IE780111L - Benzazepines. - Google Patents
Benzazepines.Info
- Publication number
- IE780111L IE780111L IE780111A IE11178A IE780111L IE 780111 L IE780111 L IE 780111L IE 780111 A IE780111 A IE 780111A IE 11178 A IE11178 A IE 11178A IE 780111 L IE780111 L IE 780111L
- Authority
- IE
- Ireland
- Prior art keywords
- denotes
- hydrogen
- gb1597911a
- benzazepine
- carbobenzyloxy
- Prior art date
Links
- 150000008038 benzoazepines Chemical class 0.000 title 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- XKRWPPWSJQGQOP-UHFFFAOYSA-N 5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-dione Chemical class C12=CC(=O)C(=O)C=C2CCNCC1C1=CC=CC=C1 XKRWPPWSJQGQOP-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- -1 C3-5-alkenyl Chemical group 0.000 abstract 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diones of the general formula II <IMAGE> in which R1 denotes a hydrogen atom, a C1-5-alkyl, hydroxyethyl, C3-5-alkenyl, benzyl, phenethyl, carbobenzyloxy or C1-5-alkanoyl group and R2 denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a trifluoromethyl, methyl, methoxy or hydroxyl group, and their salts with acids are useful as intermediates for the preparation of pharmacologically active compounds.
[GB1597911A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76050077A | 1977-01-19 | 1977-01-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780111L true IE780111L (en) | 1978-07-19 |
| IE46761B1 IE46761B1 (en) | 1983-09-21 |
Family
ID=25059291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE111/78A IE46761B1 (en) | 1977-01-19 | 1978-01-18 | Benzazepines |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS6040423B2 (en) |
| AU (1) | AU510459B2 (en) |
| BE (1) | BE862878A (en) |
| CA (1) | CA1090334A (en) |
| CH (2) | CH642634A5 (en) |
| DE (1) | DE2802086A1 (en) |
| DK (1) | DK19978A (en) |
| FR (2) | FR2378017A1 (en) |
| GB (2) | GB1597911A (en) |
| HU (1) | HU175836B (en) |
| IE (1) | IE46761B1 (en) |
| LU (1) | LU78873A1 (en) |
| NL (1) | NL7800637A (en) |
| SE (1) | SE437265B (en) |
| ZA (1) | ZA777444B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5481290A (en) * | 1977-11-17 | 1979-06-28 | Smithkline Corp | Benzazepin compound |
| US4171359A (en) * | 1978-04-12 | 1979-10-16 | Smithkline Corporation | Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4251525A (en) * | 1979-05-25 | 1981-02-17 | Smithkline Corporation | 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
| EP0022330B1 (en) * | 1979-07-10 | 1983-12-21 | Smithkline Beckman Corporation | Synergistic antihypertensive compositions |
| WO2005035504A2 (en) * | 2003-05-22 | 2005-04-21 | Schering Corporation | 5-h -benzo [d] naphth [2, 1-b] azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH555831A (en) * | 1967-02-17 | 1974-11-15 | Scherico Ltd | 1-Phenyl-tetrahydro-benzazepin derivs - with antibacterial, antidepressive and hypotensive activity, prepd. by ring-closure of di-(beta-phenyl) ethyl amine using dehydrating agents |
| US3609139A (en) * | 1969-04-01 | 1971-09-28 | Sandoz Ag | Substituted dibenzdiazonines |
| GB1561305A (en) * | 1975-07-02 | 1980-02-20 | Smithkline Corp | Benzazepine derivatives and pharmeceutical compositions containing them |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
-
1977
- 1977-12-14 ZA ZA00777444A patent/ZA777444B/en unknown
-
1978
- 1978-01-10 GB GB953/78A patent/GB1597911A/en not_active Expired
- 1978-01-10 GB GB20952/80A patent/GB1597912A/en not_active Expired
- 1978-01-13 BE BE184290A patent/BE862878A/en not_active IP Right Cessation
