IE61860B1 - Improvement to an intraruminal delivery device - Google Patents

Improvement to an intraruminal delivery device

Info

Publication number: IE61860B1
Authority: IE; Ireland
Prior art keywords: active principle; matrix; active; release; duct
Prior art date: 1986-06-09

Application number

IE145887A

Other languages

English (en)

Other versions

IE871458L (en

Inventor

Guy Derrieu

Frederick-Michel Ascher

Jacques Cuvelier

Original Assignee

Vibrac S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-09

Filing date

1987-06-03

Publication date

1994-11-30

1987-06-03 Application filed by Vibrac S A filed Critical Vibrac S A

1987-12-09 Publication of IE871458L publication Critical patent/IE871458L/en

1994-11-30 Publication of IE61860B1 publication Critical patent/IE61860B1/en

Links

239000011159 matrix material Substances 0.000 claims abstract description 28
229920001577 copolymer Polymers 0.000 claims abstract description 14
229920000642 polymer Polymers 0.000 claims abstract description 13
238000009792 diffusion process Methods 0.000 claims abstract description 8
239000007787 solid Substances 0.000 claims abstract description 6
239000000654 additive Substances 0.000 claims abstract description 4
239000002671 adjuvant Substances 0.000 claims abstract description 4
230000000507 anthelmentic effect Effects 0.000 claims abstract description 4
239000007788 liquid Substances 0.000 claims abstract description 4
230000000750 progressive effect Effects 0.000 claims abstract description 4
229920001169 thermoplastic Polymers 0.000 claims abstract description 4
239000004416 thermosoftening plastic Substances 0.000 claims abstract description 4
239000000463 material Substances 0.000 claims description 10
239000000843 powder Substances 0.000 claims description 6
239000004972 Polyurethane varnish Substances 0.000 claims description 5
239000002184 metal Substances 0.000 claims description 5
229910052751 metal Inorganic materials 0.000 claims description 5
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
239000003242 anti bacterial agent Substances 0.000 claims description 4
239000003822 epoxy resin Substances 0.000 claims description 4
229960001614 levamisole Drugs 0.000 claims description 4
229920000647 polyepoxide Polymers 0.000 claims description 4
239000002966 varnish Substances 0.000 claims description 4
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 3
239000005977 Ethylene Substances 0.000 claims description 3
230000002141 anti-parasite Effects 0.000 claims description 3
-1 antifungals Substances 0.000 claims description 3
239000003096 antiparasitic agent Substances 0.000 claims description 3
239000012256 powdered iron Substances 0.000 claims description 3
229920002379 silicone rubber Polymers 0.000 claims description 3
NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 claims description 2
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 2
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 2
RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 claims description 2
229960002669 albendazole Drugs 0.000 claims description 2
HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 claims description 2
229940088710 antibiotic agent Drugs 0.000 claims description 2
229940121375 antifungal agent Drugs 0.000 claims description 2
229940125687 antiparasitic agent Drugs 0.000 claims description 2
229960002418 ivermectin Drugs 0.000 claims description 2
229960003439 mebendazole Drugs 0.000 claims description 2
BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 claims description 2
229960005121 morantel Drugs 0.000 claims description 2
235000016709 nutrition Nutrition 0.000 claims description 2
BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 claims description 2
229960004454 oxfendazole Drugs 0.000 claims description 2
229960002762 oxibendazole Drugs 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
230000000069 prophylactic effect Effects 0.000 claims description 2
229960005134 pyrantel Drugs 0.000 claims description 2
YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
230000001225 therapeutic effect Effects 0.000 claims description 2
235000013343 vitamin Nutrition 0.000 claims description 2
239000011782 vitamin Substances 0.000 claims description 2
229940088594 vitamin Drugs 0.000 claims description 2
229930003231 vitamin Natural products 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims 1
235000015872 dietary supplement Nutrition 0.000 claims 1
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 1
239000008240 homogeneous mixture Substances 0.000 claims 1
238000000465 moulding Methods 0.000 claims 1
SGKGVABHDAQAJO-UHFFFAOYSA-N nitroxynil Chemical compound OC1=C(I)C=C(C#N)C=C1[N+]([O-])=O SGKGVABHDAQAJO-UHFFFAOYSA-N 0.000 claims 1
239000000047 product Substances 0.000 abstract description 5
241000283690 Bos taurus Species 0.000 abstract description 4
239000011785 micronutrient Substances 0.000 abstract description 3
235000013369 micronutrients Nutrition 0.000 abstract description 3
239000013589 supplement Substances 0.000 abstract description 2
241001465754 Metazoa Species 0.000 description 15
239000012530 fluid Substances 0.000 description 8
LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical compound Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 description 7
229960003734 levamisole hydrochloride Drugs 0.000 description 7
238000000338 in vitro Methods 0.000 description 6
239000010408 film Substances 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
230000003247 decreasing effect Effects 0.000 description 3
239000003814 drug Substances 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
238000007614 solvation Methods 0.000 description 3
239000002904 solvent Substances 0.000 description 3
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
239000000470 constituent Substances 0.000 description 2
230000001186 cumulative effect Effects 0.000 description 2
230000007423 decrease Effects 0.000 description 2
239000003651 drinking water Substances 0.000 description 2
235000020188 drinking water Nutrition 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000000034 method Methods 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
239000010409 thin film Substances 0.000 description 2
206010016717 Fistula Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
241000282849 Ruminantia Species 0.000 description 1
238000013019 agitation Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000003890 fistula Effects 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
244000144972 livestock Species 0.000 description 1
238000003754 machining Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000012255 powdered metal Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
210000004767 rumen Anatomy 0.000 description 1
239000012815 thermoplastic material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IE145887A 1986-06-09 1987-06-03 Improvement to an intraruminal delivery device IE61860B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8608268A FR2599624B2 (fr)	1986-06-09	1986-06-09	Dispositif a liberation programmee

