IE781013L - Pyrido-indole tranquilisers - Google Patents
Pyrido-indole tranquilisersInfo
- Publication number
- IE781013L IE781013L IE781013A IE101378A IE781013L IE 781013 L IE781013 L IE 781013L IE 781013 A IE781013 A IE 781013A IE 101378 A IE101378 A IE 101378A IE 781013 L IE781013 L IE 781013L
- Authority
- IE
- Ireland
- Prior art keywords
- pyrido
- salts
- compounds
- tranquilisers
- indole
- Prior art date
Links
- NJBMMMJOXRZENQ-UHFFFAOYSA-N 6H-pyrrolo[2,3-f]quinoline Chemical compound c1cc2ccc3[nH]cccc3c2n1 NJBMMMJOXRZENQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- CJWPRFAPIUPOSX-UHFFFAOYSA-N 5-phenyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indole Chemical class C1NCCC2C1C1=CC=CC=C1N2C1=CC=CC=C1 CJWPRFAPIUPOSX-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000698 schizophrenic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
5-Phenyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles, which are substituted in position 2, and their salts of formula I, the symbols of which are explained in Claim 1, are described. These compounds and their salts are therapeutically active and can be used as medicaments for controlling schizophrenic symptoms. The pharmaceutical compositions are also described. The new compounds and their salts can be obtained by processes which are especially distinguished from others by the formation of the substituent in position 2; the latter is obtained by processes which each contain a reduction stage, from compounds which already have the pyridoindole system. <IMAGE>
[GB1586655A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79939277A | 1977-05-23 | 1977-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE781013L true IE781013L (en) | 1978-11-23 |
| IE46975B1 IE46975B1 (en) | 1983-11-16 |
Family
ID=25175793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1013/78A IE46975B1 (en) | 1977-05-23 | 1978-05-22 | Pyrido-indole tranquilising agents |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JPS53144600A (en) |
| AR (2) | AR217688A1 (en) |
| AT (1) | AT368995B (en) |
| AU (1) | AU499618B1 (en) |
| BE (1) | BE867249A (en) |
| CA (1) | CA1094071A (en) |
| CH (1) | CH634321A5 (en) |
| CS (1) | CS207612B2 (en) |
| DD (4) | DD145536A5 (en) |
| DE (1) | DE2822465C2 (en) |
| DK (1) | DK226678A (en) |
| EG (1) | EG13590A (en) |
| FI (1) | FI63402C (en) |
| FR (1) | FR2392023A1 (en) |
| GB (1) | GB1586655A (en) |
| GR (1) | GR69985B (en) |
| HU (3) | HU188802B (en) |
| IE (1) | IE46975B1 (en) |
| IL (1) | IL54755A (en) |
| IT (1) | IT1096307B (en) |
| LU (1) | LU79684A1 (en) |
| NL (1) | NL7804210A (en) |
| NO (2) | NO150204C (en) |
| NZ (1) | NZ187333A (en) |
| PH (1) | PH13756A (en) |
| PL (5) | PL117107B1 (en) |
| PT (1) | PT68058B (en) |
| SE (2) | SE441448B (en) |
| SU (4) | SU873883A3 (en) |
| YU (4) | YU91478A (en) |
| ZA (1) | ZA782918B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224329A (en) * | 1979-01-23 | 1980-09-23 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| US4451655A (en) * | 1982-05-17 | 1984-05-29 | Pfizer Inc. | Process for preparing carboline derivatives and compounds used in their preparation |
| RU2106864C1 (en) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | New approach to treatment of alzheimer's disease |
| US6974825B1 (en) | 1996-12-20 | 2005-12-13 | Astrazeneca Canada Inc. | Compounds with analgesic effect |