- 1978-01-13 FR FR7800998A patent/FR2378017A1/en active Granted
- 1978-01-16 LU LU78873A patent/LU78873A1/en unknown
- 1978-01-16 CA CA294,973A patent/CA1090334A/en not_active Expired
- 1978-01-16 SE SE7800455A patent/SE437265B/en not_active IP Right Cessation
- 1978-01-16 DK DK19978A patent/DK19978A/en not_active Application Discontinuation
- 1978-01-16 AU AU32465/78A patent/AU510459B2/en not_active Expired
- 1978-01-18 DE DE19782802086 patent/DE2802086A1/en not_active Withdrawn
- 1978-01-18 IE IE111/78A patent/IE46761B1/en unknown
- 1978-01-18 CH CH52578A patent/CH642634A5/en not_active IP Right Cessation
- 1978-01-18 HU HU78SI1612A patent/HU175836B/en unknown
- 1978-01-18 JP JP53004769A patent/JPS6040423B2/en not_active Expired
- 1978-01-18 NL NL7800637A patent/NL7800637A/en not_active Application Discontinuation
- 1978-06-02 FR FR7816583A patent/FR2384759A1/en active Granted
-
1982
- 1982-06-09 CH CH357382A patent/CH640228A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA777444B (en) | 1978-10-25 |
| SE437265B (en) | 1985-02-18 |
| BE862878A (en) | 1978-07-13 |
| NL7800637A (en) | 1978-07-21 |
| HU175836B (en) | 1980-10-28 |
| FR2384759B1 (en) | 1980-07-18 |
| FR2378017A1 (en) | 1978-08-18 |
| LU78873A1 (en) | 1978-06-09 |
| GB1597911A (en) | 1981-09-16 |
| FR2384759A1 (en) | 1978-10-20 |
| DK19978A (en) | 1978-07-20 |
| CH640228A5 (en) | 1983-12-30 |
| CH642634A5 (en) | 1984-04-30 |
| AU3246578A (en) | 1979-07-26 |
| JPS6040423B2 (en) | 1985-09-11 |
| CA1090334A (en) | 1980-11-25 |
| GB1597912A (en) | 1981-09-16 |
| SE7800455L (en) | 1978-07-20 |
| DE2802086A1 (en) | 1978-07-20 |
| FR2378017B1 (en) | 1981-07-10 |
| AU510459B2 (en) | 1980-06-26 |
| IE46761B1 (en) | 1983-09-21 |
| JPS5390281A (en) | 1978-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE782482L (en) | Chemical compounds | |
| IE790292L (en) | Dehydrocyclicimino acids. | |
| CA2333938A1 (en) | New 3-aryl-2-hydroxypropionic acid derivative (i) | |
| IE811250L (en) | Imidazole derivatives | |
| IE791189L (en) | Benzomorphans | |
| IE45574L (en) | Piperidyl-indole derivatives | |
| ATE18910T1 (en) | SUCCINIMIDE DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE. | |
| EP0185392A3 (en) | Novel ergolinyl compounds nitrogen-substituted in the 8-position, their preparation, and use as medicinal agents | |
| EP0716083A4 (en) | Benzazepine derivative, pharmaceutical composition containing the same, and intermediate for the same | |
| IE45631L (en) | 4-hydroxyphenylalkanolamine derivatives. | |
| IE891579L (en) | 6-phenyl-3-(piperazinylalkyl)-2,4(1h,3h)-pyrimidinedione¹derivatives, their preparation and their application in¹therapy | |
| IE790630L (en) | 2, 6-dialkoxybenzamido-pyrrolidines. | |
| AU5758694A (en) | Benzoxazine derivatives, their preparation, and their application in therapy | |
| CA2274177A1 (en) | Process for the preparation of thiazole derivatives | |
| IE45109L (en) | N-2-imidazolidinylidene-benzeneamine | |
| IE43711L (en) | N-propargyl-2-phenylamino-2-imidazolines | |
| KR930703312A (en) | Preparation method of azabicyclo [2.2.2] octane-3-imine and intermediate for preparing same | |
| IE45556L (en) | 2-[n-(cycloalkylmethyl)-n-(phenyl)-amino]-2- imidazoline¹derivatives | |
| IE790996L (en) | Phenylaminothiophene derivatives | |
| IE780198L (en) | Oxadiazolopyrimidine derivatives | |
| IE44014L (en) | Amino-benzocycloheptenes. | |
| IE780126L (en) | Thiazoloisoquinoline derivatives | |
| IE43620L (en) | N-aralkyl-2-amino-propanamides, antidepressants | |
| IE812498L (en) | Pyrimidine derivatives. | |
| IE781477L (en) | IMIDAZO £2,1-a| ISOINDOLES |