Publications (2)

Publication Number	Publication Date
IE871458L IE871458L (en)	1987-12-09
IE61860B1 true IE61860B1 (en)	1994-11-30

Family

ID=9336128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE145887A IE61860B1 (en)	1986-06-09	1987-06-03	Improvement to an intraruminal delivery device

Country Status (6)

Country	Link
DE (1)	DE3719185A1 (fr)
FR (1)	FR2599624B2 (fr)
GB (1)	GB2191400B (fr)
IE (1)	IE61860B1 (fr)
NL (1)	NL192818C (fr)
NZ (1)	NZ220594A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8820353D0 (en) *	1988-08-26	1988-09-28	Staniforth J N	Controlled release tablet
GB9009331D0 (en) *	1990-04-26	1990-06-20	Polysystems Limited	Sustained release
CA2089371C (fr) *	1990-10-01	2001-12-25	Ashok Chandulal Shah	Composes pharmaceutiques a revetement sur le bord lateral et a liberation lente
GB2295316B (en) *	1994-11-25	1997-09-10	William Leslie Porter	Bolus for supplying biologically beneficial substances to ruminant animals

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3851648A (en) *	1973-10-11	1974-12-03	Mead Johnson & Co	Zero-order release device
IE54171B1 (en) *	1982-06-22	1989-07-05	Univ Glasgow	Device for introducing nutrients and/or therapeutic materials into ruminant animals
FR2560768A1 (fr) *	1984-03-07	1985-09-13	Crb Virbac Sa	Dispositif a liberation programmee
US4649042A (en) *	1984-05-31	1987-03-10	Eli Lilly And Company	Rumen delivery device

1986
- 1986-06-09 FR FR8608268A patent/FR2599624B2/fr not_active Expired - Lifetime
1987
- 1987-06-03 IE IE145887A patent/IE61860B1/en not_active IP Right Cessation
- 1987-06-04 GB GB8713086A patent/GB2191400B/en not_active Expired - Lifetime
- 1987-06-05 NL NL8701317A patent/NL192818C/nl not_active IP Right Cessation
- 1987-06-08 NZ NZ22059487A patent/NZ220594A/en unknown
- 1987-06-09 DE DE19873719185 patent/DE3719185A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
GB2191400A (en)	1987-12-16
NL8701317A (nl)	1988-01-04
NL192818B (nl)	1997-11-03
DE3719185A1 (de)	1987-12-10
FR2599624A2 (fr)	1987-12-11
IE871458L (en)	1987-12-09
NL192818C (nl)	1998-03-04
NZ220594A (en)	1990-04-26
FR2599624B2 (fr)	1990-06-29
GB8713086D0 (en)	1987-07-08
GB2191400B (en)	1990-04-18

Legal Events

Date	Code	Title	Description
1999-02-24	MM4A	Patent lapsed

Publication	Publication Date	Title
CA2032923C (fr)	2000-04-11	Dispositif d'administration de medicament permettant a la fois une liberation controlee a long terme de la substance medicamenteuse et l'administration d'une dose de mise en charge
US4663147A (en)	1987-05-05	Disc-like sustained release formulation
KR920014466A (ko)	1992-08-25	반추동물의 치료법으로서 또는 성장 및 먹이 이용성을 개선시키는데 적합한 활성 물질의 조절된 방출제제
US20250090292A1 (en)	2025-03-20	Drug delivery device
CA1245159A (fr)	1988-11-22	Dispositif de degagement programme et methode d'utilisation
EP2767289B1 (fr)	2020-08-05	Améliorations à la libération d'une substance bénéfique à partir d'un bolus
IE61860B1 (en)	1994-11-30	Improvement to an intraruminal delivery device
EP0588947B1 (fr)	1996-08-21	Dispositif de liberation prolongee comprenant une dose d'attaque
EP0178763A1 (fr)	1986-04-23	Pilule pour la panse
GB2376630A (en)	2002-12-24	Pulse-release bolus
US5431919A (en)	1995-07-11	Ruminal drug delivery device
AU618318B2 (en)	1991-12-19	Intraruminal drug delivery device
CA2991017C (fr)	2025-10-07	Dispositif d'administration de medicament
WO2024256811A1 (fr)	2024-12-19	Additif biocompatible non toxique comprenant de l'éther d'alkyle cellulose et de la smectite