IE791026L - Cephalosporin derivatives. - Google Patents
Cephalosporin derivatives.Info
- Publication number
- IE791026L IE791026L IE791026A IE102679A IE791026L IE 791026 L IE791026 L IE 791026L IE 791026 A IE791026 A IE 791026A IE 102679 A IE102679 A IE 102679A IE 791026 L IE791026 L IE 791026L
- Authority
- IE
- Ireland
- Prior art keywords
- antibiotics
- cephalosporin derivatives
- formula
- toxic
- cephalosporin
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 229940088710 antibiotic agent Drugs 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 241000588921 Enterobacteriaceae Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Cephalosporin antibiotics of general formula (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group) exhibit broad spectrum antibiotic activity, particularly high activity against members of the Enterobacteriaceae, The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I), Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics,
[CA1130279A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2291078 | 1978-05-26 | ||
| GB2291478 | 1978-05-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791026L true IE791026L (en) | 1979-11-26 |
| IE49174B1 IE49174B1 (en) | 1985-08-21 |
Family
ID=26256188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1026/79A IE49174B1 (en) | 1978-05-26 | 1979-08-08 | Cephalosporin antibiotics |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT365597B (en) |
| AU (1) | AU524692B2 (en) |
| CA (1) | CA1130279A (en) |
| CH (1) | CH646705A5 (en) |
| DE (1) | DE2921344A1 (en) |
| DK (1) | DK217079A (en) |
| ES (1) | ES480920A1 (en) |
| FR (1) | FR2426692A1 (en) |
| IE (1) | IE49174B1 (en) |
| IT (1) | IT1116187B (en) |
| NL (1) | NL7904126A (en) |
| NZ (1) | NZ190556A (en) |
| SE (1) | SE438508B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE878514A (en) * | 1978-09-04 | 1980-02-29 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY |
| US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
-
1979
- 1979-05-25 CH CH491679A patent/CH646705A5/en not_active IP Right Cessation
- 1979-05-25 AU AU47421/79A patent/AU524692B2/en not_active Ceased
- 1979-05-25 SE SE7904578A patent/SE438508B/en unknown
- 1979-05-25 IT IT49180/79A patent/IT1116187B/en active
- 1979-05-25 DK DK217079A patent/DK217079A/en not_active Application Discontinuation
- 1979-05-25 CA CA328,414A patent/CA1130279A/en not_active Expired
- 1979-05-25 DE DE19792921344 patent/DE2921344A1/en not_active Withdrawn
- 1979-05-25 ES ES480920A patent/ES480920A1/en not_active Expired
- 1979-05-25 NZ NZ190556A patent/NZ190556A/en unknown
- 1979-05-25 AT AT0383679A patent/AT365597B/en not_active IP Right Cessation
- 1979-05-25 NL NL7904126A patent/NL7904126A/en not_active Application Discontinuation
- 1979-05-28 FR FR7913526A patent/FR2426692A1/en active Granted
- 1979-08-08 IE IE1026/79A patent/IE49174B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2426692A1 (en) | 1979-12-21 |
| FR2426692B1 (en) | 1983-01-07 |
| AU4742179A (en) | 1979-11-29 |
| NL7904126A (en) | 1979-11-28 |
| AT365597B (en) | 1982-01-25 |
| AU524692B2 (en) | 1982-09-30 |
| IE49174B1 (en) | 1985-08-21 |
| ES480920A1 (en) | 1980-02-01 |
| ATA383679A (en) | 1981-06-15 |
| DE2921344A1 (en) | 1979-12-06 |
| IT7949180A0 (en) | 1979-05-25 |
| SE438508B (en) | 1985-04-22 |
| DK217079A (en) | 1979-11-27 |
| CH646705A5 (en) | 1984-12-14 |
| CA1130279A (en) | 1982-08-24 |
| SE7904578L (en) | 1979-11-27 |
| NZ190556A (en) | 1982-05-25 |
| IT1116187B (en) | 1986-02-10 |
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