IE57804B1 - Triazole antifungal agents - Google Patents

Triazole antifungal agents

Info

Publication number: IE57804B1
Authority: IE; Ireland
Prior art keywords: formula; compound; ether; ester; compounds
Prior art date: 1984-06-07

Application number

IE1416/85A

Other languages

English (en)

Other versions

IE851416L (en

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-07

Filing date

1985-06-06

Publication date

1993-04-07

1985-06-06 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1985-12-07 Publication of IE851416L publication Critical patent/IE851416L/en

1993-04-07 Publication of IE57804B1 publication Critical patent/IE57804B1/en

Links

229940121375 antifungal agent Drugs 0.000 title description 5
239000003429 antifungal agent Substances 0.000 title description 2
150000003852 triazoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 64
150000003839 salts Chemical class 0.000 claims abstract description 26
-1 5-chloropyrid-2-yl group Chemical group 0.000 claims abstract description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 9
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238000000034 method Methods 0.000 claims description 16
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125000000217 alkyl group Chemical group 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 8
206010017533 Fungal infection Diseases 0.000 claims description 7
208000031888 Mycoses Diseases 0.000 claims description 7
125000001424 substituent group Chemical group 0.000 claims description 6
239000003085 diluting agent Substances 0.000 claims description 5
125000005843 halogen group Chemical group 0.000 claims description 5
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 4
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 3
125000003545 alkoxy group Chemical group 0.000 claims description 3
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SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical class N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 claims description 2
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239000011734 sodium Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000002689 soil Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000001665 trituration Methods 0.000 description 1
229940045860 white wax Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Epoxy Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

IE1416/85A 1984-06-07 1985-06-06 Triazole antifungal agents IE57804B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848414519A GB8414519D0 (en)	1984-06-07	1984-06-07	Triazole antifungal agents

Publications (2)

Publication Number	Publication Date
IE851416L IE851416L (en)	1985-12-07
IE57804B1 true IE57804B1 (en)	1993-04-07

Family

ID=10562061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1416/85A IE57804B1 (en)	1984-06-07	1985-06-06	Triazole antifungal agents

Country Status (25)

