IE781449L - Imidazo-isoquinoline-diones - Google Patents
Imidazo-isoquinoline-dionesInfo
- Publication number
- IE781449L IE781449L IE781449A IE144978A IE781449L IE 781449 L IE781449 L IE 781449L IE 781449 A IE781449 A IE 781449A IE 144978 A IE144978 A IE 144978A IE 781449 L IE781449 L IE 781449L
- Authority
- IE
- Ireland
- Prior art keywords
- lower alkyl
- isoquinoline
- nnr2r3
- dione
- opt
- Prior art date
Links
- SOPXGJXMCCVDIF-UHFFFAOYSA-N 1h-imidazo[4,5-h]isoquinoline-2,4-dione Chemical class C1=NC=CC2=CC(=O)C3=NC(=O)NC3=C21 SOPXGJXMCCVDIF-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- MQOZWFUSUARCHC-UHFFFAOYSA-N isoquinoline-4,6-dione Chemical compound C=1N=CC(C2=CC(C=CC12)=O)=O MQOZWFUSUARCHC-UHFFFAOYSA-N 0.000 abstract 1
- RFYWTJPUXXJSEZ-UHFFFAOYSA-N n-(4,4-dimethyl-1,3-dioxoisoquinolin-7-yl)acetamide Chemical compound O=C1NC(=O)C(C)(C)C=2C1=CC(NC(=O)C)=CC=2 RFYWTJPUXXJSEZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- -1 piperidino, morpholino Chemical group 0.000 abstract 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Imidazol 4,5-h isoquinoline-4,6-dione derivs. of formula (I) and their acid-addn. salts are new. In (I) R1 is lower alkyl, phenylalkyl, 3-6C cycloalkyl, or phenyl opt. mono- or disubstd. by halogen, OH, MeO, MeS, MeSO, MeSO2 and/or benzyloxy; A is H or (CH2)nNR2R3; R2 is H or lower alkyl and R3 is lower alkyl and R3 is lower alkyl opt. substd. by dimethoxyphenyl, or NR2R3 is piperidino, morpholino or 4-alkyl-1-piperazinyl; n=2 or 3. (I; A=H) are cardiotonic agents, hypotensives and blood platelet aggregation inhibitors; (I; A=(CH2)nNR2R3) are antiarrhythmic agents. In an example a typical cpd. (I; A=H, R1=Ph) is prepd. from 4,4-dimethyl-7-acetamido-2H,4H-isoquinoline-1,3-dione.
[DE2732951A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772732951 DE2732951A1 (en) | 1977-07-21 | 1977-07-21 | 7,7-Di:methyl-imidazo-isoquinoline-4,6-di:one derivs. - with anxiolytic and cardiovascular activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE781449L true IE781449L (en) | 1979-01-21 |
| IE46963B1 IE46963B1 (en) | 1983-11-16 |
Family
ID=6014508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1449/78A IE46963B1 (en) | 1977-07-21 | 1978-07-19 | Imidazo-isoquinoline-diones |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2732951A1 (en) |
| IE (1) | IE46963B1 (en) |
| ZA (1) | ZA784123B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3410168A1 (en) | 1984-03-20 | 1985-09-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Novel isochinoline diones, process for their preparation, medicaments containing these compounds and intermediates |
| DE3614000A1 (en) * | 1986-04-25 | 1987-10-29 | Boehringer Mannheim Gmbh | NEW ISOCHINOLINDIONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE19918211A1 (en) | 1999-04-22 | 2000-10-26 | Basf Ag | New 2-carbocyclyl-benzimidazole-carboxamide derivatives, are PARP inhibitors useful e.g. for treating neurodegenerative disease, epilepsy, ischemia, tumors, inflammation or diabetes |
| US6506769B2 (en) | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| EP1222187B1 (en) * | 1999-10-06 | 2004-09-22 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
-
1977
- 1977-07-21 DE DE19772732951 patent/DE2732951A1/en not_active Ceased
-
1978
- 1978-07-19 IE IE1449/78A patent/IE46963B1/en unknown
- 1978-07-20 ZA ZA784123A patent/ZA784123B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA784123B (en) | 1980-03-26 |
| DE2732951A1 (en) | 1979-02-08 |
| IE46963B1 (en) | 1983-11-16 |
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