| SE9604786D0 (en) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| SE9904675D0 (en) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0101769D0 (en) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101773D0 (en) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101770D0 (en) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101771D0 (en) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205452A1 (en) * | 1973-12-06 | 1976-05-07 | Endo Lab | METHOD TO PREPARE NEW TRANS-2, 3, 4, 4A, 5, 9B-HEXAHYDRO-5-PHENYL-1H-PYRID (4,3-B) INDOLES |
| JPS50126699A (en) * | 1974-03-20 | 1975-10-04 | ||
| US4001263A (en) * | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
-
1978
- 1978-03-30 SE SE7803625A patent/SE441448B/en unknown
- 1978-04-17 PH PH21013A patent/PH13756A/en unknown
- 1978-04-18 YU YU00914/78A patent/YU91478A/en unknown
- 1978-04-20 NL NL7804210A patent/NL7804210A/en not_active Application Discontinuation
- 1978-04-24 AU AU35377/78A patent/AU499618B1/en not_active Expired
- 1978-04-25 EG EG276/78A patent/EG13590A/en active
- 1978-04-28 AR AR271956A patent/AR217688A1/en active
- 1978-05-18 PL PL1978215921A patent/PL117107B1/en unknown
- 1978-05-18 SU SU782615898A patent/SU873883A3/en active
- 1978-05-18 HU HU822638A patent/HU188802B/en unknown
- 1978-05-18 PL PL1978215922A patent/PL114541B1/en unknown
- 1978-05-18 PL PL1978215923A patent/PL116944B1/en unknown
- 1978-05-18 CS CS783239A patent/CS207612B2/en unknown
- 1978-05-18 PL PL1978206903A patent/PL114547B1/en unknown
- 1978-05-18 HU HU822639A patent/HU187782B/en unknown
- 1978-05-18 GB GB20350/78A patent/GB1586655A/en not_active Expired
- 1978-05-18 HU HU78PI626A patent/HU185009B/en unknown
- 1978-05-19 CA CA303,710A patent/CA1094071A/en not_active Expired
- 1978-05-19 PT PT68058A patent/PT68058B/en unknown
- 1978-05-19 BE BE187842A patent/BE867249A/en not_active IP Right Cessation
- 1978-05-19 DD DD78215015A patent/DD145536A5/en unknown
- 1978-05-19 DD DD78205479A patent/DD138321A5/en unknown
- 1978-05-19 DD DD215016A patent/DD146186A5/en unknown
- 1978-05-19 DD DD78215017A patent/DD145537A5/en unknown
- 1978-05-20 GR GR56281A patent/GR69985B/el unknown
- 1978-05-22 NZ NZ187333A patent/NZ187333A/en unknown
- 1978-05-22 FR FR7815029A patent/FR2392023A1/en active Granted
- 1978-05-22 ZA ZA00782918A patent/ZA782918B/en unknown
- 1978-05-22 IT IT23673/78A patent/IT1096307B/en active
- 1978-05-22 FI FI781612A patent/FI63402C/en not_active IP Right Cessation
- 1978-05-22 IL IL54755A patent/IL54755A/en unknown
- 1978-05-22 AT AT0369678A patent/AT368995B/en not_active IP Right Cessation
- 1978-05-22 CH CH552678A patent/CH634321A5/en not_active IP Right Cessation
- 1978-05-22 NO NO781770A patent/NO150204C/en unknown
- 1978-05-22 JP JP6087278A patent/JPS53144600A/en active Granted
- 1978-05-22 DK DK226678A patent/DK226678A/en not_active Application Discontinuation
- 1978-05-22 LU LU79684A patent/LU79684A1/en unknown
- 1978-05-22 IE IE1013/78A patent/IE46975B1/en unknown
- 1978-05-23 DE DE2822465A patent/DE2822465C2/en not_active Expired
-
1979
- 1979-04-16 AR AR276191A patent/AR221721A1/en active
- 1979-04-24 SU SU792753359A patent/SU843749A3/en active
- 1979-04-26 SU SU792759902A patent/SU818484A3/en active
- 1979-05-18 PL PL20690379A patent/PL206903A1/en unknown
- 1979-05-18 SU SU792763595A patent/SU841589A3/en active
-
1982
- 1982-10-01 YU YU2217/82A patent/YU40796B/en unknown
- 1982-10-01 YU YU02218/82A patent/YU221882A/en unknown
- 1982-10-01 YU YU02216/82A patent/YU221682A/en unknown
-
1983
- 1983-05-20 NO NO831790A patent/NO151862C/en unknown
- 1983-10-27 SE SE8305917A patent/SE448459B/en not_active IP Right Cessation
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