IE48627B1 - Injectable composition for the treatment,of helminthiasis and clostridial diseases in animals - Google Patents

Injectable composition for the treatment,of helminthiasis and clostridial diseases in animals

Info

Publication number: IE48627B1
Authority: IE; Ireland
Prior art keywords: clostridium; tetramisole; composition; salt; vaccine
Prior art date: 1978-09-11

Application number

IE163979A

Other languages

English (en)

Other versions

IE791639L (en

Original Assignee

Ici Tasman Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-11

Filing date

1979-08-28

Publication date

1985-04-03

1979-08-28 Application filed by Ici Tasman Ltd filed Critical Ici Tasman Ltd

1980-03-11 Publication of IE791639L publication Critical patent/IE791639L/xx

1985-04-03 Publication of IE48627B1 publication Critical patent/IE48627B1/en

Links

241001112695 Clostridiales Species 0.000 title claims abstract description 27
201000010099 disease Diseases 0.000 title claims abstract description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 18
208000006968 Helminthiasis Diseases 0.000 title claims abstract description 6
208000014837 parasitic helminthiasis infectious disease Diseases 0.000 title claims abstract description 6
241001465754 Metazoa Species 0.000 title claims description 28
238000011282 treatment Methods 0.000 title abstract description 11
239000007972 injectable composition Substances 0.000 title abstract description 10
239000000203 mixture Substances 0.000 claims abstract description 98
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims abstract description 64
229960005486 vaccine Drugs 0.000 claims abstract description 62
229960001614 levamisole Drugs 0.000 claims abstract description 33
241001494479 Pecora Species 0.000 claims abstract description 25
241000283690 Bos taurus Species 0.000 claims abstract description 14
241000193403 Clostridium Species 0.000 claims description 19
238000000034 method Methods 0.000 claims description 18
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 17
239000000427 antigen Substances 0.000 claims description 13
102000036639 antigens Human genes 0.000 claims description 13
108091007433 antigens Proteins 0.000 claims description 13
238000002347 injection Methods 0.000 claims description 13
239000007924 injection Substances 0.000 claims description 13
241000186581 Clostridium novyi Species 0.000 claims description 11
241000206044 Clostridium chauvoei Species 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 10
241000193466 Clostridium septicum Species 0.000 claims description 9
241000193449 Clostridium tetani Species 0.000 claims description 9
238000010254 subcutaneous injection Methods 0.000 claims description 9
239000007929 subcutaneous injection Substances 0.000 claims description 9
229910000147 aluminium phosphate Chemical class 0.000 claims description 8
239000000243 solution Substances 0.000 claims description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
239000003755 preservative agent Substances 0.000 claims description 4
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical class NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 claims description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
238000007911 parenteral administration Methods 0.000 claims description 3
159000000000 sodium salts Chemical class 0.000 claims description 3
239000011975 tartaric acid Chemical class 0.000 claims description 3
235000002906 tartaric acid Nutrition 0.000 claims description 3
229940095064 tartrate Drugs 0.000 claims description 3
229940124597 therapeutic agent Drugs 0.000 claims description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
241001112696 Clostridia Species 0.000 claims description 2
230000002378 acidificating effect Effects 0.000 claims description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
239000012646 vaccine adjuvant Substances 0.000 claims description 2
229940124931 vaccine adjuvant Drugs 0.000 claims description 2
239000012458 free base Substances 0.000 description 12
244000045947 parasite Species 0.000 description 11
230000001147 anti-toxic effect Effects 0.000 description 10
210000002966 serum Anatomy 0.000 description 9
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 7
238000009472 formulation Methods 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
206010043376 Tetanus Diseases 0.000 description 6
239000002253 acid Substances 0.000 description 6
239000002671 adjuvant Substances 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
235000019687 Lamb Nutrition 0.000 description 5
230000000507 anthelmentic effect Effects 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 5
208000001848 dysentery Diseases 0.000 description 5
210000003734 kidney Anatomy 0.000 description 5
241000193468 Clostridium perfringens Species 0.000 description 4
241000283973 Oryctolagus cuniculus Species 0.000 description 4
230000002411 adverse Effects 0.000 description 4
238000003556 assay Methods 0.000 description 4
230000003211 malignant effect Effects 0.000 description 4
229940124856 vaccine component Drugs 0.000 description 4
239000000654 additive Substances 0.000 description 3
150000001450 anions Chemical class 0.000 description 3
239000013011 aqueous formulation Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000037396 body weight Effects 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
-1 tetramisole dihydrogen phosphate salt Chemical class 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
IJFXRHURBJZNAO-UHFFFAOYSA-N 3-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC(O)=C1 IJFXRHURBJZNAO-UHFFFAOYSA-N 0.000 description 2
244000309714 Clostridium perfringens type C Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
206010030113 Oedema Diseases 0.000 description 2
241000243795 Ostertagia Species 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
206010040047 Sepsis Diseases 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
241000243797 Trichostrongylus Species 0.000 description 2
MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 2
210000003165 abomasum Anatomy 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
239000002585 base Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
244000000013 helminth Species 0.000 description 2
230000007062 hydrolysis Effects 0.000 description 2
238000006460 hydrolysis reaction Methods 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
230000002265 prevention Effects 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
238000002255 vaccination Methods 0.000 description 2
239000005711 Benzoic acid Substances 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000722721 Capparis Species 0.000 description 1
235000017336 Capparis spinosa Nutrition 0.000 description 1
241000893172 Chabertia Species 0.000 description 1
241001126267 Cooperia oncophora Species 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
241001147667 Dictyocaulus Species 0.000 description 1
241000243976 Haemonchus Species 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical compound Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 description 1
241000243789 Metastrongyloidea Species 0.000 description 1
208000000291 Nematode infections Diseases 0.000 description 1
241001137882 Nematodirus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
208000030852 Parasitic disease Diseases 0.000 description 1
102000007327 Protamines Human genes 0.000 description 1
108010007568 Protamines Proteins 0.000 description 1
241000282849 Ruminantia Species 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
241000122945 Trichostrongylus axei Species 0.000 description 1
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
229940001007 aluminium phosphate Drugs 0.000 description 1
235000011126 aluminium potassium sulphate Nutrition 0.000 description 1
238000010171 animal model Methods 0.000 description 1
229940124339 anthelmintic agent Drugs 0.000 description 1
239000000921 anthelmintic agent Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000003795 desorption Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000002070 germicidal effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
229960004068 hexachlorophene Drugs 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229940102223 injectable solution Drugs 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
229940031348 multivalent vaccine Drugs 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229940050271 potassium alum Drugs 0.000 description 1
GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229940048914 protamine Drugs 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
239000001397 quillaja saponaria molina bark Substances 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
208000024877 white muscle disease Diseases 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

