl), lower alkoxy (preferably. methoxy), halogen (preferably chlorine or bromine), amino or hydroxy, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3-(1,2,5)-thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2-(5-amino-1,3,4-thiadiazolyl) ring; Y is sulphur or a methylene group; Z is hydrogen or lower alkyl(preferably methyl); X is oxygen or sulphur; W is methylene, oxygen or sulphur: p and q are such that their sum is from 1 to 4 when W is oxygen or sulphur, or from 0 to 4 when W is methylene; Het' is a 5 or 6 membered heterocycle such as pyridine, furan,thiophen, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine or pyridazine,which ring is optionally substituted by lower alkyl, lower alkoxy, or may have a benzene ring or substituted benzene ring fused to it. The compounds have been found to be histamine H2- antagonists and are useful as inhibitors of gastric acid secrection, as antiinflammatory agents and as agents which act on the cardiovascular system.
[CA1073458A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5300175 | 1975-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45082L true IE45082L (en) | 1977-06-29 |
| IE45082B1 IE45082B1 (en) | 1982-06-16 |
Family
ID=10466233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2814/76A IE45082B1 (en) | 1975-12-29 | 1976-12-22 | Derivatives of pyrimidone and thiopyrimidone |
Country Status (37)
| Country | Link |
|---|---|
| JP (1) | JPS5283388A (en) |
| AR (1) | AR222290A1 (en) |
| AT (1) | AT360024B (en) |
| AU (1) | AU508123B2 (en) |
| BE (1) | BE849810A (en) |
| BG (1) | BG29722A3 (en) |
| CA (1) | CA1073458A (en) |
| CH (1) | CH631981A5 (en) |
| CS (1) | CS203995B2 (en) |
| DD (1) | DD128588A5 (en) |
| DE (1) | DE2658267A1 (en) |
| DK (1) | DK587076A (en) |
| EG (1) | EG12439A (en) |
| ES (1) | ES454656A1 (en) |
| FI (1) | FI62668C (en) |
| FR (1) | FR2336935A1 (en) |
| GR (1) | GR62441B (en) |
| HU (1) | HU175171B (en) |
| IE (1) | IE45082B1 (en) |
| IL (1) | IL51040A (en) |
| IT (2) | IT1124740B (en) |
| LU (1) | LU76481A1 (en) |
| MW (1) | MW5076A1 (en) |
| MX (1) | MX5119E (en) |
| NL (1) | NL7614538A (en) |
| NO (1) | NO146396C (en) |
| NZ (1) | NZ182759A (en) |
| OA (1) | OA05526A (en) |
| PH (1) | PH14723A (en) |
| PL (1) | PL104376B1 (en) |
| PT (1) | PT65949B (en) |
| RO (1) | RO72475A (en) |
| SE (1) | SE431544B (en) |
| SU (1) | SU791235A3 (en) |
| YU (1) | YU311676A (en) |
| ZA (1) | ZA767198B (en) |
| ZM (1) | ZM14376A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186511A (en) | 1977-03-19 | 1980-11-14 | Smith Kline French Lab | 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones |
| IL56265A (en) * | 1977-12-28 | 1982-08-31 | Om Lab Sa | Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor |
| US4539207A (en) * | 1978-02-13 | 1985-09-03 | Smith Kline & French Laboratories Limited | Pyrimidine compounds |
| IN151188B (en) * | 1978-02-13 | 1983-03-05 | Smith Kline French Lab | |
| PH16240A (en) * | 1978-04-11 | 1983-08-11 | Smith Kline French Lab | Process for making histamine antagonist |
| ZA792607B (en) * | 1978-05-30 | 1980-07-30 | Smith Kline French Lab | Nitro compounds |
| PT69886A (en) * | 1978-07-15 | 1979-08-01 | Smith Kline French Lab | Process for preparing isoureas and isothioureas |
| US4374836A (en) | 1978-10-16 | 1983-02-22 | Imperial Chemical Industries Ltd. | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them |