Country	Link
US (1)	US4618616A (2)
EP (1)	EP0164246B1 (2)
JP (1)	JPS611672A (2)
KR (1)	KR870001829B1 (2)
CN (1)	CN85104471B (2)
AT (1)	ATE36328T1 (2)
AU (1)	AU554476B2 (2)
CA (1)	CA1287059C (2)
DD (1)	DD235641A5 (2)
DE (1)	DE3564266D1 (2)
DK (1)	DK170301B1 (2)
ES (1)	ES8604170A1 (2)
FI (1)	FI86176C (2)
GB (1)	GB8414519D0 (2)
GR (1)	GR851382B (2)
HU (1)	HU195647B (2)
IE (1)	IE57804B1 (2)
IL (1)	IL75410A (2)
NO (1)	NO852287L (2)
NZ (1)	NZ212317A (2)
PH (1)	PH22870A (2)
PL (1)	PL144920B1 (2)
PT (1)	PT80598B (2)
YU (1)	YU94985A (2)
ZA (1)	ZA854250B (2)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3440117A1 (de) *	1984-11-02	1986-05-15	Bayer Ag, 5090 Leverkusen	Substituierte azolylcyclopropyl-azolylmethyl-carbinol-derivate
EP0180850A3 (de) *	1984-11-02	1987-05-27	Bayer Ag	Antimykotische Azolylmethyl-cyclopropyl-carbinol Derivate
DE3440114A1 (de) *	1984-11-02	1986-05-07	Bayer Ag, 5090 Leverkusen	Antimykotische mittel
GB8429932D0 (en) *	1984-11-27	1985-01-03	Pfizer Ltd	Triazole antifungal agents
DE3608792A1 (de) *	1986-03-15	1987-09-24	Hoechst Ag	1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3608727A1 (de) *	1986-03-15	1987-09-17	Hoechst Ag	1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung sowie ihre verwendung als antimykotika oder als zwischenprodukte
DE3837463A1 (de) *	1988-11-04	1990-05-10	Bayer Ag	Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3921162A1 (de) *	1989-06-28	1991-01-10	Bayer Ag	Verwendung von substituierten bis-azolyl-derivaten zur bekaempfung von pilzen im pflanzenschutz
US5247094A (en) *	1990-01-24	1993-09-21	Bayer Aktiengesellschaft	1-(3- or 5-halo-1,2,4-triazol-1-yl)ethyl phenyl ketone intermediates
US5039676A (en) *	1990-05-11	1991-08-13	Schering Corporation	Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US5488035A (en) *	1991-12-06	1996-01-30	Pioneer Hi-Bred International, Inc.	Peptide with inhibitory activity towards plant pathogenic fungi
JPH06340636A (ja) *	1993-05-31	1994-12-13	Ss Pharmaceut Co Ltd	トリアゾール誘導体又はその塩、及びこれを含有する抗真菌剤
RU2141955C1 (ru) *	1997-06-04	1999-11-27	Санкт-Петербургский государственный университет технологии и дизайна	Способ получения бис-1,2-(1,2,4-триазол-1-ил)этана
EP2951167B1 (en)	2013-02-04	2017-01-25	Syngenta Participations AG	Novel microbiocides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0051565A1 (de) *	1980-11-03	1982-05-12	Ciba-Geigy Ag	1-N,N-Dimethylcarbamoyl-3(5)-cyclopropyl-1,2,4-triazole, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung
DE3337937A1 (de) *	1982-10-28	1984-05-03	Sandoz-Patent-GmbH, 7850 Lörrach	Neue azolderivate
GB8302500D0 (en) *	1983-01-29	1983-03-02	Pfizer Ltd	Antifungal agents
DE3305834A1 (de) *	1983-02-19	1984-08-23	Bayer Ag, 5090 Leverkusen	Mikrobizides mittel zum schutz technischer mineralien
EP0180850A3 (de) *	1984-11-02	1987-05-27	Bayer Ag	Antimykotische Azolylmethyl-cyclopropyl-carbinol Derivate
DE3440114A1 (de) *	1984-11-02	1986-05-07	Bayer Ag, 5090 Leverkusen	Antimykotische mittel
GB8429932D0 (en) *	1984-11-27	1985-01-03	Pfizer Ltd	Triazole antifungal agents

1984
- 1984-06-07 GB GB848414519A patent/GB8414519D0/en active Pending
1985
- 1985-05-24 US US06/738,143 patent/US4618616A/en not_active Expired - Fee Related
- 1985-05-28 PL PL1985253666A patent/PL144920B1/pl unknown
- 1985-05-29 EP EP85303764A patent/EP0164246B1/en not_active Expired
- 1985-05-29 DE DE8585303764T patent/DE3564266D1/de not_active Expired
- 1985-05-29 AT AT85303764T patent/ATE36328T1/de not_active IP Right Cessation
- 1985-05-31 JP JP60118701A patent/JPS611672A/ja active Granted
- 1985-06-03 FI FI852223A patent/FI86176C/fi not_active IP Right Cessation
- 1985-06-05 CA CA000483188A patent/CA1287059C/en not_active Expired - Lifetime
- 1985-06-05 PH PH32370A patent/PH22870A/en unknown
- 1985-06-05 DD DD85277055A patent/DD235641A5/de unknown
- 1985-06-05 IL IL75410A patent/IL75410A/xx unknown
- 1985-06-05 KR KR1019850003935A patent/KR870001829B1/ko not_active Expired
- 1985-06-05 PT PT80598A patent/PT80598B/pt not_active IP Right Cessation
- 1985-06-05 NZ NZ212317A patent/NZ212317A/en unknown
- 1985-06-05 ZA ZA854250A patent/ZA854250B/xx unknown
- 1985-06-06 NO NO852287A patent/NO852287L/no unknown
- 1985-06-06 DK DK253685A patent/DK170301B1/da not_active IP Right Cessation
- 1985-06-06 HU HU852247A patent/HU195647B/hu unknown
- 1985-06-06 GR GR851382A patent/GR851382B/el unknown
- 1985-06-06 AU AU43348/85A patent/AU554476B2/en not_active Ceased
- 1985-06-06 YU YU00949/85A patent/YU94985A/xx unknown
- 1985-06-06 IE IE1416/85A patent/IE57804B1/en unknown
- 1985-06-07 ES ES543998A patent/ES8604170A1/es not_active Expired
- 1985-06-11 CN CN85104471A patent/CN85104471B/zh not_active Expired