IE163979A 1978-09-11 1979-08-28 Injectable composition for the treatment,of helminthiasis and clostridial diseases in animals IE48627B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPD589878		1978-09-11
AUPD680378		1978-11-16

Publications (2)

Publication Number	Publication Date
IE791639L IE791639L (en)	1980-03-11
IE48627B1 true IE48627B1 (en)	1985-04-03

Family

ID=25642248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE163979A IE48627B1 (en)	1978-09-11	1979-08-28	Injectable composition for the treatment,of helminthiasis and clostridial diseases in animals

Country Status (5)

Country	Link
BE (1)	BE878703A (fr)
FR (1)	FR2435252A1 (fr)
GB (1)	GB2030043B (fr)
IE (1)	IE48627B1 (fr)
NZ (1)	NZ191413A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3241113A1 (de) *	1982-11-06	1984-05-10	Bayer Ag, 5090 Leverkusen	Vakzinen mit zuschlagstoffen
US4781920A (en) *	1984-11-13	1988-11-01	American Cyanamid Company	Anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
ATE252316T1 (de) *	1996-06-05	2003-11-15	Ashmont Holdings Ltd	Injizierbare zusammensetzungen
CN1293918C (zh) *	2003-03-13	2007-01-10	山东农业大学	魏氏梭菌类毒素疫苗和抗毒素血清制备方法
NZ574018A (en) *	2008-12-24	2011-03-31	Bomac Research Ltd	Clostridial vaccine comprising levamisole
US8313752B2 (en)	2009-04-14	2012-11-20	Merial Limited	Macrocyclic lactone combination compositions, vaccines and methods for producing same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB958564A (en) *	1959-11-23	1964-05-21	Wellcome Found	Vaccines containing clostridium perfringens ª-toxoid
GB1024369A (en) *	1963-08-12	1966-03-30	Internat Serum Company Ltd	Antiserum preparations
GB1143545A (en) *	1965-03-25	1969-02-26	Wellcome Found	Injectable vaccine emulsions
US3639577A (en) *	1968-02-23	1972-02-01	Haver Lockhart Lab Inc	Injectable adjuvant,method of preparing same and compositions including such adjuvant
AU440746B2 (en) *	1970-06-25	1972-01-06	Ici Australia Limited	Injectable solutions of l tetramisole salts
AU450030B2 (en) *	1970-06-25	1974-06-12	Ici Australia Limited	Injectable solutions of l-tetramisole salts
US3956488A (en) *	1973-09-27	1976-05-11	Merck & Co., Inc.	Compositions and methods for the treatment of helminthiasis

1979
- 1979-08-28 NZ NZ19141379A patent/NZ191413A/xx unknown
- 1979-08-28 IE IE163979A patent/IE48627B1/en not_active IP Right Cessation
- 1979-08-31 GB GB7930236A patent/GB2030043B/en not_active Expired
- 1979-09-10 FR FR7922598A patent/FR2435252A1/fr active Granted
- 1979-09-10 BE BE0/197087A patent/BE878703A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE791639L (en)	1980-03-11
GB2030043A (en)	1980-04-02
FR2435252B1 (fr)	1983-04-29
NZ191413A (en)	1981-10-19
FR2435252A1 (fr)	1980-04-04
BE878703A (fr)	1980-03-10
GB2030043B (en)	1983-02-23

Legal Events

Date	Code	Title	Description
1996-05-15	MM4A	Patent lapsed

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