IE45460L - Propanediol derivative. - Google Patents
Propanediol derivative.Info
- Publication number
- IE45460L IE45460L IE771643A IE164377A IE45460L IE 45460 L IE45460 L IE 45460L IE 771643 A IE771643 A IE 771643A IE 164377 A IE164377 A IE 164377A IE 45460 L IE45460 L IE 45460L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- ch3o2s
- formula
- stands
- denotes
- Prior art date
Links
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229960002449 glycine Drugs 0.000 abstract 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 methylmercapto compound Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The compounds of the annexed formula <IMAGE> in which R stands for CH3S- or CH3O2S- and R1 stands for hydrogen or, if R denotes CH3O2S-, for an acyl radical of an aliphatic carboxylic acid having 15-17 C atoms or aminoacetic acid, are prepared by reaction of a compound of the annexed formula <IMAGE> with free trifluoroacetic acid or a functional derivative thereof. The corresponding esters, if R stands for CH3O2S-, are obtained by subsequent esterification to give the corresponding compound in which R1 is an acyl radical. The compound of the formula Ia in which R denotes CH3O2S and R1 denotes hydrogen is also prepared by oxidation of the corresponding methylmercapto compound using a peroxide compound. The esters of aminoacetic acid of the formula Ia can be converted into the corresponding therapeutically utilisable acid addition salts. The compounds obtained show a broad antibiotic spectrum of action and are highly suitable for use in human medicine.
[GB1534387A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT26042/76A IT1065143B (en) | 1976-08-05 | 1976-08-05 | D-TREO-1-FENYL-2-TRIFLUOROACETAMIDO-1,3-PROPANDIOL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45460L true IE45460L (en) | 1978-02-05 |
| IE45460B1 IE45460B1 (en) | 1982-08-25 |
Family
ID=11218484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1643/77A IE45460B1 (en) | 1976-08-05 | 1977-08-05 | D-threo-1-phenyl-2-trifluoroacetmido-1-3-propanediol derivatives |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5321135A (en) |
| AT (1) | AT351018B (en) |
| AU (1) | AU509278B2 (en) |
| BE (1) | BE857543A (en) |
| CA (1) | CA1087207A (en) |
| CH (1) | CH609338A5 (en) |
| DE (1) | DE2735431A1 (en) |
| ES (1) | ES461093A1 (en) |
| FR (1) | FR2360560A1 (en) |
| GB (1) | GB1534387A (en) |
| HU (1) | HU173169B (en) |
| IE (1) | IE45460B1 (en) |
| IT (1) | IT1065143B (en) |
| NL (1) | NL7708695A (en) |
| PT (1) | PT66889B (en) |
| YU (1) | YU40678B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5977276A (en) * | 1982-10-27 | 1984-05-02 | 松下冷機株式会社 | Ice machine |
| EP0677511A3 (en) | 1983-06-02 | 1996-07-24 | Zambon Spa | Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives. |
| IT1317836B1 (en) * | 2000-02-16 | 2003-07-15 | Zambon Spa | USE OF TIAMFENICOLO FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL FOR THE TREATMENT OF STAPHYLOCOCCI INFECTIONS |
-
1976
- 1976-08-05 IT IT26042/76A patent/IT1065143B/en active
-
1977
- 1977-07-18 YU YU1779/77A patent/YU40678B/en unknown
- 1977-07-28 ES ES461093A patent/ES461093A1/en not_active Expired
- 1977-08-04 PT PT66889A patent/PT66889B/en unknown
- 1977-08-04 CH CH959077A patent/CH609338A5/en not_active IP Right Cessation
- 1977-08-05 AU AU27655/77A patent/AU509278B2/en not_active Expired
- 1977-08-05 CA CA284,228A patent/CA1087207A/en not_active Expired
- 1977-08-05 NL NL7708695A patent/NL7708695A/en not_active Application Discontinuation
- 1977-08-05 DE DE19772735431 patent/DE2735431A1/en not_active Withdrawn
- 1977-08-05 HU HU77CE1140A patent/HU173169B/en unknown
- 1977-08-05 JP JP9345877A patent/JPS5321135A/en active Pending
- 1977-08-05 BE BE179956A patent/BE857543A/en not_active IP Right Cessation
- 1977-08-05 IE IE1643/77A patent/IE45460B1/en unknown
- 1977-08-05 AT AT577177A patent/AT351018B/en not_active IP Right Cessation
- 1977-08-05 GB GB32845/77A patent/GB1534387A/en not_active Expired
- 1977-08-05 FR FR7724168A patent/FR2360560A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU509278B2 (en) | 1980-05-01 |
| GB1534387A (en) | 1978-12-06 |
| HU173169B (en) | 1979-03-28 |
| BE857543A (en) | 1977-12-01 |
| PT66889B (en) | 1979-01-25 |
| ES461093A1 (en) | 1978-06-16 |
| IT1065143B (en) | 1985-02-25 |
| YU40678B (en) | 1986-04-30 |
| JPS5321135A (en) | 1978-02-27 |
| FR2360560A1 (en) | 1978-03-03 |
| DE2735431A1 (en) | 1978-02-09 |
| AT351018B (en) | 1979-07-10 |
| AU2765577A (en) | 1979-02-08 |
| YU177977A (en) | 1982-10-31 |
| PT66889A (en) | 1977-09-01 |
| FR2360560B1 (en) | 1981-02-06 |
| NL7708695A (en) | 1978-02-07 |
| IE45460B1 (en) | 1982-08-25 |
| ATA577177A (en) | 1978-12-15 |
| CA1087207A (en) | 1980-10-07 |
| CH609338A5 (en) | 1979-02-28 |
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