Also Published As

Publication number	Publication date
DK253685A (da)	1985-12-08
AU4334885A (en)	1985-12-12
JPS611672A (ja)	1986-01-07
IL75410A (en)	1989-02-28
DK253685D0 (da)	1985-06-06
YU94985A (en)	1987-10-31
EP0164246A3 (en)	1987-01-28
CN85104471B (zh)	1987-10-21
IE851416L (en)	1985-12-07
HU195647B (en)	1988-06-28
HUT38326A (en)	1986-05-28
FI852223L (fi)	1985-12-08
PL253666A1 (en)	1986-06-17
CA1287059C (en)	1991-07-30
EP0164246A2 (en)	1985-12-11
DE3564266D1 (en)	1988-09-15
FI86176B (fi)	1992-04-15
DD235641A5 (de)	1986-05-14
AU554476B2 (en)	1986-08-21
PT80598A (en)	1985-07-01
JPH0521108B2 (2)	1993-03-23
DK170301B1 (da)	1995-07-31
US4618616A (en)	1986-10-21
PH22870A (en)	1989-01-19
GR851382B (2)	1985-11-25
PT80598B (en)	1987-04-23
FI86176C (fi)	1992-07-27
ES543998A0 (es)	1986-01-16
FI852223A0 (fi)	1985-06-03
KR870001829B1 (ko)	1987-10-15
EP0164246B1 (en)	1988-08-10
NO852287L (no)	1985-12-09
PL144920B1 (en)	1988-07-30
ATE36328T1 (de)	1988-08-15
ES8604170A1 (es)	1986-01-16
CN85104471A (zh)	1986-12-10
NZ212317A (en)	1988-04-29
GB8414519D0 (en)	1984-07-11
KR860000288A (ko)	1986-01-27
ZA854250B (en)	1987-01-28

Publication	Publication Date	Title
US4616027A (en)	1986-10-07	Antifungal 1-aryl-1-fluoroalkyl-2-(1H-1,2,4-triazol-1-yl)ethanols
EP0096569A2 (en)	1983-12-21	Triazole antifungal agents
EP0164246B1 (en)	1988-08-10	Triazole antifungal agents
US4960782A (en)	1990-10-02	Triazole antifungal agents
EP0183494B1 (en)	1989-01-11	Triazole antifungal agents
NZ207509A (en)	1986-07-11	Triazole derivatives;antifungal agents
CA1270836A (en)	1990-06-26	Triazole antifungal agents
US4518604A (en)	1985-05-21	Antifungal 1-aryl-2-(1H-1,2,4-triazol-1yl)-1-perfluoroalkylethyl halides
EP0110570B1 (en)	1988-02-03	Triazole antifungal agents
US4554286A (en)	1985-11-19	Antifungal 1-triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-2-ol derivatives
US4992454A (en)	1991-02-12	Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
EP0133805B1 (en)	1988-09-21	Triazole antifungal agents
EP0153803A2 (en)	1985-09-04	Triazole antifungal agents