| US4309435A (en) | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| US4496567A (en) * | 1978-11-13 | 1985-01-29 | Smith Kline & French Laboratories Limited | Phenyl alkylaminopyrimidones |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
| US4255428A (en) | 1979-03-24 | 1981-03-10 | Smith Kline & French Laboratories Limited | 5-(Hydroxypyridylalkyl)-4-pyrimidones |
| JPS55133379A (en) * | 1979-04-05 | 1980-10-17 | Smith Kline French Lab | Pyrimidone compound |
| EP0017680B1 (en) * | 1979-04-11 | 1982-04-21 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them |
| JPS55145683A (en) * | 1979-04-26 | 1980-11-13 | Smith Kline French Lab | Pyrimidone derivative |
| CA1155842A (en) * | 1980-03-29 | 1983-10-25 | Thomas H. Brown | Compounds |
| ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
| IE53068B1 (en) * | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
| PT75074B (en) * | 1981-06-27 | 1986-02-26 | Smith Kline French Lab | Process for preparing certain pyrimidone derivatives and compositions containing them |
| US6417366B2 (en) * | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| IN146736B (en) * | 1975-10-02 | 1979-08-25 | Smith Kline French Lab |
-
1976
- 1976-11-22 MW MW50/76A patent/MW5076A1/en unknown
- 1976-11-29 NZ NZ182759A patent/NZ182759A/en unknown
- 1976-12-02 ZA ZA767198A patent/ZA767198B/en unknown
- 1976-12-02 IL IL51040A patent/IL51040A/en unknown
- 1976-12-08 CA CA267,385A patent/CA1073458A/en not_active Expired
- 1976-12-09 IT IT30235/76A patent/IT1124740B/en active
- 1976-12-10 PT PT65949A patent/PT65949B/en unknown
- 1976-12-17 PH PH19265A patent/PH14723A/en unknown
- 1976-12-17 ZM ZM143/76A patent/ZM14376A1/en unknown
- 1976-12-21 FI FI763664A patent/FI62668C/en not_active IP Right Cessation
- 1976-12-22 GR GR52462A patent/GR62441B/en unknown
- 1976-12-22 DE DE19762658267 patent/DE2658267A1/en not_active Ceased
- 1976-12-22 IE IE2814/76A patent/IE45082B1/en unknown
- 1976-12-22 YU YU03116/76A patent/YU311676A/en unknown
- 1976-12-23 AT AT960876A patent/AT360024B/en not_active IP Right Cessation
- 1976-12-23 CH CH1627876A patent/CH631981A5/en not_active IP Right Cessation
- 1976-12-23 BE BE173597A patent/BE849810A/en not_active IP Right Cessation
- 1976-12-23 JP JP15611076A patent/JPS5283388A/en active Granted
- 1976-12-27 RO RO7688851A patent/RO72475A/en unknown
- 1976-12-28 PL PL1976194772A patent/PL104376B1/en unknown
- 1976-12-28 EG EG803/76A patent/EG12439A/en active
- 1976-12-28 NO NO764370A patent/NO146396C/en unknown
- 1976-12-28 BG BG035033A patent/BG29722A3/en unknown
- 1976-12-28 LU LU76481A patent/LU76481A1/xx unknown
- 1976-12-28 HU HU76SI1556A patent/HU175171B/en unknown
- 1976-12-28 SE SE7614620A patent/SE431544B/en not_active IP Right Cessation
- 1976-12-29 CS CS768760A patent/CS203995B2/en unknown
- 1976-12-29 ES ES454656A patent/ES454656A1/en not_active Expired
- 1976-12-29 OA OA56028A patent/OA05526A/en unknown
- 1976-12-29 DK DK587076A patent/DK587076A/en not_active Application Discontinuation
- 1976-12-29 DD DD7600196703A patent/DD128588A5/en unknown
- 1976-12-29 SU SU762434655A patent/SU791235A3/en active
- 1976-12-29 FR FR7639465A patent/FR2336935A1/en active Granted
- 1976-12-29 NL NL7614538A patent/NL7614538A/en not_active Application Discontinuation
- 1976-12-29 AR AR266049A patent/AR222290A1/en active
- 1976-12-30 AU AU20976/76A patent/AU508123B2/en not_active Expired
-
1977
- 1977-01-03 MX MX775273U patent/MX5119E/en unknown
-
1979
- 1979-01-05 IT IT7919107A patent/IT7919107A0/en unknown
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