IE46001L - Process for the manufacture of 5-methyl isoxazole-4-¹carboxylic acid anilide derivatives - Google Patents
Process for the manufacture of 5-methyl isoxazole-4-¹carboxylic acid anilide derivativesInfo
- Publication number
- IE46001L IE46001L IE245377A IE245377A IE46001L IE 46001 L IE46001 L IE 46001L IE 245377 A IE245377 A IE 245377A IE 245377 A IE245377 A IE 245377A IE 46001 L IE46001 L IE 46001L
- Authority
- IE
- Ireland
- Prior art keywords
- manufacture
- acid anilide
- methyl isoxazole
- anilide derivatives
- methylisoxazole
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000003931 anilides Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- VQBXUKGMJCPBMF-UHFFFAOYSA-N 5-methyl-1,2-oxazole-4-carboxylic acid Chemical class CC=1ON=CC=1C(O)=O VQBXUKGMJCPBMF-UHFFFAOYSA-N 0.000 abstract 1
- ZYEWRBNSDKQNSJ-UHFFFAOYSA-N 5-methyl-n-phenyl-1,2-oxazole-4-carboxamide Chemical class O1N=CC(C(=O)NC=2C=CC=CC=2)=C1C ZYEWRBNSDKQNSJ-UHFFFAOYSA-N 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparation of novel 5-methylisoxazole-4-carboxanilides of the formula I <IMAGE> in which the individual symbols have the meaning given in Patent Claim 1, by reaction of a 5-methylisoxazole-4-carboxylic acid derivative with an appropriately substituted aniline. The compounds of the formula I are pharmacologically active. They exhibit potent anti-inflammatory and analgesic action.
[GB1572309A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762654797 DE2654797A1 (en) | 1976-12-03 | 1976-12-03 | PROCESS FOR THE PREPARATION OF ISOXAZOLE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE46001L true IE46001L (en) | 1978-06-03 |
| IE46001B1 IE46001B1 (en) | 1983-01-26 |
Family
ID=5994582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE245377A IE46001B1 (en) | 1976-12-03 | 1977-12-02 | Process for the manufacture of 5-methyl isoxazole-4-carboxylic acid anilide derivatives |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5371068A (en) |
| AT (1) | AT361917B (en) |
| BE (1) | BE861500R (en) |
| CA (1) | CA1095056A (en) |
| CH (1) | CH609341A5 (en) |
| DE (1) | DE2654797A1 (en) |
| DK (1) | DK538777A (en) |
| ES (1) | ES464533A2 (en) |
| FR (1) | FR2381756A2 (en) |
| GB (1) | GB1572309A (en) |
| IE (1) | IE46001B1 (en) |
| IT (1) | IT1089430B (en) |
| LU (1) | LU78614A1 (en) |
| NL (1) | NL7713083A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000964A1 (en) * | 1978-11-03 | 1980-05-15 | American Cyanamid Co | Anti-inflammatory agents including 2-carbonyl-3-hydroxy-2-alkenonitriles |
| EP0035285A3 (en) * | 1979-08-17 | 1981-10-14 | American Cyanamid Company | Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters |
| DE2854438A1 (en) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | ISOXAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING THESE COMPOUNDS AND THEIR USE |
| DE2854439A1 (en) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | AN ISOXAZOLE DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, AGENT AND USE THEREOF |
| EP0021207B1 (en) * | 1979-06-11 | 1985-08-07 | Ciba-Geigy Ag | Alphacarbamoyl-pyrrolpropionitriles, process for their preparation and pharmaceutical preparations containing them |
| DE3247454A1 (en) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituted 3-phenyl-5-methylisoxazole-4-carboxanilides, process for their preparation and pharmaceutical compositions containing these compounds |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178596C (en) * | 1975-06-05 | 1986-04-16 | Hoechst Ag | METHOD FOR PREPARING A MEDICINAL PRODUCT WITH ANTIFLOGISTIC AND / OR ANALGETIC ACTION, AND A METHOD FOR PREPARING THEIR PRODUCT TO BE USED AS MEDICINAL COMPOUNDS 5-METHYLISOXAZOLE-4-CARBONIC ACID. |
| DE2525023A1 (en) * | 1975-06-05 | 1976-12-16 | Hoechst Ag | N-Halophenyl isoxazole-4-carboxamides - are fungicides useful in plant protection |
-
1976
- 1976-12-03 DE DE19762654797 patent/DE2654797A1/en not_active Withdrawn
-
1977
- 1977-11-15 CH CH1393277A patent/CH609341A5/en not_active IP Right Cessation
- 1977-11-28 ES ES464533A patent/ES464533A2/en not_active Expired
- 1977-11-28 NL NL7713083A patent/NL7713083A/en not_active Application Discontinuation
- 1977-12-01 LU LU78614A patent/LU78614A1/xx unknown
- 1977-12-01 IT IT3028677A patent/IT1089430B/en active
- 1977-12-02 FR FR7736424A patent/FR2381756A2/en active Granted
- 1977-12-02 AT AT866177A patent/AT361917B/en not_active IP Right Cessation
- 1977-12-02 DK DK538777A patent/DK538777A/en not_active Application Discontinuation
- 1977-12-02 CA CA292,253A patent/CA1095056A/en not_active Expired
- 1977-12-02 IE IE245377A patent/IE46001B1/en unknown
- 1977-12-02 GB GB5034277A patent/GB1572309A/en not_active Expired
- 1977-12-03 JP JP14561977A patent/JPS5371068A/en active Pending
- 1977-12-05 BE BE183167A patent/BE861500R/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2381756B2 (en) | 1982-10-29 |
| AT361917B (en) | 1981-04-10 |
| NL7713083A (en) | 1978-06-06 |
| GB1572309A (en) | 1980-07-30 |
| CA1095056A (en) | 1981-02-03 |
| CH609341A5 (en) | 1979-02-28 |
| LU78614A1 (en) | 1978-07-14 |
| FR2381756A2 (en) | 1978-09-22 |
| DK538777A (en) | 1978-06-04 |
| DE2654797A1 (en) | 1978-06-08 |
| ATA866177A (en) | 1980-09-15 |
| JPS5371068A (en) | 1978-06-24 |
| IT1089430B (en) | 1985-06-18 |
| BE861500R (en) | 1978-06-05 |
| ES464533A2 (en) | 1979-10-16 |
| IE46001B1 (en) | 1983-01-26 |
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